Search results for ""Merck""

The Merck Veterinary Manual (MVM) covers all domesticated species and diseases in veterinary medicine worldwide. This completely revised and redesigned new edition of the veterinary classic uses a two-column format and color throughout for easy-to-read text and tables. Hundreds of color images enhance and illustrate the text. In addition to extensive revisions and updates, this edition includes a new section on public health and zoonoses, expanded coverage of fish and aquaculture, new chapters on backyard poultry, toxicologic workplace hazards, smoke inhalation, and additional coverage of numerous new and emerging topics in veterinary medicine. . Completely revised and redesigned in a two-column, easy-to-read format with color throughout . New section on Public Health which includes a new public health primer that covers One Health, public health functions and agencies, epidemiologic principles and study types, disease outbreak investigations, food safety, and a brief discussion of public health law . Revised and expanded information on fish, aquatic systems, and aquaculture as well as poultry, pet birds, rabbits, rodents, reptiles, and amphibians . New chapters on backyard poultry and Tasmanian devils, toxicologic hazards in the workplace for veterinarians, smoke inhalation, scorpion bites, spider flies, and xylitol toxicity . Extensively revised chapters on heart disease, diagnostic imaging, pharmacology and drug resistance, wound management, equine emergency medicine, management of the neonate and neonatal encephalopathy, wound management, equine arboviral encephalomyelitis, skeletal disorders and myopathies of poultry, and chlamydiosis . Important changes to the Behavior section such as inclusion of the most recent diagnostic techniques, methods and treatment of behavioral disorders in dogs, cats, and other domesticated animals, expanded coverage of the human-animal bond, service and assistance animals, and new material on self-care for veterinarians

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Back by popular demand: the world's most widely-used medical reference, now in its 20th edition. The Merck Manual of Diagnosis and Therapy has been thoroughly updated and expanded with a larger trim size to include 40% new and revised content, including 36 new chapters with more than 200 tables and 100 figures. Packed with essential information on diagnosing and treating medical disorders, this comprehensive guide was written by a team of renowned medical experts. It is intended for everyday use by healthcare professionals to ensure delivery of the best care to their patients. The new Merck Manual of Diagnosis and Therapy makes it easy to find the right information at the moment it's needed, with the help of section thumb tabs. It is a must-have for medical students, residents, practicing physicians, nurses, and allied health professionals. New larger trim 7 3/4 x 9 1/4 to accommodate 40% new content 36 completely new chapters Revised and expanded chapters in Cardiovascular, Genitourinary, Gynecologic, Neurologic, Pregnancy, and Infants and Children Pediatrics and trauma section significantly revised and expanded Key Points summarize the facts at-a-glance New Pearls & Pitfalls highlight noteworthy medical info and areas of caution 16-page full-color insert aids visual recognition of skin, eye, and oral disorders

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The Merck Index is the definitive reference work for scientists and professionals looking for authoritative information on chemicals, drugs and biologicals. It has been the leading source of information on chemical compounds for generations of scientists and professionals, selling over one million copies since its publication in 1889. The Merck Index contains over 10,000 monographs with information relating to compounds of significance in research, commerce and environmental impact. The 15th edition, available from Royal Society of Chemistry publishing for the first time, is fully revised and updated and contains over 500 new monographs. Over 35% of the existing entries have been updated since the last edition, molecular weights have been recalculated with the latest IUPAC standards and there are revised periodic table and atomic weight tables. The Merck Index is an essential reference for all scholarly and professional chemists, biochemists, pharmacists and toxicologists and of interest to students, teachers, academic libraries, academic researchers, information professionals, solicitors, journalists and government agencies. *The name THE MERCK INDEX is owned by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Whitehouse Station, N.J., U.S.A., and is licensed to The Royal Society of Chemistry for use in the U.S.A. and Canada.

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Challenging the study of both celebrity and the cinema, Mandy Merck argues that modern fame and film melodrama are part of the same worldview, one that cannot resolve the relation of personal worth to social esteem. Tracing the history of this conundrum back to the philosophy of the 17th century and the theatre of the 18th, she demonstrates its convergence in stage melodrama and its intensification in the Hollywood star system. Are today’s celebrities worth our attention? In that demand for judgement and the hope for its visual guidance, the melodramatic imagination survives – permeating not only fiction film, but documentary, the artist’s film, and our self-exhibition on social media. Examining a range of classical and contemporary films from Charlie Chaplin's City Lights (1931) to Laura Poitras’s Citizenfour (2014) , the many remakes of A Star Is Born, the compulsory exhibitionism of political celebrity and the unmasking of whistle-blowers, Merck illustrates the ways in which the cinema constantly restages the moral evaluation of prominent individuals, whether they are actors, artists, politicians or activists.

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Challenging the study of both celebrity and the cinema, Mandy Merck argues that modern fame and film melodrama are part of the same worldview, one that cannot resolve the relation of personal worth to social esteem. Tracing the history of this conundrum back to the philosophy of the seventeenth century and the theatre of the eighteenth, she demonstrates its convergence in stage melodrama and its intensification in the Hollywood star system. Are today’s celebrities worth our attention? In that demand for judgement and the hope for its visual guidance, the melodramatic imagination survives – permeating not only fiction film, but documentary, the artist’s film, and our self-exhibition on social media. Examining a range of classical and contemporary films from Charlie Chaplin's City Lights (1931) to Laura Poitras’s Citizenfour (2014) , the many remakes of A Star Is Born, the compulsory exhibitionism of political celebrity and the unmasking of whistle-blowers, Merck illustrates the ways in which the cinema constantly restages the moral evaluation of prominent individuals, whether they are actors, artists, politicians or activists.

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The death of Diana, Princess of Wales, was met by the deepest mourning of the twentieth century. Two and a half billion people worldwide watched the funeral on television, floral tributes flooded London's royal parks and sprung up, too, in small towns in Texas, conspiracy theories ricocheted around the Internet, commemorative stamps were issued in newly communist Hong Kong.Press coverage of the death was also unprecedented in both its scale and uniformity. Yet, in an enormous welter of schmaltz, very little was said about the meaning of what had occurred-whether Tony Blair's public emoting heralded a new kind of politics; what, if anything, the anguish of so many who never knew Diana in person revealed about modern society; how the intertwining of the ideas of celebrity and victim, physical beauty and moral worth, affected people's responses; what was implied for the future of the royal family.For those perplexed by the events surrounding Diana's death, this book provides some answers. Insisting that all aspects of the affair are open to investigation, that nothing (and especially not royalty) is sacred, it brings together a group of distinguished writers whose primary interest is to analyze the death rather than lament it.Contributors: Mark Augé, Jean Baudrillard, Sarah Benton, Homi K. Bhabha, Mark Cousins, Alexander Cockburn, Richard Coles, Régis Debray, Françoise Gaillard, Peter Ghosh, Christopher Hird, Christopher Hitchens, Linda Holt, Sara Maitland, Ross McKibbin, Mandy Merck, Tom Nairn, Glen Newey, Naomi Segal, Dorothy Thompson, Francis Wheen, Judith Williamson, and Elizabeth Wilson.

