Search results for ""beta""

Thin layer chromatography (TLC) is well suited for performing enantioseparations for research as well as larger-scale applications. A fast, inexpensive, and versatile separation technique, there are many practical considerations that contribute to its effectiveness. Thin Layer Chromatography in Chiral Separations and Analysis is the first book to focus solely on the theory, capabilities, and applications of TLC for direct and indirect enantioseparations.The first part of the book examines the fundamental principles of chirality and TLC. It describes the necessary materials, laboratory equipment, procedures, and strategies for the separation, quantification, isolation, and analysis of chiral compounds. The second part evaluates the real-world enantioseparations and densitometric analyses. Emphasizing pharmaceutical applications, the book discusses chiral separation mechanisms and methods for analyzing the chiral purity of diastereoisomers, amino acids, beta-blockers, and NSAIDS. Topics also include commercial stationary phases and chiral modifiers of mobile phases. Thin Layer Chromatography in Chiral Separations and Analysis presents a unified perspective of theory and experimental details underlying the collective developments in the field. The book offers scientists in a variety of disciplines and levels of expertise a complete guide to understanding the current and potential applications of chiral TLC.

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Common Problems in Cardiology is a comprehensive guide to common cardiology disorders. Each disorder is described by its pathophysiology, clinical presentation, diagnosis, risks, treatment and management. The book is divided into 23 chapters, each covering a specific disorder, from chest pain and hypertension, to pericardial diseases and cardioembolic stroke. A complete differential diagnosis and analysis is provided with each symptom. Information on cardiovascular risk and non cardiac surgery, preoperative cardiac diagnostic testing, preoperative assessment of patients with valvular heart disease, and revascularisation prior to noncardiac surgery is also provided. Common Problems in Cardiology covers perioperative management of coronary stents, beta-blockade, statin use, pacemakers and anticoagulation management, as well as preoperative assessment of candidates for kidney and liver transplantation. Edited by Kanu Chatterjee, Clinical Professor of Medicine at the University of Iowa and Emeritus Professor of Medicine at the University of California, this authoritative and comprehensive book is an ideal resource for postgraduates, interns, general physicians and practising cardiologists. Key Points Comprehensive guide to common cardiology disorders Format clearly presents pathophysiology, presentation diagnosis, risks, treatment and management Full colour illustrations, images and tables throughout Edited by US based expert in the field of cardiology

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Cal Newport's clearly-written manifesto flies in the face of conventional wisdom by suggesting that it should be a person's talent and skill -- and not necessarily their passion -- that determines their career path. Newport, who graduated from Dartmouth College (Phi Beta Kappa) and recently earned a PhD. from MIT, contends that trying to find what drives us, instead of focusing on areas in which we naturally excel, is ultimately harmful and frustrating to job seekers. The title is a direct quote from comedian Steve Martin who, when once asked why he was successful in his career, immediately replied: "Be so good they can't ignore you" and that's the main basis for Newport's book. Skill and ability trump passion. Inspired by former Apple CEO Steve Jobs' famous Stanford University commencement speech in which Jobs urges idealistic grads to chase their dreams, Newport takes issue with that advice, claiming that not only is thsi advice Pollyannish, but that Jobs himself never followed his own advice. From there, Newport presents compelling scientific and contemporary case study evidence that the key to one's career success is to find out what you do well, where you have built up your "career capital," and then to put all of your efforts into that direction.

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NFTs cause excitement and skepticism. How much value can a token hold? What drives this value?To properly appreciate NFTs we must first understand what they actually are, how they work and in what contexts they are used.The Everything Token is an essential primer on NFTs (non-fungible tokens), explaining their use, purpose, and how businesses can create and exploit them to develop new product lines, building customer loyalty and increased revenues at the same time.Together the authors have spent much of the past few years embedded in NFT communities and helping launch NFT products. As self-described beta testers of this brand-new technology, they’ve seen its power first-hand and aim to educate others on the importance, uses and purpose of NFT and surrounding, ever-evolving technologies.Demystifying the complexities, two experts in NFTs show why we should take NFTs much more seriously than their reputation as fun digital art collectibles suggest. They have a wider variety of uses than one may realise.Gripping and accessible, this book provides a guide and an insight into what can often be a hard-to-grasp area of technology.

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The definitive guide to fixed income securities—updated and revised with everything you need to succeed in today’s market For nearly 40 years, The Handbook of Fixed Income Securities has been providing comprehensive, current, reliable information on everything investors like you need to stay on top of the market and ahead of the curve. The fixed income market has changed dramatically in the past decade. This updated classic brings you fully up to date for a much-changed world of finance, where central banks play a bigger role, interest is low (and sometimes even in negative territory), regulations are more complex, and new types of securities have been created. Brand-new chapters cover: Relative value trades Muni analytics Financial data science Building and maintaining a bond portfolio Factor investing Relative value trades Smart beta fixed income Infrastructure and green bonds Sovereign bond markets One of the world’s leading experts on fixed income securities, Frank Fabozzi has gathered a peerless team of global experts who provide the newest and best techniques for winning in today’s markets. Fixed Income Securities, Ninth Edition is a matchless, one-stop resource for all your professional needs.

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The connection and science behind race, racism, and mental illness In 2012, an interdisciplinary team of scientists at the University of Oxford reported that - based on their clinical experiment - the beta-blocker drug, Propranolol, could reduce implicit racial bias among its users. Shortly after the experiment, an article in Time Magazine cited the study, posing the question: Is racism becoming a mental illness? In Are Racists Crazy? Sander Gilman and James Thomas trace the idea of race and racism as psychopathological categories., from mid-19th century Europe, to contemporary America, up to the aforementioned clinical experiment at the University of Oxford, and ask a slightly different question than that posed by Time: How did racism become a mental illness? Using historical, archival, and content analysis, the authors provide a rich account of how the 19th century ‘Sciences of Man’ - including anthropology, medicine, and biology - used race as a means of defining psychopathology and how assertions about race and madness became embedded within disciplines that deal with mental health and illness. An illuminating and riveting history of the discourse on racism, antisemitism, and psychopathology, Are Racists Crazy? connects past and present claims about race and racism, showing the dangerous implications of this specious line of thought for today.

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Understand the role and potential of fixed income as an asset class Systematic Fixed Income: An Investor’s Guide offers readers a powerful, practical, and robust framework for investors and asset managers to preserve the diversifying properties of a fixed income allocation, and add to that unique sources of excess returns via systematic security selection. In other words, this framework allows for efficient capture of fixed income beta and fixed income alpha. Celebrated finance professional Dr. Scott Richardson presents concrete strategies for identifying the relevant sources of risk and return in public fixed income markets and explains the tactical and strategic roles played by fixed income in typical portfolios. In the book, readers will explore: The implementation challenges associated with a systematic fixed income portfolio, including liquidity and risk The systematic return sources for rate and credit sensitive fixed income assets in both developed and emerging markets An essential read for asset managers and institutional investors with a professional interest in fixed income markets, Systematic Fixed Income: An Investor’s Guide deserves a place in the libraries of advanced degree students of finance, business, and investment, as well as other investment professionals seeking to refine their understanding of the full potential of this foundational asset class.

