Search results for ""elsevier""

Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging is a comprehensive reference on the diagnosis and management of neurological aging and associated disorders. The book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. It also examines pharmacological and non-pharmacological interventions of age-related conditions that affect the brain, including Alzheimer’s, stroke and multiple sclerosis.

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Power Quality in Power Systems, Electrical Machines, and Power-Electronic Drives uses current research and engineering practices, guidelines, standards, and regulations for engineering professionals and students interested in solving power quality problems in a cost effective, reliable, and safe manner within the context of renewable energy systems. The book contains chapters that address power quality across diverse facets of electric energy engineering, including AC and DC transmission and distribution lines; end-user applications such as electric machines, transformers, inductors, capacitors, wind power, and photovoltaic power plants; and variable-speed, variable-torque power-electronic drives. The book covers nonsinusoidal waveshapes, voltage disturbances, harmonic losses, aging and lifetime reductions, single-time events such as voltage dips, and the effects of variable-speed drives controlled by PWM converters. The book also reviews a corpus of techniques to mitigate power-quality problems, such as the optimal design of renewable energy storage devices (including lithium-ion batteries and fuel cells for automobiles serving as energy storage), and the optimal design of nonlinear loads for simultaneous efficiency and power quality.

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Biotechnology and its Applications: Using Cells to Change the World, Second Edition introduces students to the world of biotechnology in a way that runs deeper than a mere survey. Sections cover basic science, introduce cells, explain how they behave, what they are made of, demonstrate the biotechnological application of scientific principles in the laboratory, and present biotechnologies “in the real world.” Examples include recombinant proteins available to millions of patients, plants that have been engineered to produce food for people around the world, and regenerative medicine that may someday allow patients to receive organs that have been grown from their own cells. The updated edition has been expanded with the most current information available, with new chapters on gene editing, bioremediation, vaccines and immunotherapy, and processing and manufacturing, thus resulting in a modern, robust, yet highly readable applications-oriented introduction to biotechnology.

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Stiehm’s Immune Deficiencies: Inborn Errors in Immunity, Second Edition, is ideal for physicians and other caregivers who specialize in immunology, allergies, infectious diseases and pulmonary medicine. It provides a validated source of information for care delivery to patients, covering approaches to diagnosis that use both new genetic information and emphasize screening strategies. Management has changed dramatically over the past five years, so approaches to infection and autoimmunity are emphasized in an effort to improve outcomes and disseminate new information on the uses of targeted therapy.

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Molecular Dynamic Simulation: Fundamentals and Applications explains the basic principles of MD simulation and explores its recent developments and roles in advanced modeling approaches. The implementation of MD simulation and its application to various aspects of materials science and engineering including mechanical, thermal, mass transportation, and physical/chemical reaction problems are illustrated. Innovative modeling techniques that apply MD to explore the mechanics of typical nanomaterials and nanostructures and to characterize crystalline, amorphous, and liquid systems are also presented. The rich research experience of the authors in MD simulation will ensure that the readers are provided with both an in-depth understanding of MD simulation and clear technical guidance.

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Diagnosis and Management in Parkinson's Disease: The Neuroscience of Parkinson’s, Volume 1 provides a single source of material covering different scientific domains of neuropathology underlying this condition. The book covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments, and treatment regimens. It fills a much-needed gap as a "one-stop" synopsis of everything concerning the neurology and neuroscience related to Parkinson’s disease, from chemicals and cells to individuals. The book is an invaluable resource for neuroscientists, neurologists, and anyone in the field.

