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'We learn gradually to raise our eyes not only to material existence; instead we discover spiritual entities and their actions wherever we look in the universe...We get to know the deeds of these spirits. We are alive and active and we are within the spiritual entities and their activities.' - Rudolf Steiner This classic series of lectures presents systematic knowledge on many different spiritual entities, ranging from the higher hierarchies of angels down to hindering demons. Basing his presentation on spiritual-scientific research, Rudolf Steiner intends to awaken us to the existence of these beings and how they interact with all aspects of our lives. Steiner describes how animals, plants and minerals have group souls - with even an inert stone having a spiritual counterpart in the invisible world. The various planets in the cosmos are connected to great spiritual beings and hierarchies too, as is the zodiac, which is not a static band of fixed stars but is also evolving. Steiner gives a remarkable picture of how Christ relates to the zodiacal constellations and to our own higher aspects. Spiritual entities are associated with the evolution of earth and the previous stages of its existence - and here Steiner elaborates relevant chapters of his book Occult Science, An Outline, explaining how our task on earth is ultimately to develop love rather than wisdom (which was the goal of earth's previous stage). From cosmic considerations, Steiner leads to the spirits of the kingdoms of nature - the elemental beings, with their four classes connecting to the four elements - gnomes, undines, sylphs and salamanders, or earth, water, air and fire spirits. He describes how elemental beings are created by human activities - with coercion of the views of others leading to 'demons', lying leading to 'phantoms', and bad social systems to 'spectres'. Spirits are also created in the association of humans and animals, whilst other spiritual entities connect us with the arts. Steiner emphasises the importance of developing and appreciating the arts - such as music, sculpture, architecture, painting and poetry - for the sake of humanity's future evolution.

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Blind identification consists of estimating a multi-dimensional system only through the use of its output, and source separation, the blind estimation of the inverse of the system. Estimation is generally carried out using different statistics of the output. The authors of this book consider the blind identification and source separation problem in the complex-domain, where the available statistical properties are richer and include non-circularity of the sources – underlying components. They define identifiability conditions and present state-of-the-art algorithms that are based on algebraic methods as well as iterative algorithms based on maximum likelihood theory. Contents 1. Mathematical Preliminaries. 2. Estimation by Joint Diagonalization. 3. Maximum Likelihood ICA. About the Authors Eric Moreau is Professor of Electrical Engineering at the University of Toulon, France. His research interests concern statistical signal processing, high order statistics and matrix/tensor decompositions with applications to data analysis, telecommunications and radar. Tülay Adali is Professor of Electrical Engineering and Director of the Machine Learning for Signal Processing Laboratory at the University of Maryland, Baltimore County, USA. Her research interests concern statistical and adaptive signal processing, with an emphasis on nonlinear and complex-valued signal processing, and applications in biomedical data analysis and communications. Blind identification consists of estimating a multidimensional system through the use of only its output. Source separation is concerned with the blind estimation of the inverse of the system. The estimation is generally performed by using different statistics of the outputs. The authors consider the blind estimation of a multiple input/multiple output (MIMO) system that mixes a number of underlying signals of interest called sources. They also consider the case of direct estimation of the inverse system for the purpose of source separation. They then describe the estimation theory associated with the identifiability conditions and dedicated algebraic algorithms. The algorithms depend critically on (statistical and/or time frequency) properties of complex sources that will be precisely described.

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Practical budget management is at the core of this book. As well as giving an insight into the way budgets behave in certain circumstances and what can be done about it, the book also deals with practical steps the budget and resource manager can take to eliminate waste and reduce opportunities for fraud and collusion. Better budget management means that the organisation can concentrate greater resources on matters that will significantly enhance patient and client care. The book identifies the day-to-day issues that affect managers in health and social services, and provides advice and a structured approach that facilitate both comprehension of the problem areas and possible solutions. It successfully reduces complex budget issues into manageable chunks, with case studies, key points, tips, and worked examples to aid understanding. It offers practical assistance to managers, tutors, students, board members and other health and social care professionals. The book is third in a trilogy which provides practical solutions to the complex problems of resource, financial and budget management in health and social care. "Managing in Health and Social Care" provides essential checklists for frontline staff is about process quality in financial and business management. It concentrates on doing the right thing, first time, every time. "Resource Management in Health and Social Care": essential checklists is about matching available resources to the environment. It deals with workplace and environmental problems associated with resource scarcity. 'Although there may be constant change to organisation and structures, great improvements in care, treatment, and technology and ever more sophisticated ways of funding health and social care, the actual act of spending money will always be the responsibility of budget managers who are in the front line. This book identifies the day-to-day issues that affect managers in health and social services and provides advice and a structured approach that facilitate both comprehension of the problem areas and possible solutions.' - William Bryans, in the Introduction.

