Search results for ""Springer London Ltd""

Understanding the many complex cellular and molecular mechanisms underlying human vascular diseases is essential in improving the treatment of this important and wide-ranging group of diseases that affect a large proportion of the world po- lation. This book is based on lectures presented at an International Vascular Biology Workshop held in London and chaired by Professor Dame Carol Black. The c- tents are complemented by some invited chapters, all written by world experts in areas of basic science and clinical medicine highly relevant to vascular biology and disease. We are particularly grateful to Professor Arshed Quyyumi, Professor of Medicine and Cardiology at Emory University, who with his research group and clinical colleagues, has provided a substantial contribution to this book. In common with our previous book – Vascular Complications in Human Disease: Mechanisms and Consequences published by Springer in 2008, our aim with this book is to highlight some of the established relationships between basic science and clinical medicine, and to outline new and exciting fields of research and practice in vascular biology and pathobiology. There are two sections: Basic Science of Vascular Biology and Clinical Aspects of Vascular Biology. In the first section, dealing with basic science, we have included three important growth areas: “Genetics and Gene Therapy” cover approaches to gene therapy and delivery systems, “Animal Models to Study Vascular Disease” with chapters on animal models of scleroderma, animal models of atherosclerosis, and finally on the endothelin system.

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For eight decades the Primer on the Rheumatic Diseases has been the standard text from which most medical students and house ofcers have learned rheumatology. I myself will never forget thumbing through an older edition of the Primer as a second-year resident, while waiting to review a perplexing patient with my tutor. Fortunately the tutor was r- ning late with his own patients, so I had time to fip through the book – then much thinner – a couple of times. While turning the pages, per- ing the features of those diseases whose names were still exotic to me, and considering my patient’s history of conductive hearing loss and p- monary nodules, a light went on when I stumbled eventually on a part- ular chapter. I still remember the jaw-dropping efect on my tutor of my announcement then that I had a patient with Wegener’s granulomatosis. I think I became a rheumatologist that very moment! Subsequent editions of the Primer have sufered from the inevitable “obesity creep,” making it an outstanding reference textbook but virtually impossible to fip through quickly while awaiting one’s tutor, and even more difcult to slip into the pocket of a white coat to carry on rounds. For this reason we have created the Pocket Primer, a mini version that cuts the larger book down to its essentials.

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This book deals with organ failure and the way it can be managed artificially without requiring a transplant. Written by a mixture of European and US physicians and surgeons, each of the chapters compares the artificial organ to what is currently available from the transplant point of view to highlight the current and modern available techniques for organ replacement. The book will be a useful reading for postgraduate students and people interested in modern surgical and medical technology.

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This book provides a modern, algorithmic introduction to digital image p- cessing, designed to be used both by learners desiring a ?rm foundation on which to build and practitioners in search of critical analysis and modern - plementations of the most important techniques. This updated and enhanced paperbackedition ofourcomprehensivetextbookDigital Image Processing: An Algorithmic Approach Using Java packages the original material into a series of compactvolumes, therebysupporting a ?exiblesequenceofcoursesindigital image processing. Tailoring the contents to the scope of individual semester courses is also an attempt to provide a?ordable (and "backpack-compatible") textbooks without comprimising the quality and depth of content. Oneapproachtolearninganewlanguageistobecomeconversantinthecore vocabulary and to start using it right away. At ?rst, you may only know how to ask for directions, order co?ee, and so on, but once you become con?dent with the core, you will start engaging others in "conversations" and rapidly learn how to get things done. This step-by-step approach works equally well in many areas of science and engineering. In this ?rst volume, ostentatiously titled Fundamental Techniques,wehave attemptedtocompilethecore"vocabulary" ofdigitalimageprocessing,starting from the basic concepts and elementary properties of digital images through simple statistics and point operations, fundamental ? ltering techniques, loc- ization of edges and contours, and basic operations on color images. Mastering these most commonly used techniques and algorithms will enable you to start being productive right away.

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This book provides a readable introduction to modern toxicology with a particular focus on the mechanisms underlying the induction of toxicity by foreign substances. Since bioactivation is central to many toxic syndromes, special interest is devoted to chemicals that undergo conversion to toxic metabolites that induce toxic effects as diverse as cancer, birth defects and organ injury. The molecular consequences accompanying damage to cellular DNA and proteins is explored together with the relevance of toxicological paradigms to human diseases caused by alcohol and tobacco. The discipline of toxicology has developed rapidly since the thalidomide disaster in the 1960’s as scientists worldwide seek to understand the adverse health effects of human medicines, environmental pollutants, consumer chemicals and industrial reagents. An Introduction to Toxicology is intended to supplement the recommended reading list of undergraduate and graduate programs in toxicology and pharmacology as an enjoyable, accessible primer with illustrations that “unpack” the concepts being discussed in the text. ​

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This is the first textbook to address quantified risk assessment (QRA) as specifically applied to offshore installations and operations. As the second part of the two-volume updated and expanded fourth edition, it adds a new focus on the recent development of Normally Unattended Installations (NUIs), which are essentially autonomous installations that combine digitalization, big data, drones and machine learning, and can be supported by W2W (walk-to-work) vessels. These minimalistic installations with no helideck and very limited safety systems will require a new approach to risk assessment and emergency planning, especially during manned periods involving W2W vessels. Separate chapters analyse the main hazards for offshore structures: fire, explosion, collision, and falling objects, as well as structural and marine hazards. The book explores possible simplifications of risk assessment for traditional manned installations. Risk mitigation and control are also discussed, as well as how the results of quantitative risk assessment studies should be presented. In closing, the book provides an updated approach to environmental risk assessment. The book offers a comprehensive reference guide for academics and students of marine/offshore risk assessment and management. It will also be of interest to professionals in the industry, as well as contractors, suppliers, consultants and regulatory authorities.

