Search results for ""Pan Stanford Publishing Pte Ltd""

Capillary electrophoresis (CE) has become an established method with widespread recognition as an analytical technique of choice in numerous analytical laboratories, including industrial and academic sectors. Pharmaceutical and biochemical research and quality control are the most important CE applications. This book provides a comparative assessment of related techniques on mode selection, method development, detection, and quantitative analysis and estimation of pharmacokinetic parameters and broadens the understanding of modern CE applications, developments, and prospects. It introduces the fundamentals of CE and clearly outlines the procedures used to mitigate several barriers, such as detection limits, signal detection, changing capillary environment, resolution separation of analytes, and hyphenation of mass spectrometry with CE, for a range of analytical problems. Each chapter outlines a specific electrophoretic variant with detailed instructions and some standard operating procedures. In this respect, the book meets its desired goal of rendering assistance to lovers of electrophoresis.

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GaN is considered the most promising material candidate in next-generation power device applications, owing to its unique material properties, for example, bandgap, high breakdown field, and high electron mobility. Therefore, GaN power device technologies are listed as the top priority to be developed in many countries, including the United States, the European Union, Japan, and China.This book presents a comprehensive overview of GaN power device technologies, for example, material growth, property analysis, device structure design, fabrication process, reliability, failure analysis, and packaging. It provides useful information to both students and researchers in academic and related industries working on GaN power devices. GaN wafer growth technology is from Enkris Semiconductor, currently one of the leading players in commercial GaN wafers. Chapters 3 and 7, on the GaN transistor fabrication process and GaN vertical power devices, are edited by Dr. Zhihong Liu, who has been working on GaN devices for more than ten years. Chapters 2 and 5, on the characteristics of polarization effects and the original demonstration of AlGaN/GaN heterojunction field-effect transistors, are written by researchers from Southwest Jiaotong University. Chapters 6, 8, and 9, on surface passivation, reliability, and package technologies, are edited by a group of researchers from the Southern University of Science and Technology of China.

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Materials with superhydrophobic or related properties are one of the most studied subjects from a theoretical point of view and also for the large range of possible applications, for example, anticorrosion, antibacteria, optical devices, and sensors. The study of natural species with special wettability has shown us the importance of surface structures and the surface energy of the resulting surface properties. Various strategies can be used to reproduce superhydrophobic phenomena in the laboratory. General reviews on superhydrophobic properties already exist but, to our knowledge, do not focus on metallic and inorganic materials. Here, we focus especially on the strategies implemented for reaching superhydrophobic or related properties using metallic and inorganic materials. Indeed, these materials present unique properties, for example, thermal and mechanical resistance, chemical and ageing resistance, and optical (transparency, antireflection, photoluminescence) and electrical properties (conducting, semiconducting, insulating). This book will be useful for graduate students of materials chemistry and physics and for researchers in surface science, nanostructures, and bioinspired or biomimetic materials.

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This book is the first in a series compiling highly cited articles in nanomedicine recently. The series is edited by Lajos P. Balogh, a prominent nanotechnology researcher and journal editor. The first book content is about nanotechnology in cancer research. It also includes a wide variety of must-know topics that will appeal to any researcher involved in nanomedicine, macromolecular science, cancer therapy, and drug delivery research. These 31 articles collected here have already acquired more than 3500 citations (i.e., over a hundred on average), highlighting the importance and recognized professional interest of the scientists working in this field.

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The rapid development of technology based on metamaterials coupled with the recent introduction of the transformation optics technique provides an unprecedented ability for device designers to manipulate and control the behavior of electromagnetic wave phenomena. Many of the early metamaterial designs, such as negative index materials and electromagnetic bandgap surfaces, were limited to operation only over a very narrow bandwidth. However, recent groundbreaking work reported by several international research groups on the development of broadband metamaterials has opened up the doors to an exciting frontier in the creation of new devices for applications ranging from radio frequencies to visible wavelengths. This book contains a collection of eight chapters that cover recent cutting-edge contributions to the theoretical, numerical, and experimental aspects of broadband metamaterials.

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Graphene has been hailed as a rising star in photonics and optoelectronics. The wonderful optical properties of graphene make possible the multiple functions of signal emission, transmission, modulation, and detection to be realized in one material. This book compiles and details cutting-edge research in graphene photonics, plasmonics, and broadband optoelectronic devices. Particularly, it emphasizes the ability to integrate graphene photonics onto the silicon platform to afford broadband operation in light routing and amplification, which involves components such as the polarizer, the modulator, and the photodetector. It also includes other functions such as a saturable absorber and an optical limiter. The book provides a comprehensive overview of the interrelationship between the operation of these conceptually new photonic devices and the fundamental physics of graphene involved in the interactions between graphene and light.

