Search results for ""author michael g rossmann""

About 50 publications out of more than 500 have been selected from the work of Michael Rossmann covering the years from 1958 to 2012. These include his early work with Max Perutz on hemoglobin and the first protein structures to his current work on the structures of small icosahedral and large polymorphic viruses. These papers describe not only some of the first protein and virus structures, but also the crystallographic and electron microscopic technologies. Furthermore, the author's interests include evolution and protein folding.The selected papers are a personal history of structural biology and especially of structural virology. The papers describe many of the basic techniques of structural biology such as isomorphous replacement, anomalous dispersion of X-rays, the molecular replacement method, X-ray diffraction data processing and combining crystallographic data with electron microscopic images.The book covers much of the historical development of the modern flourishing field of structural biology in terms of the authors' own contributions.

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The current book attempts to give a glimpse of the scientific life of Michael Rossmann. The book begins with his very interesting and moving autobiography. His enormous energy must have been evident already from early childhood when he and his mother had to emigrate from Nazi-Germany to England, via The Netherlands. Starting school with a new language was a challenge that he managed well with the assistance of understanding teachers. Crystallography soon became the tool to explore new worlds, unknown to everybody. With a skill for mathematics, he realized that the transform of a molecular structure in the diffraction pattern could be used for analysis of both symmetry and structural relationships. This method, molecular replacement (MR, also the initials of his name) became one of his great successes of his career. The previous book by him in this series (Selected Papers by Michael G Rossmann with Commentaries) covers his main contributions in this area.With an interest in symmetry, viruses became obvious objects to study. Rossmann attacked these monstrously large molecular assemblies with his unfailing energy and his appetite for real challenges. The amazing variation of molecular arrangements with icosahedral symmetry is truly amazing. This book includes a selection of reports of the structures of some giant viruses. As always, knowing the structure enhances the understanding of function greatly, in the case of viruses the mechanism of infection is a key problem. Rossmann has contributed many central insights in this area.Thus, this book is of interest both as an interesting personal story but also for research into viruses that repeatedly plague all living organisms on the planet, right now in the form of the corona virus pandemic.

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International Tables for Crystallography Volume F is an expert guide to macromolecular crystallography for the structural biologist. It was commissioned by the International Union of Crystallography in recognition of the extraordinary contributions that knowledge of macromolecular structure has made, and will make, to the analysis of biological systems, from enzyme catalysis to the workings of a whole cell. The volume covers all stages of a crystallographic analysis from the preparation of recombinant proteins, through crystallization, diffraction data collection, phase determination, structure validation and structure analysis. Although the volume is written for experienced scientists, it is recognized that the reader is more likely to be a biologist interested in structure than a classical crystallographer interested in biology. Thus, there are chapters on the fundamentals, history and current perspectives of macromolecular crystallography, as well as on useful programs and databases such as the Protein Data Bank. Each chapter is written by one or more internationally recognized experts. This second edition features 19 new articles and many articles from the first edition have been revised. The new articles cover topics such as standard definitions for quality indicators, expression of membrane proteins, protein engineering, high-throughput crystallography, radiation damage, merohedral twinning, low-resolution ab initio phasing, robotic crystal loading, whole-cell X-ray diffraction imaging and halogen interactions in biological crystal structures. There are also new articles on relevant software, including software for electron microscopy. These enhancements will ensure that Volume F continues to be a key reference for macromolecular crystallographers and structural biologists.More information on the series can be found at: http://it.iucr.org

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