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"Jewish Food Hero blogger Alfond charms in this cheerful guide to vegan Jewish cooking...This vegan twist on Jewish cuisine hits all of the right notes." –Publishers Weekly Jewish food’s “greatest hits” receive a makeover in the newest recipe collection from the author of the Jewish Food Hero Cookbook and Feeding Women of the Bible, Feeding Ourselves. Beyond Chopped Liver: 59 Jewish Recipes Get a Vegan Health Makeover shares new and better ways to enjoy quintessentially Jewish food with delicious, plant-based recipes– from challah to matzo ball soup! The Jewish recipes in this cookbook are inspired by recipes from Jewish pre-modern Diaspora communities: Ashkenazi, Sephardi, Mizrahi, Beta Israel/Ethiopian and Indian Jewish communities, and from modern Israel and American Jewish food cultures. The updates in this collection speak to the Jewish community today, as we seek to honor inherited Jewish food traditions while living in ways that are healthier for our bodies and our planet. Communal meals are essential for family and community cohesion and health, and there should be no conflict between Jewish life and ethical eating. Offering healthier plant-based and vegan Jewish recipes is author Kenden Alfond’s way of problem-solving and providing resources for the community so that everyone can share delicious, healthy meals.

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This open access book is a pedagogical text on nuclear reactor experiments, covering almost all the experiments that can be carried out at the University Training Reactor, Kindai University (UTR-KINKI) with respect to reactor physics and radiation detection, and additionally including academic materials of test and research reactors, nuclear instrumentation, nuclear laws and regulations, in this main body. The book is an excellent primer for students who are interested in reactor physics, radiation detection, nuclear laws and regulations at universities, and the best textbook for students who have started to study the nuclear energy related fields to understand the basic theories and principles of the experiments in the fields of reactor physics and radiation detection. UTR-KINKI has been used for educational reactor experiments and basic research in a wide range of fields related to the use of radiation (neutrons, gamma-ray, beta-ray, alpha-ray, and X-ray), including reactor physics, radiation detection, radiation health physics, activation analysis, radiation biology, medical applications and archaeology. Also, UTR-KINKI has been actively engaged in nuclear education with its long history of operation, and has gained extensive experience in educational activities for undergraduate and graduate students, elementary, junior high and high school teachers, junior high and high school students, and general audiences.

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This open access book is a pedagogical text on nuclear reactor experiments, covering almost all the experiments that can be carried out at the University Training Reactor, Kindai University (UTR-KINKI) with respect to reactor physics and radiation detection, and additionally including academic materials of test and research reactors, nuclear instrumentation, nuclear laws and regulations, in this main body. The book is an excellent primer for students who are interested in reactor physics, radiation detection, nuclear laws and regulations at universities, and the best textbook for students who have started to study the nuclear energy related fields to understand the basic theories and principles of the experiments in the fields of reactor physics and radiation detection. UTR-KINKI has been used for educational reactor experiments and basic research in a wide range of fields related to the use of radiation (neutrons, gamma-ray, beta-ray, alpha-ray, and X-ray), including reactor physics, radiation detection, radiation health physics, activation analysis, radiation biology, medical applications and archaeology. Also, UTR-KINKI has been actively engaged in nuclear education with its long history of operation, and has gained extensive experience in educational activities for undergraduate and graduate students, elementary, junior high and high school teachers, junior high and high school students, and general audiences.

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Benjamin Zephaniah: To Do Wid Me is both a Selected Poems by Benjamin Zephaniah and a film portrait of Benjamin Zephaniah by Pamela Robertson-Pearce drawing on both live performances and informal interviews. The film shows him performing his poetry for different audiences and talking about his work, life, beliefs and much else. You see him live on stage at Ledbury Poetry Festival, Newcastle's Live Theatre, Hexham's Queen's Hall and Brunel University, and engaging with school children at Keats House in London, where he was writer-in-residence. As well as the main film, the DVD also has a bonus feature: music videos made by Zephaniah with the Beta Brothers. This is a new concept in poetry publishing: not a book with a DVD but a DVD-book. The book supplements the film and includes the texts of all the poems and songs from the film and videos. (But because the DVD is a free giveaway inside the book, it is classed as a book not a DVD so you don't have to pay VAT, hence the great price.) The DVD is PAL format compatible with DVD players in most countries apart from Canada, Japan, Mexico, Philippines, Taiwan and the United States but playable on laptops produced for those countries.

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This second volume of Reviews in Food and Nutrition Toxicity follows on directly from the successes of the first volume published last year. This series disseminates important data pertaining to food and nutrition safety and toxicology that is relevant to humans. Chapters in this series extend from the introduction of toxins in the manufacture or production of artificial food substances, to the ingestion of microbial contaminants or toxins and the cellular or physiological changes that arise.The present volume has a broad range chapters reviewing contaminants in beer, the effects of alcohol on the intestine, ciguatera fish poisoning, hepatitis A, beta-nitropropionic acid, Vibrio parahaemolyticus, bacterial toxins, pesticide toxicity, polyhalogenated and polycyclic aromatic hydrocarbons and a survey of contamination episodes.Each chapter is written by experts with supportive tables and figures. These concise and informative articles should stimulate a scientific dialogue. Food production processes and nutritional or dietary habits are continually changing and it is important to learn from past lessons and embrace a multidisciplinary approach. For example, some cellular mechanisms elucidated by studying one toxin may also be relevant to other areas of food pathology. Therefore it is the intention of the Editors to impart such comprehensive information in a single series, namely Reviews in Food and Nutrition Toxicity.

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Lynn Raven may be the boss master of WarMonger 2050 with her online persona of "Larry the Snake," but when the CEO of Tsunami Entertainment personally asks her, as a favor, to beta test a new augmented reality game, she has to face her greatest fear: Going outside and dealing with, ugh, people. As she becomes more immersed in the game, the stakes rise and so do the obstacles. Strife between teammates, a ruthless rival team, and these strange glitches that make it seem like the game algorithm (or maybe “game AI”?) has it in for her. Now she has to face a new fear: is she willing to step into the real to win the future she’s always wanted? What do you do when a game and real life merge? About John Ringo: “. . . the thinking reader’s zombie novel . . . Ringo fleshes out his theme with convincing details . . . the proceedings become oddly plausible.”—Publishers Weekly on Under a Graveyard Sky “[Ringo’s work is] peopled with three-dimensional characters and spiced with personal drama as well as tactical finesse.”—Library Journal “Explosive . . . fans . . . will appreciate Ringo’s lively narrative and flavorful characters.”—Publishers Weekly “. . . practically impossible not to read in one sitting . . . exceedingly impressive . . . executed with skill, verve, and wit.”—Booklist “Crackerjack storytelling.”—Starlog

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The first of two, this volume comprises a collection of papers devoted to the understanding of thymosins—proteins originally isolated from the thymus and possess a unique array of biological properties. Thymosins in Health and Disease I brings together short reviews organized to explore the basic characteristics of these peptides and their hormone-like properties, recent preliminary evidence for their medicinal utility, and a focus on the alpha and beta thymosin families. In particular, Thymosin β4 (Tβ4) holds considerable promise for the treatment of many conditions and diseases. Of note, contributions to this volume include information on the application of thymosins to stem cell differentiation, neurological and cardiovascular regeneration, as well as accounts of thymosins in relation to basic regulatory and cancer cell functions. NOTE: Annals volumes are available for sale as individual books or as a journal. For more information on institutional journal subscriptions, please visit: http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632 ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information on becoming a member.