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At a time when "sexy" can be an adjective for anything, when sexual awareness is declared to be advancing faster in months than in the past half century, and when pundits warn of sexual overload, the actual representation of sex is still deemed confrontational, aggressive, "in your face." While critics accuse the academy of an obsession with sexuality, they also complain that nothing that appears to refer to sex really does. In readings ranging across film, drama, opera, fine art, and critical theory, Mandy Merck considers these phenomena as well as the role of the dog in anti-porn propaganda, the unacknowledged significance of the lesbian hand, and the early retirement of the phallus. Other topics include the relationship of women's tennis and prostitution, the gendering of the wild and the tame in the age of AIDS, and the sexlessness of postmodern criticism. In Your Face ends with the face and its alleged desecration by fellatio. Germaine Greer's condemnation of Bill Clinton for "fucking the faces of little girls" is examined in the light of one of Monica Lewinsky's endearments for the President--"fuckface." In a country whose last great Presidential scandal revolved around a key witness known only as "Deep Throat" and whose current Chief Executive works in the "Oral Office," giving head is going down in history. Analyzing the strange relationship of Linda Lovelace, Camille Paglia, and Paul de Man, In Your Face concludes by considering desire and disgust in high and low places.

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Moving images of the British monarchy are almost as old as the moving image itself, dating back to an 1895 American drama, The Execution of Mary Queen of Scots. And from 1896, actual British monarchs appeared in the new 'animated photography', led by Queen Victoria. Half a century later the 1953 coronation of Elizabeth II was a milestone in the adoption of television, watched by 20 million Britons and 100 million North Americans. At the century's end, Princess Diana's funeral was viewed by 2.5 billion worldwide. In the first book length examination of film and television representations of this enduring institution, distinguished scholars of media and political history analyze the screen representations of royalty from Henry VIII to 'William and Kate'. Seventeen essays by Ian Christie, Elisabeth Bronfen, Andrew Higson, Karen Lury, Glynn Davies, Jane Landman and other international commentators examine the portrayal of royalty in the 'actuality' picture, the early extended feature, amateur cinema, the movie melodrama, the Commonwealth documentary, New Queer Cinema, TV current affairs, the big screen ceremonial and the post-historical boxed set. A long overdue contribution to film and television studies, this book will be essential reading for scholars and students of British media and political history.

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Veterinary Forensics, Second Edition is a practical reference on applying veterinary forensic findings in animal cruelty cases. Now providing a greater focus on findings in animals, the second edition continues to offer guidance with more detailed information on crime scene investigation, forensic testing and findings, handling evidence, and testifying in court. Key changes to the new edition include new chapters on abuse in large animals, poultry, and birds; a standalone chapter on entomology; a new section on large scale cruelty investigation; an expanded section on pain and suffering; more pathology information; and more photos, forms, and information throughout. Logs and workbooks from the book are available on a companion website at www.wiley.com/go/vetforensics, allowing readers to download, customize, and use these forms in forensics investigations. Veterinary Forensics is an essential resource for veterinarians, pathologists, attorneys, and investigators working on animal abuse cases.

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Has Queer Theory 'grown out' of Feminism - in both senses? If it has, is that process a coming-out story?

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Has Queer Theory 'grown out' of Feminism - in both senses? If it has, is that process a coming-out story?

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Develop and manage chemical information systems This text provides a comprehensive overview of analyzing chemical problems using computer-aided methods for both newcomers and advanced computer scientists and chemists. In addition to practical how-to information and step-by-step descriptions, this resource includes case studies from Merck & Co., Inc., to further aid your understanding. This guide covers a wide range of cheminformatics topics, including: * Software development principles * Object-oriented approach * Building and buying * Agile and Iterative Development Process * UML Modeling * Deployment and Software Architecture * Presentation, Business, and Data Persistence Layer * Producing an entity dictionary * Chemistry Intelligence API * Plug and play--integrating with third-party tools Written by a former lead architect on the design of said systems at Merck & Co., Inc., this text not only lays out information, but also shares the author's experiences and advice on cheminformatics.

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What has industrial slaughter got to do with poetry? "The Cow" performs an autopsy of the twentieth century on the bodies of ruined women, ransacking texts from the Bible to "Baudelaire" and "The Merck Veterinary Manual". It is hopeless, sexual, scarified, and alive. "No doubt about it, this is strong and original work. Scary in the best possible way." - Richard Foreman.

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Fast track route to understanding and implementing the best ideas from the world's top technology businesses Covers all key aspects of technology leadership, from open technology to entrepreneurial leadership, and from boundaryless product development to resource allocation Examples, cases and ideas from the world's greatest technology companies, including Hewlett Packard, Cisco, IBM, Schlumberger, Gillette and Merck. Includes a glossary of key concepts and a comprehensive resources guide

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Gibbons on Trade Marks Law, Third Edition, is fully updated and includes: • Full analysis of the statutory position in Ireland concerning the opposition, registration, invalidity and revocation of trade marks; • A detailed consideration of the jurisprudence concerning online trade mark disputes including website targeting; • The impact of the Supreme Court Merck judgment on interlocutory trade mark injunctions; • The position of unorthodox trade marks in relation to registration and invalidity; • A review of the remedies available including the position of damages and declaratory relief; • Comprehensive analysis of IPOI decisions under the Trade Marks Act 1996; • Recent developments in passing off and comparative advertising.

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A behind-the-scenes look at the most lucrative discipline within biotechnology Bioinformatics represents a new area of opportunity for investors and industry participants. Companies are spending billions on the potentially lucrative products that will come from bioinformatics. This book looks at what companies like Merck, Glaxo SmithKline Beecham, and Celera, and hospitals are doing to maneuver themselves to leadership positions in this area. Filled with in-depth insights and surprising revelations, Digital Code of Life examines the personalities who have brought bioinformatics to life and explores the commercial applications and investment opportunities of the most lucrative discipline within genomics. Glyn Moody (London, UK) has published numerous articles in Wired magazine. He is the author of the critically acclaimed book Rebel Code.

