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BY THE AUTHOR OF THE SUNDAY TIMES BESTSELLER TOMORROW, AND TOMORROW, AND TOMORROW'Marvelously optimistic about the future of books and bookstores and the people who love both' Washington PostA.J. Fikry, the grumpy owner of Island Books, is going through a hard time: his bookshop is failing, he has lost his beloved wife, and his prized possession - a rare first edition book has been stolen. Over time, he has given up on people, and even the books in his store, instead of offering solace, are yet another reminder of a world that is changing too rapidly.But one day A.J. finds two-year-old Maya sitting on the bookshop floor, with a note attached to her asking the owner to look after her. His life - and Maya's - is changed forever.Gabrielle Zevin's enchanting novel is a love letter to the world of books - an irresistible affirmation of why we read, and why we love.Readers say:'A lovely uplifting book' five star reader review'Devoured in a day. So much heart and control. Love it' five star reader review'the writing style and characters made this novel a firm five stars' five star reader review'This book has become my absolute favourite and not just best of the year but ever. I had to make a new shelf for it on GoodReads. I was completely blown away by it' five star reader review

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The chilling Sunday Times bestseller perfect for fans of Knives Out. A Richard & Judy Book Club pick.'In this fast-paced, twisted family saga, Shari Lapena keeps you guessing until the very last page...' PAULA HAWKINSThe new unputdownable thriller from the multi-million-copy bestselling author of THE COUPLE NEXT DOOR.In this family, everyone is keeping secrets - even the dead.In the quiet, wealthy enclave of Brecken Hill, an older couple is brutally murdered hours after a tense Easter dinner with their three adult children. Who, of course, are devastated.Or are they? They each stand to inherit millions. They were never a happy family, thanks to their vindictive father and neglectful mother, but perhaps one of them is more disturbed than anyone knew. Did someone snap after that dreadful evening? Or did another person appear later that night with the worst of intentions? That must be what happened. After all, if one of the family were capable of something as gruesome as this, you'd know.Wouldn't you?'Nobody does a vicious family circle like Shari Lapena. Highly recommended' Cara Hunter'Queen of the modern crime novel, Shari Lapena, is back with another tale of murder... Shari will keep you guessing until the very end' Sunday Express'A cross between Big Little Lies and Miss Marple' Woman's Weekly'[A] dramatic, tense and satisfying murder mystery' My Weekly

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A captivating and taut thriller that will leave you holding your breath, from Sunday Times bestselling author Simon Kernick, the UK's answer to Harlan Coben.'The next time I see Simon Kernick's name on a book, I will pick it up. Brilliant!' - RICHARD MADELEY'This thriller is so authentic that it completely takes your breath away, and then some.' - THE MIRROR'Kernick is the master of the literary rabbit punch, thumping his readers when they least expect it, and from a different direction...Cracking stuff.' - THE TIMES'If it's heart-thudding tension you want, Simon Kernick is your man.' - DAILY MAIL'Simon Kernick uses every trick in the book to keep the action breakneck.' - TIME OUT********************************************************************'WE'VE GOT YOUR DAUGHTER.'It's evening, you're back late from work - and the house is in darkness.You step inside, and the phone rings. You answer it - and your world is turned upside down.Your fourteen-year-old daughter's been taken, and her kidnappers demand half a million pounds in cash. They give you 48 hours to raise the money. If you call the police, she will die.As the nightmare unravels, you can be certain of only two things: that you will do anything to get your daughter back alive - and that time is running out...

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Woman. Wife. Smuggler. Spy . . .TV SERIES IN DEVELOPMENT STARRING ELIZABETH DEBICKI (TENET, THE CROWN) AS NANCY WAKEA thrilling and heart-wrenching novel inspired by the astonishing real life story of Nancy Wake. Perfect for fans of Suzanne Goldring's MY NAME IS EVA, Kate Quinn's THE ALICE NETWORK and Imogen Kealey's LIBERATION, soon to be a blockbuster movie. 'Lawhon breathes new life into Nancy Wake's extraordinary story. Rich and thoroughly researched, an exciting, well-written account of wartime valour and the protagonist's qualities shine through' The Times'This is the next book I won't be able to stop talking about...so, so good!' 5 stars (Goodreads reviewer)'Readers will be transfixed by this story of a woman who should be a household name' Library Journal'A gripping thriller based on the life of Nancy Wake... Will keep readers turning the pages' Publishers WeeklyIn 1936, foreign correspondent, Nancy Wake, witnesses first-hand the terror of Hitler's rise in Europe. No sooner has Nancy met, fallen in love with and agreed to marry French industrialist Henri Fiocca, than the Germans invade France and force her to take on her first code name of many. The Gestapo call her the White Mouse for her remarkable ability to evade capture when smuggling Allied soldiers across borders. She becomes Hélène when she leaves France to train in espionage with an elite special forces group in London. Then, when she returns to France, she is the deadly Madame Andrée. But the closer France gets to liberation, the more exposed Nancy - and the people she loves - will become.Inspired by true wartime events, Code Name Hélène is a gripping and moving story of extraordinary courage, unfaltering resolve, remarkable sacrifice - and enduring love.Just some of the 5-star reader reviews for Code Name Hélène: 'I finished this a few weeks ago and I'm still thinking about Hélène . . . exceptional' 5 stars (Goodreads reviewer)'Will have you turning off phones and TVs and staying up late to read it' 5 stars (Goodreads reviewer)