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Diabetes mellitus is a major global health problem. According to the most recent projections, the worldwide prevalence of diabetes mellitus is expected to reach 220 million in the year 2010 and 300 million in 2025 compared to the current prevalence of around 160 million. This volume focuses on recent advances in the area of diabetes mellitus and its complications, from basic research at the molecular level to clinical medicine, spanning several areas including epidemiology, diagnosis, complications, prevention, treatment, beta cell function and dysfunction, metabolic syndrome, glucose and lipid metabolism and drug targets. The international conference of which this is the proceedings provided a forum for the exchange of ideas and the dissemination of current knowledge about the full range of issues concerning type I and type II diabetes mellitus. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member

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Active managers persistently lag the returns of benchmarks and index funds that track them, with the excuses for underperformance recycled every year. This comprehensive book is the antidote for the active managers’ siren song. If you understand the benefits of indexing, or systematic investing, it will reinforce your commitment while increasing your knowledge. If you don’t yet believe, Swedroe and Berkin provide a compelling case that you’re playing the loser’s game of active management. Alpha, or outperformance against appropriate risk-adjusted benchmarks, is shrinking as it gets converted into beta, or factor exposures. They demonstrate that even for the most talented managers, their ability to add value is waning because: the amount of alpha available is declining; it must be split among an increasing amount of investment dollars; and the competition is getting tougher. In this greatly expanded second edition, Swedroe and Berkin show you how to develop an investment plan that focuses on what risks to take, and how much of them, as well as how to build a diversified portfolio. They present a list of vehicles to consider when implementing your plan and provide guidance on the care and maintenance of your portfolio. As a bonus they add appendices that will make you a more informed and, therefore, better investor.

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Forthright and wryly humorous, philosopher Susan Haack deploys her penetrating analytic skills on some of the most highly charged cultural and social debates of recent years. Relativism, multiculturalism, feminism, affirmative action, pragmatisms old and new, science, literature, the future of the academy and of philosophy itself—all come under her keen scrutiny in Manifesto of a Passionate Moderate."The virtue of Haack's book, and I mean virtue in the ethical sense, is that it embodies the attitude that it exalts. . . Haack's voice is urbane, sensible, passionate—the voice of philosophy that matters. How good to hear it again."—Jonathan Rauch, Reason"A tough mind, confident of its power, making an art of logic . . . a cool mastery."—Paul R. Gross, Wilson Quarterly"Few people are better able to defend the notion of truth, and in strong, clear prose, than Susan Haack . . . a philosopher of great distinction."—Hugh Lloyd-Jones, National Review"If you relish acute observation and straight talk, this is a book to read."—Key Reporter (Phi Beta Kappa)"Everywhere in this book there is the refreshing breeze of common sense, patiently but inexorably blowing."—Roger Kimball, Times Literary Supplement"A refreshing alternative to the extremism that characterizes so much rhetoric today."—Kirkus Reviews

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Charlie Asher is a pretty normal guy. A little hapless, somewhat neurotic, more of a Beta than an Alpha Male. Charlie's been lucky, though. He owns a building in the heart of San Francisco, and runs a second-hand store with the help of a couple of loyal, if marginally insane, employees. He's married to a bright and pretty woman who actually loves him for his normality. And she, Rachel, is about to have their first child. But normal service is about to be interrupted. As Charlie prepares to go home after the birth, he sees a strange man dressed in mint-green at Rachel's hospital bedside - a man who claims that no one should be able to see him. But see him Charlie does, and from here on out, things get really weird. . . .People start dropping dead around him, giant ravens perch on his building, and it seems that everywhere he goes, a dark presence whispers to him from under the streets. Strange names start appearing on his nightstand notepad, and before he knows it, those people end up dead, too. Yep, it seems that Charlie Asher has been recruited for a new job, an unpleasant but utterly necessary one: Death. It's a dirty job. But hey, somebody's gotta do it.

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Cal Newport's clearly-written manifesto flies in the face of conventional wisdom by suggesting that it should be a person's talent and skill - and not necessarily their passion - that determines their career path. Newport, who graduated from Dartmouth College (Phi Beta Kappa) and earned a PhD. from MIT, contends that trying to find what drives us, instead of focusing on areas in which we naturally excel, is ultimately harmful and frustrating to job seekers.The title is a direct quote from comedian Steve Martin who, when once asked why he was successful in his career, immediately replied: "Be so good they can't ignore you" and that's the main basis for Newport's book. Skill and ability trump passion. Inspired by former Apple CEO Steve Jobs' famous Stanford University commencement speech in which Jobs urges idealistic grads to chase their dreams, Newport takes issue with that advice, claiming that not only is thsi advice Pollyannish, but that Jobs himself never followed his own advice.From there, Newport presents compelling scientific and contemporary case study evidence that the key to one's career success is to find out what you do well, where you have built up your 'career capital,' and then to put all of your efforts into that direction.

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This textbook explores a selection of topics in complex analysis. From core material in the mainstream of complex analysis itself, to tools that are widely used in other areas of mathematics, this versatile compilation offers a selection of many different paths. Readers interested in complex analysis will appreciate the unique combination of topics and connections collected in this book. Beginning with a review of the main tools of complex analysis, harmonic analysis, and functional analysis, the authors go on to present multiple different, self-contained avenues to proceed. Chapters on linear fractional transformations, harmonic functions, and elliptic functions offer pathways to hyperbolic geometry, automorphic functions, and an intuitive introduction to the Schwarzian derivative. The gamma, beta, and zeta functions lead into L-functions, while a chapter on entire functions opens pathways to the Riemann hypothesis and Nevanlinna theory. Cauchy transforms give rise to Hilbert and Fourier transforms, with an emphasis on the connection to complex analysis. Valuable additional topics include Riemann surfaces, steepest descent, tauberian theorems, and the Wiener–Hopf method. Showcasing an array of accessible excursions, Explorations in Complex Functions is an ideal companion for graduate students and researchers in analysis and number theory. Instructors will appreciate the many options for constructing a second course in complex analysis that builds on a first course prerequisite; exercises complement the results throughout.

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The connection and science behind race, racism, and mental illness In 2012, an interdisciplinary team of scientists at the University of Oxford reported that - based on their clinical experiment - the beta-blocker drug, Propranolol, could reduce implicit racial bias among its users. Shortly after the experiment, an article in Time Magazine cited the study, posing the question: Is racism becoming a mental illness? In Are Racists Crazy? Sander Gilman and James Thomas trace the idea of race and racism as psychopathological categories., from mid-19th century Europe, to contemporary America, up to the aforementioned clinical experiment at the University of Oxford, and ask a slightly different question than that posed by Time: How did racism become a mental illness? Using historical, archival, and content analysis, the authors provide a rich account of how the 19th century ‘Sciences of Man’ - including anthropology, medicine, and biology - used race as a means of defining psychopathology and how assertions about race and madness became embedded within disciplines that deal with mental health and illness. An illuminating and riveting history of the discourse on racism, antisemitism, and psychopathology, Are Racists Crazy? connects past and present claims about race and racism, showing the dangerous implications of this specious line of thought for today.