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Cutting-edge and fresh new outlooks on medieval literature, emphasising the vibrancy of the field. New Medieval Literatures is an annual of work on medieval textual cultures, aiming to engage with intellectual and cultural pluralism in the Middle Ages and now. Its scope is inclusive of work across the theoretical, archival, philological, and historicist methodologies associated with medieval literary studies, and embraces the range of European cultures, capaciously defined. Essays in this volume investigate a range of writers from late antiquity to the fifteenth century. They explore encounters between humans and animals in French romance; reflect on what contemporary sound studies can offer to Anglo-French poetry; trace how the reception of Trojan history is influenced by late medieval military practices; attend to the complex multilingualism of a devotional poetry that tests the limits of both language and theology; analyse the ways in which Christ's sexuality upsets religious typology inlate medieval drama; document the lines of national and European affinities found in French poetic manuscripts; and argue for why we should study "ugly" manuscripts of practical instruction not only for what they teach us but alsofor their insights into medieval literacy. Texts discussed include romances such as Chrétien de Troyes's Yvain and Béroul's Tristan; the theologian John of Howden's adaptation of the Philomela legend in his Rossignos; Chaucer's Troilus and Criseyde read alongside siege chronicles of the Hundred Years War; Bruder Hans's quadrilingual Ave Maria; the York Corpus Christi Plays; the poetry of Charles d'Orléans; and a group oflate medieval manuscripts which include herbals, account books, and medical treatises. KELLIE ROBERTSON is Professor of English and Comparative Literature at the University of Maryland; WENDY SCASE is Geoffrey Shepherd Professor of Medieval English Literature at the University of Birmingham; LAURA ASHE is Professor of English at the University of Oxford and Fellow and Tutor at Worcester College, Oxford; PHILIP KNOX Is University Lecturer inEnglish and Fellow of Trinity College, Cambridge, Contributors: Lukas Hadrian Ovrom, Terrence Cullen, Steven Rozenski, Tison Pugh, Rory G. Critten, Daniel Wakelin.

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'Having been one of many collaborating with Charles on this journey, I believe this publication is valuable in bringing together the many streams of thinking, exploration and practice behind the notion of a truly ''Creative City''.' - Richard Brecknock, Brecknock Consulting, Australia 'At last the comprehensive story of the creative city and the many streams of thought it inspires - by the most significant author and thinker in this space. As Charles argues, thinking with imagination and creativity is no longer a choice for cities, it's essential for them to thrive.' - Margie Caust, Urban Strategist 'Now that the ''shock and awe'' of claim and counterclaim has blown over; an inspiring reflective synthesis of both the practices and the potentials for the Creative City.' - Andy C. Pratt, City University of London, UK Elgar Advanced Introductions are stimulating and thoughtful introductions to major fields in the social sciences and law, expertly written by the world's leading scholars. Designed to be accessible yet rigorous, they offer concise and lucid surveys of the substantive and policy issues associated with discrete subject areas. Written by the leading authority Charles Landry, inventssor of the concept of the creative city, this timely book offers an insightful and engaging introduction to the field. Exploring the development of the concept, it discusses the characteristics of cities, the qualities of creativity, the creative and regeneration repertoires and the gentrification dilemma. Other key topics of this definitive work include ambition and creativity, cities and psychology, digitization and the creative bureaucracy. Key features include: clear and compact style a unique survey of contemporary developments in the field provides a theoretical base for evaluating the concept of creative cities considerations of the urban-sociological context of creative cities sets an agenda for future research in the field. The Advanced Introduction to the Creative City will be an indispensable guide for scholars and students working in urban geography, urban sociology, urban planning and urban studies.

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This first monograph from New York-based Young Projects explores a new approach to spatial design that combines digital and analog methods at the intersection of exploration and architecture. This monograph introduces the cutting-edge research and work of Young Projects, founded by Bryan Young, where materiality, structure, and form intersect to generate new architectural typologies. The book presents a selection of the practice’s most relevant projects: five innovative houses completed between 2015 and 2020 as well as less in-depth looks at other projects that define the practice. Each house serves as a chapter through which Young Projects’ broader body of work is explored across scales, illustrated through a rich landscape of drawings, diagrams, renderings, mock-ups, prototypes, and photography. The through-line connecting all chapters is the studio’s interest in using ambiguity and anomaly to create novel and accessible spaces, whether for high profile clients like Heidi Klum or a new resort in St Kitts. Young Projects seeks to draw users into immersive spatial experiences that unfold over time, in a manner that is familiar but subtly foreign. This quality of “allure” is a result of a unique and experimental approach to materiality and spatial legibility. These are the threads that tie the work together and have set Young Projects apart as an emerging practice, as well as inform the larger-scale projects the studio undertakes as it enters its second decade. Young Projects’ process often begins with simple exercises in making: form-finding experiments they undertake within their Brooklyn studio. Material research has included hand-pulling plaster with an irregular knife, using furniture foam as a casting bed, and forming concrete with palm stems. These experiments, among many others, mine characteristics that are not typically associated with conventional architectural materials and break traditional methodology, allowing for qualities of randomness and spontaneity to enter the process of making. The studio finds that letting go of control (at the right moments) produces results that are often surprising, entirely bespoke, and resist replication.

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"I would highly recommend this book...It is high quality, clear and comprehensive and will no doubt prove an invaluable source of reference. Five stars on all counts." Tim Kevan, co-editor, PIBULJ.COM This book remains the only text of its kind to cover both the medical and legal aspects of medical negligence. Written by a team of more than 60 experts, it continues to provide the most comprehensive and authoritative guidance on all aspects of clinical negligence claims, from bringing an action for damages to presenting expert evidence in court. It also includes detailed consideration of funding and cost implications. Those needing clear guidance to make the best possible preparations for an action will find all they need here. The new 6th edition has been fully revised and restructured, including new chapters on the future of clinical negligence litigation, cardiology, gynaecology, obstetrics, haematology , and also includes coverage and analysis of recent key cases such as: - Williams v Bermuda Hospitals [2016] UKPC 4 (causation) - R (on the application of Maughan) v HM Senior Coroner for Oxfordshire [2020] UKSC 46 (suicide in inquests) - Darnley v Croydon Health Authority [2018] UKSC 50 (duty of care owed by receptionist) - ABC v St George's Hosp [2020] EWHC 455 (Huntington's chorea confidentiality) - Swift v Carpenter [2020] EWCA Civ 1295 (future accommodation costs) - Whittington Hospital NHS Trust v XX [2020] UKSC 14 (damages for surrogacy) - Khan v Meadows [2021] UKSC 21 (scope of duty of care) - Nguyen v HM Assistant Coroner for Inner West London [2021] EWHC 3354 (sufficiency of inquiry) Easy-to-access structure The new edition maintains its easy-to-access, two-part structure. The first part, set out in 16 chapters, deals with legal aspects of medical malpractice, including complaints procedures, poor performance and medical professional governance, preparation of medical evidence, settlements and trial. There are also chapters on product liability, and coronial law. The final 27 chapters in the second part cover the risks associated with particular areas of specialist medical practice. This title is included in Bloomsbury Professional's Clinical Negligence online service.

