Search results for ""pan stanford publishing pte ltd""

Nanoparticles may be used in industrial processes, incorporated into consumer products, or applied as biomedical agents. Isotopic (radio)labeling is one of the most powerful methods for nanoparticle tracing in experimental studies. This book presents an introduction to some commonly used nanomaterials, describes various methods with which they may be radiolabeled, and provides illustrative examples of applications of the labeled particles. Finally, it discusses the use of nanomaterials in radiotherapy, the stable isotope labeling technique, and operational health and safety aspects related to the manipulation of nanoparticles in controlled areas. The book will appeal to anyone involved in nanotechnology, molecular imaging, radiochemistry, and nanomedicine.

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The rapid advancement of integrated optoelectronics has been driven considerably by miniaturization. Following the path taken in electronics of reducing devices to their ultimately fundamental forms, for instance single-electron transistors, now optical devices have also been scaled down, creating the increasingly active research fields of integrated and coupled photonic systems. The interactions between the coupled integrated micro- and nanostructures can provide us with the fundamental understanding and engineering of complex systems for a variety of applications.This book aims to bring to the readers the latest developments in the rapidly emerging field of integrated nanophotonic resonators and devices. It compiles cutting-edge research from leading experts who form an interdisciplinary team around the world. The book also introduces the fundamental knowledge of coupled integrated photonic/electronic/mechanical micro- and nanoresonators and their interactions, as well as advanced research in the field.

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Conjugated polymer composites with high dielectric constants are being developed by the electronics industry in response to the need for power-grounded decoupling to secure the integrity of high-speed signals and to reduce electromagnetic interference. Electrically conducting polymers are materials that simultaneously possess the physical and chemical properties of organic polymers and the electronic characteristics of metals. Multifunctional micro- and nanostructures of conjugated polymers, such as of pyrrole, have received great attention in recent years because they can polymerize easily and have high conductivity and good thermal stability. They, however, have some disadvantages such as brittleness and hard processability, which can be overcome by developing their nanocomposites. Nanofiber materials with different dielectric properties can be made from conjugated polymer composites and used in the electronics industry, in sensors and batteries, for electrical stimulation to enhance nerve-regeneration process, and for constructing scaffolds for nerve tissue engineering. Electrospinning is a versatile technique that is used to produce ultrathin continuous fibers with high surface-to-volume and aspect ratios from a variety of materials, including polymers, composites, and ceramics. Conductive materials in fibrillar shape may be advantageous compared with films because of their inherent properties such as anisotropy, high surface area, and mechanical strength. They are of particular interest in electroactive composites as they can be efficiently distributed in an insulating polymer matrix to improve both electrical and mechanical properties. Combination of electrical properties with good mechanical performance is of particular interest in electroactive polymer technology. This book covers the general aspects of electrospinning and discusses the fundamental concepts that can be used to produce nanofibers with the help of mathematical models and equations. It also details the methods through which different polymeric structures can be included in conjugated polymers during electrospinning to form composites or blends of conjugated polymer nanofibers.

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Enzyme immobilization on solid supports has been considered for a long time as an attractive solution to perform sophisticated organic synthesis, which is required in the preparation of fine pharmaceutical chemicals. But in the late 1990s, the tremendous progress in molecular biology fundamentals opened up the possibility of feeding a toolbox for building new bioinspired nanotechnologies. Among them is the goal of repositioning biocatalysts in environments mimicking their genuine working place—the cell. The research presented in this book was selected among the most impressive achievements in the fields of enzyme bioconjugation and bioinspired nanosupports. It opens up potential applications in nanocatalysis and for lab-on-a-chip and biosensor devices, drug delivery vectors, and nanometrology. Most of the supports described pertain to soft materials (cells, virus, polymers, DNA) and most of the examples benefit from the amazing properties of proteins and DNA to self-assemble, according to the "bottom-up law," a specific feature of all living systems. The enzyme nanocarriers also have the potential to be grafted on solid supports through "top-down" technologies, spanning orders of magnitude from the nano- to the mesoscale and above. The book is a rich source of inspiration for researchers seeking to build smart materials requiring nanoscale positional control of functional proteins on various carriers.

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This book was derived from a talk that the author gave at the International Conference on Advanced Nanodevices and Nanotechnology in Hawaii. The book is about science and engineering, but is not on science and engineering. It is not a textbook which develops the understanding of a small part of the field, but a book about random encounters and about the strengths and the foibles of living as a physicist and engineer for half a century. It presents the author’s personal views on science, engineering, and life and is illustrated by a number of lively stories about various events, some of which shaped his life.

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This book focuses on the fabrication and applications of cantilever beams with nanoscale dimensions. Nanometer-size mechanical structures show exceptional properties generated by their reduced dimensions. These properties enable new sensing concepts and transduction mechanisms that will allow the enhancement of the performance of devices to their fundamental limits. A number of scientists are conducting research in the area of nanocantilever beams. The book will particularly benefit researchers and help them consolidate their background in the field. The book aims to be an excellent scientific reference for an audience with diverse backgrounds and interests, including students, academic researchers, industry specialists, policymakers, and enthusiasts.