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Dynamics and Control of Mechanical Systems in Offshore Engineering is a comprehensive treatment of marine mechanical systems (MMS) involved in processes of great importance such as oil drilling and mineral recovery. Ranging from nonlinear dynamic modeling and stability analysis of flexible riser systems, through advanced control design for an installation system with a single rigid payload attached by thrusters, to robust adaptive control for mooring systems, it is an authoritative reference on the dynamics and control of MMS. Readers will gain not only a complete picture of MMS at the system level, but also a better understanding of the technical considerations involved and solutions to problems that commonly arise from dealing with them. The text provides: · a complete framework of dynamical analysis and control design for marine mechanical systems;· new results on the dynamical analysis of riser, mooring and installation systems together with a general modeling method for a class of MMS;· a general method and strategy for realizing the control objectives of marine systems with guaranteed stability the effectiveness of which is illustrated by extensive numerical simulation; and · approximation-based control schemes using neural networks for installation of subsea structures with attached thrusters in the presence of time-varying environmental disturbances and parametric uncertainties.Most of the results presented are analytical with repeatable design algorithms with proven closed-loop stability and performance analysis of the proposed controllers is rigorous and detailed.Dynamics and Control of Mechanical Systems in Offshore Engineering is primarily intended for researchers and engineers in the system and control community, but graduate students studying control and marine engineering will also find it a useful resource as will practitioners working on the design, running or maintenance of offshore platforms.

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This text is a rigorous introduction to ergodic theory, developing the machinery of conditional measures and expectations, mixing, and recurrence. Beginning by developing the basics of ergodic theory and progressing to describe some recent applications to number theory, this book goes beyond the standard texts in this topic. Applications include Weyl's polynomial equidistribution theorem, the ergodic proof of Szemeredi's theorem, the connection between the continued fraction map and the modular surface, and a proof of the equidistribution of horocycle orbits. Ergodic Theory with a view towards Number Theory will appeal to mathematicians with some standard background in measure theory and functional analysis. No background in ergodic theory or Lie theory is assumed, and a number of exercises and hints to problems are included, making this the perfect companion for graduate students and researchers in ergodic theory, homogenous dynamics or number theory.

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This book clarifies and explains perineal anatomy and the pathophysiology of anal incontinence as well as applied pharmacology. It also institutes the new recommended classification of perineal tears, and describes anal sphincter repair techniques. The emphasis is on correct post-operative management, management of pregnancy following previous anal sphincter injury, and prevention of anal sphincter tears. The book will interest students, colorectal surgeons, physiotherapists, midwives, continence advisors, labour wards and lawyers.

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This is a ‘how to’ book for scientific visualization. The book does not treat the subject as a subset of information visualisation, but rather as a subject in its own right. An introduction on the philosophy of the subject sets the scene and the theory of colour perception is introduced. Next, using Brodlie’s taxonomy to underpin its core chapters, it is shown how to classify data. Worked examples are given throughout the text and there are practical ‘sidebars’ for readers with access to the IRIS Explorer software who can try out the demonstrations on an accompanying website. The book concludes with a ‘taster’ of ongoing research.

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Adult ADHD: Diagnostic Assessment and Treatment, Third Edition covers not only diagnostic assessment, but also comorbidity patterns as well as differential diagnosis of ADHD with for example bipolar disorder and borderline personality disorder. The symptom overlap and misdiagnosis of chronic fatigue syndrome in girls and women with the inattentive subtype of ADHD, ADD is explored. The chronic delayed sleep phase syndrome associated with ADHD based on disturbances in the circadian rhythm, and the possible consequences for general health (obesity, diabetes, cardiovascular diseases and cancer) are discussed. There are sections on ADHD and intelligence, criminality, sexuality, dyslexia and autism. Adult ADHD can be treated effectively but as yet the disorder is not always recognised by professionals and this book aims to help correct this.Diagnostic tools are included, such as the structured Diagnostic Interview for Adult ADHD (DIVA), and an ultra-short and somewhat longer screening tool, all based on the DSM-IV criteria for ADHD. Treatment options cover psychoeducation and motivation and individual and group coaching; long-acting stimulants and other new drugs for treating ADHD; use of melatonin to treat the delayed sleep-phase disorder. Useful information is included on the setting up and organisation of a department for adult ADHD with a multidisciplinary team. References, websites and useful international addresses have all been updated. Adult ADHD: Diagnostic Assessment and Treatment, Third Edition is intended for students, junior doctors/residents, psychologists, psychiatrists, other mental healthcare professionals and interested parties and provides a quick overview of the current state of the science and of the methods used in diagnosis and treatment.Adult ADHD: Diagnostic Assessment and Treatment, Third Edition was originally published by Pearson Assessment and Information BV, The Netherlands.

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