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A filmmaker whose work exhibits a wide range of styles and approaches, Louis Malle (1932–1995) was the only French director of his generation to enjoy a significant career in both France and the United States. Although Malle began his career alongside members of the French New Wave like François Truffaut, Jean-Luc Godard, and Claude Chabrol, he never associated himself with that group. Malle is perhaps best known for his willingness to take on such difficult or controversial topics as suicide, incest, child prostitution, and collaboration with the Nazis during World War II. His filmography includes narrative films like Zazie dans le Métro, Murmur of the Heart, Atlantic City, My Dinner with Andre, and Au revoir les enfants, as well as several major documentaries. In the late 1970s, Malle moved to the United States, where he worked primarily outside of the Hollywood studio system. The films of his American period display his keen outsider’s eye, which allowed him to observe diverse aspects of American life in settings that ranged from turn-of-the-century New Orleans to present-day Atlantic City and the Texas Gulf Coast. Louis Malle: Interviews covers the entirety of Malle’s career and features seventeen interviews, the majority of which are translated into English here for the first time. As the collection demonstrates, Malle was an extremely intelligent and articulate filmmaker who thought deeply about his own choices as a director, the ideological implications of those choices, and the often-controversial themes treated in his films. The interviews address such topics as Malle’s approach to casting and directing actors, his attitude toward provocative subject matter and censorship, his understanding of the relationship between documentary and fiction film, and the differences between the film industries in France and the US. Malle also discusses his sometimes-challenging work with such actors as Brigitte Bardot, Pierre Blaise, and Brooke Shields, and sheds new light on the making of his films.

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Human Computer Interface Technologies for the Motor Impaired examines both the technical and social aspects of human computer interface (HCI). Written by world-class academic experts committed to improving HCI technologies for people with disabilities, this all-inclusive book explores the latest research, and offers insight into the current limitations of this field. It introduces the concept of HCI, identifies and describes the fundamentals associated with a specific technology of HCI, and provides examples for each. It also lists and highlights the different modalities (video, speech, mechanical, myoelectric, electro-oculogram, and brain-waves) that are available, and discusses their relevant applications. Easily and readily understood by researchers, engineers, clinicians, and the common layperson, the book describes a number of HCI technologies ranging from simple modification of the computer mouse and joystick to a brain–computer interface (BCI) that uses the electrical recording of the brain activity of the user. The text includes photographs or illustrations for each device, as well as references at the end of each chapter for further study.In addition, this book: Describes the mechanical sensors that are used as an interface to control a computer or screen for the aged and disabled Discusses the BCI using brain waves recorded by noninvasive electrodes to recognize the command from the user Presents the myoelectric interface for controlling devices such as the prosthetic/robotic hand Explains the technology of tracking the eye gaze using video Provides the fundamentals of voice recognition technologies for computer and machine control applications Examines a secure and voiceless method for the recognition of speech-based commands using video of lip movement Human Computer Interface Technologies for the Motor Impaired considers possible applications, discusses limitations, and presents the current research taking place in the field of HCI. Dedicated to enhancing the lives of people living with disabilities, this book aids professionals in biomedical, electronics, and computer engineering, and serves as a resource for anyone interested in the developing applications of HCI.

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A history of Toxic Shock Syndrome In 1978, doctors in Denver, Colorado observed several healthy children who suddenly and mysteriously developed a serious, life-threatening illness with no visible source. Their condition, which doctors dubbed ‘toxic shock syndrome’ (TSS) was rare, but observed with increasing frequency over the next few years in young women, and was soon learned to be associated with a bacterium and the use of high-absorbency tampons that had only recently gone on the market. In 1980, the Centers for Disease Control identified Rely tampons, produced by Procter & Gamble, as having the greatest association with TSS over every other tampon, and the company withdrew them from the market. To this day, however, women are frequently warned about contracting TSS through tampon use, even though very few cases are diagnosed each year. Historian Sharra Vostral’s Toxic Shock is the first and definitive history of TSS. Vostral shows how commercial interests negatively affected women’s health outcomes; the insufficient testing of the first super-absorbency tampon; how TSS became a ‘women’s disease,’ for which women must constantly monitor their own bodies. Further, Vostral discusses the awkward, veiled and vague ways public health officials and the media discussed the risks of contracting TSS through tampon use because of social taboos around discussing menstruation, and how this has hampered regulatory actions and health communication around TSS, tampon use, and product safety. A study at the intersection of public health and social history, Toxic Shock brings to light the complexities behind a stigmatized and under-discussed issue in women’s reproductive health. Importantly, Vostral warns that as we move forward with more and more joint replacements, implants, and internal medical devices, we must understand the relationship of technology to bacteria and recognize that both can be active agents within the human body. In other words, unexpected consequences and risks of bacteria and technology interacting with each other remain.