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Jasper Fforde, the acclaimed SUNDAY TIMES NUMBER ONE BESTSELLER, invites you to imagine a world where your position in society depends on what bit of the colour spectrum you can see... It's the UK, but not as we know it: civilisation has rebuilt after an unspoken 'Something that Happened' five hundred years before. Society is now colour-based, the strict levels of hierarchy dictated by the colours you can see, and the economy, health service and citizen's aspirations all dominated by visual colour, run by the shadowy National Colour in far-off Emerald City. Out on the fringes of Red Sector West, Eddie Russett and Jane Grey have discovered that all is neither fair nor truthful within their cosy environment, and currently face trumped up charges that will see them die of the fatally soporific tones within the Green Room. Negotiating the narrow boundaries of the Rules within their society, Jane and Edward must find out the truth of their world: What is it, where is it and even when it is. As they unpeel the lies that cloak their existence they come to the worrying conclusion that they may not be alone: That there might be a Somewhere Else beyond the sea, and more, Someone Else living there - and observing them all, purposefully unseen. Red Side Story delves into the strictures of a society imposed on itself by itself, immovable dogma and the spirit of humans trying to love and survive and make sense of a world that makes no sense at all. Only it does, of course - you just have to look harder, look further, and forget everything you've ever been told. 'Fforde's books are more than an ingenious idea. They are written with buoyant zest and are tautly plotted . . . and are embellished with the rich details of a Dickens or Pratchett' Independent 'No summaries can do justice to the sheer inventiveness, wit, complexity, erudition, unexpectedness and originality' The Times 'Brilliantly inventive' Mail on Sunday

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'Full of love and warmth, tears and laughter, another gorgeous book from Jo Thomas' Katie Fforde---A dream homeBeca Valentino is ready to escape the city. When she sees the perfect house for sale in her hometown, it seems like fate. Is this her chance to build the foster family she dreams of, on the beautiful Pembrokeshire coast?A big mistake?Returning home isn't as easy as she thought, however. Her family's beloved ice cream café is gone - turned into a soulless wine bar by her hateful ex-boyfriend. Reconnecting with her oldest friend, fisherman Griff, isn't straightforward either. And when, instead of the children she expected to take in, two wary teenage boys appear on her doorstep, Beca fears she's made a terrible mistake.A recipe for changeBut an old family recipe book is just the inspiration she needs. Soon, with a little help from friends old and new, Beca is selling mouth-watering homemade gelato from a pop-up café on the beach.Then disaster strikes. Will the Valentino family legacy be lost forever? Or can Beca create a new recipe for happiness?

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Jasper Fforde, the acclaimed SUNDAY TIMES NUMBER ONE BESTSELLER, invites you to imagine a world where your position in society depended on what bit of the colour spectrum you could see...It's the UK, but not as we know it: civilisation has rebuilt after an unspoken 'Something that Happened' five hundred years before. Society is now colour-based, the strict levels of hierarchy dictated by the colours you can see, and the economy, health service and citizen's aspirations all dominated by visual colour, run by the shadowy National Colour in far-off Emerald City.Out on the fringes of Red Sector West, Eddie Russett and Jane Grey have discovered that all is neither fair nor truthful within their cosy environment, and currently face trumped up charges that will see them die of the fatally soporific tones within the Green Room.Negotiating the narrow boundaries of the Rules within their society, Jane and Edward must find out the truth of their world: What is it, where is it and even when it is. As they unpeel the lies that cloak their existence they come to the worrying conclusion that they may not be alone: That there might be a Somewhere Else beyond the sea, and more, Someone Else living there - and observing them all, purposefully unseen.Red Side Story delves into the strictures of a society imposed on itself by itself, immovable dogma and the spirit of humans trying to love and survive and make sense of a world that makes no sense at all. Only it does, of course - you just have to look harder, look further, and forget everything you've ever been told.'Fforde is one of literature's most enjoyable visionaries, and his long-awaited Shades of Grey sequel will be eagerly seized upon by his admirers... The jokes are excellent, the pacing breathless and the last line a classic' Observer'Fforde's books are more than an ingenious idea. They are written with buoyant zest and are tautly plotted . . . and are embellished with the rich details of a Dickens or Pratchett' Independent'No summaries can do justice to the sheer inventiveness, wit, complexity, erudition, unexpectedness and originality' The Times'Brilliantly inventive' Mail on Sunday