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The current state and perspectives in natural and life sciences are strongly linked to the development of novel complex organic-inorganic materials at various levels of organization, including semiconductor quantum dots (QDs) and QD-based nanostructures with unique optical and physico-chemical properties. This book provides a comprehensive description of the morphology and main physico-chemical properties of self-assembled inorganic-dye nanostructures as well as some applications in the field of nanotechnology. It crosses disciplines to examine essential nanoassembly principles of QD interaction with organic molecules, excited state dynamics in nanoobjects, theoretical models, and methodologies. Based on ensemble and single-nanoobject detection, the book quantitatively shows (for the first time on a series of nanoassemblies) that surface-mediated processes (formation of trap states) dictate the probability of several of the most interesting and potentially useful photophysical phenomena (FRET- or non-FRET-induced quenching of QD photoluminescence) observed for colloidal QDs and QD–dye nanoassemblies. Further, nanostructures can be generated by nanolithography and thereafter selectively decorated with dye molecules. A similar approach applies to natural nanosized surface heterogeneities.

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Over the past decade, fluorine (19F) magnetic resonance imaging (MRI) has garnered significant scientific interest in the biomedical research community owing to the unique properties of fluorinated materials and the 19F nucleus. Fluorine has an intrinsically sensitive nucleus for MRI. There is negligible endogenous 19F in the body and thus there is no background signal. Fluorine-containing compounds are ideal tracer labels for a wide variety of MRI applications. Moreover, the chemical shift and nuclear relaxation rate can be made responsive to physiology via creative molecular design. This book is an interdisciplinary compendium that details cutting-edge science and medical research in the emerging field of 19F MRI. Edited by Ulrich Flögel and Eric Ahrens, two prominent MRI researchers, this book will appeal to investigators involved in MRI, biomedicine, immunology, pharmacology, probe chemistry, and imaging physics.

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Plasmonic resonators, composed of metallic micro- and nanostructures, belong to the category of excited-state physics on resonances from gigahertz to petahertz. Dynamical physics is in contrast to ground-state physics, which includes thermal states, and is connected to diverse applications to enhance existing photo-induced effects and phenomena such as plasmon-enhanced photoluminescence and Raman scattering. This book has three main aims: to provide fundamental knowledge on plasmonic resonators, to explain diverse plasmonic resonators, and to stimulate further development in plasmonic resonators. Plasmon-related studies, which are sometimes called plasmonics and include a substantial portion of metamaterials, have shown significant development since the 1980s. The piled-up results are too numerous to study from the beginning, but this book summarizes those results, including the history (past), all the possible types of plasmonic resonators (present), and their wide range of applications (future). It provides the basics of plasmons and resonant physics for undergraduate students, the systematic knowledge on plasmonic resonators for graduate students, and cutting-edge and in-depth information on plasmon-enhancement studies for researchers who are not experts in plasmonics and metamaterials, thereby benefitting a wide range of readers who are interested in the nanotechnology involving metallic nanostructures.

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In the recent decades, laser cooling or optical refrigeration—a physical process by which a system loses its thermal energy as a result of interaction with laser light—has garnered a great deal of scientific interest due to the importance of its applications. Optical solid-state coolers are one such application. They are free from liquids as well as moving parts that generate vibrations and introduce noise to sensors and other devices. They are based on reliable laser diode pump systems. Laser cooling can also be used to mitigate heat generation in high-power lasers.This book compiles and details cutting-edge research in laser cooling done by various scientific teams all over the world that are currently revolutionizing optical refrigerating technology. It includes recent results on laser cooling by redistribution of radiation in dense gas mixtures, three conceptually different approaches to laser cooling of solids such as cooling with anti-Stokes fluorescence, Brillouin cooling, and Raman cooling. It also discusses crystal growth and glass production for laser cooling applications. This book will appeal to anyone involved in laser physics, solid-state physics, low-temperature physics or cryogenics, materials research, development of temperature sensors, or infrared detectors.

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This handbook (55 chapters) provides a comprehensive roadmap of basic research in nanomedicine as well as clinical applications. However, unlike other texts in nanomedicine, it not only highlights current advances in diagnostics and therapeutics but also explores related issues like nomenclature, historical developments, regulatory aspects, nanosimilars and 3D nanofabrication. While bridging the gap between basic biomedical research, engineering, medicine and law, the handbook provides a thorough understanding of nano’s potential to address (i) medical problems from both the patient and health provider's perspective, and (ii) current applications and their potential in a healthcare setting.

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Thanks to the pioneering works of Ashkin and coworkers, optical tweezers (OTs) have become an invaluable tool for myriad studies throughout the natural sciences. Their success relies on the fact that they can be considered as exceptionally sensitive transducers that are able to resolve pN forces and nm displacements, with high temporal resolution, down to μs. Hence their application to study a wide range of biological phenomena such as measuring the compliance of bacterial tails, the forces exerted by a single motor protein, and the mechanical properties of human red blood cells and of individual biological molecules. The number of articles related to them totals to a whopping 58,000 (source Google Scholar)!Microrheology is a branch of rheology, but it works at micrometer length scales and with microliter sample volumes. Therefore, microrheology techniques have been revealed to be very useful tools for all those rheological/mechanical studies where rare or precious materials are employed, such as in biological and biomedical studies.The aim of this book is to provide a pedagogical introduction to the physics principles governing both the optical tweezers and their application in the field of microrheology of complex materials. This is achieved by following a linear path that starts from a narrative introduction of the "nature of light," followed by a rigorous description of the fundamental equations governing the propagation of light through matter. Moreover, some of the many possible instrumental configurations are presented, especially those that better adapt to perform microrheology measurements. In order to better appreciate the microrheological methods with optical tweezers explored in this book, informative introductions to the basic concepts of linear rheology, statistical mechanics, and the most popular microrheology techniques are also given. Furthermore, an enlightening prologue to the general applications of optical tweezers different from rheological purposes is provided at the end of the book.