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A Complex and Growing FieldThe study of vascularization in tissue engineering and regenerative medicine (TERM) and its applications is an emerging field that could revolutionize medical approaches for organ and tissue replacement, reconstruction, and regeneration. Designed specifically for researchers in TERM fields, Vascularization: Regenerative Medicine and Tissue Engineering provides a broad overview of vascularization in TERM applications. This text summarizes research in several areas, and includes contributions from leading experts in the field. It defines the difficulties associated with multicellular processes in vascularization and cell-source issues. It presents advanced biomaterial design strategies for control of vascular network formation and in silico models designed to provide insight not possible in experimental systems. It also examines imaging methods that are critical to understanding vascularization in engineered tissues, and addresses vascularization issues within the context of specific tissue applications. This text is divided into three parts; the first section focuses on the basics of vascularization. The second section provides general approaches for promoting vascularization. The final section presents tissue and organ-specific aspects of vascularization in regenerative medicine. Presents Areas of Substantial Clinical and Societal ImpactThe material contains research and science on the process of vessel assembly with an emphasis on methods for controlling the process for therapeutic applications. It describes the tissue and organ-specific aspects of vascularization in regenerative medicine, and refers to areas such as bone tissue engineering, vascularization of encapsulated cells, adipose tissue, bone and muscle engineering. It also provides a mechanistic understanding of the process and presentation of experimental and computational approaches that facilitate the study of vascular assembly, and includes enabling technologies such as nanotechnology, drug delivery, stem cells, microfluidics, and biomaterial design that are optimized for supporting the formation of extensive vascular networks in regenerative medicine.A guide for researchers developing new methods for modulating vessel assembly, this text can also be used by senior undergraduate and graduate students taking courses focused on TERM.

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Following in the tradition of its popular predecessor, the Manual of Geospatial Science and Technology, Second Edition continues to be the authoritative volume that covers all aspects of the field, both basic and applied, and includes a focus on initiating, planning, and managing GIS projects. This comprehensive resource, which contains contributions from 53 leading experts and professors in the areas of GIS, GPS, and remote sensing, reflects the very latest advances in the technology, applications, and usage of the geospatial sciences in many key disciplines, from natural resource analysis to transportation planning.Significantly updated and expanded, this reader-friendly manual introduces the fundamentals in mathematics and physics needed to perform area-wide mapping, inventory, data conversion, and analysis. The text maintains a focus on the practical aspects of these technologies and remains the only resource to cover the areas of GIS, GPS, and remote sensing with such breadth and clarity. An expanded index, new and revised figures, a color insert, and an easier to read format are among the many improvements to this edition. New to the Second Edition: Revised chapters reflecting the changes that have occurred in the technology, applications, and usage of geospacial science Coverage of GIS applications in automobile navigation and enterprise-wide applications A new chapter devoted to basic statistics and least squares solutions Expanded international scope that addresses the other Global Navigation Satellite Systems (GNSS), including the Russian Federation system (GLONASS), the Chinese system (COMPASS), and the European space agency system (GALILEO) A new chapter covering Light Detection and Ranging (LiDAR) A new chapter that addresses privacy issues, legal concerns, and the emerging field of public participation GIS (PPGIS) New material on the expanding field of geovisualization The text presents many real-world applications, including road map navigation using GPS, as well as problems associated with mapping, inventory of land parcels, and data analysis. Complete with helpful references, decision making tools, and many new case studies, this time-saving resource provides the practical understanding required to harness the potential of these dynamic technologies.

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'The chapters in this book explore in detail the choices regarding both the structure and administration of the property tax, drawing on the extensive knowledge the authors have acquired in studying property taxes around the world. The chapters provide a wide-ranging treatment of the design choices and administrative tasks, both in terms of the breadth of design options and administrative tasks covered and the depth of the discussion. The authors describe the range of design choices, discuss the associated issues and the advantages and disadvantages for each, and present the criteria to help choose among the options.’ From the book’s Foreword by David L. Sjoquist, Professor of Economics and Dan E. Sweat Scholar Chair in Educational and Community Policy, Georgia State University Property taxation is a key element in providing a solid foundation and a stable funding source for basic public services. Developing and implementing a property tax system is a complex task. This complexity is compounded by the diversity of legal, cultural and historical contexts of policymakers and tax administrators. The World Development Report (1999-2000), Entering the 21st Century puts fiscal decentralization at the top of the development agenda. This makes local taxation - and especially the property tax option - of critical importance to both tax and land policy, as well as the broader development agenda. A Primer on Property Tax: Administration and Policy provides the reader with an analysis of issues surrounding property tax, including economics, law, public finance, decentralisation, valuation, GIS and property tax reform. A key strength of the book lies in the vast international experience of the authors and the book will provide for the first time material which is topical, cutting-edge and highly relevant to many of the disciplines involved in property taxation. The authors examine the criteria applied to evaluate the strengths and weaknesses of property tax, discuss the main valuation methods and the economic principles underpinning them and review the legal and administrative aspects of property tax worldwide.