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Discovery of one-dimensional material carbon nanotubes in 1991 by the Japanese physicist Dr. Sumio Iijima has resulted in voluminous research in the field of carbon nanotubes for numerous applications, including possible replacement of silicon used in the fabrication of CMOS chips. One interesting feature of carbon nanotubes is that these can be metallic or semiconducting with a bandgap depending on their diameter. In search of non-classical devices and related technologies, both carbon nanotube-based field-effect transistors and metallic carbon nanotube interconnects are being explored extensively for emerging logic devices and very large-scale integration. Although various models for carbon nanotube-based transistors and interconnects have been proposed in the literature, an integrated approach to make them compatible with the present simulators is yet to be achieved. This book makes an attempt in this direction for the carbon-based electronics through fundamentals of solid-state physics and devices.

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Biocatalysis has become an essential tool in the chemical industry and is the core of industrial biotechnology, also known as white biotechnology, making use of biocatalysts in terms of enzymes or whole cells in chemical processes as an alternative to chemical catalysts. This shift can be seen in the many areas of daily life where biocatalysts—with their environmentally friendly properties—are currently employed. Drivers are the big societal challenges resulting from concerns about the global climate change and the need for an assured energy supply. Modern biocatalysis relies to a large extent on the tremendous advances in the so-called omics techniques and the structural elucidation of biomolecules, which have led to synthetic biology and metabolic engineering as new research fields with high application potential for the rational design of enzymes and microbial production strains. In this book, renowned scientists discuss the actual developments in these research fields together with a variety of application-oriented topics.

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Nanocomposites have better adsorption capacity, selectivity, and stability than nanoparticles. Therefore, they find diversified applications in many areas. Recently, various methods for heavy metal detection from water have been extensively studied. The adsorption of various pollutants such as heavy metal ions and dyes from the contaminated water with the help of nanocomposites has attracted significant attention.This book presents a comprehensive discussion on wastewater research. It covers a vast background of the recent literature. It describes the applications of nanocomposites in various areas, including environmental science. Particularly, it is highly useful to researchers involved in the environmental and water research on nanocomposites and their applications. The book covers a broad research area of chemistry, physics, materials science, polymer science and engineering, and nanotechnology to present an interdisciplinary approach and also throws light on the recent advances in the field.

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Environmental and economic concerns have significantly spurred the search for novel, high-performance thermoelectric materials for energy conversion in small-scale power generation and refrigeration devices. This quest has been mainly fueled by the introduction of new designs and the synthesis of new materials. In fact, good thermoelectric materials must simultaneously exhibit extreme properties: they must have very low thermal conductivity values and both electrical conductivity and Seebeck coefficient high values as well. Since these transport coefficients are interrelated, the required task of optimization is a formidable one. Thus, thermoelectric materials provide a full-fledged example of interdisciplinary research connecting fields such as solid-state physics, materials science engineering, and structural chemistry and raise the need of gaining proper knowledge of the role played by the electronic structure in the thermal and electrical transport properties of solid matter. This book presents a detailed, updated introduction to the field of thermoelectric materials in a tutorial way, focusing on both basic notions and fundamental questions and illustrating the abstract concepts with suitable application examples. It discusses thermoelectric effects, the transport coefficients and their mutual relations, the efficiency of thermoelectric devices, and some notions on the characterization and related industry standards. It also reviews the two basic strategies for optimizing the thermoelectric performance of materials: the control of thermal conductivity and the power factor enhancement. It discusses structural complexity approach, focusing on complex enough lattice structures with heavy atoms in the unit-cell or nanostructured systems characterized by low-dimensional effects, and introducing different kinds of bulk materials of growing chemical and structural complexity. It also discusses the electronic structure engineering approach that focuses on obtaining a guiding principle, in terms of an electronic band structure tailoring process, and describes the role played by the electronic structure in the thermoelectric performance of different materials.

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Questions of values, ontologies, ethics, aesthetics, discourse, origins, language, literature, and meaning do not lend themselves readily, or traditionally, to equations, probabilities, and models. However, with the increased adoption of natural science tools in economics, anthropology, and political science—to name only a few social scientific fields highlighted in this volume—quantitative methods in the humanities are becoming more common. The theory of complexity holds significant promise for better understanding social and human phenomena based on interactions among the participating "agents," whatever they may be: a thought, a person, a conversation, a sentence, or an email. Such systems can exhibit phase transitions, feedback loops, self-organization, and emergent properties. These dynamic systems lend themselves naturally to the kind of analysis made possible by models and simulations developed with complex science tools. This volume offers a tour of quantitative analyses, models, and simulations of humanities and social science phenomena that have been historically the purview of qualitative methods.