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When a mother-daughter duo set out on a road trip, the last thing they expect to find along the way is each other... The new, heartfelt and hilarious novel from the bestselling author of THE BOOKISH LIFE OF NINA HILL.'GORGEOUS' Marian Keyes'Charmed by its funny loveliness' Nina StibbeJessica and her daughter Emily are touring colleges. For Jessica, this is going to be the chance to reconnect with the daughter she seems to have lost. But for Emily, it's a preview of freedom, and the chance to explore a new and exciting future.Yet before any of this can happen, their perfectly planned trip is derailed into a series of off-roading misadventures: mother-daughter skiving, skipped mandatory meetings, and a scuffle with the FBI...With seatbelts fastened, physical and emotional baggage safely stowed away, this mother-daughter duo might be ready to hit the road, but are they ready to reconnect to the person sitting next to them?Praise for Abbi Waxman!'Book lovers will absolutely relate' O, THE OPRAH MAGAZINE'Like a conversation with the funniest person you know - just lovely' KATIE FFORDE'I hope you're in the mood to be downright delighted, because that's the state you'll find yourself in'POPSUGAR'Waxman shines at creating characters that feel like best friends'BOOKLIST'Meet our bookish millennial heroine - a modern-day Elizabeth Bennet'THE WASHINGTON POST'A quirky, eccentric romance that will charm any bookworm'ENTERTAINMENT WEEKLY

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SECRETS FROM THE PAST, UNRAVELLING IN THE PRESENT From the million-copy Sunday Times bestseller comes a gripping and moving story spanning 25 years and World War II, secrets, family and enduring love.The streets of Paris hide a dark past… September, 1937. Kitty Travers enrols at the Conservatoire on the banks of the Seine to pursue her dream of becoming a concert pianist. But then war breaks out and the city of light falls into shadow. Nearly twenty-five years later, Fay Knox, a talented young violinist, visits Paris on tour with her orchestra. She barely knows the city, so why does it feel so familiar? Soon touches of memory become something stronger, and she realises her connection with these streets runs deeper than she ever expected. As Fay traces the past, with only an address in an old rucksack to help her, she discovers dark secrets hidden years ago, secrets that cause her to question who she is and where she belongs…Praise for Rachel Hore's novels: ‘A tour de force. Rachel's Paris is rich, romantic, exotic and mysterious’ JUDY FINNIGAN ‘An elegiac tale of wartime love and secrets’ Telegraph ‘A richly emotional story, suspenseful and romantic, but unflinching in its portrayal of the dreadful reality and legacy of war’ Book of the Week, Sunday Mirror 'Pitched perfectly for a holiday read' Guardian 'Engrossing, pleasantly surprising and throughly readable' SANTA MONTEFIORE 'A beautifully written and magical novel about life, love and family' CATHY KELLY

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Celebrate the 10th anniversary of a groundbreaking book on creativity with this limited anniversary hardcover, with a new afterword, color endpapers pulled from Austin Kleon’s sketchbooks, and a ribbon marker. Ten years after its initial publication, the message of Steal Like an Artist remains powerful: embrace influence, follow interests wherever they take us, forget old clichés like writing about what you know—instead, write the book that you want to read, make the movie you want to watch. And above all, find the space you need to be wild and daring in your imagination and your work. This 10th anniversary edition includes a new afterword by the author, discussing the book’s influence and how “stealing” has been misunderstood, and offering a unique, personal perspective on a book that’s touched so many. Unlock your creativity 1.Steal like an artist. 2.Don’t wait until you know who you are to get started. 3.Write the book you want to read. 4.Use your hands. 5.Side projects and hobbies are important. 6.The secret: Do good work and share it with people. 7.Geography is no longer our master. 8.Be nice. (The world is a small town.) 9.Be boring. (It’s the only way to get work done.) 10.Creativity is subtraction.