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Forensic Genetic Approaches for Identification of Human Skeletal Remains: Challenges, Best Practices, and Emerging Technologies provides best practices on processing bone samples for DNA testing. The book outlines forensic genetics tools that are available for the identification of skeletal remains in contemporary casework and historical/archaeological investigations. Although the book focuses primarily on the use of DNA for direct identification or kinship analyses, it also highlights complementary disciplines often used in concert with genetic data to make positive identifications, such as forensic anthropology, forensic odontology, and forensic art/sculpting. Unidentified human remains are often associated with tragic events, such as fires, terrorist attacks, natural disasters, war conflicts, genocide, airline crashes, homicide, and human rights violations under oppressive totalitarian regimes. In these situations, extensive damage to soft tissues often precludes the use of such biological samples in the identification process. In contrast, bone material is the most resilient, viable sample type for DNA testing. DNA recovered from bone often is degraded and in low quantities due to the effects of human decomposition, environmental exposure, and the passage of time. The complexities of bone microstructure and its rigid nature make skeletal remains one of the most challenging sample types for DNA testing.

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Engineers solve problems and work on emerging challenges in a wide range of areas important to improving quality of life; areas like sustainable energy, access to clean water, and improved communications and health care technologies. Kosky et al’s Exploring Engineering explores the world of engineering by introducing the reader to what engineers do, the fundamental principles that form the basis of their work, and how they apply that knowledge within a structured design process. The three-part organization of the text reinforces these areas, making this an ideal introduction for anyone interested in exploring the various fields of engineering and learning how engineers work to solve problems. The 5th edition has been revised to better reflect the knowledge base of incoming freshmen, and new content has been added for several new and emerging engineering disciplines, such as environmental engineering, cybersecurity, additive manufacturing, and mechatronics, as well as new design projects

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Digital Signal Processing: Fundamentals and Applications, Third Edition, not only introduces students to the fundamental principles of DSP, it also provides a working knowledge that they take with them into their engineering careers. Many instructive, worked examples are used to illustrate the material, and the use of mathematics is minimized for an easier grasp of concepts. As such, this title is also useful as a reference for non-engineering students and practicing engineers. The book goes beyond DSP theory, showing the implementation of algorithms in hardware and software. Additional topics covered include adaptive filtering with noise reduction and echo cancellations, speech compression, signal sampling, digital filter realizations, filter design, multimedia applications, over-sampling, etc. More advanced topics are also covered, such as adaptive filters, speech compression such as PCM, µ-law, ADPCM, and multi-rate DSP, over-sampling ADC subband coding, and wavelet transform.

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Methods in Stream Ecology: Volume 2: Ecosystem Structure, Third Edition, provides a complete series of field and laboratory protocols in stream ecology that are ideal for teaching or conducting research. This new two-part edition is updated to reflect recent advances in the technology associated with ecological assessment of streams, including remote sensing. Volume two covers community interactions, ecosystem processes and ecosystem quality. With a student-friendly price, this new edition is key for all students and researchers in stream and freshwater ecology, freshwater biology, marine ecology and river ecology. This book is also supportive as a supplementary text for courses in watershed ecology/science, hydrology, fluvial geomorphology and landscape ecology. Methods in Stream Ecology, 3rd Edition, Volume 1: Ecosystem Structure, is also available now!

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Plant Flow Measurement and Control Handbook is a comprehensive reference source for practicing engineers in the field of instrumentation and controls. It covers many practical topics, such as installation, maintenance and potential issues, giving an overview of available techniques, along with recommendations for application. In addition, it covers available flow sensors, such as automation and control. The author brings his 35 years of experience in working in instrumentation and control within the industry to this title with a focus on fluid flow measurement, its importance in plant design and the appropriate control of processes. The book provides a good balance between practical issues and theory and is fully supported with industry case studies and a high level of illustrations to assist learning. It is unique in its coverage of multiphase flow, solid flow, process connection to the plant, flow computation and control. Readers will not only further understand design, but they will also further comprehend integration tactics that can be applied to the plant through a step-by-step design process that goes from installation to operation.

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Crime Scene Investigation Laboratory Manual, Second Edition, is written by a former crime scene investigator and forensic scientist who provides practical, straightforward, and immediately applicable best practices. Readers will learn the latest techniques and procedures, including deconstructing first responder contamination, the preliminary walk-through, utilizing associative evidence, enhancing trace, biological and chemical evidence, and reconstructing scenes through wound dynamics, glass fracture patterns, bloodstain patterns, ballistics, and more. This lab manual provides information and examples for all aspects of crime scene investigation. In addition, included exercises teach the proper techniques for securing, documenting and searing a crime scene, how to visualize or enhance the evidence found, how to package and preserve the evidence, and how to reconstruct what happened at the crime scene. This manual is intended to accompany any crime scene investigation textbook.