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Recently, there has been a surge of activity to elucidate the behavior of highly charged soft matter and Coulomb fluids in general. Such systems are ubiquitous, especially in biological matter where the length scale and the strength of the interaction between highly charged biomolecules are governed by strong electrostatic effects. Several interesting limits have been discovered in the parameter space of highly charged many-particle Coulomb matter where analytical progress is possible and completely novel and unexpected results have been obtained. One of the challenges in highly charged matter is to correctly describe systems with finite coupling strength in the transition regime between weak and strong couplings. After studying the fluctuations of both, several theories have been developed that describe this experimentally highly relevant regime. At the same time, computer simulation algorithms and computing power have advanced to the level where all-ion simulations, including many-body and polarization effects, are possible; the new theories thus can be subjected to numerical confirmation. Another important question is the effect of the structural disorder on electrostatic interactions. It has recently been demonstrated, both theoretically and experimentally, that charge disorder can impose long-range interaction between charged or even uncharged surfaces. These interactions might become very significant in biological processes. Filling a void in the literature, this volume cross-pollinates different theoretical and simulation approaches with new experiments and ties together the low temperature, high coupling constant, and disorder parameters in a unified description of the electrostatic interactions, which largely determine the stability and conformations of most important biological macromolecules.With striking graphical illustrations, the book presents a unified view of the current advances in the field of Coulomb (bio)colloidal systems, building on previous literature that summarized the field over 20 years ago. Leading scientists in the field offer a detailed introduction to different modern methods in statistical physics of Coulomb systems. They detail various approaches to elucidate the behavior of strongly charged soft matter. They also provide experimental and theoretical descriptions of disorder effects in Coulomb systems, which have not been discussed in any other book.

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By exploiting the novel properties of quantum dots and nanoscale Aharonov–Bohm rings together with the electronic and magnetic properties of various semiconductor materials and graphene, researchers have conducted numerous theoretical and computational modeling studies and experimental tests that show promising behavior for spintronics applications. The book provides researchers investigating this cutting-edge field with detailed background descriptions of spin-based effects and devices and their theoretical analysis in nanoelectronic circuits.

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Biophotonics involves understanding how light interacts with biological matter, from molecules and cells, to tissues and even whole organisms. Light can be used to probe biomolecular events, such as gene expression and protein–protein interaction, with impressively high sensitivity and specificity. The spatial and temporal distribution of biochemical constituents can also be visualized with light and, thus, the corresponding physiological dynamics in living cells, tissues, and organisms in real time. Light can also be used to alter the properties and behaviors of biological matter, such as to damage cancerous cells by laser surgery or therapy, and manipulate the neuronal signaling in a brain network. Fueled by the innovations in photonic technologies in the past half century, biophotonics continues to play a ubiquitous role in revolutionizing basic life science studies as well as biomedical diagnostics and therapies. Advancements in biophotonics in the past few decades can be seen not only in biochemistry and cell/molecular biology, but also in numerous preclinical applications. Researchers around the world are searching for ways to bring biophotonic technologies into real clinical practices, particularly cellular and molecular optical imaging. Meanwhile, emerging technologies, such as laser nanosurgery and nanoplasmonics, have created new insights for understanding, monitoring, and even curing diseases on a molecular basis. This book presents the essential basics of optics and biophotonics to newcomers (senior undergraduates or postgraduate researchers) who are interested in this multidisciplinary research field. With stellar contributions from leading experts, the book highlights the major advancements in preclinical diagnostics using optical microscopy and spectroscopy, including multiphoton microscopy, super-resolution microscopy, and endomicroscopy. It also introduces a number of emerging techniques and toolsets for biophotonics applications, such as nanoplasmonics, microresonators for molecular detection, and subcellular optical nanosurgery.

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The book explores how build a mechanical inferences by making use of arithmetic operations on a string of numbers representing statements. In this way logic is reduced to a branch of the combinatory calculus. It covers the field of traditional logic by showing that any kind of inference can be mechanically reduced to three-variables and two-premise inferences. Meriological inferences can also be easily treated in this way. The book covers the following subjects: structural description of space; three-variable inferences through products, sums, subtractions, and divisions; generalization to n variables; relations; and applications.

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Nanomaterials, their synthesis, and property studies have been an obsession with modern current physicists, chemist, and materials scientists for their vast array of technological implications and the remarkable way their properties are modified or enhanced when the size dimensions are reduced to the realm of nanometers. Although nanomaterials, for a lot of practical purposes have been in existence since the remotest past of civilization, it is only in the last few decades that the field has been gaining the attention that it deserves from the scientific and industrial fraternity. A lot of this has to do with the immense improvement we made in tools to study and characterize these materials.Metal oxides have been one of the well documented and hottest branches of nanomaterials revolution with oxides such as TiO2, ZnO, CuO, Fe3O4, Cr2O3, Co3O4, MnO2 and many more being an integral part to a variety of technological advancements and industrial applications. From green power issues like photovoltaic cells to rechargeable batteries, from drug delivery agents to antimicrobial and cosmetic products, from superconductor materials to semiconductors and insulators, metal oxides have been omnipresent in terms of both commercial prerogatives and research highlights. This book is solely devoted towards this special section of nanomaterials with an aim to partially access the science pertaining to the oxides of metals.

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This book compiles multidisciplinary efforts to conceptualize the environment in research and clinical setting that creates the fertile ground for the practical utility of personalized medicine decisions and also enables clinical pharmacogenomics for establishing pharmacotyping in drug prescription. Its covers innovative drug formulations and nanotheranostics, molecular imaging and signatures, translational nanomedicine and informatics, stem cell therapy approaches, modeling and predictability of drug response, pharmacogenetics-guided drug prescription, pediatric drug dosing, pharmacovigilance and regulatory aspects, ethical and cost-effectiveness issues, pharmacogenomics knowledge bases, personal genome sequencing, molecular diagnostics, as well as information-based medicine.