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Vitamin A has an important role to play in vision, bone growth, reproduction, cell division, and cell differentiation. With the focus on Vitamin A and Carotenoids, this book includes the latest research in these areas and starts with an overview putting the compounds in context with other vitamins, supplementation and discussing the importance of beta-carotene. Details of the chemistry, structure and biochemistry of the compounds begins with nomenclature followed by information on encapsulation, thermal degradation and occurrence. Developments in analytical and bioanalytical techniques concerning these compounds in plant, milk and human tissue systems are covered in detail. Finally, the book covers the extensive functions and effects of Vitamin A on eg developmental growth, immune function, cancer risk, the brain and lungs as well as vision. Delivering high quality information, this book will be of benefit to anyone researching this area of health and nutritional science. It will bridge scientific disciplines so that the information is more meaningful and applicable to health in general. Part of a series of books, it is specifically designed for chemists, analytical scientists, forensic scientists, food scientists, dieticians and health care workers, nutritionists, toxicologists and research academics. Due to its interdisciplinary nature it could also be suitable for lecturers and teachers in food and nutritional sciences and as a college or university library reference guide.

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Which of these bizarre phenomena, if any, can really exist in our universe? Black holes, down which anything can fall but from which nothing can return; wormholes, short spacewarps connecting regions of the cosmos; singularities, where space and time are so violently warped that time ceases to exist and space becomes a kind of foam; gravitational waves, which carry symphonic accounts of collisions of black holes billions of years ago; and time machines, for traveling backward and forward in time. Kip Thorne, along with fellow theorists Stephen Hawking and Roger Penrose, a cadre of Russians, and earlier scientists such as Oppenheimer, Wheeler and Chandrasekhar, has been in the thick of the quest to secure answers. In this masterfully written and brilliantly informed work of scientific history and explanation, Dr. Thorne, a Nobel Prize-winning physicist and the Feynman Professor of Theoretical Physics Emeritus at Caltech, leads his readers through an elegant, always human, tapestry of interlocking themes, coming finally to a uniquely informed answer to the great question: what principles control our universe and why do physicists think they know the things they think they know? Stephen Hawking's A Brief History of Time has been one of the greatest best-sellers in publishing history. Anyone who struggled with that book will find here a more slowly paced but equally mind-stretching experience, with the added fascination of a rich historical and human component. Winner of the Phi Beta Kappa Award in Science.

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The untold story behind one of the most controversial album releases in modern music history, for fans of the Wu-Tang Clan, hip-hop music, and all those interested in the music industry. Take a kid with a dream. A legendary hip hop group. 6 years of secret recordings. A casing worthy of a king. A single artifact. Hallowed establishment institutions. An iconoclastic auction house. The world's foremost museum of modern art. A bidding war. Endless crises of conscience. An angry mob. A furious beef. A sale. A villain of Lex Luthor-like proportions. Bill Murray. The FBI. The internet gone wild. In 2007, the innovative Wu-Tang producer, Cilvaringz, feeling that digitisation increasingly supported the perception of music as disposable, took an incendiary idea to his mentor, hip hop legend, RZA: create a unique physical copy of a secret Wu-Tang album, to be encased in silver and sold through auction as a work of contemporary art. The plan raised a number of complex questions: Would selling one album for millions be the ultimate betrayal of music? How would fans react to an album that's sold on condition it could not be commercialised? And could anyone justify the ultimate sale of the album to the infamous pharmaceutical mogul Martin Shkreli? "An epic battle between colorful, creative maniacal heroes and one of the blandest beta-villains of our time. Couldn't put it down."Patton Oswalt, comedian and bestselling author of Silver Screen Fiend

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Winner of the 2014 Christian Gauss Award for excellence in literary scholarship from the Phi Beta Kappa Society Having excavated the world’s earliest novels in his previous book, literary historian Steven Moore explores in this sequel the remarkable flowering of the novel between the years 1600 and 1800—from Don Quixote to America’s first big novel, an homage to Cervantes entitled Modern Chivalry. This is the period of such classic novels as Tom Jones, Candide, and Dangerous Liaisons, but beyond the dozen or so recognized classics there are hundreds of other interesting novels that appeared then, known only to specialists: Spanish picaresques, French heroic romances, massive Chinese novels, Japanese graphic novels, eccentric English novels, and the earliest American novels. These minor novels are not only worthy of attention in their own right, but also provide the context needed to appreciate why the major novels were major breakthroughs. The novel experienced an explosive growth spurt during these centuries as novelists experimented with different forms and genres: epistolary novels, romances, Gothic thrillers, novels in verse, parodies, science fiction, episodic road trips, and family sagas, along with quirky, unclassifiable experiments in fiction that resemble contemporary, avant-garde works. As in his previous volume, Moore privileges the innovators and outriders, those who kept the novel novel. This sequel, like its predecessor, is a “zestfully encyclopedic, avidly opinionated, and dazzlingly fresh history of the most ‘elastic’ of literary forms” (Booklist).

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Black Jews in Africa and the Americas tells the fascinating story of how the Ashanti, Tutsi, Igbo, Zulu, Beta Israel, Maasai, and many other African peoples came to think of themselves as descendants of the ancient tribes of Israel. Pursuing medieval and modern European race narratives over a millennium in which not only were Jews cast as black but black Africans were cast as Jews, Tudor Parfitt reveals a complex history of the interaction between religious and racial labels and their political uses.For centuries, colonialists, travelers, and missionaries, in an attempt to explain and understand the strange people they encountered on the colonial frontier, labeled an astonishing array of African tribes, languages, and cultures as Hebrew, Jewish, or Israelite. Africans themselves came to adopt these identities as their own, invoking their shared histories of oppression, imagined blood-lines, and common traditional practices as proof of a racial relationship to Jews.Beginning in the post-slavery era, contacts between black Jews in America and their counterparts in Africa created powerful and ever-growing networks of black Jews who struggled against racism and colonialism. A community whose claims are denied by many, black Jews have developed a strong sense of who they are as a unique people. In Parfitt’s telling, forces of prejudice and the desire for new racial, redemptive identities converge, illuminating Jewish and black history alike in novel and unexplored ways.

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Dark Matter, Neutrinos, and Our Solar System is a unique enterprise that should be viewed as an important contribution to our understanding of dark matter, neutrinos and the solar system. It describes these issues in terms of links, between cosmology, particle and nuclear physics, as well as between cosmology, atmospheric and terrestrial physics. It studies the constituents of dark matter (classified as hot warm and cold) first in terms of their individual structures (baryonic and non-baryonic, massive and non-massive, interacting and non-interacting) and second, in terms of facilities available to detect these structures (large and small). Neutrinos (an important component of dark matter) are treated as a separate entity. A detailed study of these elusive (sub-atomic) particles is done, from the year 1913 when they were found as byproducts of beta decay — until the discovery in 2007 which confirmed that neutrino flavors were not more than three (as speculated by some).The last chapter of the book details the real-time stories about the “regions” that were not explored thus far, for lack of advanced technology. Their untold fascinating stories (which span up to 2010) are illustrated here datewise in full.The book concludes with the latest news that the Large Hadron Collider team at CERN has finally succeeded in producing 7 trillion electronic Volts of energy by creating head-on-collisions of protons and more protons (in search of God-particle). The energy produced was three times more than previous records.