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Discover the addictive and gripping novel from the bestselling author of You'll Never See Me Again, Lesley Pearse'A gripping novel' HELLO! Magazine_______________London, 1960.The lives of teenage twins Maisy and Duncan change for ever the night their mother is sent away.Sent to live in the New Forest with their cold-hearted grandmother, Mrs Mitcham, they feel unloved and abandoned.And when one day Duncan doesn't come home from exploring in the forest, no one - least of all his grandmother - appears to care about his disappearance. The police, who've found the bodies of other missing boys, offer little hope of finding Duncan alive.Yet Maisy refuses to give up.Though she doesn't know the woods well, she knows someone who does. The strange old woman who lives at their heart . . .Dare Maisy enlist the help of the woman in the wood?And what will she find if she does?_______________'A real page-turner, a family story that is multi-layered just as you'd expect from Lesley Pearse, who is deservedly one of the world's favourite story tellers' My Weekly'Characters it is impossible not to care about . . . this is storytelling at its very best' Daily Mail

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An exploration of the mysterious world of the unconscious for dreamers age 12 to 16.

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A Viking saga of warmongering, honour and loyalty from the Sunday Times bestselling author of Lancelot, Giles Kristian. Perfect for fans of Bernard Cornwell and Games of Thrones."A fitting end to a trilogy that fans of Bernard Cornwell should devour" -- THE TIMES"The master storyteller...whose books throw the reader headlong into the Viking age." -- BEN KANE"This remains Viking writing at its best: thrilling in it truest sense, heart-rendering and, yes, glorious." -- MANDA SCOTT"Probably the best Viking saga I have ever read -- ***** Reader review "Wonderfully written and researched, the whole series makes the entire Nordic world come alive" -- ***** Reader review"This trilogy is gripping from start to finish" -- ***** Reader review*****************************************THE GODS MUST BE FAVOURED...Norway, AD 785. A wild place, a place of blood, a place where the gods hold sway . . .Sigurd Haraldarson and his oathsworn band are winning fame and reputation. But to confront his hated enemy - the oath-breaker and betrayer King Gorm - they must win riches too.When a daring raid goes wrong, Sigurd finds himself a prisoner of the powerful Jarl Guthrum. Bound like a slave, he is taken to the sacred temple at Ubsola to face the sacrificial knife.But here Sigurd discovers a potent relic: Gungnir, a great spear that would give him the power to assemble a host strong enough to challenge King Gorm, and avenge the betrayal of his father and the murder of his family.The roar of Odin and the wild hunt will be as nothing compared to Sigurd's rage, for he and his warriors will be borne on the wings of the storm . . .Wings of the Storm concludes the Viking saga, started in God of Vengeance and Winter's Fire.

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'[Gervase Phinn is] a worthy successor to James Herriot, and every bit as endearing.' - bestselling author Alan Titchmarsh'A shining light in our dark days' - 5 STAR reader reviewAfter an eventful start to his first ever teaching post in the sleepy village of Risingdale, Tom Dwyer is hoping for a bit of calm. Nursing a broken heart after a romantic disappointment, he just wants to keep his head down and get on with his job. But it is not to be. A beautiful London artist sets tongues wagging when she moves into the village, and her precocious yet frail son is in Tom's class. On top of that, his colleague's malicious ex-husband is back, determined to create mischief, and a tragedy on one of the winding country roads sends the village reeling. And all this alongside a class of children who still seem to know more about farming than fractions. With its colourful mix of characters both old and new and its many laugh-out-loud moments, Tales Out of School is a warm, humorous portrayal of life in a small Yorkshire village.Readers are loving TALES OUT OF SCHOOL:'Loved it. So easy to read, lovely story, unforgettable characters.' - 5 STARS'Brilliant!' - 5 STARS'Could not put the book down. Gervase Phinn is an expert story teller.' - 5 STARS'Such a relaxing and calming read' - 5 STARS'I have been waiting for this sequel and it didn't disappoint.' - 5 STARS