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Chemicals are used worldwide to protect crops and structures, manage pests, and prevent the spread of disease. While beneficial to society, these pesticides can pose human health and environmental risks. Pesticides provides a comprehensive and international collection of data concerning the substances used to repel or mitigate pests ranging from insects, animals and weeds to microorganisms. A valuable feature of this reference is its organization by functional category. The 1,844 chemical entities are divided into the following 17 functional categories: Acaricides, Algicides, Animal Repellants, Bactericides, Bird Repellants, Fungicides, Herbicides, Insecticides, Molluscicides, Nematicides, Piscicides, Plant Growth Regulators, Rodenticides, Safeners, Slimicides, Termiticides and Miscellaneous Chemicals. This compilation provides important chemical and toxicity data for the 1800 substances registered by the US Environmental Protection Agency and used largely in the agricultural environment. The chemical, physical and bioactivity properties of each agent are recorded along with a comprehensive listing of product trade names and synonyms as well as manufacturers. The EPA status of each agent is given and each record carries the appropriate CAS Registry Number and the associated EINECS Number where available. The Merck Index number is provided for all chemicals in this edition which also appear in the 13th edition of the Merck Index. Wherever possible, the following information is also displayed for each entry: melting point, boiling point, density or specific gravity, refractive index, optical rotation, ultraviolet absorption, and solubility as well as chronic and acute toxicities. A key strength of this new reference is the extensive coverage of synonyms. The book includes an index of 28,000 chemical synonyms and trade names with a cross-reference to their main entry. This extraordinarily comprehensive view of trade name and generic synonyms makes Pesticides one of the world's most exhaustive references for agricultural chemical synonyms.

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The practical toolbox for readers of Million Dollar Consulting This useful guide provides specific checklists, guidelines, templates, and actual examples for every step of the consulting process. It covers marketing, sales, meetings, implementation, follow-up, invoicing, practice management, insurance, equipment, subcontracting, and scores of other elements. Thousands of people have bought Weiss's Million Dollar Consulting and started their own consultancy. Now, this handy resource goes hand-in-hand to provide all the tools new consultants need to enact all the recommendations and ideas in Million Dollar Consulting. Alan Weiss, PhD (East Greenwich, RI), has consulted for hundreds of organizations around the world, including Mercedes-Benz, Hewlett-Packard, Merck, Chase, American Press Institute, and the Times-Mirror Group. He is the author of 12 books, including Getting Started in Consulting (0-471-47969-1) and Organizational Consulting (0-471-26378-8).

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Join journalist Barry Werth as he pulls back the curtain on Vertex, a start-up pharmaceutical company, and witness firsthand the intense drama being played out in the pioneering and hugely profitable field of drug research.Founded by Joshua Boger, a dynamic Harvard- and Merck-trained scientific whiz kid, Vertex is dedicated to designing—atom by atom—both a new life-saving immunosuppressant drug, and a drug to combat the virus that causes AIDS. You will be hooked from start to finish, as you go from the labs, where obsessive, fiercely competitive scientists struggle for a breakthrough, to Wall Street, where the wheeling and dealing takes on a life of its own, as Boger courts investors and finally decides to take Vertex public. Here is a fascinating no-holds-barred account of the business of science, which includes an updated epilogue about the most recent developments in the quest for a drug to cure AIDS.

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Más de 8.000 profesionales conocieron de primera mano las estrategias de marketing más novedosas de 26 grandes marcas en el evento HOY ES MARKETING. El encuentro celebrado por la escuela de negocios ESIC en 7 ciudades españolas (Madrid, Barcelona, Valencia, Bilbao, Zaragoza, Sevilla y Pamplona).Un total de 34 ponencias, recogidas en un libro que incluye los resúmenes y un DVD con las grabaciones íntegras y las presentaciones utilizadas por los máximos representantes de compañías de éxito como:ADIDASAGUSTÍN MEDINABARRABÉS BERLYSBUONGIORNOCHRYSLERCORREOSEL CORTE INGLÉSDRAFTFCB eBAYEL PAÍSFIATGOOGLEIKEAMERCKMUTUA MADRILEÑANIELSEN ORACLEPRINCIPE DE VIANARUSTICAESAUNIER DUVALSEARCH MEDIATELEFÓNICA MÓVILESTUTTI PASTAUNILEVERWASKMAN STUDIOSA través de este libro y siguiendo con la filosofía del primer libro de ponencias de Hoy es marketing, editado por ESIC en 2007, los profesionales tendrán la p

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Your Career Game demonstrates how game theory can help readers to understand and proactively take charge of their career strategy. Authors Nathan Bennett and Stephen A. Miles teach readers to manage the interdependencies and interconnectedness among coworkers, managers, and others in a manner that supports personal career efforts. Then, they show how readers can become better players. The key to learning how to play the career game is "career agility"—in short, nimble individuals are better game players. Thois book includes conversations with a wide range of successful professionals such as Ursula Burns (Xerox), Stephen Elop (Microsoft), Marius Kloppers (BHP Billiton), Ken Frazier (Merck), and Liz McCartney (The St. Bernard Project), and discusses how their career moves demonstrate elements of a game theory approach to career management. This is a must-read strategic guide for anyone who seeks to advance their career and navigate today's job market.

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Your Career Game demonstrates how game theory can help readers to understand and proactively take charge of their career strategy. Authors Nathan Bennett and Stephen A. Miles teach readers to manage the interdependencies and interconnectedness among coworkers, managers, and others in a manner that supports personal career efforts. Then, they show how readers can become better players. The key to learning how to play the career game is "career agility"—in short, nimble individuals are better game players. Thois book includes conversations with a wide range of successful professionals such as Ursula Burns (Xerox), Stephen Elop (Microsoft), Marius Kloppers (BHP Billiton), Ken Frazier (Merck), and Liz McCartney (The St. Bernard Project), and discusses how their career moves demonstrate elements of a game theory approach to career management. This is a must-read strategic guide for anyone who seeks to advance their career and navigate today's job market.

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Virtually all cervical cancer cases are caused by human papilloma viruses (HPV), mainly HPV-16 and HPV-18. Furthermore, HPVs may cause other types of cancer, such as squamous anal cancers and vulvar cancer. In men, HPVs are associated with genital lesions, anal cancer, penile cancer, and head and neck cancers. As such, this compilation focuses on recent findings in HPV epidemiology, prevention, and updates regarding prophylatic HPV vaccines. Bioinformatics tool are important in the analysis of molecular and biological data, which could provide novel insights on the development of treatment and prevention methods for disease control. Through bioinformatics, it is possible to analyze and simulate HPV molecular data through the use of universal databases and analysis tools, in order to better understand the virus genetics and infection cycle. In conclusion, Human Papillomaviruses (HPVs): Detection, Infection and Protection appraises HPV vaccines for the prophylaxis of HPV infection in healthy individuals. Vaccines used for earlier varieties are Gardasil (Merck, Kenilworth, NJ, U.S.A.) and Cervarix (GlaxoSmithKline, Brentford, U.K.).