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Bladder Cancer is designed for researchers and clinicians involved in urologic practice, including urologists, medical oncologists, pathologists and radiologists. It provides comprehensive guidance for treating and understanding bladder cancer and serves as an up-to-date reference reflecting evidence-based research. The biological behavior of this disease entity shows a heterogeneous pattern with diverse morbidity and mortality depending on a variety of factors, such as tumor characteristics (tumor stage, grade, size, number, shape, and histologic subtypes) and applied treatment modalities (surgery or non-surgical management). This book presents the substantial academic developments in the field of bladder cancer in one convenient reference.

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Reasoning: The Neuroscience of How We Think is a comprehensive guide to the core topics related to a thorough understanding of reasoning. It presents the current knowledge of the subject in a unified, complete manner, ranging from animal studies, to applied situations, and is the only book available that presents a sustained focus on the neurobiological processes behind reasoning throughout all chapters, while also synthesizing research from animal behavior, cognitive psychology, development, and philosophy for a truly multidisciplinary approach. The book considers historical perspectives, state-of-the-art research methods, and future directions in emerging technology and cognitive enhancement. Written by an expert in the field, this book provides a coherent and structured narrative appropriate for students in need of an introduction to the topic of reasoning as well as researchers seeking well-rounded foundational content. It is essential reading for neuroscientists, cognitive scientists, neuropsychologists and others interested in the neural mechanisms behind thinking, reasoning and higher cognition.

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Geriatric Neurology, Volume 167, serves as an update on the basic biological and behavioral mechanisms underlying the aging process, with an emphasis on neurological aging and state-of-the-art reviews on our understanding of vascular, cognitive, neurodegenerative and neuropsychiatric diseases in the elderly. Developed with an eye to providing both the basic underpinnings of age-related changes and the clinical information necessary to aid in diagnostics and treatment, the book serves as a useful volume for students, basic and translational scientists, and practicing clinicians on how to understand and treat common neurological disorders in the elderly.

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Participants in Asian financial markets have witnessed the unprecedented growth and sophistication of their investments since the 1997 crisis. Handbook of Asian Finance: REITs, Trading, and Fund Performance analyzes the forces behind these growth rates. Insights into banking, fund performance, and the effects of trading technologies for practitioners to tax evasion, market manipulation, and corporate governance issues are all here, presented by expert scholars. Offering broader and deeper coverage than other handbooks, the Handbook of Asian Finance: REITs, Trading, and Fund Performance explains what is going on in Asia today.

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This comprehensive handbook is a "one-stop-shop" for all researchers involved in the field of alcohol-related harm at the whole body or cellular level. Over 100 chapters provide abundant information of a wide range of topics that extend from the evolutionary aspects of alcohol consumption and the prevalence of alcohol misuse to programmed cell death. Each chapter is highly illustrated with tables and figures making this a valuable reference for students, clinicians and researchers alike.

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The new edition of Seeds contains new information on many topics discussed in the first edition, such as fruit/seed heteromorphism, breaking of physical dormancy and effects of inbreeding depression on germination. New topics have been added to each chapter, including dichotomous keys to types of seeds and kinds of dormancy; a hierarchical dormancy classification system; role of seed banks in restoration of plant communities; and seed germination in relation to parental effects, pollen competition, local adaption, climate change and karrikinolide in smoke from burning plants. The database for the world biogeography of seed dormancy has been expanded from 3,580 to about 13,600 species. New insights are presented on seed dormancy and germination ecology of species with specialized life cycles or habitat requirements such as orchids, parasitic, aquatics and halophytes. Information from various fields of science has been combined with seed dormancy data to increase our understanding of the evolutionary/phylogenetic origins and relationships of the various kinds of seed dormancy (and nondormancy) and the conditions under which each may have evolved. This comprehensive synthesis of information on the ecology, biogeography and evolution of seeds provides a thorough overview of whole-seed biology that will facilitate and help focus research efforts.