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'[Gervase Phinn is] a worthy successor to James Herriot, and every bit as endearing.' - bestselling author Alan Titchmarsh'A shining light in our dark days' - 5 STAR reader reviewAfter an eventful start to his first ever teaching post in the sleepy village of Risingdale, Tom Dwyer is hoping for a bit of calm. Nursing a broken heart after a romantic disappointment, he just wants to keep his head down and get on with his job. But it is not to be. A beautiful London artist sets tongues wagging when she moves into the village, and her precocious yet frail son is in Tom's class. On top of that, his colleague's malicious ex-husband is back, determined to create mischief, and a tragedy on one of the winding country roads sends the village reeling. And all this alongside a class of children who still seem to know more about farming than fractions. With its colourful mix of characters both old and new and its many laugh-out-loud moments, Tales Out of School is a warm, humorous portrayal of life in a small Yorkshire village.Readers are loving TALES OUT OF SCHOOL:'Loved it. So easy to read, lovely story, unforgettable characters.' - 5 STARS'Brilliant!' - 5 STARS'Could not put the book down. Gervase Phinn is an expert story teller.' - 5 STARS'Such a relaxing and calming read' - 5 STARS'I have been waiting for this sequel and it didn't disappoint.' - 5 STARS

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Famous Essex Authors, that you have never heard, that will in fact heard of. There are literally dozens of names that have been, sadly, forgotten over time. You may recognise some book titles, however (The French Lieutenant's Woman? One Hundred and One Dalmatians?). Some of the romance writers featured may not have famous names or even famous "titles" but they were so prolific and popular that they deserve to be foregrounded for their contribution to the world of books.Who knew, for instance, that a working class girl from Dagenham (Sheila Holland) would become so successful as a romantic novelist under her various pseudonyms that she went into tax exile on a mansion on the Isle of Man, or that a quiet introvert from Leigh-on-Sea was capable of writing raunchy novels about Arab sheikhs although she had never travelled beyond England (Violet Winspear). Then there is the impressive R.D.Wingfield, whose books about Detective Frost were a huge favourite of the author, revealed as being from Basildon, not far from her own home in Southend. Finding out why these people started writing, what motivated them, how they enjoyed success by using their lively imaginations, and how they sometimes struggled, has revealed a fascinating insight into the people of Essex. Even the 17th century aristocracy produced its memorable scribes with a Duchess from Colchester flaunting her exoticism and style with both the written and spoken word (Margaret Cavendish). Peppered throughout these pages are boxes featuring additional relevant trivia which should hopefully extend readers' knowledge of Essex authors and their works.Title includes a fold out map.

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The Thesaurus Linguae Graecae: A Bibliographic Guide to the Canon of Greek Authors and Works (TLG®) is a comprehensive catalog of the authors and works that have survived in Greek from antiquity (eighth century BCE) to the present era and have been collected and digitized by the TLG® in its fifty-year history. It provides biographical information about each author, such as dates, place of birth, and literary activity, as well as a list of their extant works and print publications. This volume encompasses more than 4,400 authors and 17,000 individual works. It offers a concise and authoritative literary history of Greek literature and is an indispensable reference source for its study.

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If you loved From Lukov with Love - the sensational TikTok hit that is captivating readers all over the world - then you don't want to miss any of Mariana's unique romances! No one writes slow burn like Mariana Zapata and her millions of fans agree!'Just so incredibly sweet that it reaches into your soul . . . Thank you, MZ, for sharing such an incredible gift' ⭐ ⭐ ⭐ ⭐ ⭐ reader review'There is nothing Mariana will put out that I wouldn't put on a pedestal. Ahhhhh. This book was so good I don't want it to end. I swooned. I cried. I laughed. And I enjoyed every bit of it' ⭐ ⭐ ⭐ ⭐ ⭐ reader review'As always Mariana brings us a story that we can get lost in . . . we have amazing characters . . . a second chance romance . . . the slow burn as always . . . but so much banter and emotional you cant help but know you are in a Zapata book!' ⭐ ⭐ ⭐ ⭐ ⭐ reader review'Mariana Zapata, I love your words, your humour and your imaginary characters . . . A deliciously funny and heartfelt read. Definitely recommend. A 5 STAR READ' ⭐ ⭐ ⭐ ⭐ ⭐ reader review'This is one of my all-time favourite books from Mariana Zapata' ⭐ ⭐ ⭐ ⭐ ⭐ reader review'Man, I loved this book!!! MZ has done it again, another amazing slow-burn romance' ⭐ ⭐ ⭐ ⭐ ⭐ reader review'This slow-burn romance burned me in the best way. It was definitely the best thing I did the day I decided to pick it up' ⭐ ⭐ ⭐ ⭐ ⭐ reader review'A beautiful, slow burn, with characters that actually seem like human beings, in classic Zapata fashion' ⭐ ⭐ ⭐ ⭐ ⭐ reader review'So many feels in one book: I laughed, I cried and I sobbed . . . the characters all felt so real to me I loved everything about this book. I know that this will stay with me for a long time an absolute must-read' ⭐ ⭐ ⭐ ⭐ ⭐ reader review'Never disappointed with a Mariana Zapata book. Special and amazing, as always' ⭐ ⭐ ⭐ ⭐ ⭐ reader review.........................................Some things are easily forgiven. Other things . . . not so much.Lenny DeMaio made herself a promise: she was done.Done thinking about him.Done worrying about him.Done reaching out to a man who clearly didn't want to be found.Too bad no one gave Jonah Collins the memo..........................................Want more of Mariana's delicious slow burn? Why not start with her sensational hit, From Lukov with Love! And don't miss any of her romances beloved by millions of readers!Dear AaronLingusRhythm, Chord & MalykhinThe Best ThingUnder LockeKultiThe Wall of Winnipeg and MeWait for ItLuna and the LieHands DownAll Rhodes Lead Here