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Occupational Therapy with Children draws on contemporary research to examine children’s roles, their occupations and the skills which underpin their ability to participate in society. The book will develop the occupational therapist’s understanding of how to optimise the participation of children in the various environments in which they are required or choose to engage. Occupational Therapy with Children maintains a developmental perspective and incorporates child-centred interventions to improve performance deficits. Section one examines children’s roles and occupations in contemporary society at a broad level. Coverage includes the child’s participation in the family, at school and in the community. This section considers environmental influences on childhood activities, and highlights children’s changing occupational time use and the impact this has on health and wellbeing. Section two focuses on childhood as a period of significant development and skill acquisition. This is profiled as a dynamic period for the therapist to encourage occupational mastery across the spectrum of childhood experience: in play; in self-care; as a student; and beyond the school grounds. Topical chapters evaluate participation in physical activity and consider the potential for ‘healthy’ leisure, along with the risk characteristics associated with certain approaches to leisure. Occupational Therapy with Children is aimed at students and practitioners of occupational therapy. Other childhood professionals, particularly early childhood educators, will also appreciate the articulate approach this book takes towards the development of the child. Highly illustrated with contemporary photographs, drawings and succinct tables Includes case studies; providing worked examples of therapeutic applications Draws on the World Health Organisation International Classification of Functioning, Disability and Health (ICF) to frame the concept of children’s occupations and societal participation Responsive to developments in occupational science Expert contributors provide international perspectives "[Occupational therapists] will find that this book provides a framework that makes planning effective therapy with children practical, relevant, and effective . . . [Rodger & Ziviani's] contribution to the literature has helped unleash the genie of occupation in the service of improved therapy with children."—From the Foreword by Professor Charles Christiansen, The University of Texas Medical Branch, Galveston

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During the Global Financial Crisis in 2008, our financial infrastructure failed. Governments bailed out the very institutions that let the economy down. This episode spurred a serious rethink of our financial system. Does it make any sense that it takes two days to settle a stock transaction? Why do retailers, operating on razor thin margins, have to pay 3% for every customer credit card swipe? Why does it take two days to transfer money from a bank account to a brokerage—or any other company? Why are savings rates miniscule or negative? Why is it so difficult for entrepreneurs to get financing at traditional banks? In DeFi and the Future of Finance, Campbell R. Harvey, Ashwin Ramachandran and Joey Santoro, introduce the new world of Decentralized Finance. The book argues that the current financial landscape is ripe for disruption and we are seeing, in real time, the reinvention of finance. The authors provide the reader with a clear assessment of the problems with the current financial system and how DeFi solves many of these problems. The essence of DeFi is that we interact with peers—there is no brick and mortar and all of the associated costs. Savings and lending are reinvented. Trading takes place with algorithms far removed from traditional brokerages. The book conducts a deep dive on some of the most innovative protocols such as Uniswap and Compound. Many of the companies featured in the book you might not have heard of—however, you will in the future. As with any new technology, there are a myriad of risks and the authors carefully catalogue these risks and assess which ones can be successfully mitigated. Ideally suited for people working in any part of the finance industry as well as financial policy makers, DeFi and the Future of Finance gives readers a vision of the future. The world of finance will fundamentally be changed over the coming decade. The book enables you to become part of the disruption – not the target of the disruption.

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Highly useful guide for all members of a multidisciplinary team managing children suffering from heart disease Built on the success of previous editions and brought to you by a stellar author team, Moller’s Essentials of Pediatric Cardiology, 4th Edition provides a unique, concise, and extremely practical overview of heart disease in children. From history-taking, physical examination, ECG, and chest X-ray—the basics that enable clinicians to uncover possible problems and eliminate areas of false concern—this work goes on to examine the range of more complex topics in the diagnosis and treatment/management of childhood cardiovascular disease. Every chapter is fully updated with the very latest clinical guidelines and management options from the AHA, ACC, and ESC. Recent updates also include an enhanced section on imaging, including recent advances in cardiac MRI and fetal echocardiography, new techniques in genetic testing for heart disease in special populations, and much more emphasis on the importance of echocardiography in understanding the pathophysiology of congenital cardiac malformations. This work also includes an expanded section on cardiac conditions in the neonate, specifically on prenatal diagnosis and management, and neonatal screening for congenital heart disease. Moller’s Essentials of Pediatric Cardiology, 4th Edition also provides: Tools to diagnose cardiac conditions in children and environmental and genetic conditions associated with heart disease in children Anomalies with a left-to-right shunt in children, conditions obstructing blood flow in children, and congenital heart disease with a right-to-left shunt in children Unusual forms of congenital heart disease in children, unique cardiac conditions in newborn infants, and the cardiac conditions acquired during childhood Abnormalities of heart rate and conduction in children and congestive heart failure in infants and children Moller’s Essentials of Pediatric Cardiology, 4th Edition is a succinct and accessible yet highly detailed and informative resource for treating children suffering from heart disease. It is an invaluable reference for anyone working on a multidisciplinary team treating patients with these attributes.

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Discover how the NG-RAN architecture is, and isn't, ready for the challenges introduced by 5G 5G Radio Access Network Architecture: The Dark Side of 5G explores foundational and advanced topics in Radio Access Network (RAN) architecture and why a re-thinking of that architecture is necessary to support new 5G requirements. The distinguished engineer and editor Sasha Sirotkin has included numerous works written by industry insiders with state of the art research at their disposal. The book explains the relevant standards and technologies from an academic perspective, but also explains why particular standards decisions were made and how a variety of NG-RAN architecture options could be deployed in real-life networks. All major standards and technologies associated with the NG-RAN architecture are discussed in this book, including 3GPP, O-RAN, Small Cell Forum, IEEE, and IETF. Readers will learn about how a re-design of the RAN architecture would ensure that 5G networks can deliver their promised throughput and low latency KPIs consistently and sustainably. The book is structured as follows: An overview of the market drivers of the NG-RAN architecture, like spectrum models, 5G-relevant regulatory considerations, and 5G radio interface technical requirements An overview of the 5G System, from the core network, to the RAN, to the radio interface protocols and physical layer, with emphasis on how these are different compared to 4G Release-15 RAN architectures defined in 3GPP, O-RAN, and Small Cell Forum RAN architecture evolution in Release-16 and Release-17 Enabling technologies, like virtualization, open source technologies, multi-access edge (MEC) computing, and operations, administration, and management (OAM) NG-RAN deployment considerations, objectives, and challenges, like costs, spectrum and radio propagation considerations, and coverage Perfect for network designers and operators who require a solid understanding of the NG-RAN architecture, 5G Radio Access Network Architecture also belongs on the bookshelves of network engineers who aim to increase their understanding of the standards and technologies relevant to the NG-RAN architecture.