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The Encyclopedia of the Solar System, Third Edition—winner of the 2015 PROSE Award in Cosmology & Astronomy from the Association of American Publishers—provides a framework for understanding the origin and evolution of the solar system, historical discoveries, and details about planetary bodies and how they interact—with an astounding breadth of content and breathtaking visual impact. The encyclopedia includes the latest explorations and observations, hundreds of color digital images and illustrations, and over 1,000 pages. It stands alone as the definitive work in this field, and will serve as a modern messenger of scientific discovery and provide a look into the future of our solar system. New additions to the third edition reflect the latest progress and growth in the field, including past and present space missions to the terrestrial planets, the outer solar systems and space telescopes used to detect extrasolar planets.

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Since its first edition in 1982, the Paxinos and Watson rat brain atlas has become the most trusted source of accurate coordinates and anatomical information in laboratories throughout the world. It has been cited over 60,000 times, making it the most cited publication in neuroscience. The seventh edition incorporates new findings on developmental gene expression and presents the boundaries of neuromeres in sagittal sections.

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Advances in Catalysis, Volume 69 fills the gap between journal papers and textbooks across the diverse areas of catalysis research. For more than 60 years, this series has dedicated itself to record and present the latest progress in the field of catalysis, providing the scientific community with comprehensive and authoritative reviews. This series is an invaluable and comprehensive resource for chemical engineers and chemists working in the field of catalysis in both academia and industry, with this release focusing on solid acids, surface acidity and heterogeneous acid catalysis.

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Cognitive Systems and Signal Processing in Image Processing presents different frameworks and applications of cognitive signal processing methods in image processing. This book provides an overview of recent applications in image processing by cognitive signal processing methods in the context of Big Data and Cognitive AI. It presents the amalgamation of cognitive systems and signal processing in the context of image processing approaches in solving various real-word application domains. This book reports the latest progress in cognitive big data and sustainable computing. Various real-time case studies and implemented works are discussed for better understanding and more clarity to readers. The combined model of cognitive data intelligence with learning methods can be used to analyze emerging patterns, spot business opportunities, and take care of critical process-centric issues for computer vision in real-time.

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Fundamentals of Heat and Fluid Flow in High Temperature Fuel Cells introduces key-concepts relating to heat, fluid and mass transfer as applied to high temperature fuel cells. The book briefly covers different type of fuel cells and discusses solid oxide fuel cells in detail, presenting related mass, momentum, energy and species equation. It then examines real case studies of hydrogen- and methane-fed SOFC, as well as combined heat and power and hybrid energy systems. This comprehensive reference is a useful resource for those working in high temperature fuel cell modeling and development, including energy researchers, engineers and graduate students.

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Gigantism and Acromegaly brings together pituitary experts, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches. This book serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable as it provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as recommended approaches to evaluation and management. Acromegaly is a rare pituitary disorder that slowly changes its adult victim’s appearance over time: larger hands and feet, bigger jaw, forehead, nose, and lips. Generally, a benign pituitary tumor is the cause and symptoms of acromegaly can vary from patient to patient, making a diagnosis difficult and prolonging suffering for years. Early detection is key in the management of acromegaly as the pathologic effects of increased growth hormone (GH) production are progressive and can be life-threatening as the result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies.

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Cell and Tissue Destruction: Mechanisms, Protection, and Disorders provides an overview of the main mechanisms responsible for degradation in human beings and summarizes important strategies to counter these mechanisms. This book details the properties and limits of protective mechanisms, along with disturbances to systematic physiological functions. It provides examples of disease states resulting from the limits of protective systems. Three sections consider the physical and chemical reasons for destruction in living systems, protection against cytotoxic components, and the development of pathologic states. This book provides neuroscientists, cancer researchers and physicians with robust, overall coverage of the interrelated processes involved in cell and tissue destruction in living structures, and concomitant protective mechanisms and their limitations.