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Life and leadership lessons from an Asian perspective, based on the career of a man who has risen to the top of the Western corporate ladder and left it all behind to start something new Chris Lee had a cushy role. For a decade, he led the Asia-Pacific division of Medtronic, a multibillion dollar business and one of the world's largest manufacturers of medical devices, and consistently produced excellent business outcomes. Then, at fifty-six, he threw all of that away to start VentureBlick, an international fundraising platform matching healthcare startups and medical investors. Why did Lee do that? Lee takes us through his journey as one of the youngest Asian leaders in an MNC (youngest director in Merck at age twenty-seven, youngest country manager at thirty, first Asia-Pacific leader reporting to Bayer HQ at thirty-nine), how he brought Asian leadership sensibilities into multiple global companies, and reveals why he believes it's important for corporate leaders to adopt an Asian le

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„Family businesses are the archetype of all business activities. Since family businesses provide even today about 70 percent of all jobs in Germany, most people know these structures from their own experience,” writes Jon Baumhauer, the chief executive of the family holding of the Merck Group, in his Preface to this volume. The special thing about family businesses is that the persons involved are simultaneously members of family and firm. These two systems overlap with their very different emotional and rational logic, and sometimes put their decisionmakers in situations that are impossible to solve and have the quality of true paradoxes. This circumstance is a great challenge to both the family and the company and sometimes exposes both to such unreasonable and untenable demands.The goal of this volume is to illuminate the interaction of family, shareholders and company from various perspectives and to ask questions that can help the reader to better understand the complexity with which the parties concerned are confronted.

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Treatment of endocrine disorders is an important branch of medicine and many drugs have been developed for use in this area. Endocrine disorders and the drugs used to treat them are quite diverse, ranging from iodine-containing thyroxine analogs used to treat hypothyroidism, to steroid androgens, progestins and estrogens. This Handbook contains records for all the major drugs currently used in endocrinology. Monographs are provided for 818 endocrine agents and steroids. For each main entry, the following information is provided: the chemical name and a list of trade names and synonyms; the Chemical Abstracts Service (CAS) Registry Number; the European Inventory of Existing Commercial Chemical Substances (EINECS) Number, and the Merck Index (12th edition) Number. The physical properties of each compound are described and the known biological activity and indicated applications are presented. The structure of each compound is provided, together with a summary of the acute toxicity data associated with it, and the manufacturers and suppliers of the drug are also given. Indexes, including a master index of names and synonyms, are appended.

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The expert guide to effective internal consulting This book guides internal consultants through the steps necessary to bolster their credibility, build relationships within the organization, develop internal marketing abilities, and apply proper methodologies to their work. Alan Weiss, an experienced consultant, provides practical techniques the internal consultant, internal human resources practitioner, and any other internal change agent can use to excel at work, advance their careers, and become valued assets to their organizations. Some of the major subjects covered include setting up the proper environment for success and establishing peer-level interactions. Alan Weiss, PhD (East Greenwich, CT), has consulted with hundreds of organizations around the world, including Mercedes-Benz, Hewlett-Packard, Merck, and Chase. He lectures widely and appears regularly on radio and television to discuss productivity and performance. He is the author of twelve books, including Getting Started in Consulting (Wiley: 0-471-38455-0), The Ultimate Consultant (Jossey-Bass: 0-7879-5508-6), How to Acquire Clients (Jossey-Bass: 0-7879-5514-0), and Process Consulting (Jossey-Bass: 0-7879-5512-4).

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For business to flourish, society must flourish. In today's global economy, business serves the common good not only by producing goods and services but also by reaching out to the many who are not even in the market because they lack marketable skills and the resources to acquire them. Sustainable Development: The UN Millennium Development Goals, the UN Global Compact, and the Common Good contains twenty-two essays that document the work of Western companies, working through the UN Global Compact and its Principles of Responsible Investment and the Principles for Responsible Management Education, to shape more peaceful and just societies. Seven case studies by leading businesses and private-public partnerships—including Microsoft, Merck, Sumitomo Chemical, Nestlé, Coca-Cola, Novartis, and Levi Strauss—outline their projects, especially those advancing the MDGs (Millennium Development Goals) designed to alleviate dire poverty. Twelve chapters reflect on some of the conceptual issues involved with the MDGs, and the three concluding essays examine the future of the UN Global Compact, of the Millennium Development Goals, and of the role of business enterprise in society.

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European Competition Law Handbook provides a comprehensive digest of Commission decisions and competition cases before the EU and national courts, conveniently cross-referenced by subject matter, for the swift location of the full list of relevant case-law, regulations and notices. Comprehensive but simple to use reference system and clear structure: Distinct sections on: General Competition Rules and Mergers and Acquisitions The analytical digest divided by subject matter guides you through the maze of legislation, cases and decisions Detailed tables show the type of decision reached by the Commission or Court of Justice, the type of agreement or activity, the product in question and any fine imposed Tinted thumb tabs aid your navigation through the book Key new cases include: Mergers: EU Commission Phase 2 clearances with remedies including London Stock Exchange Group/Refinitiv Business, Danfoss/Eaton Hydraulics and FCA/PSA; many Phase 1 decisions with and without remedies; a decision imposing a penalty under Article 14 in Merck/Sigma-Aldrich; EU General Court judgments in Altice, Canon, LOT, Wieland-Werke and UPS; as well as many other cases on jurisdictional and substantive points, including data and digital platforms, innovation, media and telecoms mergers.

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The discovery, in the 1930s and 1940s, of antibiotics revolutionized the practice of medicine. Beginning with the streptomycins and the penicillins, hundreds of antibiotics have been developed and have come into routine use for the management of infectious diseases, opportunistic infections and infections resulting from trauma. This cornucopia of anti-infective agents has created a number of problems, not the least of which is the organization of information concerning them. This Handbook contains records for all the major drugs currently used in the treatment of infection. Monographs are provided for 1600 anti-infective agents. For each main entry, the following information is provided: the chemical name and a list of proprietary names and synonyms; the Chemical Abstracts Service (CAS) Registry Number; the European Inventory of Existing Commercial Chemical Substances (EINECS) number; and the Merck Index (12th edition) number. The physical properties of each compound are described and the known biological activity and indicated applications are presented. The structure of each compound is provided, together with a summary of the acute toxicity data associated with it, and the manufacturers and suppliers of the drug are also given. Indexes, including a master index of names and synonyms, are appended.