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Now there is an up-to-date guide for optimizing pharmacologic therapy in treating patients with heart failure. Reflecting current practice at leading medical centers, Heart Failure: Pharmacologic Management provides both the biologic and pathologic underpinnings of each pharmacologic agent in current use. It also supplies detailed discussions of the clinical investigations that support current understanding of the risks and benefits associated with the use of these drugs. Thorough references make the book useful to the novice as well as the experienced clinician. Initial chapters focus on agents that are considered standard care: diuretics ACE inhibitors angiotensin receptor antagonists aldosterone antagonists beta-blockers The discussion moves to agents currently under investigation: Vasopressin antagonists erythropoietin Next, the authors consider some controversial drugs: inotropic agents antiarrhythmic drugs anticoagulants An insightful examination of pharmacogenetics considers: how studies of the genetic profile of patients helps determine which patient populations are most likely to respond to a given class of drugs the potential use of pharmacogenetics to tailor a pharmacologic regimen for maximum benefit and minimum risk Multidrug pharmacy for heart failure therapy An extremely helpful concluding chapter provides a roadmap of drugs with which to approach the patient with heart failure, along with an overview of the skills you need to use it most effectively. This straightforward, step-by-step algorithm will save you countless hours of research and help you make your prescribing decisions with confidence.

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The second book in Darbyshire and Hampton’s Hedge Fund Modelling and Analysis series, Hedge Fund Modelling and Analysis Using MATLAB® takes advantage of the huge library of built-in functions and suite of financial and analytic packages available to MATLAB®. This allows for a more detailed analysis of some of the more computationally intensive and advanced topics, such as hedge fund classification, performance measurement and mean-variance optimisation. Darbyshire and Hampton’s first book in the series, Hedge Fund Modelling and Analysis Using Excel & and VBA, is seen as a valuable supplementary text to this book. Starting with an overview of the hedge fund industry the book then looks at a variety of commercially available hedge fund data sources. After covering key statistical techniques and methods, the book discusses mean-variance optimisation, hedge fund classification and performance with an emphasis on risk-adjusted return metrics. Finally, common hedge fund market risk management techniques, such as traditional Value-at-Risk methods, modified extensions and expected shortfall are covered. The book’s dedicated website, www.darbyshirehampton.com provides free downloads of all the data and MATLAB® source code, as well as other useful resources. Hedge Fund Modelling and Analysis Using MATLAB® serves as a definitive introductory guide to hedge fund modelling and analysis and will provide investors, industry practitioners and students alike with a useful range of tools and techniques for analysing and estimating alpha and beta sources of return, performing manager ranking and market risk management.

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Once upon a time, in Westchester and Orlando, there were four betas just waiting for their alpha. It took a miracle to bring the Pretty Committee together - or rather, a New Years Yves party. Because sometimes when you meet someone, it just cliques. Massie: Is destined to lead but trapped as a beta in the Ahnabees, the top clique at PMS (Presbyterian Middle School). She has ah-mazing ideas - Friday night sleepovers, Gossip Points and matching charm bracelets. When will it be her time to rule? Alicia: Is dying to lead the Body Alive Dance Studio Squad. With the real captain on vacation, BADSS' live performance on Merri Lee Marvil's New Years Yves show is her chance to shine but when disaster strikes, will she prove herself alpha-worthy - or will she need to find a whole new clique? Dylan: Is done, doneand done with people kissing her teeny butt just because her mom is famous but who would be brave enough to stand up to someone so Marvilous? Kristen: Has made a New Year's resolution to make friends and get a life. Escape from Planet Loser starts...now! Claire: Is psyched times ten to win a last-minute invitation to the New Year's Yves satellite party in Orlando but first she needs to sneak out of the house. And the countdown to midnight begins in ten...nine...eight...The Clique...the only thing harder than getting in is staying in.

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Although few physicians, nurses, dentists, and other health professionals perform laboratory tests themselves, they all need to be able to interpret the results as well as understand findings reported in the medical literature. A general understanding of probability and statistics is essential for those needing to make daily decisions about the significance of research data, drug interaction precautions, or a patient's positive laboratory test for a rare disease. Written with these needs in mind, Probability without Equations offers a thorough explanation of the subject without overwhelming the reader with equations and footnotes. Award-winning teacher Bart Holland presents a nontechnical treatment of intuitive concepts and presents numerous examples from medical research and practice. In plain language, this book explains the topics that clinicians need to understand: * Analysis of variance * "P-values" and the "t-test" * Hazard models * Regression and correlations * Alpha and beta errors "The Nobel prize-winning physicist Ernest Rutherford was fond of saying that if you need statistics to analyze the results of an experiment, you don't have a very good experiment. In a way he was right. However, a recurrent problem in medicine is that in a certain sense you commonly don't have a good experiment-but not because medical research scientists are generally incompetent! The nature of the data they work with is simply not as predictable as the data in some other fields, so the predictive nature of findings in medical science is generally rather imperfect."-from the introduction

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“Dylan Marron is the internet’s Love Warrior. His work is fresh, deeply honest, wildly creative, and right on time.” —Glennon Doyle, #1 New York Times bestselling author “Dylan Marron is like a modern Mister Rogers for the digital age.” —Jason Sudeikis ​​From the host of the award-winning, critically acclaimed podcast Conversations with People Who Hate Me comes a thought-provoking, witty, and inspirational exploration of difficult conversations and how to navigate them. Dylan Marron’s work has racked up millions of views and worldwide support. From his acclaimed Every Single Word video series highlighting the lack of diversity in Hollywood to his web series Sitting in Bathrooms with Trans People, Marron has explored some of today’s biggest social issues. Yet, according to some strangers on the internet, Marron is a “moron,” a “beta male,” and a “talentless hack.” Rather than running from this online vitriol, Marron began a social experiment in which he invited his detractors to chat with him on the phone—and those conversations revealed surprising and fascinating insights. Now, Marron retraces his journey through a project that connects adversarial strangers in a time of unprecedented division. After years of production and dozens of phone calls, he shares what he’s learned about having difficult conversations and how having them can help close the ever-growing distance between us. Charmingly candid and refreshingly hopeful, Conversations with People Who Hate Me will serve as both a guide to anyone partaking in dif­ficult conversations and a permission slip for those who dare to believe that connection is possible.

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William C. Morris YA Debut Award Winner!A hilarious YA contemporary realistic novel about a witty Black French Canadian teen who moves to Austin, Texas, and experiences the joys, clichés, and awkward humiliations of the American high school experience—including falling in love. Perfect for fans of Nicola Yoon, When Dimple Met Rishi, and John Green. Norris Kaplan is clever, cynical, and quite possibly too smart for his own good. A Black French Canadian, he knows from watching American sitcoms that those three things don’t bode well when you are moving to Austin, Texas.Plunked into a new high school and sweating a ridiculous amount from the oppressive Texas heat, Norris finds himself cataloging everyone he meets: the Cheerleaders, the Jocks, the Loners, and even the Manic Pixie Dream Girl. Making a ton of friends has never been a priority for him, and this way he can at least amuse himself until it’s time to go back to Canada, where he belongs.Yet against all odds, those labels soon become actual people to Norris…like loner Liam, who makes it his mission to befriend Norris, or Madison the beta cheerleader, who is so nice that it has to be a trap. Not to mention Aarti the Manic Pixie Dream Girl, who might, in fact, be a real love interest in the making. But the night of the prom, Norris screws everything up royally. As he tries to pick up the pieces, he realizes it might be time to stop hiding behind his snarky opinions and start living his life—along with the people who have found their way into his heart.