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Traditional Life Cycle Analysis (LCA) methodologies affect the public health and environmental impacts from a material, product, process or activity. The authors of this book suggest that a more holistic approach that incorporates societal and behavioral dimensions will create better results. They discuss how to develop an adaptive framework that would include a wider range of perspectives and disciplines. The book will also include discussions about "Technological Black Swans," trading zones, ethics, behavioral nanotechnology, governance, risk, green design, tools for practitioners, and conclude with a chapter presenting a "strategic outlook."

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This book focuses on nanostructured semiconductors, their fabrication, and their application in fields such as optics, acoustics, and biomedicine. It presents recent developments in nanostructured and hybrid materials and also contains a collection of principles and approaches related to nano-size semiconductors. The text summarizes the recent work by renowned scientists, emphasizing the synthesis by self-assembly or prestructuring and characterization methods of such nanosize materials and also discusses the potential applications of nanostructured semiconductors and hybrid systems. It also gives adequate coverage to the novel properties of nanostructured and low-dimensional materials.

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This book introduces readers to the basic concepts, classical approaches, and the newest design, development, and applications of biometrics. It also provides a glimpse of future designs and research directions in biometrics. In addition, it discusses some latest concerns and issues in this area. Suitable for a wide range of readers, the book explains professional terms in plain English and is ahead of time. Some concepts and designs discussed are so new that commercial systems based on them may not arrive in the market in the next 10 to 20 years.

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Novel breakthroughs in the cutting-edge field of nanotechnology, as a cross-sectional technology, show potential for being applied across the whole value chain of the energy sector (energy sources, energy conversion, energy distribution, energy storage, and energy use). This book gives an overview of nanotechnological applications within the value chain of the energy sector and evaluates selected applications and their direct and indirect impacts on the energy sector. It presents selected nanotechnological applications that influence the energy economy significantly. Furthermore, the authors give a comprehensive description of the impacts and outcomes of selected nanotechnological applications on energy consumption, energy sources, energy supply, and the energy industry in Germany and show the potential of these applications for energy savings, improvement in energy efficiency, and the reduction of emissions until 2030.

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This book provides a concise state of the art of the synthesis and properties of nanocomposite particles with interest for diverse bio-applications. Contributions are mainly related to the chemical design of nanocomposite particles, their properties as well as their constituent materials, and the tailoring of bio-interfaces that may be relevant to the fields of clinical diagnosis and drug delivery procedures, among other bio-applications.

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This volume introduces in a coherent and comprehensive fashion the Pan Stanford Series on Nanobiobiotechnology by defining and reviewing the major sectors of Nanobiotechnology and Nanobiosciences with respect to the most recent developments. Nanobiotechnology indeed appears capable of yielding a scientific and industrial revolution along the routes correctly foreseen by the numerous programs on Nanotechnology launched over the last decade by numerous Councils and Governments worldwide, beginning in the late 1995 by the Science and Technology Council in Italy and by the President Clinton in USA and ending this year with President Putin in Russian Federation.

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The book covers a broad multidisciplinary arena including applications for energy conservation, materials performance enhancement, electronic circuitry, video displays, lighting, photovoltaics, quantum computing, memory, chemo- and biosensors, pharmaceuticals and medical diagnostics inter alia. It presents a comprehensive introductory overview of the photophysics, instrumentation and experimental methodology of nanomaterial luminescence. Invited experts highlight more specific advanced research areas that have either shown potential for, or have already realized, significant impact on the day-to-day aspects of modern life and the world economy.

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This textbook links characteristic features of atomic and electronic structures of disordered semiconductors to the device design process. It begins with a description of general concepts of disordered semiconductors, their atomic structures, the structure of energy bands, and their defects, as well as their electrical, optical, and photovoltaic properties. Since weak sensitivity to impurities is a distinguishing feature of disordered semiconductors, methods of property control and thin-film preparation methods are the areas of focus. Finally, applications of disordered semiconductors in various devices are considered.

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Nanoscale materials are showing great promise in various optoelectronics applications, especially the fast-developing fields of optical communication and optical computers. With silicon as the leading material for microelectronics, the integration of optical functions into silicon technology is a very important challenge. This book concentrates on the optoelectronic properties of silicon nanocrystals, associated phenomena and related topics, from basic principles to the most recent discoveries. The areas of focus include silicon-based light-emitting devices, light modulators, optical wavevguides and interconnectors, optical amplifiers and memory elements. The book comprises theoretical and experimental analyses of various properties of silicon nanocrystals, research methods and preparation techniques, and some promising applications.

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This book provides a broad overview of nanotechnology as applied to contemporary electronics and photonics. The areas of application described are typical of what originally set off the nanotechnology revolution. An account of original research contributions from researchers all over the world, the book is extremely valuable for gaining an understanding of the latest developments in applied nanotechnology. Clearly structured and readable, the book is useful for both students and researchers alike: students can learn about the various aspects of nanotechnology, and professional researchers can update themselves on the new developments in this dynamic field.The book covers nanoscale materials and devices for both electronics and optical technologies. The emphasis throughout is on experimental methods rather than theoretical modeling. The material will provide food for thought for researchers and research students keen to develop new technologies at the ultra-small scale and to open up new avenues for research.