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From the number one bestselling author Claudia Carroll comes a warm, feel-good story that will make you laugh and cry, and above all, leave you with a feeling of hope.'A wise, warm and witty gem . . . I loved it' Carmel Harrington'Funny, smart and thoroughly engaging' Liz Nugent'It made me laugh and it made me weep . . . a stunning book' Sinead MoriartySo many stories hidden behind closed doors . . .It's late at night and the rain is pouring down on the Dublin city streets. A mother is grieving for her dead child. She stands silently outside the home of the teenage boy she believes responsible. She watches . . .In a kitchen on the same square, a girl waits anxiously for her mum to come home. She knows exactly where she is, but she knows she cannot reach her.A few doors down, and a widow sits alone in her room. She has just delivered a bombshell to her family during dinner and her life is about to change forever.And an aspiring theatre director has just moved in to a flat across the street. Her landlord is absent, but there are already things about him that don't quite add up . . .Welcome to Primrose Square.Praise for Claudia Carroll:'Modern, warm, insightful and filled with characters that felt like friends at the end' Emma Hannigan'Original, poignant and funny . . . [full of] wit and humour' Sheila O'Flanagan'It bubbles and sparkles like pink champagne' Patricia Scanlan'Full of warmth, humour and emotion . . . I guarantee you'll love it' Melissa Hill

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G protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, with more than 800 members identified thus far in the human genome. They regulate the function of most cells in the body, and represent approximately 3% of the genes in the human genome. These receptors respond to a wide variety of structurally diverse ligands, ranging from small molecules, such as biogenic amines, nucleotides and ions, to lipids, peptides, proteins, and even light. Ligands (agonists and antagonists) acting on GPCRs are important in the treatment of numerous diseases, including cardiovascular and mental disorders, retinal degeneration, cancer, and AIDS. It is estimated that these receptors represent about one third of the actual identified targets of clinically used drugs. The determination of rhodopsin crystal structure and, more recently, of opsin, 1 and 2 adrenergic and A2A adenosine receptors provides both academia and industry with extremely valuable data for a better understanding of the molecular determinants of receptor function and a more reliable rationale for drug design. GPCR structure and function constitutes a hot topic. The book, which lies between the fields of chemical biology, molecular pharmacology and medicinal chemistry, is divided into three parts. The first part considers what receptor structures tell us about the mechanism of receptor activation. Part II focuses on receptor function. It discusses what the data from biophysical and mutational studies, and the analysis of the interactions of the receptor with ligands and regulator proteins, tell us about the process of signal transduction. The final part, on modelling and simulation, details new insights on the link between structure and mechanism and their implications in drug design.

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The AMA Manual of Style is a must-have resource for anyone involved in medical, health, and scientific publishing. Written by an expert committee of JAMA Network editors, this latest edition addresses issues that face authors, editors, and publishers in the digital age. Extensive updates are included in the References chapter, with examples of how to cite digital publications, preprints, databases, data repositories, podcasts, apps and interactive games, and social media. Full-color examples grace the chapter on data display, with newer types of graphic presentations and updated guidance on formatting tables and figures. The manual thoroughly covers ethical and legal issues such as authorship, conflicts of interest, scientific misconduct, intellectual property, open access and public access, and corrections. The Usage chapter has been revised to bring the manual up-to-date on word choice, especially in writing about individuals with diseases or conditions and from various socioeconomic, racial/ethnic, and sexual orientation populations. Specific nomenclature entries in many disciplines are presented to guide users in issues of diction, formatting, and preferred terminology. Guidance on numbers, SI units, and math has been updated, and the section on statistics and study design has undergone a major expansion. In sum, the answer to nearly any issue facing a writer or editor in medicine, health care, and related disciplines can be found in the 11th edition of the AMA Manual of Style. Available for institutional purchase or subscription or individual subscription. Visit AMAManualofStyle.com or contact your sales rep for more details.