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Atlas of the Morphology of the Human Cerebral Cortex on the Average MNI Brain provides a comprehensive identification of the sulci and gyri of the human brain on a series of coronal sections of the average MNI brain and identifies the likely location of the cytoarchitectonic areas of the cerebral cortex. Presentation in MNI Stereotaxic Space enables the atlas to serve as a useful working tool for structural/functional neuroimagers attempting to identify the sulcus or gyrus and the likely cytoarchitectonic area within which a functional activation or a structural change has occurred. A brief introductory section discusses the history and current state of studies of the sulcal and gyral morphology and cytoarchitecture of the human cerebral cortex.

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Advanced Topics in Forensic DNA Typing: Interpretation builds upon the previous two editions of John Butler’s internationally acclaimed Forensic DNA Typing textbook with forensic DNA analysts as its primary audience. Intended as a third-edition companion to the Fundamentals of Forensic DNA Typing volume published in 2010 and Advanced Topics in Forensic DNA Typing: Methodology published in 2012, this book contains 16 chapters with 4 appendices providing up-to-date coverage of essential topics in this important field. Over 80 % of the content of this book is new compared to previous editions.

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In the forensic context it is quite common for nonhuman bones to be confused with human remains and end up in the medical examiner or coroner system. It is also quite common for skeletal remains (both human and nonhuman) to be discovered in archaeological contexts. While the difference between human and nonhuman bones is often very striking, it can also be quite subtle. Fragmentation only compounds the problem. The ability to differentiate between human and nonhuman bones is dependent on the training of the analyst and the available reference and/or comparative material. Comparative Osteology is a photographic atlas of common North American animal bones designed for use as a laboratory and field guide by the forensic scientist or archaeologist. The intent of the guide is not to be inclusive of all animals, but rather to present some of the most common species which also have the highest likelihood of being potentially confused with human remains.

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Advances in Food and Nutrition Research, Volume 87 provides updated information on nutrients in foods and how to avoid deficiency, especially the essential nutrients that should be present in the diet to reduce disease risk and optimize health. The book provides the latest advances on the identification and characterization of emerging bioactive compounds with putative health benefits. Chapters in this new release include discussions of the function and application of bioactive peptides from corn gluten meal, Dietary fatty acids and metabolic syndrome, the Microbial ecology of plant-based fermented foods and current knowledge on their impact on human health, and much more.

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Mathematica by Example, Sixth Edition is an essential resource for the Mathematica user, providing step-by-step instructions on achieving results from this powerful software tool. The book fully accounts for the changes to functionality and visualization capabilities and accomodates the full array of new extensions in the types of data and problems that Mathematica can immediately handle, including cloud services and systems, geographic and geometric computation, dynamic visualization, interactive applications and other improvements. It is an ideal text for scientific students, researchers, and aspiring programmers seeking further understanding of Mathematica. Written by seasoned practitioners with a view to practical implementation and problem-solving, the book's pedagogy is delivered clearly and without jargon using representative biological, physical and engineering problems. Code is provided on an ancillary website to support the use of Mathematica across diverse applications and subject areas.

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Differential Equations with Mathematica, Fifth Edition uses the fundamental concepts of the popular platform to solve (analytically, numerically, and/or graphically) differential equations of interest to students, instructors, and scientists. Mathematica’s diversity makes it particularly well suited to performing calculations encountered when solving many ordinary and partial differential equations. In some cases, Mathematica’s built-in functions can immediately solve a differential equation by providing an explicit, implicit, or numerical solution. In other cases, Mathematica can be used to perform the calculations encountered when solving a differential equation. Because one goal of elementary differential equations courses is to introduce students to basic methods and algorithms so that they gain proficiency in them, nearly every topic covered this book introduces basic commands, also including typical examples of their application. A study of differential equations relies on concepts from calculus and linear algebra, so this text also includes discussions of relevant commands useful in those areas. In many cases, seeing a solution graphically is most meaningful, so the book relies heavily on Mathematica’s outstanding graphics capabilities.