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What has gone wrong in Japan that has led to innovation crisis? Prof. Eiichi Yamaguchi has been committed to answer this question, and his quest has spanned several years and academic disciplines. Initially it appeared as if it had no context, but when he put the pieces together, he realized that it was actually one story. This book is a summary of his research over the last 20 years, especially after he moved out of the field of physics, to which he had devoted 21 years. He felt that it was essential for him to do his bit to save this sinking ship, or it would be disrespectful to the future generation.The book integrates his research on innovation policy, innovation theory, and trans-science. It begins with a detailed story of the innovation of blue LEDs, for which three Japanese scientists received the Nobel Prize in Physics in 2014. It describes the current innovation and science crises in Japan and presents evidence that the strong international competitiveness of science-based industries in the United States is a result of the invention of the Small Business Innovation Research (SBIR) system. It discusses a new theory of innovation structures, showing the error in Clayton M. Christensen’s argument of “disruptive innovation.” It also proposes a new concept for “paradigm disruptive innovation,” emphasizing that abduction and transilience are essential factors for accomplishing it and that their decline has led to the innovation crisis in Japan. Finally, it analyzes the future vision of the innovation ecosystem, which promotes abduction and transilience, for scientists to develop new science-based industries.

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Nanomaterials have the potential to shift the paradigm for the diagnosis and treatment of many diseases, especially neoplasms, because of the intriguing behaviors associated with their unique size-/shape-influenced chemical, physical, and physiological features. Currently, there is a huge imbalance between the several nanoplatforms reported in the literature and the few ones approved for clinical applications. This disequilibrium affects, in particular, plasmonic nanomaterials, which present no approved platforms and few candidates in clinical trials. This trend can be reversed by promoting collaborations among scientists from different fields as well as by improving the multidisciplinary background of researchers interested in this area. This book is a collection of must-read peer-reviewed papers focusing on (i) the main behaviors of nanomaterials for nanomedicine, (ii) key features nanomaterials need for successful translation to the clinical setting, and (iii) market analysis of nanomaterials at the bedside or on the way. The main aim of this book is to offer a comprehensive point of view to students and researchers in order to promote the translation of new technologies to patients. It is a unique reference for advanced undergraduate- and graduate-level students of nanotechnology and researchers in materials science, nanotechnology, chemistry, biology, and medicine, especially those with an interest in cancer theranostics.

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Since its invention, the integrated circuit has necessitated new process modules and numerous architectural changes to improve application performances, power consumption, and cost reduction. Silicon CMOS is now well established to offer the integration of several tens of billions of devices on a chip or in a system. At present, there are important challenges in the introduction of heterogeneous co-integration of materials and devices with the silicon CMOS 2D- and 3D-based platforms. New fabrication techniques allowing strong energy and variability efficiency come in as possible players to improve the various figures of merit of fabrication technology. Integrated Nanodevice and Nanosystem Fabrication: Breakthroughs and Alternatives is the second volume in the Pan Stanford Series on Intelligent Nanosystems. The book contains 8 chapters and is divided into two parts, the first of which reports breakthrough materials and techniques such as single ion implantation in silicon and diamond, graphene and 2D materials, nanofabrication using scanning probe microscopes, while the second tackles the scaling and architectural aspects of silicon devices through HiK scaling for nanoCMOS, nanoscale epitaxial growth of group IV semiconductors, design for variability co-optimization in SOI FinFETs, and nanowires for CMOS and diversifications.

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The manipulation of light at the nanometer scale is highly pursued for both fundamental sciences and wide applications. The diffraction limit of light sets the limit for the smallest size of photonic devices to the scale of light wavelength. Fortunately, the peculiar properties of surface plasmons in metal nanostructures make it possible to squeeze light into nanoscale volumes and enable the manipulation of light and light–matter interactions beyond the diffraction limit. Studies on surface plasmons have led to the creation of a booming research field called plasmonics. Because of its various scientific and practical applications, plasmonics attracts researchers from different fields, making it a truly interdisciplinary subject.Nanophotonics: Manipulating Light with Plasmons starts with the general physics of surface plasmons and a brief introduction to the most prominent research topics, followed by a discussion of computational techniques for light scattering by small particles. Then, a few special topics are highlighted, including surfaceenhanced Raman scattering, optical nanoantennas, optical forces, plasmonic waveguides and circuits, and gain-assisted plasmon resonances and propagation. The book discusses the fundamental and representative properties of both localized surface plasmons and propagating surface plasmons. It explains various phenomena and mechanisms using elegant model systems with well-defined structures, is illustrated throughout with excellent figures, and contains an extensive list of references at the end of each chapter. It will help graduate-level students and researchers in nanophotonics, physics, chemistry, materials science, nanoscience and nanotechnology, and electrical and electronic engineering get a quick introduction to this field.