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Reese Witherspoon, Oprah and Roxane Gay LOVE her! Readers love her!Have you discovered New York Times bestseller and Reese's Book Club pick Jasmine Guillory yet? 'The queen of contemporary romance' OprahMag.com'She writes the sexiest and smartest romances' Red Magazine'Just as essential to a good summer holiday as SPF' GraziaJoin the Party of Two fans!'Funny, romantic, real. All the feels' ⭐ ⭐ ⭐ ⭐ ⭐'[A] must-have for anyone who likes a good romance!' ⭐ ⭐ ⭐ ⭐ ⭐'A romantic whirlwind of a novel that will sweep you off your feet' ⭐ ⭐ ⭐ ⭐ ⭐...........................................................It's the whirlwind affair that has everyone talking . . . Dating is the last thing on Olivia Monroe's mind when she moves to LA to start her own law firm. An entire night of flirting with a gorgeous man at a hotel bar could change her mind though - until she discovers that he's hotshot junior senator Max Powell. Max's determination to win Olivia over proves him to be sweet, funny, and noble - not just some privileged white politician she assumed him to be. Dating in secret is fun at first, but when they finally go public, the intense media scrutiny results in the exposure of Olivia's rocky past, criticism of her job, and questions about her suitability as a trophy girlfriend. Olivia knows what she has with Max is special, but is it strong enough to survive the heat of the spotlight?...........................................................PERFECT FOR FANS OF EMILY HENRY, CHRISTINA LAUREN AND TESSA BAILEY!'A charming, warm, sexy gem' ROXANE GAY'The undisputed queen of the modern-day romance' Vogue'Juicy yet meaningful, like every Guillory classic' Elle'Steamy and swoonworthy' PopSugar'When Jasmine Guillory comes out with a book, buy it' Refinery29If you love this, be sure to check out all of Jasmine's smart and sexy rom-coms:The Wedding DateThe ProposalThe Wedding PartyRoyal HolidayParty of TwoWhile We Were DatingDrunk on Love

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"...the structure of G. E. Kidder Smith Builds, which traces his career first through books and then with exhibitions, means the book is more bibliographical than biographical... it illuminates many aspects of his life not widely known." — Archidose George Everard Kidder Smith (1913–1997) was a multidimensional figure within the wide-ranging field of North American architectural professionals in the second half of the twentieth century. Although he trained as an architect, he chose not to practice within the conventional strictures of an architecture office. Instead, Kidder Smith “designed,” researched, wrote, and photographed a remarkably diverse collection of books about architecture and the built environment. His work and life were deeply interwoven and punctuated by travel related to the research, writing, and promotion of books that sought to reveal the genius loci of the countries whose built environments he admired and wished to share with a broader audience. From the early 1940s to the late 1950s his interest in architecture led him to describe visually the architectural and historical identity of many European countries. After his far-flung travels over the decades, with his wife Dorothea, Kidder Smith focused on his own country and produced a series of ambitious books focused on the United States. Kidder Smith’s vision and narrative betray the gaze of the traveller, the scholar, and the architect.

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'Gripping and skilfully told, with an economy and freshness of approach that is all Tade Thompson's own. The setting is interstellar, but it feels as real, immediate and lethal as today's headlines' Alastair ReynoldsArthur C. Clarke Award winner Tade Thompson makes a triumphant return to science fiction with this unforgettable vision of humanity's future in the chilling emptiness of space.The colony ship Ragtime docks in the Lagos system, having travelled light years from home to bring one thousand sleeping souls to safety among the stars.Some of the sleepers, however, will never wake - and a profound and sinister mystery unfolds aboard the gigantic vessel. Its skeleton crew are forced to make decisions that will have repercussions for all of humanity's settlements - from the scheming politicians of Lagos station, to the colony planet of Bloodroot, to other far flung systems and indeed Earth itself.'A gripping space opera with characters fighting for their lives aboard a dying starship. I enjoyed it so much and can't wait to see what Thompson does next' Martha Wells, author of the Murderbot Diaries'Simultaneously brutally grounded and wildly imaginative' Adrian Tchaikovsky, author of Children of Time'Perfectly balances inspired universe building with both high-octane action and emotional depth' Big Issue'Readers looking for a smart sci-fi mystery should snap this up' Publishers Weekly'First-rate space opera from one of the genre's most exciting voices' Gareth L. Powell'Tade Thompson is a writer of enormous heart and talent. Just brilliant' Dave Hutchinson