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An indispensable resource for busy researchers Your time is valuable-too valuable to spend hunting through the technical literature in search of the right HPLC assay techniques for your projects. With HPLC Methods for Recently Approved Pharmaceuticals, you'll quickly identify and replicate the ideal procedures for your project needs, without having to refer to original source publications. More of your time can then be spent in the lab, not the library. Covering the relevant world literature through 2003, this book picks up where Dr. Lunn's acclaimed HPLC Methods for Pharmaceutical Analysis left off. It arms you with established HPLC assay techniques for hundreds of newly approved drugs, as well as drugs for which assay methods were only recently developed. Combining detailed descriptions of procedures with specially annotated references, this practical handbook gives you: * HPLC methods for 390 commonly prescribed pharmaceutical compounds * Various procedures for each drug listed together-making it easy to mix and match for customized approaches * Methods for drugs in biological fluids and for bulk and formulated drugs * Chemical structures, molecular weights and formulas, and CAS Registry Numbers * Cross-references to The Merck Index * Retention times of other drugs that can be assayed using the same methods

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HPLC and CE Methods for Pharmaceutical Analysis The complete, up-to-date library at the click of a mouse This invaluable database gives you fast, easy access to more than 13,000 abstracts from the current literature on HPLC and capillary electrophoresis (CE). Incorporating the four-volume HPLC Methods for Pharmaceutical Analysis plus the newly introduced Capillary Electrophoresis for Pharmaceutical Analysis, this CD-ROM features an extensive library of methods used in the analysis of most pharmaceutical compounds. It lists available HPLC techniques for more than 1,300 compounds and CE methods for more than 700 compounds, with a number of techniques described for each compound. Detailed, precise information lets you replicate methods without having to refer to the original publications as well as customize methods for very specific needs. You can instantly locate basic compound information--molecular weight and formula, CAS number, and Merck index number--plus experimental conditions for each method. Complex and substructure searching capabilities let you search the entire database by compound, matrix, HPLC variables, and author--saving you countless hours of online or library research. Minimum system requirements: * IBM-compatible PC 486 * Win95 or higher * CD-ROM drive * 8MB RAM * XXXMB free hard disk space Visit us on the Internet: www.wiley.com

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The Autonomic Nervous System (ANS) supplies all innervated structures of the body other than skeletal muscle, and its effects are therefore pervasive. The range of available ANS-active compounds can effectively modulate any or all body systems. The ANS-active agents include drugs used to treat a wide spectrum of conditions including hypertension, myocardial insufficiency, migraine, nasal congestion, obesity, Parkinson's disease, and glaucoma. Drugs from an array of therapeutic categories, including vasodilators, muscle relaxants, gastroprokinetics, and bronchodilators, can be classified as ANS agents. This Handbook contains records for all the major drugs that mimic or block the actions of ANS neurotransmitters or whose activities involve a direct effect on ANS neurotransmitter production, destruction or reuptake, or on junctional transmission. Monographs are provided for 1,996 ANS agents. For each main entry, the following information is provided: the chemical name and a list of proprietary names and synonyms; the Chemical Abstracts Service (CAS) Registry Number; the European Inventory of Existing Commercial Chemical Substances (EINECS) number, and the Merck Index (12th edition) number. The physical properties of each compound are described and the known biological activity and indicated applications are presented. The structure of each compound is provided, together with a summary of the acute toxicity data associated with it, and the manufacturers and suppliers of the drug are also given. Indexes, including a master index of names and synonyms, are appended.

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Build your best life by forging your own path to business success After speaking to companies such as Merck, Land O'Lakes, and Cargill, and to over 2000 audiences across the world, Damian Mason, successful businessman, agriculturalist, podcaster, and writer, wants to help you achieve your entrepreneurial goals and live a better life. While other business books claim to tell you how to reach success, they fall short because they don’t address the fact that success is different for each of us. Do Business Better helps you define success on your terms, then shows you how to achieve it. You’ll learn the Four Unwavering Traits of Entrepreneurial Success and how to discover the differences between routines and habits, then implement your changes through meaningful actions that create permanent improvement. Along the way, you’ll learn from real-world examples and relatable stories, and discover a wealth of applicable advice on starting, managing, and growing your own enterprise. Discover your best life, then build a path to achieve it Learn how other entrepreneurs have adapted their lives to achieve their goals Find out what’s really standing between you and your dreams Rid yourself of ineffective thinking patterns and develop habits that actually help you Do Business Better is the go-to guide for business people, entrepreneurs, and the self-employed looking to jumpstart their journey and build their dreams into reality. If your goal is prosperity, longevity, and a life and business on your terms, this book is for you.

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In 2007, Texas governor Rick Perry issued an executive order requiring that all females entering sixth grade be vaccinated against the human papillomavirus (HPV), igniting national debate that echoed arguments heard across the globe over public policy, sexual health, and the politics of vaccination. Three Shots at Prevention explores the contentious disputes surrounding the controversial vaccine intended to protect against HPV, the most common sexually transmitted infection. When the HPV vaccine first came to the market in 2006, religious conservatives decried the government's approval of the vaccine as implicitly sanctioning teen sex and encouraging promiscuity while advocates applauded its potential to prevent 4,000 cervical cancer deaths in the United States each year. Families worried that laws requiring vaccination reached too far into their private lives. Public health officials wrestled with concerns over whether the drug was too new to be required and whether opposition to it could endanger support for other, widely accepted vaccinations. Many people questioned the aggressive marketing campaigns of the vaccine's creator, Merck & Co. And, since HPV causes cancers of the cervix, vulva, vagina, penis, and anus, why was the vaccine recommended only for females? What did this reveal about gender and sexual politics in the United States? With hundreds of thousands of HPV-related cancer deaths worldwide, how did similar national debates in Europe and the developing world shape the global possibilities of cancer prevention? This volume provides insight into the deep moral, ethical, and scientific questions that must be addressed when sexual and social politics confront public health initiatives in the United States and around the world.

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Praise for THE CHIEF HR OFFICER The Chief HR Officer offers the most current thinking on the evolving role of the chief human resource officer (CHRO). An essential resource for experienced and aspiring CHROs, the book shows leaders how to best prepare for and perform this critical role. This comprehensive book shows how, in today’s extremely competitive work environment, the job of the CHRO has expanded to encompass many important roles. Among other things, HR leaders must adapt to and address the demands of an increasingly diverse and demanding workforce, globalization, stricter regulatory requirements, increased accountability to the CEO and board of directors, and the complexity of leading the HR function with often limited resources. This vital guide is filled with rare insights and practical guidance from some of the country’s most successful CHROs who have been in the trenches as well as top academics researching the field including Randy MacDonald (IBM), Eva Sage-Gavin (Gap Inc.), L. Kevin Cox (American Express), Mirian M. Graddick-Weir (Merck), and Dave Ulrich (Ross School of Business, University of Michigan, and The RBL Group). Sponsored by the National Academy of Human Resources (NAHR), the book covers a wealth of topics including how to develop a perspective and set of skills to effectively lead and perform in the role and how to approach strategy, management, leadership, ethics, and talent. In addition, the authors include information on forming and implementing activities that will further the firm’s strategy, advice for coaching and counseling the CEO, and much more.