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William C. Morris YA Debut Award Winner!A hilarious YA contemporary realistic novel about a witty Black French Canadian teen who moves to Austin, Texas, and experiences the joys, clichés, and awkward humiliations of the American high school experience—including falling in love. Perfect for fans of Nicola Yoon, When Dimple Met Rishi, and John Green. Norris Kaplan is clever, cynical, and quite possibly too smart for his own good. A Black French Canadian, he knows from watching American sitcoms that those three things don’t bode well when you are moving to Austin, Texas.Plunked into a new high school and sweating a ridiculous amount from the oppressive Texas heat, Norris finds himself cataloging everyone he meets: the Cheerleaders, the Jocks, the Loners, and even the Manic Pixie Dream Girl. Making a ton of friends has never been a priority for him, and this way he can at least amuse himself until it’s time to go back to Canada, where he belongs.Yet against all odds, those labels soon become actual people to Norris…like loner Liam, who makes it his mission to befriend Norris, or Madison the beta cheerleader, who is so nice that it has to be a trap. Not to mention Aarti the Manic Pixie Dream Girl, who might, in fact, be a real love interest in the making. But the night of the prom, Norris screws everything up royally. As he tries to pick up the pieces, he realizes it might be time to stop hiding behind his snarky opinions and start living his life—along with the people who have found their way into his heart.

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Atoms, Radiation, and Radiation Protection Discover the keys to radiation protection in the fourth edition of this best-selling textbook A variety of atomic and sub-atomic processes, including alpha, beta, and gamma decay or electron ejection from inner atom shells, can produce ionizing radiation. This radiation can in turn produce environmental and biological effects both harmful – including DNA damage and other impacts of so-called ‘radiation sickness’ – and helpful, including radiation treatment for cancerous tumors. Understanding the processes that generate radiation and the steps which can be taken to mitigate or direct its effects is therefore critical in a wide range of industries and medical subfields. For decades, Atoms, Radiation, and Radiation Protection has served as the classic reference work on the subject of ionizing radiation and its safeguards. Beginning with a presentation of fundamental atomic structure and the physical mechanisms which produce radiation, the book also includes thorough discussion of how radiation can be detected and measured, as well as guide-lines for interpreting radiation statistics and detailed analysis of protective measures, both individual and environmental. Now updated by a new generation of leading scholars and researchers, Atoms, Radiation, and Radiation Protection will continue to serve global scientific and industrial research communities. Readers of the fourth edition of Atoms, Radiation, and Radiation Protection will also find: Detailed updates of existing material, including the latest recommendations of the ICRP and NCRP Treatment of current physiokinetic and dosimetric models All statistics now presented in SI units, making the book more globally accessible Atoms, Radiation, and Radiation Protection is a foundational guide for graduate students and researchers in health physics and nuclear physics, as well as related industries.

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The opening chapter of Horizons in World Cardiovascular Research. Volume 16 discusses the functions of the internal jugular veins, particularly how they are usually valveless except for a single valve situated just above the junction of the vein with the brachiocephalic vein. Additionally, the authors assess the frequency, nature, duration and significance of cardiovascular disorders associated with rotavirus infection in the human body. A careful analysis of electrocardiograms and other diagnostic tools is included with the goal of helping to early identify high risk beta-thalassemia major patients for arrhythmias and sudden cardiac death. The authors also examine the coronary vasospasm as a potential risk for thrombus formation in patients with drug-eluting stents implantation by showing several clinical studies and case reports in terms of mechanism and prevention. Following this, an overview of the structure of smooth muscle cells and their main functions in the human umbilical artery is presented. The anatomy and physiology of venous outflow from the brain is described. Since physical effects play an important role in regulating this outflow, it is important to present some basic physical principles governing the flow in the tubes. Moreover, the authors review a transgenic mouse model to study its genetic contribution to Moyamoya syndrome, a cerebrovascular condition defined by the chronic progressive stenosis of the intracranial internal carotid arteries and their major branches, as well as describe a recently-developed surgical model. The closing chapter posits that it would be beneficial to describe the difficulties and challenges that occur during the implantation of permanent biventricular defibrillating systems in cases of Superior Vena Cava is Persistent Left Superior Vena Cava.

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The various types of special functions have become essential tools for scientists and engineers. One of the important classes of special functions is of the hypergeometric type. It includes all classical hypergeometric functions such as the well-known Gaussian hypergeometric functions, the Bessel, Macdonald, Legendre, Whittaker, Kummer, Tricomi and Wright functions, the generalized hypergeometric functions ρFq, Meijer's G-function, Fox's H-function, etc.Application of the new special functions allows one to increase considerably the number of problems whose solutions are found in a closed form, to examine these solutions, and to investigate the relationships between different classes of the special functions.This book deals with the theory and applications of generalized associated Legendre functions of the first and the second kind, Pm,nκ(z) and Qm,nκ(z), which are important representatives of the hypergeometric functions. They occur as generalizations of classical Legendre functions of the first and the second kind respectively. The authors use various methods of contour integration to obtain important properties of the generalized associated Legnedre functions as their series representations, asymptotic formulas in a neighborhood of singular points, zero properties, connection with Jacobi functions, Bessel functions, elliptic integrals and incomplete beta functions.The book also presents the theory of factorization and composition structure of integral operators associated with the generalized associated Legendre function, the fractional integro-differential properties of the functions Pm,nκ(z) and Qm,nκ(z), the classes of dual and triple integral equations associated with the function Pm,n-1/2+iς(chα) etc.

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Volume 20 first explores preventive cardiology, a new subspecialty in cardiovascular medicine, discussing how it is possible to modify lifestyle and coronary risk factors well in advance of clinical events. The authors describes an approach to echocardiography of the aortic arch for reliable demonstration of the arch segments while reducing confounding from a patent ductus arteriosus. This compilation goes on to discuss intravascular ultrasound, which complements the conventional angiographic study and allows for the acquirement of high definition images of arteries for the evaluation of atheroma plaques. Additionally, a brief presentation of the X-ray angiography image processing methods is provided. The perioperative use of dexmedetomidine in cardiac surgery, specifically its role in early extubation, delirium management, and reducing morbidity is assessed. Evidence-based treatments for secondary prevention of ischemic heart diseases are described, including the use of antiplatelet agents, beta-blockers, angiotensin-converting enzyme inhibitors, and statins, as well as lifestyle modifications. The authors propose that the assessment of renal function in patients with heart failure is very important because it can reflect their hemodynamic status and provide a better prognostic score. The authors describe some of the common drug-related problems in patients with cardiovascular diseases, as well as their consequences, so as to identify patients who may be at risk and review several interventions designed to limit their occurrence. The closing study discusses how, to further evaluate for an aortic dissection, additional official radiologic studies likely need to be obtained to aid in diagnosis and operative planning.