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Full-field optical coherence microscopy (FF-OCM) is an imaging technique that provides cross-sectional views of the subsurface microstructure of semitransparent objects. The technology is based on low-coherence interference microscopy, which uses an area camera for en face imaging of the full-field illuminated object. FF-OCM benefits from the lateral imaging resolution of optical microscopy along with the capacity of optical axial sectioning at micrometer-scale resolution. The technique can be employed in diverse applications, in particular for non-invasive examination of biological tissues.This handbook is the first to be entirely devoted to FF-OCM. It is organized into four parts with a total of 21 chapters written by recognized experts and major contributors to the field. After a general introduction to FF-OCM, the fundamental characteristics of the technology are analyzed and discussed theoretically. The main technological developments of FF-OCM for improving the image acquisition speed and for endoscopic imaging are presented in part II. Extensions of FF-OCM for image contrast enhancement or functional imaging are reported in part III. The last part of the book provides an overview of possible applications of FF-OCM in medicine, biology, and materials science.A comprehensive compilation of self-contained chapters written by leading experts, this handbook is a definitive guide to the theoretical analyses, technological developments, and applications of FF-OCM. Using the rich information the book is replete with, a wide range of readers, from scientists and physicists to engineers as well as clinicians and biomedical researchers, can get a handle on the latest major advances in FF-OCM.

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Biomaterials research requires the union of materials scientists, engineers, biologists, biomedical doctors, and surgeons. Societal implications have invoked tremendous interest in this area of research in recent years. What started as a search for strong and durable implant materials has now led to path-breaking developments in tissue engineering, targeted drug delivery, and tissue scaffolds. Viable applications of mesoporous structures, polymer biocomposites, and fibers (synthetic and natural) in the areas of clinical orthopedics, controlled drug delivery, tissue engineering, orthodontics, etc., have emerged as relatively recent concepts. This book presents recent results related to both materials aspects and implant issues. The focus is on structural, magnetic, antibacterial, bioactivity/compatibility, mechanical, and other related properties and the implication of these results on biomedical applications. The book discusses technical problems faced by the surgeon during implant fixation in total hip replacement and the selection of materials based on the patient’s requirement. It also addresses recent advances in implant materials, including the reinforcement and biocompatibility issues.

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Nanobiophysics is a new branch of science that operates at the interface of physics, biology, chemistry, material science, nanotechnology, and medicine. This book is the first one devoted to nanobiophysics and introduces this field with a focus on some selected topics related to the physics of biomolecular nanosystems, including nucleosomal DNA and model lipid membranes, nanobiohybrids involving DNA/RNA and single-walled carbon nanotubes, biomolecules deposited on nanoparticles, and nanostructured surfaces. It describes unique experimental physical methods that are used to study nanosized biostructures. It outlines the applied aspects of nanobiophysics, considering the state of art in the fabrication of two types of sensors: gas sensors, with a focus on breath gas detection, and nanophotonic sensors, with a focus on polycyclic aromatic hydrocarbon detection in water samples. It also covers the development of nanoscale scaffolds for delivery of therapeutic nucleic acids to cells, which is an important example of the possible application of nanobiophysics researches in nanomedicine.

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As computational hardware continues to develop at a rapid pace, quantitative computations are playing an increasingly essential role in the study of biomolecular systems. One of the most important challenges that the field faces is to develop the next generation of computational models that strike the proper balance of computational efficiency and accuracy, so that the problems of increasing complexity can be tackled in a systematic and physically robust manner. In particular, properly treating intermolecular interactions is fundamentally important for the reliability of all computational models. In this book, contributions by leading experts in the area of biomolecular simulations discuss cutting-edge ideas regarding effective strategies to describe many-body effects and electrostatics at quantum, classical, and coarse-grained levels. The goal of the book is to not only provide an up-to-date snapshot of the current simulation field but also stimulate exchange of ideas across different sub-fields of modern computational (bio)chemistry. The text will be a useful reference for the biomolecular simulation community and help attract talented young students into this exciting frontier of research.

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Microelectromechanical systems (MEMS)-based sensors and actuators have become remarkably popular in the past few decades. Rapid advances have taken place in terms of both technologies and techniques of fabrication of MEMS structures. Wet chemical–based silicon bulk micromachining continues to be a widely used technique for the fabrication of microstructures used in MEMS devices. Researchers all over the world have contributed significantly to the advancement of wet chemical–based micromachining, from understanding the etching mechanism to exploring its application to the fabrication of simple to complex MEMS structures. In addition to its various benefits, one of the unique features of wet chemical–based bulk micromachining is the ability to fabricate slanted sidewalls, such as 45° walls as micromirrors, as well as freestanding structures, such as cantilevers and diaphragms. This makes wet bulk micromachining necessary for the fabrication of structures for myriad applications.This book provides a comprehensive understating of wet bulk micromachining for the fabrication of simple to advanced microstructures for various applications in MEMS. It includes introductory to advanced concepts and covers research on basic and advanced topics on wet chemical–based silicon bulk micromachining. The book thus serves as an introductory textbook for undergraduate- and graduate-level students of physics, chemistry, electrical and electronic engineering, materials science, and engineering, as well as a comprehensive reference for researchers working or aspiring to work in the area of MEMS and for engineers working in microfabrication technology.

