Search results for ""Author Victor Hoffbrand""

The story of folate (vitamin B9) is one of outstanding achievements which have advanced major areas of medical practice and also of scandals of international significance. Folate was the only one of the 13 vitamins to have been discovered by a woman, Lucy Wills. She showed in1931 that the yeast extract Marmite could cure the anaemia of pregnant women in Bombay. The vitamin, first isolated from spinach, was subsequently shown not only to correct anemia but also to prevent the birth of babies with the severe defect spina bifida. The first effective anti-bacterial drugs and anti-cancer drugs were anti-folates. The scandals in the story of folate include the opposition, mainly by men, to women becoming doctors, the lack of any public recognition of Lucy Wills’s achievements, the vicious treatment the British Government gave to Waldemar Haffkine who had made for them the world’s first two anti-bacterial vaccines and saved millions of lives, and the incorrect use of folic acid to treat pernicious anaemia leading to irreversible paralysis. The most significant scandal, the failure of worldwide fortification of the diet with folic acid. This catastrophe allows thousands of babies to be born each year with the major birth defect spina bifida ,which could be prevented by this cheap, safe public health measure, already mandated for in over 80 countries, in North America since 1998.

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Following the familiar, easy-to-use at a Glance format, Haematology at a Glance, Fourth Edition is a broad and accessible introduction to the study of blood. Fully revised and updated to reflect advances in the field and in clinical practice, this new edition covers essential knowledge, from basic hematological physiology to blood disorders and their diagnosis and treatment. This new edition of Haematology at a Glance: • Features expanded sections on the underlying mechanisms, diagnostic techniques and management of the malignant haematological diseases. Also incorporates recent advances in knowledge of thrombosis and the newer oral anticoagulants • Contains the very latest clinical treatments • Includes updated illustrations and clinical photographs to illustrate concepts and aid understanding • Features extensive online self-assessment at www.ataglanceseries.com/haematology This book is an invaluable resource for medical students and health professionals wanting to consolidate and expand their knowledge of haematology.

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Provides coverage of the pathogenesis, clinical, morphologic, molecular and investigational aspects of a full range of blood disorders seen in daily practice The revised fifth edition of this renowned atlas presents readers with a comprehensive, visual guide to clinical hematology, featuring 2700 full-color photographs and figures depicting the spectrum of hematological diseases. Ranging from photographs of the clinical manifestations and key microscopic findings to diagrams of the molecular aspects of these diseases, the book provides up-to-date information of the blood diseases that clinicians encounter every day. Color Atlas of Clinical Hematology: Molecular and Cellular Basis of Disease offers the reader an understanding of normal cell machinery, and of the molecular basis for such processes as DNA and cell replication, RNA species, trafficking and splicing, protein synthesis, transcription factors, growth factor signal transduction, epigenetics, cell differentiation, autophagy, and apoptosis. The text goes on to explore how these processes are disturbed in the various diseases of the bone marrow, blood, and lymphoid systems. Helps solve difficult diagnostic challenges and covers complex principles using highly illustrative, full-color images Explores all aspects of benign and malignant hematology, including blood transfusion and coagulation with extensive coverage of the pathogenesis of common clinical entities Provides a quick and easy reference of key diagnostic issues in a comprehensive yet concise format Includes and illustrates the WHO Classification of Hematologic Malignancies Illustrates the new knowledge of the molecular basis of inherited and acquired blood diseases Color Atlas of Clinical Hematology: Molecular and Cellular Basis of Disease is the must-have resource for both trainee and practising hematologists, and for every department of hematology."Substantially updated and now multi-authored so that all aspects of haematology are equally covered, including the newest developments in molecular biology and genomic sequencing""There is a surplus of invention in communicating complex problems here and an admirable effort to keep the reader totally up-to-date"

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This comprehensive textbook is the key resource for postgraduate trainees or residents in haematology. Now in its seventh edition, the book continues to provide everything the reader needs for examination preparation or clinical practice. Postgraduate Haematology discusses up-to-date knowledge of the pathogenesis, clinical and laboratory features, management and treatment of a wide range of blood and bone marrow disorders in a concise and user friendly style. It presents essential information for everyday use and teaching, as well more detailed scientific background for more in-depth reading, accompanied by thoughtful referencing. The clearly illustrated full-colour figures and charts demonstrate key facts, and are supplemented by numerous high quality photomicrographs of blood cells and tissues. Over 51 chapters from international authors, including the WHO Classification of Haematopoietic and Lymphoid Tissues, Postgraduate Haematology provides an expert review of malignant and non-malignant haematology. New sections reflect advances in the specialty, e.g. knowledge gained from new generation sequencing, latest anticoagulant drugs, diagnostic laboratory tools, and treatment strategies Superb four-color illustrations and photomicrographs of blood cells and tissues throughout Includes algorithms to aid with decision-making for treatment Companion website featuring figures and tables from the book Arm yourself with the textbook of choice for trainees and practitioners in haematology.

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