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Understanding the impact of diet, exercise, genetics, and hormones on the risk and development of Alzheimer’s and other neurogenerative diseases Diet is widely known to impact on neurological function. Nevertheless, academic texts discussing this relationship are relatively few in number. This book therefore fills an important gap in the current literature. Opening with an overview of neurodegenerative diseases, particularly Alzheimer’s disease, the text then focuses on explaining the means by which glycemic control and lipid metabolism – and associated nutritional and lifestyle variables – may factor into such disorders’ prevention and treatment. An international group of experts in the fields of food science and neurodegeneration have contributed chapters that examine Alzheimer’s disease within a broad range of contexts. Offering dietary, genetic, and hormonal perspectives, the authors explore topics ranging from sugar consumption to digestive fermentation, and Alzheimer’s disease animal models to the cognition-enhancing effects of physical exercise. Also included are overviews of the latest research into current and developing methods of treatment and diagnosis, as well as differential diagnostics. This groundbreaking book: Explores how glucose metabolism, insulin resistance, lipid metabolism, and high intake of refined carbohydrates are linked to Alzheimer's disease Discusses how genetic makeup can impact risk of Alzheimer’s and Parkinson’s disease Examines cognitive changes in neurodegeneration, lists current tests for determining cognitive impairment, and provides information concerning differential diagnosis Discusses potential advantages of increasing antioxidant and micronutrient intake Reviews hormonal influences on neurodegeneration Examines the links between protein intake and Alzheimer’s disease. Neurodegeneration and Alzheimer's Disease is an essential resource for researchers, medical practitioners, dietitians, and students with an interest in neurological diseases and their diagnosis and risk factors, as well as diet-related conditions such as diabetes and obesity. Lifestyle and diet influence neurodegeneration risk, and a better understanding of this evidence amongst health professionals will hopefully lead to greater public awareness of how to reduce the likelihood of these widespread conditions.

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A comprehensive introduction to the core issues of stochastic differential equations and their effective application Introduction to Stochastic Differential Equations with Applications to Modelling in Biology and Finance offers a comprehensive examination to the most important issues of stochastic differential equations and their applications. The author — a noted expert in the field — includes myriad illustrative examples in modelling dynamical phenomena subject to randomness, mainly in biology, bioeconomics and finance, that clearly demonstrate the usefulness of stochastic differential equations in these and many other areas of science and technology. The text also features real-life situations with experimental data, thus covering topics such as Monte Carlo simulation and statistical issues of estimation, model choice and prediction. The book includes the basic theory of option pricing and its effective application using real-life. The important issue of which stochastic calculus, Itô or Stratonovich, should be used in applications is dealt with and the associated controversy resolved. Written to be accessible for both mathematically advanced readers and those with a basic understanding, the text offers a wealth of exercises and examples of application. This important volume: Contains a complete introduction to the basic issues of stochastic differential equations and their effective application Includes many examples in modelling, mainly from the biology and finance fields Shows how to: Translate the physical dynamical phenomenon to mathematical models and back, apply with real data, use the models to study different scenarios and understand the effect of human interventions Conveys the intuition behind the theoretical concepts Presents exercises that are designed to enhance understanding Offers a supporting website that features solutions to exercises and R code for algorithm implementation Written for use by graduate students, from the areas of application or from mathematics and statistics, as well as academics and professionals wishing to study or to apply these models, Introduction to Stochastic Differential Equations with Applications to Modelling in Biology and Finance is the authoritative guide to understanding the issues of stochastic differential equations and their application.

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Essential information for architects, designers, engineers, equipment suppliers, and other professionals who are working in or entering the biopharmaceutical manufacturing field Biomanufacturing facilities that are designed and built today are radically different than in the past. The vital information and knowledge needed to design and construct these increasingly sophisticated biopharmaceutical manufacturing facilities is difficult to find in published literature—and it’s rarely taught in architecture or design schools. This is the first book for architects and designers that fills this void. Process Architecture in Biomanufacturing Facility Design provides information on design principles of biopharmaceutical manufacturing facilities that support emerging innovative processes and technologies, use state-of-the-art equipment, are energy efficient and sustainable, and meet regulatory requirements. Relying on their many years of hands-on design and operations experience, the authors emphasize concepts and practical approaches toward design, construction, and operation of biomanufacturing facilities, including product-process-facility relationships, closed systems and single use equipment, aseptic manufacturing considerations, design of biocontainment facility and process based laboratory, and sustainability considerations, as well as an outlook on the facility of the future. Provides guidelines for meeting licensing and regulatory requirements for biomanufacturing facilities in the U.S.A and WHO—especially in emerging global markets in India, China, Latin America, and the Asia/Pacific regions Focuses on innovative design and equipment, to speed construction and time to market, increase energy efficiency, and reduce footprint, construction and operational costs, as well as the financial risks associated with construction of a new facility prior to the approval of the manufactured products by regulatory agencies Includes many diagrams that clarify the design approach Process Architecture in Biomanufacturing Facility Design is an ideal text for professionals involved in the design of facilities for manufacturing of biopharmaceuticals and vaccines, biotechnology, and life-science industry, including architects and designers of industrial facilities, construction, equipment vendors, and mechanical engineers. It is also recommended for university instructors, advanced undergraduates, and graduate students in architecture, industrial engineering, mechanical engineering, industrial design, and industrial interior design.