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Diagnosis and Treatment of Traumatic Brain Injury will improve readers’ understanding of the complexities of diagnosis and management of traumatic brain injuries. Featuring chapters on drug delivery, different treatments, and rehabilitation, this volume discusses in detail the impact early diagnosis and effective management has on the long-term prognosis of these injuries and the lives of those affected. This book will be relevant for neuroscientists, neurologists, clinicians, and anyone working to better understand these injuries.

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Elementary Linear Algebra, Sixth Edition provides a solid introduction to both the computational and theoretical aspects of linear algebra, covering many important real-world applications, including graph theory, circuit theory, Markov chains, elementary coding theory, least-squares polynomials and least-squares solutions for inconsistent systems, differential equations, computer graphics and quadratic forms. In addition, many computational techniques in linear algebra are presented, including iterative methods for solving linear systems, LDU Decomposition, the Power Method for finding eigenvalues, QR Decomposition, and Singular Value Decomposition and its usefulness in digital imaging.

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Applied Numerical Methods for Chemical Engineers emphasizes the derivation of a variety of numerical methods and their application to the solution of engineering problems, with special attention to problems in the chemical engineering field. These algorithms encompass linear and nonlinear algebraic equations, eigenvalue problems, finite difference methods, interpolation, differentiation and integration, ordinary differential equations, boundary value problems, partial differential equations, and linear and nonlinear regression analysis. MATLAB is adopted as the calculation environment throughout the book because of its ability to perform all the calculations in matrix form, its large library of built-in functions, its strong structural language, and its rich graphical visualization tools. Through this book, students and other users will learn about the basic features, advantages and disadvantages of various numerical methods, learn and practice many useful m-files developed for different numerical methods in addition to the MATLAB built-in solvers, develop and set up mathematical models for problems commonly encountered in chemical engineering, and solve chemical engineering related problems through examples and after-chapter problems with MATLAB by creating application m-files.

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Wetzel’s Limnology: Lake and River Ecosystems, Fourth Edition, presents a fully updated revision of the classic textbook Limnology: Lake and River Ecosystems - last published in 2001. The coverage has been thoroughly updated with recent research and theoretical developments. Each chapter of this edited volume has been written by an expert, or team of experts, providing a comprehensive and global perspective, with the editors working closely with the authors to maintain continuity within and between the chapters. This is not only an essential textbook for undergraduate and graduate students in limnology but also a standard reference book for seasoned limnologists and other scientists.

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Mitochondrial Diseases, Volume 194 presents the most common clinical manifestations, providing an up-to-date summaries on the clinical presentations, diagnostic processes, genetic counseling and treatment options in mitochondrial diseases. Contents include specialist biochemical analyses and targeted molecular genetic testing, as well as first-line genome-wide sequencing to accelerate speed of diagnosis while avoiding time-consuming, expensive and invasive investigations. Establishing a genetic diagnosis allows patients with mitochondrial diseases to have reproductive options, all of which are covered within. This book is intended for neurologists to help them recognize and manage patients with mitochondrial diseases.

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Basic Statistics with R: Reaching Decisions with Data provides an understanding of the processes at work in using data for results. Sections cover data collection and discuss exploratory analyses, including visual graphs, numerical summaries, and relationships between variables - basic probability, and statistical inference - including hypothesis testing and confidence intervals. All topics are taught using real-data drawn from various fields, including economics, biology, political science and sports. Using this wide variety of motivating examples allows students to directly connect and make statistics essential to their field of interest, rather than seeing it as a separate and ancillary knowledge area. In addition to introducing students to statistical topics using real data, the book provides a gentle introduction to coding, having the students use the statistical language and software R. Students learn to load data, calculate summary statistics, create graphs and do statistical inference using R with either Windows or Macintosh machines.