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This book deals with the difference electron nanoscope (DEN), whose principles have been invented and realised by the book author. The DEN is based on a smart combination of diffractometric and spectroscopic data and uses a visualisation of three-dimensional difference electron densities (in our case stemming from 3d orbitals) in order to obtain the key quantity involved, the electric field gradient (efg). However, the DEN is no machine, as the title of the book might infer. It is a computer program running on a fast computer system displaying 3D difference electron hyperareas floating in space and the relevant efg as a wire frame model within the unit cell of the sample involved. In this sense, it acts on a sub-nanometer scale (hence the term "nanoscope") and generates images of uncompared symmetrical and physical evidence—and beauty.For the first time, diffractometry and spectroscopy have been integrated for the common synergetic effects that may contribute to a better understanding of electric and magnetic interactions in a crystal. The experimental derivation of the common quantity, the efg, is not confined to iron-containing samples, as the use of Mössbauer spectroscopy might infer, but can also be determined by nuclear quadrupole resonance that is not confined to special nuclides. Hence, the DEN can be applied to a huge multitude of scientifically interesting specimens since the main method involved, diffractometry in a wide sense, has no general limitations at all. So it is a rather universal method, and the monograph might contribute to a wide distribution of the method in the scientific world. Has anyone seen a real orbital before: a real orbital distribution in a crystal unit cell together with its efg tensor ellipsoid? In this book, one can see it.

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The use of light for probing and imaging biomedical media is promising for the development of safe, noninvasive, and inexpensive clinical imaging modalities with diagnostic ability. The advent of ultrafast lasers has enabled applications of nonlinear optical processes, which allow deeper imaging in biological tissues with higher spatial resolution. This book provides an overview of emerging novel optical imaging techniques, Gaussian beam optics, light scattering, nonlinear optics, and nonlinear optical tomography of tissues and cells. It consists of pioneering works that employ different linear and nonlinear optical imaging techniques for deep tissue imaging, including the new applications of single- and multiphoton excitation fluorescence, Raman scattering, resonance Raman spectroscopy, second harmonic generation, stimulated Raman scattering gain and loss, coherent anti-Stokes Raman spectroscopy, and near-infrared and mid-infrared supercontinuum spectroscopy. The book is a comprehensive reference of emerging deep tissue imaging techniques for researchers and students working in various disciplines.

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This book describes at the introductory level how modern technology has made the scenario of the classic science-fiction movie Fantastic Voyage a reality. The movie is about a submarine and its crew members being shrunk to microscopic size and ventured into the body. Exactly 50 years following the release of the film, such reality takes the form of a medical interventional room capable of mimicking this scenario. Based on 15 years of intensive research and development by the world-leading team in this specific field, the book goes through the scenes of the movie while explaining how it is implemented in this first-of-a-kind interventional facility.This is the first book that explains the fundamentals of navigation of therapeutic agents in the vascular network. The scope of the book is twofold: (1) to initiate readers into various technologies, including, but not limited to, nanotechnology, robotics, and biochemistry (more importantly, it shows how critical the integration of all these disciplines is to solving problems that indeed require a multidisciplinary environment); (2) to inspire the younger generation by showing that science and technology can bring one everywhere with the power to transform fiction to reality that can help humankind.

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Today, the concepts of single-electron tunneling (SET) are used to understand and model single-atom and single-molecule nanoelectronics. The characteristics of nanoelectronic devices, especially SET transistors, can be understood on the basis of the physics of nanoelectronic devices and circuit models. A circuit theory approach is necessary for considering possible integration with current microelectronic circuitry. To explain the properties and possibilities of SET devices, this book follows an approach to modeling these devices using electronic circuit theory. All models and equivalent circuits are derived from the first principles of circuit theory. Based on energy conservation, the circuit model of SET is an impulsive current source, and modeling distinguishes between bounded and unbounded currents. The Coulomb blockade is explained as a property of a single junction. In addition, this edition differs from the previous one by elaborating on the section on spice simulations and providing a spice simulation on the SET electron box circuit, including the spice netlist. Also, a complete, new proof of the two-capacitor problem in circuit theory is presented; the importance of this proof in understanding energy conservation in SET circuits cannot be underestimated. This book will be very useful for advanced undergraduate- and graduate-level students of electrical engineering and nanoelectronics and researchers in nanotechnology, nanoelectronic device physics, and computer science.Only book modeling both single-electron tunneling and many electron tunneling from the points of view of electronics; starting from experiments, via a physics description, working towards a circuit description; and based on energy conservation, in electrical circuits, developing the impulse circuit model for single-electron tunneling.

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This book deals with evolving intelligence systems and their use in immune algorithm (IM), particle swarm optimization (PSO), bacterial foraging (BF), and hybrid intelligent system to improve plants, robots, etc. It discusses the motivation behind research on and background of evolving intelligence systems and illustrates IM-based approach for parameter estimation required for designing an intelligent system. It approaches optimal intelligent tuning using a hybrid genetic algorithm–particle swarm optimization (GA-PSO) and illustrates hybrid GA-PSO for intelligent tuning of vector system.

