Search results for ""Author Michael Shapiro""

“Knowledgeable, probing, and thoughtful.” —Foreword Reviews Smokey Robinson • Barbara Kingsolver • Francis Ford Coppola • David Sedaris • Jane Goodall and other luminaries reveal the secrets to their creative success. Amy Tan talks about how she finds truth by writing fiction. Melissa Etheridge tells us how she channels her fire into her music. Pico Iyer shares how seeking stillness enhances his creativity. And Coppola discusses how he found the courage to make groundbreaking films. In The Creative Spark, a collection of interviews prefaced by brief biographies, these luminaries join dozens of other voices to create a symphony of inspiration. Lucinda Williams talks about honesty and making every word count; Jane Goodall cites the value of persistence and believing in yourself; and Smokey Robinson heralds the timeless power of love songs. For more than a decade, award-winning author Michael Shapiro (A Sense of Place) has interviewed many of our brightest creators. In The Creative Spark, musicians, authors, explorers, and chefs speak about what drives them, what helps them see the world in fresh ways, and what inspires them to turn their visions into art. Shapiro’s work as a music journalist has led to interviews with legends including Graham Nash, Lyle Lovett, Melissa Etheridge, Jake Shimabukuro, Merle Haggard, and Jethro Tull bandleader Ian Anderson. And he’s spoken with creative masters in other fields, such as comedian Joan Rivers and author Frances Mayes. Yet it’s not simply that Shapiro has had access to so many supremely talented people—it’s that he gets them to go deep. Moments into his penetrating conversation with Lucinda (her fans call her by her first name), she tells Shapiro about how decisions made about her mother’s funeral led to fissures in her family. From this achingly personal conversation, readers can glean fresh insights into why Lucinda has such a devoted following and why her songs open listeners’ hearts. Unexpected revelations pop up in every chapter of The Creative Spark. Iowa folksinger Greg Brown isn’t a household name, but his fellow musicians revere his poetic compositions. Then there’s San Francisco Giants announcer Mike Krukow, who turns every broadcast into a work of art. Chefs, including SingleThread’s Kyle Connaughton, discuss how they’re transforming the way we approach fine dining and why social responsibility is essential. Each chapter starts with a short biography of the creative person being profiled, then segues into Q+A. This collection brings together some of the best-known artists of our time with others who may not be as famed but who have valuable insights about living an artful life. The Creative Spark stands as a testament to human achievement, showing how creativity illuminates our world. And how it resides in each and every one of us, just waiting to break out.

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Fragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical companies that have embraced this approach and the biotechnology companies who use fragments as their sole source of drug discovery. Fragment-Based Drug Discovery: A Practical Approach is a guide to the techniques and practice of using fragments in drug screening. The emphasis is on practical guidance, with procedures, case studies, practical tips, and contributions from industry. Topics covered include: an introduction to fragment based drug discovery, why using fragments is a more efficient process than predominant models, and what it means to have a successful FBDD effort. setting up an FBDD project library building and production NMR in fragment screening and follow up application of protein-ligand NOE matching to the rapid evaluation of fragment binding poses target immobilized NMR screening: validation and extension to membrane proteins in situ fragment-based medicinal chemistry: screening by mass spectrometry computational approaches to fragment and substructure discovery and evaluation virtual fragment scanning: current trends, applications and web based tools fragment-based lead discovery using covalent capture methods case study from industry: the identification of high affinity beta-secretase inhibitors using fragment-based lead generation With contributions from industry experts who have successfully set up an industrial fragment-based research program, Fragment-Based Drug Discovery: A Practical Approach offers essential advice to anyone embarking on drug discovery using fragments and those looking for a new approach to screening for drugs.

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The theory of holomorphic functions of several complex variables emerged from the attempt to generalize the theory in one variable to the multidimensional situation. Research in this area has led to the discovery of many sophisticated facts, structures, ideas, relations, and applications. This deepening of knowledge, however, has also revealed more and more paradoxical differences between the structures of the two theories. The authors of this Research Note were driven by the quest to construct a theory in several complex variables that has the same structure as the one-variable theory. That is, they sought a reproducing kernel for the whole class that is universal and from same class. Integral Theorems for Functions and Differential Forms in Cm documents their success. Their highly original approach allowed them to obtain new results and refine some well-known results from the classical theory of several complex variables. The 'hyperholomorphic" theory they developed proved to be a kind of direct sum of function theories for two Dirac-type operators of Clifford analysis considered in the same domain.In addition to new results and methods, this work presents a first-look at a brand new setting, based upon the natural language of differential forms, for complex analysis. Integral Theorems for Functions and Differential Forms in Cm reveals a deep link between the fields of several complex variables theory and Clifford analysis. It will have a strong influence on researchers in both areas, and undoubtedly will change the general viewpoint on the methods and ideas of several complex variables theory.

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