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The Blame Game is a dark, entertaining and suspenseful thriller from Sandie Jones, the author of The Other Woman and The Guilt Trip. There are two sides to every story as a psychologist and her client become entangled in each other's lives.'A brilliant page-turner' – Sarah Pearse, author of The RetreatThere are two sides to every story.He came to me for help with his marriage.I was alone and afraid. She was there when I needed to talk.I needed to make him understand that he had to get away.I knew what I needed to do. I just couldn’t do it on my own. I trusted her.Now it has gone too far. And I can’t tell anyone what I have done.Now I have nowhere to turn and I just pray they find me before she does.And then there's the truth.Praise for Sandie Jones:'Will leave you breathless' – Liv Constantine, author of The Stranger in the Mirror'A perfect beach read' – Kristin Hannah, author of The Four Winds'Twisting, suspenseful, artfully tricksy' – C. M. Ewan, author of The Interview

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The brand-new escapist summer novel from Sunday Times bestseller Jenny Colgan. Fall in love with a new cast of characters and get swept away in a breath-taking romance you'll want to read again and again . . .'A glorious, breathtaking, tender romance. I loved every moment of the ride' SOPHIE KINSELLA'[A] blast of feelgood fiction [...] it makes me want to head for the Highlands' THE TIMES'You'll be racing through the pages' INDEPENDENT'Another Colgan classic for the beach bag' WOMEN'S WEEKLY___________________________________Born into a family of successful pilots, Morag is used to flying high. But when a tragic accident above the clouds grounds her, could the future she'd always imagined be suddenly out of reach?When she receives a call telling her that her beloved grandfather has been taken ill, Morag leaves her fast-paced life in London to return home to the tranquil Scottish Highlands. With her grandfather out of action, Morag has no choice but to take over flying the local route in his rickety old plane, ferrying locals across the beautiful islands of the archipelago.But as the weather takes a dramatic turn, Morag is forced to crash-land on a remote island and suddenly finds herself far from civilisation and all alone. Then she discovers Gregor, the gruff and reclusive ornithologist taking care of the island for the season. Though the pair don't see eye to eye, Morag is forced to seek shelter at his cabin and it seems the pair are stuck together until help arrives. However long that may be . . .As she awaits rescue, might Morag discover that a remote Scottish island, cut off from real-life, is exactly the place she needs to be? Don't miss Jenny's new festive treat, Midnight at the Christmas Bookshop, available to pre-order now!

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In the late 1980s, gangsta rap music emerged in urban America, giving voice to-and making money for-a social group widely considered to be in crisis: young, poor, black men. From its local origins, gangsta rap went on to flood the mainstream, generating enormous popularity and profits. Yet the highly charged lyrics, public battles, and hard, fast lifestyles that characterize the genre have incited the anger of many public figures and proponents of "family values." Constantly engaging questions of black identity and race relations, poverty and wealth, gangsta rap represents one of the most profound influences on pop culture in the last thirty years. Focusing on the artists Ice Cube, Dr. Dre, the Geto Boys, Snoop Dogg, and Tupac Shakur, Quinn explores the origins, development, and immense appeal of gangsta rap. Including detailed readings in urban geography, neoconservative politics, subcultural formations, black cultural debates, and music industry conditions, this book explains how and why this music genre emerged. In Nuthin'but a "G" Thang, Quinn argues that gangsta rap both reflected and reinforced the decline in black protest culture and the great rise in individualist and entrepreneurial thinking that took place in the U.S. after the 1970s. Uncovering gangsta rap's deep roots in black working-class expressive culture, she stresses the music's aesthetic pleasures and complexities that have often been ignored in critical accounts.

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The ultimate collection of basic patterns that can be sewn, modified, and styled to yield more than 100 unique looks Make It Yours with Mimi G is all about creating a fully functional wardrobe to love. Starting with six base patterns, Mimi G then hacks each pattern to create 26 new designs that will be styled both together and separately for a total of more than 100 looks. But this book isn’t just about hacking patterns to give you a complete wardrobe; it’s also about showing you how to style each garment and make your DIY wardrobe work for you. Fashion and style are an integral part of making your own clothing, and this book offers a complete guide to making the perfect wardrobe for each individual. Mimi G’s own understanding of fit, her size-inclusive patterns, and ability to make what most would call “basic patterns” into unforgettable looks give this book incredible appeal. Focused on the modern maker wanting to create a sustainable wardrobe—with sewing, style, and design options—Mimi G’s take is unlike any other.

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