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Protein-mediated charge transport is of relevant importance in the design of protein-based electronics and in attaining an adequate level of understanding of protein functioning. This book reviews a variety of experiments devoted to the investigation of charge transport in proteins and presents a unified theoretical model to interpret macroscopic results in terms of the amino acids backbone-structure of the single protein. It aims to serve a broad audience of researchers involved in the field of electrical characterization of biological materials and in the development of new molecular devices based on proteins and also as a reference platform that surveys existing data and presents the basis for future development of a new branch of nano-electronics, which by mixing proteomics, that is, the large-scale study of proteins, particularly their structures and functions, and electronics is introduced here as proteotronics.

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In the area of controlled release of active substances, such as drugs, a strong interest in nanoparticles as carriers of active ingredients has arisen. Some of the active components are extremely hydrophobic, without cellular permeability and susceptible to metabolic degradation. Owing to this, their use is limited. This kind of agent can be transported without any problem through physiological media by using nanoparticles. The size of particles is an important parameter because it governs the efficiency of the delivery system. For this type of application, particles that have a diameter smaller than 1 μm are especially useful. Polymeric nanoparticles that have diameters in the colloidal range are produced by means of polymerization processes in dispersed media. Drugs are taken up into the nanoparticles by adsorption, absorption, or “entrapment," or covalent bonding and they are delivered (release) by desorption, diffusion, polymer degradation, or a combination of these mechanisms. Nanoparticles (including nanogels) that release their contents by external triggering open up new possibilities for therapeutic strategies. External triggering by light, heat, change in pH, or application of ultrasound opens up the possibility to release the material on demand. If only a part of the wall of the nanoparticle (nanocapsule) is responsive, we are dealing with the so-called nanobottles, a nanocontainer with the active substance and a lid on the container that can be "opened" and "closed" by external triggering. This book focuses on responsive nanoparticles and brings together two interesting areas: nanoparticles and responsive polymers. The concept of the book is that of a systematic approach from nanoparticles synthesis via responsive polymers to nanobottles. The second part of the book presents contributions from experts in the field and provides a state-of-the-art overview of the field.

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This book focuses on polymer–clay nanocomposite materials. It introduces readers to polymers, clays, and organo-clay and discusses the nature of interparticle interactions and physical adsorption, which are predominant in the synthesis of organo-clay; conversion of clay to organo-clay; interactions between functional groups in the interlayer region of clay and modifier ions; synthesis of organo-clays and their uses; and the commercial utilization of organo-clays. The text then covers the preparation of polymer–clay nanocomposites and their characterization, properties, performance, and applications.The primary goal of this book is to aid readers who wish to engage in the research and development of polymer–clay nanocomposites and to offer them an overview of the commonly used polymer–clay nanocomposites and their origins, manufacture, properties, and potential applications. This book will serve as a general introduction to researchers just entering the field and as a useful reference for scholars from other subfields.

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Through natural evolvement in thousands of years, biosurfaces have become highly adaptable to display their biological functions perfectly. Interestingly, they have developed micro-/nanostructures with gradient features to achieve smart wetting controls, such as ultra-hydrophobic water repellency in lotus leaf, directional water collection in wetted spider silk, directional adhesion in superhydrophobic butterfly wing, and fog-collecting hydrophobic/hydrophilic pattern on beetle back. These surfaces provide endless inspiration for the design and fabrication of functional interface materials with unique wettability, generating promising applications such as micro-fluidic devices, functional textiles, corrosion resistance, liquid transportation, antifogging, and water-collecting devices. In recent years there has been an exciting confluence of research areas of physics, chemistry, biology, and materials science to develop functional micro- and nanosurfaces. A kernel consists of organic materials with high/low surface energy and regular/irregular order/disorder, which can be rough/smooth and endlessly arranged and combined with various styles of micro- and nanostructures. This book introduces recent research on wettability of biological and bio-inspired surfaces. It discusses the mechanism of smart wetting controls, such as water collection/repellency on biological micro-/nanostructure gradient interfaces. It suggests ways to mimic these biological features to realize bio-inspired functional surfaces with unique wettability. The book will help researchers innovate designs with novel materials for future scientific works.

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Crystalline semiconductors in the form of thin films are crucial materials for many modern, advanced technologies in fields such as microelectronics, optoelectronics, display technology, and photovoltaic technology. Crystalline semiconductors can be produced at surprisingly low temperatures (as low as 120 ˚C) by crystallization of amorphous semiconductors, which are put in contact with a metal. This so-called metal-induced crystallization process has attracted great scientific and technological interest because it allows the production of crystalline semiconductor-based advanced devices at very low temperatures, for example, directly on low-cost (but often heat-sensitive) substrates.This book provides the first comprehensive and in-depth overview of the current fundamental understanding of the metal-induced crystallization process and further elucidates how to employ this process in different technologies, for example, in thin-film solar cells and display technologies. It aims to give the reader a comprehensive perspective of the metal-induced crystallization process and thereby stimulate the development of novel crystalline semiconductor-based technologies.