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Over the past few decades, carbon nanomaterials, most commonly fullerenes, carbon nanotubes, and graphene, have gained increasing interest in both science and industry, due to their advantageous properties that make them attractive for many applications in nanotechnology. Another class of the carbon nanomaterials family that has slowly been gaining (re)newed interest is diamond molecules, also called diamondoids, which consist of polycyclic carbon cages that can be superimposed on a cubic diamond lattice. Derivatives of diamondoids are used in pharmaceutics, but due to their promising properties—well-defined structures, high thermal and chemical stability, negative electron affinity, and the possibility to tune their bandgap—diamondoids could also serve as molecular building blocks in future nanodevices. This book is the first of its kind to give an exhaustive overview of the structures, properties, and current and possible future applications of diamondoids. It contains a brief historical account of diamondoids, from the discovery of the first diamondoid member, adamantane, to the isolation of higher diamondoids about a decade ago. It summarizes the different approaches to synthesizing diamondoids. In particular, current research on the conventional organic synthesis and new approaches based on microplasmas generated in high-pressure and supercritical fluids are reviewed and the advantages and disadvantages of the different methods discussed. The book will serve as a reference for advanced undergraduate- and graduate-level students in chemistry, physics, materials science, and nanotechnology and researchers in macromolecular science, nanotechnology, chemistry, biology, and medicine, especially those with an interest in nanoparticles.

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Millions of patients suffer from end-stage organ failure or tissue loss annually, and the only solution might be organ and/or tissue transplantation. To avoid poor biocompatibility–related problems and donor organ shortage, however, around 20 years ago a new, hybridized method combining cells and biomaterials was introduced as an alternative to whole-organ and tissue transplantation for diseased, failing, or malfunctioning organs—regenerative medicine and tissue engineering. This handbook focuses on all aspects of intelligent scaffolds, from basic science to industry to clinical applications. Its 10 parts, illustrated throughout with excellent figures, cover stem cell engineering research, drug delivery systems, nanomaterials and nanodevices, and novel and natural biomaterials. The book can be used by advanced undergraduate- and graduate-level students of stem cell and tissue engineering and researchers in macromolecular science, ceramics, metals for biomaterials, nanotechnology, chemistry, biology, and medicine, especially those interested in tissue engineering, stem cell engineering, and regenerative medicine.

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Plasmonics is an emerging field mainly developed within the past two decades. Due to its unique capabilities to manipulate light at deep subwavelength scales, plasmonics has been commonly treated as the most important part of nanophotonics. Plasmonic-assisted optical microscopy techniques, especially super-resolution microscopy, have shown tremendous potential and attracted much attention. This book aims to collect cutting-edge studies in various optical imaging technologies with advanced performances that are enabled or enhanced by plasmonics. The basic working principles, development details, and potential future direction and perspectives are discussed. Edited by Zhaowei Liu, a prominent researcher in the field of super-resolution microscopy, this book will be an excellent reference for anyone in the field of nanophotonics, plasmonics, and optical microscopy.

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This book covers almost all fields of cancer genetics and genomics for personalized medicine. Targeted therapy, or precision medicine, or personalized medicine is becoming a standard treatment for many diseases, including cancer. However, how much do we know about the personalized medicine approach? This lucid book helps undergraduate and graduate students, professional researchers, and clinicians to better understand the key concept of personalized medicine.The most up-to-date topics on personalized medicine in this book cover the recent trends in and updates on lung, gastric, liver, breast, and other types of cancers. Circulating tumor cell, cell-free circulating DNA, and microRNAs are discussed as new diagnostic and prognostic markers for cancer. The avatar mouse model is also discussed for maximizing treatment efficacy and prognosis prediction, and so is microenvironment as a drug resistance mechanism. With classical and new pathological approaches, the book provides a systemic overview of personalized immunotherapies and hyperthermic intraperitoneal chemotherapy, followed by new emerging fields of hereditary cancer, thereby equipping readers to eventually contribute in developing more advanced tools and therapies for curing cancer.

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Despite substantial evidence showing the feasibility of Atomic Force Microscopy (AFM) to identify cells with altered elastic and adhesive properties, the use of this technique as a complementary diagnostic method remains controversial. This book is designed to be a practical textbook that teaches how to assess the mechanical characteristics of living, individual cells by AFM. Following a step-by-step approach, it introduces the methodology of measurements in the case of both determination of elastic properties and quantification of adhesive properties.

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This book contains fascinating vignettes depicting future societies and the implications which increasing technological change has on society and the environment. The topics discussed include nanotechnology, medicine, computational science, biotechnology, synthetic biology, and cognitive technology, among others in science. In addition, social norms, attitudes, and policy are also featured. The upshot of this combination is an entertaining, educational, and thought-provoking volume.The glimpses into future societies subsequent to the introduction and incorporation of various emerging technologies depict scenarios of how we view ourselves, how we view others, how we are viewed by others, how our surroundings are viewed, how our leaders and political structures are viewed, what our social and behavioral norms are, what our temperament/mood is, and so forth. The introduction features a focused discourse on current trends of the impacts of emerging technologies and the conclusion highlights where society should go from here.