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"A day draws to a close. Helen worries about when her children will get home; Gloria considers her day at work and, again, thoughts cross her mind about telling them at church that she is a lesbian; Gayle prepares for a meeting at the Women's Shelter...; Ellen gets ready for a class. Chip and Jessica plan another party at their house; Diana paces her kitchen, troubled that Meg still intends to see Bronwyn..." These are some of the people who come to life in this unique book about a lesbian community. It is an experiment, both in women's language and in social science method, and is composed of an interplay of voices that echo, again and again, themes of self and community, sameness and difference, merger and separation, loss and change. Although the method of presentation is unusual, the book is based on solid research. The author lived for a year with the community and then spent two intensive months interviewing 78 women who were either members of the community or importantly associated with it. The author began by addressing several basic questions about privacy that quickly led her to explore dilemmas of identity. In time an even more compelling problem emerged: the loss of sense of self, how it occurs and how it may be dealt with in a social setting. The nature of the community itself raised this issue because it was a community of likeness, intimacy, and ideology. It was also a stigmatized or deviant community - and of women, individuals with life experiences that tended to encourage the giving up of the self to others. The book is organized around particular kinds of situations and relationships in the community where conflicts concerning control over identity are especially prominent. It concludes with an essay on the author's method, "Fiction and Social Science." Author note: Susan Krieger is Visiting Scholar, Department of Sociology, Stanford University.

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There is an estimated 2.5 million epileptics in the US and perhaps some 40 million worldwide. As research has become increasingly molecular in scope, fewer scientists are trained in the US on basic, integrated epilepsy techniques. One frustration in neuroscience today is the application of state-of-the-art molecular biology techniques to inappropriate animal models of epilepsy - frequently resulting in inconclusive results. Epilepsy research will be increasingly undertaken by scientists well-trained in reductionist methodology, but who may be unfamiliar with integrated, whole-animal techniques. This situation appears even more difficult considering there has been no updated textbook on experimental models of epilepsy over the last twenty years - until now.Neuropharmacology Methods in Epilepsy Research describes fundamental methodologies and procedures in this field, representing the only detailed text concerning experimental models of epilepsy published in the last 20 years. This guide studies the reproduction of well-characterized and readily interpretable experimental models of epilepsy to which state-of-the-art molecular biology techniques can be applied.Each chapter features:Introduction - providing a brief background and historical account of the techniques and their use Methodology - describing equipment, solutions, species, electrodes as well as considering variations of techniques and stimulation parameters Interpretations - demonstrating the relevance of techniques to epilepsy as well as describing what exactly is being studied and how the data is appropriately applied to understanding epilepsyTopics include electroshock, chemoconvulsions, kindling, audiogenic seizures, focal seizures, and brain slice preparations.Discussions also include: Recently developed seizure models, including status epilepticus and massed trial simulations Influence of circadian and diurnal rhythms on convulsive activity Behavior al and cognitive deficits associated with anticonvulsant drug testing Technical approaches, i.e. slice models, microdialysis techniques, intracranial implant surgery, audiogenic seizure testing, kindling paradigms, and the rhythmic nature of seizuresThis unique text provides a thorough reference for the diverse methodologies within this area of neuropharmacological research - providing the basis for on-going cellular and molecular investigations as well as novel therapeutic approaches to the treatment of epilepsy.

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Since it first emerged from Britain’s punk-rock scene in the late 1970s, goth subculture has haunted postmodern culture and society, reinventing itself inside and against the mainstream. Goth: Undead Subculture is the first collection of scholarly essays devoted to this enduring yet little examined cultural phenomenon. Twenty-three essays from various disciplines explore the music, cinema, television, fashion, literature, aesthetics, and fandoms associated with the subculture. They examine goth’s many dimensions—including its melancholy, androgyny, spirituality, and perversity—and take readers inside locations in Los Angeles, Austin, Leeds, London, Buffalo, New York City, and Sydney. A number of the contributors are or have been participants in the subculture, and several draw on their own experiences.The volume’s editors provide a rich history of goth, describing its play of resistance and consumerism; its impact on class, race, and gender; and its distinctive features as an “undead” subculture in light of post-subculture studies and other critical approaches. The essays include an interview with the distinguished fashion historian Valerie Steele; analyses of novels by Anne Rice, Poppy Z. Brite, and Nick Cave; discussions of goths on the Internet; and readings of iconic goth texts from Bram Stoker’s Dracula to James O’Barr’s graphic novel The Crow. Other essays focus on gothic music, including seminal precursors such as Joy Division and David Bowie, and goth-influenced performers such as the Cure, Nine Inch Nails, and Marilyn Manson. Gothic sexuality is explored in multiple ways, the subjects ranging from the San Francisco queercore scene of the 1980s to the increasing influence of fetishism and fetish play. Together these essays demonstrate that while its participants are often middle-class suburbanites, goth blurs normalizing boundaries even as it appears as an everlasting shadow of late capitalism.Contributors: Heather Arnet, Michael Bibby, Jessica Burstein, Angel M. Butts, Michael du Plessis, Jason Friedman, Nancy Gagnier, Ken Gelder, Lauren M. E. Goodlad, Joshua Gunn, Trevor Holmes, Paul Hodkinson, David Lenson, Robert Markley, Mark Nowak, Anna Powell, Kristen Schilt, Rebecca Schraffenberger, David Shumway, Carol Siegel, Catherine Spooner, Lauren Stasiak, Jeffrey Andrew Weinstock