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The cardiovascular system serves to carry essential compounds to the tissues and to remove metabolic by-products. It also plays an important role in maintaining homeostasis, and functions directly or indirectly in the regulation of body temperature, oxygen supply, nutrient distribution, water and electrolyte balance, and endocrine activity. Consisting of a pump, connecting tubes, exchange membranes and blood, this system is governed by a diverse and complex array of regulatory mechanisms, encompassing central neural, autonomic, endocrine, paracrine, and autocrine control. Drugs used in the treatment of cardiovascular disease are disseminated widely in western industrialized countries. In the US alone, nearly $18 billion was spent on drugs for the treatment of cardiovascular disease and stroke in 1999. This Handbook contains records for all the major drugs that directly affect the cardiovascular system. Monographs are provided for over 1900 cardiovascular agents. For each main entry, the following information is provided: the chemical name and a list of proprietary names and synonyms; the Chemical Abstracts Service (CAS) Registry Number; the European Inventory of Existing Commercial Chemical Substances (EINECS) number; and the Merck Index (12th edition) number. The physical properties of each compound are described and the known biological activity and indicated applications are presented. The structure of each compound is provided, together with a summary of the acute toxicity data associated with it, and the manufacturers and suppliers of the drug are also given. Indexes, including a master index of names and synonyms, are appended.

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In ihrem Buch diskutieren Christopher Wünsche und Sebastian May, wie sich Unternehmen im Spannungsfeld zwischen Kontinuität und notwendiger Veränderung erfolgreich positionieren und transformieren können. Die Autoren skizzieren, was eine Unternehmensmarke ausmacht und was sie in Transformationsprozessen für CEOs und andere Markenverantwortliche als Möglichmacher leisten kann. Etwa bei Fragen wie: Wie unterstützt sie eine Fusion zweier Unternehmen? Wie gelingt die erfolgreiche Ausgliederung eines Unternehmensteils oder der Gang an die Börse? Wie gelingt es, eine Unternehmensstrategie in der Unternehmensmarke so abzubilden, dass die Welt sie versteht? Wie wichtig ist in diesem Zusammenhang ein Purpose und wie sehr muss ein Unternehmen darauf ausgerichtet werden, auch im Hinblick auf das große neue Nachhaltigkeitsthema ESG - Environmental, Social, Governance? Und welche Kriterien muss ein Purpose erfüllen, soll er wirklich Sinn stiften und echte Relevanz für das Geschäftstätigkeit erlangen? Und nicht zuletzt: Woraus besteht eine Markenidentität überhaupt und warum ist es notwendig, sich bei der inhaltlich-strategischen Entwicklung der Unternehmensmarke intensiv mit der Unternehmensstrategie und der Unternehmenskultur auseinanderzusetzen? Im ausführlichen Praxisteil des Buches zeigen die Autoren anhand konkreter Unternehmensbeispiele (u. a. Apleona, Bilfinger, Vonovia, Ledvance, Merck und Audi) wie Marke hier ganz konkrete Transformationsprozesse maßgeblich unterstützen konnte oder diese sogar erst möglich machte. Auch Hürden und Erfolgsfaktoren, wie z. B. die zielführende Gestaltung von Implementierungsprozessen, benennen Wünsche und May und zeigen Lösungswege auf - flankiert von aufschlussreichen Insights von zahlreichen CEOs und Markenverantwortlichen. Schließlich erfordert Branding in Transformationsprozessen Expertise in gleich drei Disziplinen: in Markenführung, in Change-Management und in interner wie externer Unternehmenskommunikation. Verdichtung, Erklärung und Vermittlung sind entscheidend, um im Wandel Orientierung zu geben, Momentum zu erzeugen und die Marke als Kompass und Katalysator erfolgreicher Veränderung zu nutzen.

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In 2007, Texas governor Rick Perry issued an executive order requiring that all females entering sixth grade be vaccinated against the human papillomavirus (HPV), igniting national debate that echoed arguments heard across the globe over public policy, sexual health, and the politics of vaccination. Three Shots at Prevention explores the contentious disputes surrounding the controversial vaccine intended to protect against HPV, the most common sexually transmitted infection. When the HPV vaccine first came to the market in 2006, religious conservatives decried the government's approval of the vaccine as implicitly sanctioning teen sex and encouraging promiscuity while advocates applauded its potential to prevent 4,000 cervical cancer deaths in the United States each year. Families worried that laws requiring vaccination reached too far into their private lives. Public health officials wrestled with concerns over whether the drug was too new to be required and whether opposition to it could endanger support for other, widely accepted vaccinations. Many people questioned the aggressive marketing campaigns of the vaccine's creator, Merck & Co. And, since HPV causes cancers of the cervix, vulva, vagina, penis, and anus, why was the vaccine recommended only for females? What did this reveal about gender and sexual politics in the United States? With hundreds of thousands of HPV-related cancer deaths worldwide, how did similar national debates in Europe and the developing world shape the global possibilities of cancer prevention? This volume provides insight into the deep moral, ethical, and scientific questions that must be addressed when sexual and social politics confront public health initiatives in the United States and around the world.

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This title is the first in a series of essential overviews of green building trends from around the world. The 'green building revolution' is a worldwide movement for energy-efficient, environmentally aware architecture and design. Europe has been in the forefront of green building technology, and "Green Building Trends: Europe" provides an indispensable overview of these cutting edge ideas and applications.In order to write this book, well-known U.S. green building expert Jerry Yudelson interviewed a number of Europe's leading architects and engineers and visited many exemplary projects. With the help of copious photographs and illustrations, Yudelson describes some of the leading contemporary green buildings in Europe, including the new Lufthansa headquarters in Frankfurt, the Norddeutsche Landesbank in Hannover, a new school at University College London, the Beaufort Court Zero-Emissions building, the Merck Serono headquarters in Geneva, and a zero-net-energy, all-glass house in Stuttgart.In clear, jargon-free prose, Yudelson provides profiles of progress in the journey towards sustainability, describes the current regulatory and business climates, and predicts what the near future may bring. He also provides a primer on new technologies, systems, and regulatory approaches in Western Europe that can be adopted in North America, including building-integrated solar technologies, radiant heating and cooling systems, dynamic facades that provide natural ventilation, innovative methods for combining climate control and water features in larger buildings, zero-net-energy homes built like Thermos bottles, and strict government timetables for achieving zero-carbon buildings."Green Building Trends: Europe" is an essential resource for anyone interested in the latest developments in this rapidly growing field.