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Machine Learning: A Bayesian and Optimization Perspective, 2nd edition, gives a unified perspective on machine learning by covering both pillars of supervised learning, namely regression and classification. The book starts with the basics, including mean square, least squares and maximum likelihood methods, ridge regression, Bayesian decision theory classification, logistic regression, and decision trees. It then progresses to more recent techniques, covering sparse modelling methods, learning in reproducing kernel Hilbert spaces and support vector machines, Bayesian inference with a focus on the EM algorithm and its approximate inference variational versions, Monte Carlo methods, probabilistic graphical models focusing on Bayesian networks, hidden Markov models and particle filtering. Dimensionality reduction and latent variables modelling are also considered in depth. This palette of techniques concludes with an extended chapter on neural networks and deep learning architectures. The book also covers the fundamentals of statistical parameter estimation, Wiener and Kalman filtering, convexity and convex optimization, including a chapter on stochastic approximation and the gradient descent family of algorithms, presenting related online learning techniques as well as concepts and algorithmic versions for distributed optimization. Focusing on the physical reasoning behind the mathematics, without sacrificing rigor, all the various methods and techniques are explained in depth, supported by examples and problems, giving an invaluable resource to the student and researcher for understanding and applying machine learning concepts. Most of the chapters include typical case studies and computer exercises, both in MATLAB and Python. The chapters are written to be as self-contained as possible, making the text suitable for different courses: pattern recognition, statistical/adaptive signal processing, statistical/Bayesian learning, as well as courses on sparse modeling, deep learning, and probabilistic graphical models. New to this edition: Complete re-write of the chapter on Neural Networks and Deep Learning to reflect the latest advances since the 1st edition. The chapter, starting from the basic perceptron and feed-forward neural networks concepts, now presents an in depth treatment of deep networks, including recent optimization algorithms, batch normalization, regularization techniques such as the dropout method, convolutional neural networks, recurrent neural networks, attention mechanisms, adversarial examples and training, capsule networks and generative architectures, such as restricted Boltzman machines (RBMs), variational autoencoders and generative adversarial networks (GANs). Expanded treatment of Bayesian learning to include nonparametric Bayesian methods, with a focus on the Chinese restaurant and the Indian buffet processes.

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The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is a comprehensive reference to the aspects, features and effects of depression. This book provides readers with the behavior and psychopathological effects of depression, linking anxiety, anger and PSTD to depression. Readers are provided with a detailed outline of the genetic aspects of depression including synaptic genes and the genome-wide association studies (GWAS) of depression, followed by a thorough analysis of the neurological and imaging techniques used to study depression. This book also includes three full sections on the various effects of depression, including diet, nutrition and molecular and cellular effects. The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is the only resource for researchers and practitioners studying depression.

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Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator’s fields. This book bridges the knowledge gaps that invariably lead to communication issues in a new scientist’s early career, providing a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development. It provides students, new industrial scientists, and academics with a basic understanding of the drug discovery and development process. The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles of in vivo pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process.

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Biomedical Engineering Design presents the design processes and practices used in academic and industry medical device design projects. The first two chapters are an overview of the design process, project management and working on technical teams. Further chapters follow the general order of a design sequence in biomedical engineering, from problem identification to validation and verification testing. The first seven chapters, or parts of them, can be used for first-year and sophomore design classes. The next six chapters are primarily for upper-level students and include in-depth discussions of detailed design, testing, standards, regulatory requirements and ethics. The last two chapters summarize the various activities that industry engineers might be involved in to commercialize a medical device.

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Paxinos and Franklin's The Mouse Brain in Stereotaxic Coordinates, Compact Fifth Edition, is the compact version of the most widely used and cited atlas of the mouse brain in print. It emulates in design and accuracy Paxinos and Watson’s The Rat Brain in Stereotaxic Coordinates, the most cited publication in neuroscience. The compact edition provides the coronal plates and diagrams of the full mouse atlas in a smaller, more convenient spiral format and at a student friendly price. High resolution digital photographs of the coronal plane of section from the full 5th edition complement the coronal drawings. Unique to the compact, it includes an introduction to the use of the atlas in stereotaxic surgery.

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