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The rapidly evolving field of nanomedicine refers to the clinical application of nanotechnologies. However, as with all new technologies, there are ethical, safety, and regulatory issues. This handbook, written by leading international experts, provides a meticulous overview of the state of the art of safety assessment of nanomaterials (nanotoxicology) in the context of their application in nanomedicine. The volume includes a historical perspective on the development of nanomedicine and its regulation, and a personal view of the future of (nano)medicine by Patrick Hunziker, president of the European Society of Nanomedicine. Ethical considerations in relation to nanomedicine are discussed. There are a series of chapters on organ-specific toxicities of nanomaterials, including pulmonary and cardiovascular toxicity, neurotoxicity, dermatotoxicity, and reproductive toxicity, as well as a discussion on immunotoxicity and genotoxicity. The importance of a thorough characterization of physicochemical properties of nanomaterials is emphasized. The handbook also contains a critical discussion on the applicability of in vitro versus in vivo methods and models for nanosafety assessment, along with an introduction to mathematical modeling approaches with a view to a predictive toxicology of nanomaterials. The overall aim is to provide a comprehensive, science-based framework for safety assessment of current and future nanomedicines.

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An optical cavity confines light within its structure and constitutes an integral part of a laser device. Unlike traditional gas lasers, semiconductor lasers are invariably much smaller in dimensions, making optical confinement more critical than ever. In this book, modern methods that control and manipulate light at the micrometer and nanometer scales by using a variety of cavity geometries and demonstrate optical resonance from ultra-violet (UV) to infra-red (IR) bands across multiple material platforms are explored.The book has a comprehensive collection of chapters that cover a wide range of topics pertaining to resonance in optical cavities and are contributed by leading researchers in the field. The topics include theory, design, simulation, fabrication, and characterization of micrometer- and nanometer-scale structures and devices that support cavity resonance via various mechanisms such as Fabry–Pérot, whispering gallery, photonic bandgap, and plasmonic modes. The chapters discuss optical cavities that resonate from UV to IR wavelengths and are based on prominent III-V material systems, including Al, In, and Ga nitrides, ZnO, and GaAs.

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After a brief introduction to the fundamental properties of graphene, this book focuses on synthesis, characterization and application of various types of two-dimensional (2D) nanocarbons ranging from single/few layer graphene to carbon nanowalls and graphene oxides. Three major synthesis techniques are covered: epitaxial growth of graphene on SiC, chemical synthesis of graphene on metal, and chemical vapor deposition of vertically aligned carbon nanosheets or nanowalls. One chapter is dedicated to characterization of 2D nanocarbon using Raman spectroscopy. It provides extensive coverage for applications of 2D carbon in energy storage including supercapacitor, lithium ion battery and fuel cells.

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The impending energy crisis brought on by the running out of finite and non-homogenously distributed fossil fuel reserves and the worldwide increase in energy demand has prompted vast research in the development of sustainable energy technologies in the last few decades. However, the efficiency of most of these new technologies is relatively small and therefore it needs to be increased to eventually replace conventional technologies based on fossil fuels. The required efficiency increase primarily relies on the ability to improve the performance of the functional materials which are at the heart of these technologies. The purpose of this book is to give a unified and comprehensive presentation of the fundamentals and the use and design of novel materials for efficient sustainable energy applications, such as conversion, storage, transmission, and consumption. The book presents general coverage of the use and design of advanced materials for sustainable energy applications. Thus, the book addresses all the relevant aspects, such as materials for energy conversion, storage, transmission, and consumption.

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Recent developments in atomic force microscopy (AFM) have been accomplished through various technical and instrumental innovations, including high-resolution and recognition imaging technology under physiological conditions, fast-scanning AFM, and general methods for cantilever modification and force measurement. All these techniques are now highly powerful not only in material sciences but also in basic biological sciences. There are many nanotechnology books that focus on materials, instruments, and applications in engineering and medicine, but only a few of them are directed toward basic biological sciences. This book tries to bridge this gap.Edited by a prominent researcher, this volume provides an overview of modern AFM technologies: the basic AFM protocols in Part I, newly developed technologies in Part II, and the most recent applications of AFM technologies in biological sciences in Parts III and IV. The chapters are contributed by some of the leading scientists in the field of nanobiology.

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Successful biofunctional surface engineering will determine the future of medical devices such as orthopedic implants, stents, catheters, vaccine scaffolds, wound dressings, and extracorporeal circulation devices. Moreover, the biosensor and diagnostic chip technology will evolve rapidly due to the growing medical need for personalized medicine. A major drawback in these technologies is the need for terminally sterilized products. However, novel and safe technologies, including coupling, stabilization, and protection of effector molecules, enable terminal sterilization without functional loss. This book provides a comprehensive overview on the state of the art and the future of biofunctional surface engineering and is of major interest for those working in the fields of medicine and medical devices.