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Transport of pharmaceutical agents in the body is paramount to therapeutic efficacy. Advances in the past decades have rendered a remarkable improvement of drug delivery strategies, which has helped to increase the bioavailability of therapeutic agents by protecting them from degradation, targeting them to diseased sites, and controlling their circulation time and release rate. Additionally, for most therapeutics, reaching the targets of action require penetration across tissues and/or entry within cells. The design of strategies to control the transport of therapeutic compounds through these physiological barriers has become an imperative and a challenging need in the quest for better therapeutics. This book provides an overview of the current advances in this field, including considerations on the biological regulation and natural mechanisms overcoming these barriers, as well as drug delivery strategies facilitating the transport of drugs and their carriers at the tissue, cell, and subcellular levels.

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This book presents state-of-the-art contributions related to advanced structural characterization techniques in the field of clean energy materials with particular emphasis on solid oxide fuel cells and hydrogen storage materials. It describes several diffraction and spectroscopic techniques for the investigation of both average and local structures with several examples of the most recent materials for clean energy applications. It is the first authoritative collection of contributions on the importance of the application of the most advanced structural techniques to shed light on the properties and mechanisms of materials currently investigated for the use in alternative energy devices. The book provides key techniques for ex situ and in situ investigation of clean energy materials and, hence, is an essential guide for researchers working on the structural analysis of advanced materials.

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Direct alcohol fuel cells (DAFCs), such as methanol and ethanol ones, are very promising advanced power systems that may considerably reduce dependence on fossil fuels and are, therefore, attracting increased attention worldwide. Nanostructured materials can improve the performance of the cathodes, anodes, and electrolytes of DAFCs. This book focuses on the most recent advances in the science and technology of nanostructured materials for direct alcohol fuel cells, including novel non-noble or low noble metal catalysts deposited on the graphene layer and metal-free doped carbon black for oxygen electroreduction reaction, Sn-based bimetallic and trimetallic nanoparticles for alcohol electro-oxidation reaction, and novel nanomaterials for promoting proton transfer in electrolytes. In addition, the book includes chapters from not only experimentalists but also computational chemists who have worked in the development of advanced power systems for decades.Illustrated throughout with excellent figures, this multidisciplinary work is not just a reference for researchers in chemistry and materials science, but a handy textbook for advanced undergraduate- and graduate-level students in nanoscience- and nanotechnology-related courses, especially those with an interest in developing novel materials for advanced power systems.

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These days, advanced multiscale hybrid materials are being produced in the industry, studied by universities, and used in several applications. Unlike for macromaterials, it is difficult to obtain the physical, mechanical, electrical, and thermal properties of nanomaterials because of the scale. Designers, however, must have knowledge of these properties to perform any finite element analysis or durability and damage tolerance analysis. This is the book that brings this knowledge within easy reach.What makes the book unique is the fact that its approach that combines multiscale multiphysics and statistical analysis with multiscale progressive failure analysis. The combination gives a very powerful tool for minimizing tests, improving accuracy, and understanding the effect of the statistical nature of materials, in addition to the mechanics of advanced multiscale materials, all the way to failure. The book focuses on obtaining valid mechanical properties of nanocomposite materials by accurate prediction and observed physical tests, as well as by evaluation of test anomalies of advanced multiscale nanocomposites containing nanoparticles of different shapes, such as chopped fiber, spherical, and platelet, in polymeric, ceramic, and metallic materials. The prediction capability covers delamination, fracture toughness, impact resistance, conductivity, and fire resistance of nanocomposites. The methodology employs a high-fidelity procedure backed with comparison of predictions with test data for various types of static, fatigue, dynamic, and crack growth problems. Using the proposed approach, a good correlation between the simulation and experimental data is established.

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The phenomenal success of nanostructures in various applications has led to the exploration of a plethora of novel nanomaterials. Nanoboron is no exception. Boron as material has the ability to form covalently bonded stable networks and finds use in a large variety of applications. This book provides a complete overview of the latest developments in the field of boron nanostructures. It starts with an introductory chapter on the fundamentals of boron chemistry, followed by chapters by experts devoted to discussions on boron nanoclusters, nanosheets, nanotubes, and nanowires, respectively. Applications of boron in nanomedicine are also discussed in wide detail.Very few titles covering Boron have surfaced to date; however, most of them are introductory text on boron chemistry and its properties along with couple of others covering specialized topics such as uses of boron in steel making, etc. This text provides state-of-the-art knowledge along with recent developments in boron nanostructures through succulent discussions.

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Magnetic nanoparticles appear naturally in rock magnetism together with a large distribution of sizes and shapes. They have numerous applications from nano-size magnetic memories to metamaterials for electromagnetic waves as well as biological applications such as nanosurgery with minimal traumatism. Their long-ranged size- and shape-dependent dipolar interactions provide numerous useful properties.This book describes the preparation as well as the magnetic properties of nanoparticles and also considers 2D dots, nearly spherical samples, elongated samples, and various assemblies of nanoparticles. The authors report the static magnetic structures and dynamic properties of these nanoparticles and the topological defects in 2D and 3D nanoparticles with new examples of S-shaped vortex or antivortex and of bent vortex or antivortex in 3D nanoparticles. The spectrum of magnetic excitations is shown to exhibit the occurrence of gaps, a key for magnonic metamaterial devices. Magnetic excited states are also considered with their coupling to nanoparticle elastic properties.

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