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Connecting Microsoft Exchange Server covers how to connect Microsoft Exchange server into mixed messaging environments. Exchange has powerful integration capabilities and the ability to integrate with many different messaging systems. It is not always obvious how to even begin an integration project, and it is usually a fairly complex task. This book explores how connections can be made, offers tricks and tips, and warns of potential pitfalls. The content extends from the simple task of connecting an Exchange server to another Exchange server to the complex issues associated with X.400 and SMTP backbones. Direct connections to other third party products such as MS Mail, cc:Mail, Linkage and PROFS are also covered. E-mail is one of the must-have Internet applications. The Internet is driving interest in connecting people together and to information sources. Together, these influences dictate an increased interest in messaging integration, yet skills and expertise in the area are limited and restricted to a relatively small number of experts. This book helps to fill that void by communicating the author's experience gained in a large number of messaging integration projects. Digital/Microsoft Exchange server collaboration: Digital was one of the early adopters of Microsoft Exchange and were part of the ¦Bravehearts¦ -- 40 official customers who ran mission-critical messaging on beta versions of Exchange server. Digital's deployment rate of Exchange server has overtaken Microsoft's in number of seats, and Digital is currently the largest operational Exchange Server implementation in the world. There is no other organization in the world that has more employees involved today in designing and deploying customer implementations of Exchange Server.

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Written by leading market risk academic, Professor Carol Alexander, Pricing, Hedging and Trading Financial Instruments forms part three of the Market Risk Analysis four volume set. This book is an in-depth, practical and accessible guide to the models that are used for pricing and the strategies that are used for hedging financial instruments, and to the markets in which they trade. It provides a comprehensive, rigorous and accessible introduction to bonds, swaps, futures and forwards and options, including variance swaps, volatility indices and their futures and options, to stochastic volatility models and to modelling the implied and local volatility surfaces. All together, the Market Risk Analysis four volume set illustrates virtually every concept or formula with a practical, numerical example or a longer, empirical case study. Across all four volumes there are approximately 300 numerical and empirical examples, 400 graphs and figures and 30 case studies many of which are contained in interactive Excel spreadsheets available from the the accompanying CD-ROM . Empirical examples and case studies specific to this volume include: Duration-Convexity approximation to bond portfolios, and portfolio immunization; Pricing floaters and vanilla, basis and variance swaps; Coupon stripping and yield curve fitting; Proxy hedging, and hedging international securities and energy futures portfolios; Pricing models for European exotics, including barriers, Asians, look-backs, choosers, capped, contingent, power, quanto, compo, exchange, ‘best-of’ and spread options; Libor model calibration; Dynamic models for implied volatility based on principal component analysis; Calibration of stochastic volatility models (Matlab code); Simulations from stochastic volatility and jump models; Duration, PV01 and volatility invariant cash flow mappings; Delta-gamma-theta-vega mappings for options portfolios; Volatility beta mapping to volatility indices.

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“As lively, thorough, and engaging as the team it chronicles” (Nathaniel Friedman), Betaball is a compelling look at how the Golden State Warriors embraced savvy business practices, next generation science, and Silicon Valley’s technocentric culture not only to produce one of the greatest basketball teams in history but also to revolutionize the NBA—perfect for fans of Moneyball and The Book of Basketball.Betaball is the definitive, inside account of how the Golden State Warriors, under the ownership of venture capitalist Joe Lacob and Hollywood producer Peter Guber, quickly became one of the greatest success stories in both sports and business. In just five years, they turned a declining franchise with no immediate hope into the NBA’s dominant force—and facilitated the rise of All-Star point guard Stephen Curry. By operating in “beta,” the Warriors morphed into a model organization for American professional sports, instituting the best workplace principles found inside the world’s most successful corporations, and instilling a top-down organizational ethos that allows employees—from the front office to the free-throw line—to thrive. With in-depth access and meticulous reporting on and off the court, acclaimed journalist Eric Malinowski recounts a gripping tale of a team’s reinvention, of worlds colliding, of ordinary people being pushed to extraordinary heights, and the Golden State Warriors’ chase for a second straight NBA championship during the 2015-’16 season. Betaball is “a book for fans of all sports and science, business and analytics, Silicon Valley and Wall Street, front offices and locker rooms, money and winning” (Don Van Natta Jr., ESPN reporter and New York Times bestselling author).

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Now in its fully revised and expanded second edition, this textbook remains the definitive resource on pancreas transplantation. Enlarged, updated and improved, it consists of 93 chapters over 11 sections, with chapter authors who are recognized international leaders in their fields and represent institutions from five continents.Since the publication of the original edition in 2004, substantial progress has been made in the field of pancreas transplantation, specifically in regard to standardization of operative techniques and immunosuppression; significant improvements in patient and graft survival rates; and improved diagnosis and therapy of graft rejection and recurrence of disease. Pancreas transplants are no longer primarily performed in the USA and Europe for Type 1 diabetes mellitus; over the past 15 years, they have been performed with increasing frequency worldwide and also for Type 2 diabetes mellitus.The new edition of this textbook covers all aspects of pancreas transplantation: indications, recipient categories, surgical donor and recipient techniques, living donor transplantation, postoperative management and follow-up, post-transplant complications and malignancies, immunosuppression, treatment and diagnosis of rejection, impact on endocrine function and secondary complications of diabetes, recurrence of disease, quality of life, economic issues and overall outcome results. In addition, state-of-the art chapters focus on the classification, epidemiology and pathogenesis of Type 1 and 2 diabetes mellitus as well as on other beta-cell replacement therapies including islet auto- and allo-transplantation.This textbook is the primary reference on pancreas transplantation for transplant surgeons (established and in-training), pancreas and HPB surgeons, diabetologists, endocrinologists, gastroenterologists, pancreatologists and other health professionals with a focus on transplantation and diabetes (cardiologists, neurologists, urologists, ophthalmologists).

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Fragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical companies that have embraced this approach and the biotechnology companies who use fragments as their sole source of drug discovery. Fragment-Based Drug Discovery: A Practical Approach is a guide to the techniques and practice of using fragments in drug screening. The emphasis is on practical guidance, with procedures, case studies, practical tips, and contributions from industry. Topics covered include: an introduction to fragment based drug discovery, why using fragments is a more efficient process than predominant models, and what it means to have a successful FBDD effort. setting up an FBDD project library building and production NMR in fragment screening and follow up application of protein-ligand NOE matching to the rapid evaluation of fragment binding poses target immobilized NMR screening: validation and extension to membrane proteins in situ fragment-based medicinal chemistry: screening by mass spectrometry computational approaches to fragment and substructure discovery and evaluation virtual fragment scanning: current trends, applications and web based tools fragment-based lead discovery using covalent capture methods case study from industry: the identification of high affinity beta-secretase inhibitors using fragment-based lead generation With contributions from industry experts who have successfully set up an industrial fragment-based research program, Fragment-Based Drug Discovery: A Practical Approach offers essential advice to anyone embarking on drug discovery using fragments and those looking for a new approach to screening for drugs.