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Since four decades, rapid detection and monitoring in clinical and food diagnostics and in environmental and biodefense have paved the way for the elaboration of electrochemical biosensors. Thanks to their adaptability, ease of use in relatively complex samples, and their portability, electrochemical biosensors now are one of the mainstays of analytical chemistry. In particular, electrochemistry has played a pivotal role in the development of transduction methods for biological processes and biosensors. In parallel, the explosion of activity in nanoscience and nanotechnology and their huge success have profoundly affected biosensor technology, opening new avenues of research for electrode materials and transduction.This book provides an overview of biosensors based on amperometry, conductimetry, potentiometry, square-wave voltammetry, impedance, and electrochemiluminescence and describes the use of ultramicroelectrodes for the real-time monitoring and understanding of exocytosis. Areas of particular interest are the use of silver and gold nanoparticles for signal amplification, photocurrent transduction, and aptamer design. Moreover, advanced insights in the innovative concept of self-powered biosensors derived from biofuel cells are also discussed.

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This book focuses on applications of compound library design and virtual screening to expand the bioactive chemical space, to target hopping of chemotypes to identify synergies within related drug discovery projects or to repurpose known drugs, to propose mechanism of action of compounds, or to identify off-target effects by cross-reactivity analysis. Both ligand-based and structure-based in silico approaches, as reviewed in this book, play important roles for all these applications. Computational chemogenomics is expected to increase the quality and productivity of drug discovery and lead to the discovery of new medicines.

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A comprehensive overview of detonation nanodiamond particles produced by detonation of carbon-containing explosives, this book discusses the technology of synthesis and the effect of various technological parameters on the structure and physicochemical properties of nanodiamonds. It explores the possibilities of targeted chemical modification of the surface, describes methods of structural modification of nanodiamonds aimed at obtaining nanographite, analyzes the various methods employed in studies of nanodiamonds as a carbon nanostructure, and suggests and explores at length the potential of nanodiamond application in technology and medicine.

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This book comprehensively reviews the considerations of nanotechnology elaborated in philosophy, ethics, and the social sciences and systematizes and develops them further. It focuses on the issues of ethical responsibility regarding chances and risks of nanotechnology and its possible applications in the fields of synthetic nanoparticles, synthetic biology, animal enhancement, and human enhancement. The book has been, thus, put in the context of the keywords "responsible innovation" and "reflective sciences," which have been central concepts in the debates about the relationship between science and society for the last few years.

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Molecular imprinting focuses on the fabrication of an artificial receptor with perfect molecular recognition abilities. It has attracted a great deal of scientific attention because of the enormous opportunities it opens in the fields of separation, catalysis, and analysis. The advantages of the molecular imprinting enable to target a wide class of substances ranging from small molecules to big conglomerates, such as proteins or even cells. In recent years, sensor applications based on molecular imprinting have started to attract greater attention because of the easy creation of robust receptor sites with high specificity and sensitivity toward a target compound.A collection of contributions from distinguised experts, Handbook of Molecular Imprinting: Advanced Sensor Applications provides a comprehensive overview on the specific challenges of molecular imprinting in sensor applications. It covers various molecular imprinting approaches. As a result, a perspective of future device ensembles for sensing is acquired. The text lays particular emphasis on fundamental aspects as well as novel ideas in the context of sensor applications. It also highlights the operation principles of various sensor transducers that are generally employed in combination with molecular imprinting recognition elements.

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This book focuses on the fundamental concepts and physical and chemical aspects of pulsed laser ablation of solid targets in liquid environments and its applications in the preparation of nanomaterials and fabrication of nanostructures. The areas of focus include basic thermodynamic and kinetic processes of laser ablation in liquids, and its applications in metal and metal oxides nanocrystals synthesis and semiconductor nanostructures fabrication. The book comprises theoretical and experimental analysis of laser ablation in liquids, research methods, and preparation techniques.

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Emulation is a hybrid experimentation technique intended to bridge the gap between simulation and real-world testing. The key idea of emulation is to reproduce in real time and in a controlled manner the essential functionality of a system, so that it can interact with other real systems that can thus be evaluated. This book describes the technique of network emulation and compares it with the other experimental approaches: the scholarly analytical modeling, the popular network simulation, and the demanding real-world testing. To emphasize the practical aspects related to emulation, this book presents a large number of examples of network emulators on the market, as well as provides an in-depth analysis of a case study, the wireless network emulation testbed called QOMB.

