Search results for ""Author Dr Sue Clark""

Intensive research over the last fifteen years has yielded a vast expansion in our understanding of the role of inheritance and genetics in a variety of cancers. Several inherited conditions have been identified which result in a high risk of various cancers; some of these were previously recognised, but the genetic basis underlying them has now been elucidated. This knowledge is now entering the sphere of routine clinical care. Once the preserve of researchers and highly specialised units, genetic testing for cancer predisposition is now accessible to most clinicians via regional genetics units; in the USA patients can access commercial genetic testing facilities. There is a growing evidence base to guide family screening and clinical management of affected individuals. Surgeons, gastroenterologists, gynaecologists, oncologists, endocrinologists and many others need an awareness of these disorders, an understanding of genetic testing and when it is indicated, and how to manage patients with inherited cancer predisposition and their families. Testing for these conditions has potential legal, ethical and financial implications different from those which most clinicians regularly encounter, and continuing scientific and clinical advance means that patients and their doctors will face regular changes in management. This book covers the basic concepts of cancer genetics. The common inherited cancer syndromes are each dealt with in greater depth, with the current management outlined. This book is aimed at all clinicians who may encounter these conditions in their practice. It aims to facilitate identification of high-risk individuals and families, to inform interaction with geneticists and other sub-specialists, to provide a basis for patient management and to stimulate interest in these fascinating conditions.

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This book is a topical review of issues the editors consider to be 'hot topics' and will be of interest to qualified consultant colorectal surgeons and those performing general surgery with an interest in colorectal surgery. In addition, the topics picked are likely to be ones that candidates taking the Intercollegiate Examination in General Surgery will be quizzed upon. It is not intended to be a textbook covering all aspects of colorectal surgery. Rather, it is meant to be an up-to-date view of current and probable near future advances. Frontiers in neoplasia, inflammatory bowel disease, anal disorders and management are covered by acknowledged experts, known to be active in the field. The implications of deep pelvic dissection and pouch surgery in males and females are sensitively explored. Each chapter contains three main sections entitled 'What is the problem/issue?', 'Where are we now?' and 'Where are we going?'. Referencing for the first two is key and current; the last section is speculative with the occasional reference. This volume should find a place on the coloproctologist's bookshelf as an exciting review of contemporary themes, complementing traditional textbooks.

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