Search results for ""Author Ana Martinez""

Multiple sclerosis (MS) is a complex disease with a presumed autoimmune aetiology and few current effective treatments. Disease modifying therapies focus on the altering the natural course of relapsing and remitting MS, targeting the inflammatory response. Other targets involve tacking the cause of the disease – demyelination of axons through remyelination therapies. Due to several recent breakthroughs in the understanding of the pathophysiology of MS new targets for remyelination and immunomodulation are rapidly emerging. This book provides a comprehensive overview of drug discovery and development for the molecular basis of the disease, from new targets to drugs currently in clinical development, cellular and animal disease models to biomarkers for diagnosis and assessment in clinical trials. Emerging Drugs and Targets for Multiple Sclerosis is an ideal reference for any student or researcher interested in drug development for neurodegenerative diseases, autoimmune diseases and MS in particular.

Read more less

No 109: LA CIUDADANIA IMAGINADA.Analiza como se defienden en la novela popular española, los valores y modos de comportamiento más deseables, como la tolerancia, el trabajo, el ahorro o los placeres de una vida tranquila vida doméstica, y cómo, en este aspecto, entre los autores de folletines y los grandes novelistas del periodo se establecen notables coincidencias.

Read more less

Considerada por algunos especialistas como la obra maestra de su autor, ?Las formas elementales de la vida religiosa? resume el enfoque durkheimiano y ejemplifica claramente su visión del mundo social. En este trabajo sobre la religión primitiva, Émile Durkheim (1858-1917) realiza una excelente descripción de la cultura y la sociedad de los aborígenes australianos. Santiago González Noriega señala en su prólogo el interés de esta obra como teoría de la unidad grupal y del simbolismo, a la vez que destaca algunas de sus tesis básicas, como la búsqueda de un equivalente funcional de las viejas religiones en nuestras sociedades laicas contemporáneas y la relación estrechísima entre la delimitación de grupos humanos y el sistema de creencias compartidas por sus miembros que se hacen visibles en símbolos sensibles. Otras obras de Durkheim en esta colección: ?Las reglas del método sociológico y otros escritos sobre filosofía de las ciencias sociales?.

Read more less

Affecting over 1.5 million people across the world, Parkinson's disease is a progressive neurological condition characterized, in part, by the loss of dopaminergic neurons in the substantia nigra pars compacta. It affects 1.5% of the global population over 65 years of age. As life expectancy is increasing, over the next few years the number of patients with Parkinson´s disease will grow exponentially. To date, there are no available treatments that are capable of curing Parkinson´s disease, and the current goal of therapy, dopamine replacement strategies, is to reduce symptoms. After several years of disease progression, treatment is complicated by the onset of motor fluctuations and dyskinesias. This information reveals the great importance and social need of finding an effective therapeutic intervention for Parkinson´s disease. This exemplary new book reviews some of the most outstanding examples of new drugs currently in pharmaceutical development or new targets currently undergoing the validation process to try to reach the Parkinson´s drug market in the next few years as potential disease modifying drugs. Providing up to date and comprehensive coverage, this book is essential reading for researchers working in academia and industry in any aspect of medicinal chemistry or drug discovery.

Read more less

Gingrich the Witch takes her cooking very seriously, from the perfect utensils -cages and couldrons- to the perfect recipes- a Sleeping Beauty omelet or a Cinderella hamburger… Follow along as she prepares her favorite ‘legendary’ meals.

Read more less

Gingrich the Witch takes her cooking very seriously, from the perfect utensils -cages and couldrons- to the perfect recipes- a Sleeping Beauty omelet or a Cinderella hamburger… Follow along as she prepares her favorite ‘legendary’ meals.

Read more less

Many researchers believe that GSK-3 and its inhibitors could lead to effective treatments for neurogenerative disorders, type II diabetes, depression and bipolar disorder, and some forms of cancer. This book provides a thorough introduction to GSK-3, presents up-to-date information, and mentions the birth of several chemical families of GSK-3 inhibitors with varying selectivity. It’s a great reference for researchers in drug design and development.

Read more less