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This book introduces readers to the structure and characteristics of nanomaterials and their applications in dentistry. With currently available implant materials, the clinical failure rate varies from a few percent to over 10 percent and new materials are clearly needed. Nanomaterials offer the promise of higher strength, better bonding, less toxicity, and enhanced cytocompatibility, leading to increased tissue regeneration. Mieczyslaw Jurczyk, director of the Institute of Materials Science and Engineering at the Poznan University of Technology in Poland, has drawn from work in his laboratory and elsewhere in Poland to show that nanomaterials have important biological applications including in the stomatognathic system consisting of mouth, jaws, and associated structures. The book is written from a materials science and medical point of view and has 13 chapters and about 400 pages. The book can be divided approximately into three sections: the first five chapters introduce nanobiomaterials, the next five chapters describe their dental applications, and the last chapters describe their biocompatibility. Chapter 3 is a compendium on metallic biomaterials such as stainless steel, cobalt alloys, and titanium alloys; bioactive, bioresorbable polymers; and composites and ceramic biomaterials. The "top-down" approach to producing nanomaterials such as high-energy ballmilling and severe plastic deformation, as well as Feynman’s "bottom-up technique" of building atom by atom, are discussed in the next chapter. Subsequent chapters discuss each material in depth and point out how new architectures and properties emerge at the nanoscale.Chapter 8 is devoted to shape-memory materials, which now include not only NiTi but also polymers and magnetic materials. In order to improve bonding, nanomaterials can be used to synthesize implants with surface roughness similar to that of natural tissues. Chapter 9 is devoted to different surface treatments for Ti-based nanomaterials, such as anodic oxidation to improve the bioactivity of titanium and improve the corrosion resistance of porous titanium and its alloys. The use of carbon in various forms—nanoparticles, nanofibers, nanotubes, and thin films—is discussed next with emphasis on the microstructure and properties of these materials, their implant applications, and their interaction with subcutaneous tissues. Nanomaterials can be used in preventive dentistry and therefore can reduce the amount of dental treatment that is necessary to maintain a healthy mouth as argued in chapter 11. In a subsequent chapter, the author explains osseointegration (direct bone-to-metal interface) from a biological point of view and early tissue response. The mechanism of the interaction between the implanted materials with the cellular protein in the tissues is described. The last chapter discusses the application of new nanostructured materials in permanent and bioresorbable implants, nanosurface dental implants, and nanostructured dental composite restorative materials. This book not only focuses on nanomaterials but also on nanoengineering to achieve the best results in dentistry. It is recommended to anyone interested in nanomaterials and their applications in dental science. People with a background in materials, chemistry, physics, and biology will benefit from it.

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The book comes in three parts: "The Rising Sun in a Developing World", "Solar Power for the World" and "PV Today and Forever". It provides a historical summary and gives a comprehensive overview of the present photovoltaic (PV) situation worldwide and future strategies for development and implementation. The author is a world leader in PV and all renewable energies.The book is illustrated with about 100 pictures.

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This book focuses on the various functional properties and potential applications of one-dimensional ZnO nanostructures, from basic principles to our most recent discoveries. It comprises experimental analysis of various properties of ZnO nanostructures, preparation techniques, research methods, and some promising applications. The areas of focus include ZnO-based gas/biochemical sensing devices, field emitters, solar cells, light-emitting diodes, e-papers, and single-nanowire-based transistors.

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Nanoplasmonics is one of the most important growth areas of this century. It is part of nano-optics and nanophotonics and deals with oscillations of electrons in metallic nanoparticles and nanostructures. Also, it is a multidisciplinary subject covering atomic, molecular, and solid-state physics, as well as much of chemistry. Nanoplasmonics makes it possible to combine the nanoscale properties of smart devices with their optical frequencies of operation.Nanoplasmonics presents, for the first time, both the physical principles and mathematical descriptions of main nanoplasmonic effects that now are scattered over thousands of research articles. Importantly, it contains many methods, accompanied by diagrams, for fast estimations and calculations of main properties of nanoparticles of very different shapes and their clusters. It also presents the most important applications of nanoplasmonics, including in medicine, nanolasers, electronics, perfect lenses, and invisibility cloaks.

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This book serves as a guide for practicing engineers, researchers, and students interested in MEMS devices that use biomaterials and biomedical applications. It is also suitable for engineers and researchers interested in MEMS and its applications but who do not have the necessary background in biomaterials.Biomaterials for MEMS highlights important features and issues of biomaterials that have been used in MEMS and biomedical areas. Hence this book is an essential guide for MEMS engineers or researchers who are trained in engineering institutes that do not provide the background or knowledge in biomaterials. The topics include fabrication of devices using biomaterials; biocompatible coatings and issues; thin-film biomaterials and MEMS for tissue engineering; and applications involving MEMS and biomaterials.

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Consisting of ten chapters written by some of the world’s leaders in the field, this book combines experimental, theoretical and numerical studies of current-driven phenomena in the nanoscale. The topics covered range from single-molecule, site-specific nanochemistry induced by a scanning tunneling microscope, through inelastic tunneling spectroscopy and current-induced heating, to current-triggered molecular machines. The various chapters focus on experimental and numerical method development, the description of specific systems, and new ideas and novel phenomena.

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This book on nanodiamonds is the first of its kind. Nanodiamonds are indispensable for polishing industrial materials (e.g., computer hard drives and read heads) and advanced ceramics (e.g., silicon carbide and gem diamond). The book is valuable for those dealing with nanodiamonds as well as for those interested in a general education of nanosize materials.