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The first book to tell the shocking story of Golden Rice, a genetically modified grain that provides essential Vitamin A and can save lives in developing countries—if only they were allowed to grow it.Ordinary white rice is nutrient poor; it consists of carbohydrates and little else. About one million people who subsist on rice become blind or die each year from vitamin A deficiency. Golden Rice, which was developed in the hopes of combatting that problem by a team of European scientists in the late '90s, was genetically modified to provide an essential nutrient that white rice lacks: beta-carotene, which is converted into vitamin A in the body. But twenty years later, this potentially sight- and life-saving miracle food still has not reached the populations most in need—and tens of millions of people in India, China, Bangladesh, and throughout South and Southeast Asia have gone blind or have died waiting. Supporters claim that the twenty-year delay in Golden Rice's introduction is an unconscionable crime against humanity. Critics have countered that the rice is a "hoax," that it is "fool's gold" and "propaganda for the genetic engineering industry." Here, science writer Ed Regis argues that Golden Rice is the world's most controversial, maligned, and misunderstood GMO. Regis tells the story of how the development, growth, and distribution of Golden Rice was delayed and repeatedly derailed by a complex but outdated set of operational guidelines and regulations imposed by the governments and sabotaged by anti-GMO activists in the very nations where the rice is most needed. Writing in a conversational style, Regis separates hyperbole from facts, overturning the myths, distortions, and urban legends about this uniquely promising superfood. Anyone interested in GMOs, social justice, or world hunger will find Golden Rice a compelling, sad, and maddening true-life science tale.

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The classic guide that taught a generation of institutional investors how to construct and manage high-yield quant portfolios—now updated for the new generationQuantitative Equity Portfolio Management is a comprehensive guide to the entire process of constructing and managing a high-yield quantitative equity portfolio. This detailed handbook begins with the basic principles of quantitative active management and then clearly outlines how to build an equity portfolio using those powerful concepts. This edition of the go-to guide for quant investing has been updated with critical new data, information, and insights, including: All table and graph data updated to 2020 The secret ingredients to building smart beta ETFs and mutual funds A new list of behavioral biases that lead to investment anomalies Entirely new factor definitions and test of their outperformance with real stock return data New labs using real data written in R, MATLAB, and STATA with new techniques to optimize professional portfolios New methods to deal with outlier data The author’s new research on transaction cost problems Detailed uses of ESG data to create socially responsible portfolios Downloadable monthly factor returns from the authors Quantitative Equity Portfolio Management delivers a complete, easy-to-apply methodology for creating an equity portfolio that maximizes returns and minimizes risks. It covers every step of the process, including basic models, stock screening and ranking, fundamental and economic factor modelling, forecasting factor premiums and exposures, building market neutral portfolios, tax management, performance measurement and attribution, and backtesting. An essential reference for professional money managers and students taking advanced investment courses, Quantitative Equity Portfolio Management offers a full array of methods for effectively developing high-performance equity portfolios that deliver lucrative returns for clients.

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What is the role of the senses in the creation and reception of poetry? How does poetry carry on the long tradition of making experience and suffering understood by others? With Poetry and the Fate of the Senses, Susan Stewart traces the path of the aesthetic in search of an explanation for the role of poetry in our culture. The task of poetry, she tells us, is to counter the loneliness of the mind, or to help it glean, out of the darkness of solitude, the outline of others. Poetry, she contends, makes tangible, visible, and audible the contours of our shared humanity. It sustains and transforms the threshold between individual and social existence.Herself an acclaimed poet, Stewart not only brings the intelligence of a critic to the question of poetry, but the insight of a practitioner as well. Her new study draws on reading from the ancient Greeks to the postmoderns to explain how poetry creates meanings between persons. Poetry and the Fate of the Senses includes close discussions of poems by Stevens, Hopkins, Keats, Hardy, Bishop, and Traherne, of the sense of vertigo in Baroque and Romantic works, and of the rich tradition of nocturnes in visual, musical, and verbal art. Ultimately, Stewart explores the pivotal role of poetry in contemporary culture. She argues that poetry can counter the denigration of the senses and can expand our imagination of the range of human expression.Poetry and the Fate of the Senses won the 2004 Truman Capote Award for Literary Criticism in Memory of Newton Arvin, administered for the Truman Capote Estate by the University of Iowa Writers' Workshop. It also won the Phi Beta Kappa Society's 2002 Christian Gauss Award for Literary Criticism.

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Step-by-Step Toolkit to Turn Your Passion Project into a Successful Business“...a much-needed guide for all of us who need a blueprint to becoming a successful entrepreneur.” —Eva Longoria, award-winning actress, producer, director, activist, philanthropist and CEO of UnbeliEVAble Entertainment#1 New Release in Hispanic American Demographic StudiesWomen, now is the time to build your enterprise. Jefa in Training is the only Spanglish project-launching toolkit and female entrepreneur planner specially made for a new generation of boss women.A solopreneur and small business guide. A business startup planner and toolkit for women in leadership, business, and beyond, Jefa in Training offers women entrepreneurs the female empowerment needed to take a side hustle to the next level. Whether it’s learning to define your brand, set up a beta test group, or draft an LLC operating agreement, this compendium of lessons, anecdotes, worksheets, templates, and quotes teaches the next generation of women in business how to work for yourself and turn your ideas into something much bigger.A Latina book by Latinas, for Latinas. Solopreneurs and creatives, you are invited to let go of your fears and finally launch your blog, project, or platform. Jefa in Training isn’t your typical small business book. Part Latinx book, it is a conversation with a special tribe of Latina immigrants, Hispanic American generations, and women of color in financial, media, entrepreneurial, and creative spaces. Explore a more complex view of Latinidad, covering everything from imposter syndrome to micro-aggressions and bilingualism.Inside find: Author's first-hand experiences Guest stories from successful business-women in Latinx companies Worksheets and more! If you’re looking for Hispanic books, women entrepreneur books, women leadership books, or women of color gifts―like Mind Your Business, The Memo, In the Company of Women, or De Colores Means All of Us―then you’ll love Jefa in Training.

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"This book was written by a senior lecturer in health science with a great deal of input from nurses. It highlights the burden of treatment and is a resource for non-medical prescribers in identifying adverse drug reactions and for recognising definitions and classifications. ... The sections on ‘potential problems’ and ‘suggestions for prevention and management’ were particularly enlightening. The book provides ideas for better patient consultations through discussions about medications and their effects."Nursing Standard"This likeable little book is a definite contributionto the field and should find a home in every ward,unit and hospital library shelf."International Emergency Nursing"This book is exceedingly timely. I am certain it will be invaluable to both undergraduate and post graduate student nurses, and, also act as a continuing reference source. Thoroughly recommended."Molly Courtenay, Reading University, UK"Sue Jordan has combined her deep understanding of her own discipline with her long experience of teaching nurses, to produce just the right type and level of information that nurses need, in a format that they will find relevant to their practice and easy to use. This book will be an essential reference resource for every ward bookshelf." Professor Dame June Clark, Swansea University, UKThis popular Nursing Standard prescription drug series is now available for the first time in book format! Organised by drug type and presented in an easy-to-use reference format, this book outlines the implications for practice of 20 drug groups: ACE inhibitors Antibacterial drugs Anti-coagulants Antidepressants Anti-emetics Anti-epileptic drugs Antipsychotics Beta blockers Bronchodilators Controlling gastric acidity Corticosteroids Cytotoxic drugs Diuretics Insulin Laxatives NSAIDs Opioids Oral anti-diabetic drugs Thyroid and anti-thyroid drugs Vasodilators (calcium channel blockers and nitrates) Each drug group is presented in handy quick check format, and covers: Drug actions Indications Administration Adverse effects Practice suggestions Cautions/contra-indications Interactions

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