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Today’s most sought-after “customer service sleuth” and turnaround expert unlocks the secrets to transforming customer service and building unshakeable customer engagement and loyaltyCustomer service done right is one of today’s most powerful competitive advantages. In Can Your Customer Service Do This? Micah Solomon—who has worked with brands from Auberge Resorts to Audi of America, from Cleveland Clinic to the NFL Players Association—shares everything he knows about creating a world-class customer experience and building sustainable bottom-line success. With wit and clarity, Micah shares real-life customer service detective examples and the customer service transformation that follows.• Micah Solomon is one of the top customer service trainers, training designers, keynote speakers, and authors on the subjects of customer service, customer experience, and hospitality. • This comprehensive guide and toolkit builds on Solomon's 3 decades’ experience of building and rebuilding customer service at some of the great companies and brands of our time.• The author's clients include Microsoft, Audi of America, Merck Pharmaceuticals, Cleveland Clinic, The Museum of Modern Art (MoMA), and some of the leading Five-Star (Forbes-rated) hotels and resorts in America and around the world. Solomon helps readers to learn the art of anticipatory customer service—getting inside the heads of the customer, empathizing with their dissatisfaction, examining processes and procedures that are antiquated or not competitive enough, and learning to be innovative about modifying or optimizing various different modes of customer service and the methods available today, and he also shares the customer service training he uses to transform customer service performance across multiple industries, including his well-known “MAMA Method” of working successfully with upset customers. Whether your business is an established brand or just starting out, Micah Solomon offers step-by-step secrets that will one-up the competition and build sustainable bottom line success through lasting customer engagement and loyalty.

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William H. Foege, one of the most respected leaders in global public health, takes readers on a tour of his time at the CDC.In its seventy years, the Centers for Disease Control and Prevention (CDC) has evolved from a malaria control program to an institution dedicated to improving health for all people across the world. The Fears of the Rich, The Needs of the Poor is a revealing account of the CDC’s development by its former director, public health luminary William H. Foege.Dr. Foege tells the stories of pivotal moments in public health, including the eradication of smallpox (made possible due in part to Foege’s research) and the discovery of Legionnaires’ disease, Reye syndrome, toxic shock syndrome, and HIV/AIDS. With good humor and optimism, he recounts the various crises he surmounted, from threats of terrorist attacks to contentious congressional hearings and funding cuts. Highlighting the people who made possible some of public health’s biggest successes, Foege outlines the work required behind the scenes and describes the occasional tensions between professionals in the field and the politicians in charge of oversight. In recent years, global public health initiatives have come from unanticipated sources. Giants in the field now include President Jimmy Carter and his wife, Rosalynn, who promote programs aimed at neglected diseases. Melinda and Bill Gates have invigorated the field through research and direct program support, especially in the area of vaccine-preventable diseases. And the Merck Mectizan program has dramatically reduced river blindness in Africa. Foege has been involved in all of these efforts, among others, and he brings to this book the knowledge and wisdom derived from a long and accomplished career. The Fears of the Rich, The Needs of the Poor is an inviting but unvarnished account of that career and offers a plethora of lessons for those interested in public health.

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LEADING THE VIRTUAL WORKFORCE World markets are unsteady, unemployment is on the rise, housing foreclosures are up, asset values are down, and the political landscape is shifting. Under such tumultuous conditions, people often look to leaders to soothe battered nerves. But in today's rough and tumble environment, there are reportedly few leaders the average person relies upon. Over 80 percent of Americans believe that we are in the midst of a major leadership crisis. And over 75 percent of executives from around the world are seriously concerned about whether businesses can develop good leaders for the future. And yet not one leadership book squarely addresses the issue of the changed workforce, the virtual workforce, and why old leadership models just don't work—until now. Leading the Virtual Workforce builds off the ground-breaking concept of Virtual Distance introduced in Sobel Lojeski's seminal first book, Uniting the Virtual Workforce. And in never-before-published interviews, leaders from IBM, Merck, Western Union, Alcatel-Lucent, HP, AT&T, and more share detailed case studies about what's different about leadership today and how to become a great leader in the Digital Age. Leading the Virtual Workforce covers: The most common myths about leadership for today's virtual workforce Why old leadership models need to be reshaped for a new era What great leaders do differently to thrive in the globally connected enterprise A new leadership model custom-built for today's workforce realities Advice from the greats for those looking to advance their leadership and management effectiveness for the virtual workforce The virtual workforce is a relatively new phenomenon. The Virtual Distance Model provides the quantitative data and predictive power needed to understand how new behaviors, born out of the Digital Age, impact performance, innovation, and other critical success factors. And now the time has come to reshape leadership models to best serve worldwide organizations in the twenty-first century. Leading the Virtual Workforce does just that—paving the way for future leaders to create unmatched competitive advantage and performance improvements in the growing world of virtual work.

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The United States has the first and the farthest-reaching newborn genetic screening program in the world. In recent years, individual states have expanded their newborn screening programs to include many more genetic conditions, as new medical knowledge and new testing technologies have become available. The contributors to this provocative collection study the complex ethical and policy challenges present in the changing newborn screening environment and offer guidance to professionals, policymakers, and the general public. Experts from the fields of bioethics, genetics, pediatrics, public health, health policy, law, and political science identify and analyze four social and ethical issues critical to newborn screening policy: the distribution of costs and benefits; information, consent, and privacy; consultation and decision making; and race, ethnicity, and socioeconomic status. In the process, the contributors capture the difficulties of trying to forge ethical public policy at the intersection of parental concerns, new technologies, and economic interests. Contributors: Andrea Bonnicksen, Ph.D., Northern Illinois University; Jeffrey R. Botkin, M.D., M.P.H., University of Utah; Ned Calonge, M.D., M.P.H., Department of Public Health and Environment, Denver; Toby Citrin, J.D., University of Michigan School of Public Health; Ellen Wright Clayton, M.D., M.S., J.D., Vanderbilt University; Jannine De Mars Cody, Ph.D., University of Texas Health Science Center; Anne Marie Comeau, Ph.D., University of Massachusetts Medical School; James R. Eckman, M.D., Emory University School of Medicine; Scott D. Grosse, Ph.D., National Center on Birth Defects and Developmental Disabilities; Bruce Jennings, M.A., Yale School of Public Health; Donna E. Levin, J.D., Massachusetts Department of Public Health; Michele A. Lloyd-Puryear, M.D., Ph.D., U.S. Department of Health and Human Services; Marie Y. Mann, M.D., M.P.H., U.S. Department of Health and Human Services; Karen J. Maschke, Ph.D., The Hastings Center; Stephen M. Modell, M.D., M.S., University of Michigan School of Public Health; Virginia A. Moyer, M.D., M.P.H., Baylor College of Medicine and Texas Children's Hospital; Lainie Friedman Ross, M.D., Ph.D., University of Chicago; Joseph Telfair, Dr.P.H., M.S.W., M.P.H., University of North Carolina at Greensboro; Steven M. Teutsch, M.D., M.P.H., Merck & Co., Inc.; Bradford L. Therrell, Ph.D., University of Texas Health Science Center; Benjamin S. Wilfond, M.D., University of Washington