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Over the past decade biophotonics has appeared as a new department within the academic structure across the globe. With experimental work going back for more than a century, application of the scientific method has shown the importance of biophotonics within biological and medical practice. At the same time, a new mathematical description of physics and biophysics has emerged. Self-Field Theory (SFT) describes the role of photon as a binding agent between an electron and a proton within atomic structures. SFT is being rapidly accepted by the physics community as a distinct physical theory. This is now an alternative view, in addition to classical electromagnetics and the quantum theories, that forms the basis of a chemical bond. Atomic chemistry underpins biochemistry, the pharmaceutical approach to medical therapy, and has been a staple of biological and medical knowledge over the 20th century. The biophoton within SFT provides another layer of structural organization that sits underneath atomic chemistry. This book is the first to describe SFTs role within biophotonics and as such provides a theory of biophotonics capable of describing a wide range of experimental biophotonic phenomena. Inside the Photon: A Journey towards Health describes the newly discovered layer of biophotonics underlying all atomic chemistry and biochemistry. As with the variety of snowflakes, the range in biological species within flora for instance is dependent on this biophotonic layer of interaction within atomic and biomolecular structures. A new range of energies that can be balanced only within the biophotonic states are responsible for these innumerable varieties of biological species. The phonon, the quantum of acoustic, or vibrational, energy is also described and given status alongside the photon. Hence the ‘biophonon’ sits aside the biophoton as an element within biological structures. Sounds can create structure in the same way biophotons can use structure to communicate. Therapies such as homeopathy, acupuncture, traditional Chinese medicines are given fresh impetus including putative understanding of mechanism. Mitosis is understood via the cell cycle and how electric, acoustic, and magnetic fields can induce changes at the biophotonic level. The possibility arises of medical therapy without invasive surgery and without the side effects of drug-based therapies.

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This book is a guide for users of new technologies, as it includes accurately proven protocols, allowing readers to prepare their samples for experiments. Additionally, it is a guide for the bioinformatics tools that are available for the analysis of the obtained tags, including the design of the software, the sources and the Web. Finally, the book provides examples of the application of these technologies to identify promoters, annotate genomes, identify new RNAs and reconstruct models of transcriptional control. Although examples mainly concern mammalians, the discussion expands to other groups of eukaryotes, where these approaches are complementing genome sequencing.

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This book provides a comprehensive overview of the chalcogenide glass science and various applications based on the glasses. It starts with a review on the glass-forming ability of various systems, followed by a discussion on the structural and physical properties of various chalcolgenide glasses and their application in integrated optics. The chapters have been contributed by prominent experts from all over the world, and therefore, the book presents the recent research advances in the area. This book will appeal to anyone who is involved in glass science and technology and glass application.

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The inclusion of qualitative social data into global environmental and economic input-output (IO) models remained illusive for many years. It was not until around 2013 that researchers found ways to include data, for example, on poverty, inequality, and worker safety, into IO models capable of tracing global supply chains. The sustainable development goals have now propelled this work onto the world stage with some urgency. They have shone a spotlight onto social conditions around the world and brought global trade into the frame for its ability to influence social conditions for good or ill.This book provides a compilation of groundbreaking work on social indicators from the most prominent IO research groups from a wide range of academic backgrounds and from around the world. In addition, it frames this work in the real world of politics, human rights, and business, bringing together a multidisciplinary team to demonstrate the power of IO to illuminate some of the world’s most pressing problems. Edited by well-known researchers in the area, Joy Murray, Arunima Malik, and Arne Geschke, the book is designed to appeal to a broad academic and business audience. While many chapters include technical details and references for follow-up reading, it is possible to omit those sections and yet gain a deep appreciation of the power of IO to address seemingly intractable problems.

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This book focuses on the conventional and emerging applications of radiations, which include radio waves and ultraviolet and gamma radiations. It discusses new techniques in radiation therapy and the effects of ionizing radiations on biological systems. The applications of radiations in the synthesis and use of nanoparticles along with the effects of hypergravity indicate a new trend. The book offers a concise account of the latest studies carried out so far and shows the new initiatives to be undertaken in the field of medicine and biology. It covers the medical use of radiations, such as ferrous sulfate–benzoic acid–xylenol orange dosimetry, Co-60 tomotherapy, radio-electro-chemotherapy, and fractional radiotherapy, and radiobiological effects, such as the effects of cell phone radiations on human health parameters and the combined effects of radiations and hypergravity on plants.

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This is the first textbook dedicated to CEST imaging and covers the fundamental principles of saturation transfer, key features of CEST agents that enable the production of imaging contrast, and practical aspects of preparing image-acquisition and post-processing schemes suited for in vivo applications. CEST is a powerful MRI contrast mechanism with unique features, and the rapid expansion it has seen over the past 15 years since its original discovery in 2000 has created a need for a graduate-level handbook describing all aspects of pre-clinical, translational, and clinical CEST imaging. The book provides an illustrated historical perspective by leaders at the five key sites who developed CEST imaging, from the initial saturation transfer NMR experiments performed in the 1960s in Stockholm, Sweden, described by Sture Forsén, to the work on integrating the basic principles of CEST into imaging by Robert Balaban, Dean Sherry, Silvio Aime, and Peter van Zijl in the United States and Italy.The editors, Drs. Michael T. McMahon, Assaf A. Gilad, Jeff W. M. Bulte, and Peter C. M. van Zijl, have been pioneers developing this field at the Johns Hopkins University School of Medicine and the Kennedy Krieger Institute including contributions to Nature Medicine, Nature Biotechnology, Nature Materials, and the Proceedings of the National Academy of Sciences. As recognition for their initial development of the field, Drs. van Zijl and Balaban were awarded the Laukien Prize in April 2016, established in 1999 to honor the memory of Professor Gunther Laukien, a co-founder of Bruker Biospin GmbH.

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