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The challenges facing today's sales executives and their organizations continue to grow, but so do the expectations that they will find ways to overcome them and drive consistent sales growth. There are no simple solutions to this situation, but in this thoroughly updated Second Edition of Sales Growth, experts from McKinsey & Company build on their practical blueprint for achieving this goal and explore what world-class sales executives are doing right now to find growth and capture it—as well as how they are creating the capabilities to keep growing in the future. Based on discussions with more than 200 of today's most successful global sales leaders from a wide array of organizations and industries, Sales Growth puts the experiences of these professionals in perspective and offers real-life examples of how they've overcome the challenges encountered in the quest for growth. The book, broken down into five overarching strategies for successful sales growth, shares valuable lessons on everything from how to beat the competition by looking forward, to turning deep insights into simple messages for the front line. Page by page, you'll learn how sales executives are digging deeper than ever to find untapped growth, maximizing emerging markets opportunities, and powering growth through digital sales. You'll also discover what it takes to find big growth in big data, develop the right "sales DNA" in your organization, and improve channel performance. Three new chapters look at why presales deserve more attention, how to get the most out of marketing, and how technology and outsourcing could entirely reshape the sales function. Twenty new standalone interviews have been added to those from the first edition, so there are now in-depth insights from sales leaders at Adidas, Alcoa, Allianz, American Express, BMW, Cargill, Caterpillar, Cisco, Coca-Cola Enterprises, Deutsche Bank, EMC, Essent, Google, Grainger, Hewlett Packard Enterprise, Intesa Sanpaolo, Itaú Unibanco, Lattice Engines, Mars, Merck, Nissan, P&G, Pioneer Hi-Bred, Salesforce, Samsung, Schneider Electric, Siemens, SWIFT, UPS, VimpelCom, Vodafone, and Würth. Their stories, as well as numerous case studies, touch on some of the most essential elements of sales, from adapting channels to meet changing customer needs to optimizing sales operations and technology, developing sales talent and capabilities, and effectively leading the way to sales growth. Engaging and informative, this timely book details proven approaches to tangible top-line growth and an improved bottom line. Created specifically for sales executives, it will put you in a better position to drive sales growth in today's competitive market.

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Dramatically improve your decisions with data and AI In Decision Intelligence: Transform Your Team and Organization with AI-Driven Decision-Making, a team of pioneering decision and AI strategists delivers a digestible and hands-on resource for professionals at every part of the decision-making journey. The book discusses the latest technology and approaches that bridge the gap between behavioral science, data science, and technological innovation. Discover how leaders from various industries and environments are using data and AI to make better future decisions, taking both human as well as business factors into account. This book covers: A demystifying behind-the-scenes peek inside how AI models, forecasts, and optimization for business challenges really work, and why they open up entirely new possibilities. A business-ready introduction to decision intelligence, exploring why traditional decision-making strategies are outdated and how to transition to decision-intelligence. The evolution of Decision Intelligence, coming from analytics and modern techniques like process mining and robotic process automation An examination of decision intelligence at the organizational level, including discussions of agile transformation, transparent organizational culture, and why psychological safety is a crucial enabler for new ways of decision-making in modern companies An overview of why (and where exactly) AI still needs human expertise and how to incorporate this topic in daily planning and decision making Decision Intelligence is essential reading for managers, executives, board members, other business leaders and soon-to-be leaders looking to improve the quality, adaptability, and speed of their decision-making.Praise for Decision Intelligence "In Decision Intelligence, Thorsten Heilig and Ilhan Scheer build a compelling case for the world of tomorrow’s version of decision-making.”―Martin Lindstrom, New York Times best-selling author"Decision Intelligence will be one of the big topics for this decade and completely change the way organizations manage, plan, and operate. This book provides a comprehensive guide from the basics to the applications."―Niklas Jansen, Entrepreneur and Tech Investor, Founding Partner Interface Capital and Co-Founder Blinkist "The book impressively demonstrates the potential and entry points into the world of AI-powered decision making. A very valuable reading for managers and their organizations".―Michael Kleinemeier, Member of the Merck KG Board of Partners, former Member of the SAP SE Executive Board“The AI hype perfectly captured, easy to understand, de-mystified and mapped to clear use cases - a must-read for today's managers.”―Dr. Daniela Gerd tom Markotten, Member of the Management Board for Digitalization and Technology, Deutsche Bahn AG

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In the early twentieth century the relevance of chirality to the pharmaceutical industry was established by the fact that one enantiomer of hyoscyamine possessed greater pharmacological activity than the other. Today, most new drugs and those under development consist of a single optically active isomer, and chirality is also becoming an issue for the agrochemical and other industries. Regulatory agencies throughout the world are currently reviewing the importance of chirality with regard to pharmaceutical and agrochemical products. New guidelines from such agencies have been key drivers for the focus on single enantiomer products in these industries. These scientific and regulatory developments have created the need for a guide for workers in the pharmaceutical and chemical industries seeking information on chiral molecules, processes, and commercially available chiral chemicals. Chiral Intermediates presents the chemical professional with a comprehensive listing of over 4700 available chiral chemicals including specific data of interest for each entry in the listing. Its companion volume, Chiral Drugs presents the same detailed information for over 2000 chiral drugs. The 'Chiral Pool' of readily available, relatively inexpensive chiral compounds has been expanding at a rapid rate as more and more products are produced in large quantities at economical prices. New developments in various technologies for isolating, preparing, and purifying chiral materials have greatly increased the opportunities for utilizing optically pure compounds in commercial applications. Novel techniques for classical resolution, new methodologies for developing selective enzymes for biocatalysis, advances in the application of microorganisms for chemical production, and continued progress in the area of asymmetric synthesis have all contributed to the growth of this field. Part I contains four chapters which provide an introduction to topics relevant to the field of chiral chemistry and includes a brief overview of chirality, a short discussion on the current market drivers in the area of chiral chemistry, and a basic presentation of the various sources and methods for obtaining chiral compounds. Part II presents entries for 4700 commercially available chiral compounds. For each main entry, the chemical name and a list of trade names and synonyms is provided; the CAS Registry Number, the European Inventory of Existing Commercial Chemical Substances (EINECS) number, and the Merck Index (12th edition) number are given when available. The physical properties, including specific rotation, of each compound are described and indicated applications are presented. The structure of nearly every compound is provided, and the manufacturers and suppliers of the compounds are also given. Indexes, including a master index of names and synonyms and an index of custom manufacturing services for production of chiral compounds, are appended. Chiral Intermediates provides an introduction to the types of sources and methods currently in use for obtaining chiral molecules and is an invaluable resource for information on available chiral molecules. Chiral Intermediates and Chiral Drugs are the most comprehensive and detailed guides to chiral compounds available.

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