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In this creative ethnography Les W. Field challenges a post-Sandinista national conception of identity, one that threatens to constrict the future of subaltern Nicaraguans. Drawing on the works and words of artisans and artisanas, Indians, and mestizos, Field critiques the national ideology of ethnic homogeneity and analyzes the new forms of social movement that have distinguished late-twentieth-century Nicaragua. As a framework for these analytic discussions, Field uses the colonial-era play El Güegüence o Macho Ratón and the literature relating to it.Elite appropriations of El Güegüence construe it as an allegory of mestizo national identity in which mestizaje is defined as the production of a national majority of ethnically bounded non-Indians in active collaboration with the state. By contrast, Field interprets the play as a parable of cultural history and not a declaration of cultural identity, a scatological reflection on power and the state, and an evocation of collective loss and humor broadly associated with the national experience of disempowered social groups. By engaging with those most intimately involved in the performance of the play—and by including essays by some of these artisans—Field shows how El Güegüence tells a story about the passing of time, the absurdity of authority, and the contradictions of coping with inheritances of the past. Refusing essentialist notions of what it means to be Indian or artisan, Field explains the reemergence of politicized indigenous identity in western Nicaragua and relates this to the longer history of artisan political organization. Parting ways with many scholars who associate the notion of mestizaje with identity loss and hegemony, Field emphasizes its creative,productive, and insightful meanings. With an emphasis on the particular struggles of women artisans, he explores the reasons why forms of collective identity have posed various kinds of predicaments for this marginalized class of western Nicaraguans.This book will appeal to readers beyond the field of Latin American anthropology, including students and scholars of literature, intellectual history, women’s studies, and the politics of ethnicity.

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Winner, Body and Embodiment Award presented by the American Sociological Association Imagine yourself without a face—the task seems impossible. The face is a core feature of our physical identity. Our face is how others identify us and how we think of our ‘self’. Yet, human faces are also functionally essential as mechanisms for communication and as a means of eating, breathing, and seeing. For these reasons, facial disfigurement can endanger our fundamental notions of self and identity or even be life threatening, at worse. Precisely because it is so difficult to conceal our faces, the disfigured face compromises appearance, status, and, perhaps, our very way of being in the world. In Saving Face, sociologist Heather Laine Talley examines the cultural meaning and social significance of interventions aimed at repairing faces defined as disfigured. Using ethnography, participant-observation, content analysis, interviews, and autoethnography, Talley explores four sites in which a range of faces are “repaired:” face transplantation, facial feminization surgery, the reality show Extreme Makeover, and the international charitable organization Operation Smile,. Throughout, she considers how efforts focused on repair sometimes intensify the stigma associated with disfigurement. Drawing upon experiences volunteering at a camp for children with severe burns, Talley also considers alternative interventions and everyday practices that both challenge stigma and help those seen as disfigured negotiate outsider status. Talley delves into the promise and limits of facial surgery, continually examining how we might understand appearance as a facet of privilege and a dimension of inequality. Ultimately, she argues that facial work is not simply a conglomeration of reconstructive techniques aimed at the human face, but rather, that appearance interventions are increasingly treated as lifesaving work. Especially at a time when aesthetic technologies carrying greater risk are emerging and when discrimination based on appearance is rampant, this important book challenges us to think critically about how we see the human face.

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Why do the vast majority of heroin users live in cities? In his provocative history of heroin in the United States, Eric C. Schneider explains what is distinctively urban about this undisputed king of underworld drugs. During the twentieth century, New York City was the nation's heroin capital—over half of all known addicts lived there, and underworld bosses like Vito Genovese, Nicky Barnes, and Frank Lucas used their international networks to import and distribute the drug to cities throughout the country, generating vast sums of capital in return. Schneider uncovers how New York, as the principal distribution hub, organized the global trade in heroin and sustained the subcultures that supported its use. Through interviews with former junkies and clinic workers and in-depth archival research, Schneider also chronicles the dramatically shifting demographic profile of heroin users. Originally popular among working-class whites in the 1920s, heroin became associated with jazz musicians and Beat writers in the 1940s. Musician Red Rodney called heroin the trademark of the bebop generation. "It was the thing that gave us membership in a unique club," he proclaimed. Smack takes readers through the typical haunts of heroin users—52nd Street jazz clubs, Times Square cafeterias, Chicago's South Side street corners—to explain how young people were initiated into the drug culture. Smack recounts the explosion of heroin use among middle-class young people in the 1960s and 1970s. It became the drug of choice among a wide swath of youth, from hippies in Haight-Ashbury and soldiers in Vietnam to punks on the Lower East Side. Panics over the drug led to the passage of increasingly severe legislation that entrapped heroin users in the criminal justice system without addressing the issues that led to its use in the first place. The book ends with a meditation on the evolution of the war on drugs and addresses why efforts to solve the drug problem must go beyond eliminating supply.

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This book challenges the accepted view of the early Royal Society of London that holds that its fellows did not seriously attempt to implement Francis Bacon’s program for the methodological reform of the sciences. Instead, the book shows that Bacon’s program shaped the Society’s earliest work in important, if often contradictory, ways as fellows wedded Bacon’s ideas to their various interests and problem areas. Developing Bacon’s program in different directions resulted in a richer understanding of his method than the undirected empiricism often associated with his name. The author demonstrates that Bacon’s call for a focus on “things themselves” was built upon three distinct images of objects of knowledge, in opposition to recent accounts that focus on the collective witnessing of matters of fact. He identifies at the core of Bacon’s method a threefold metaphorical ontology of objects of knowledge and corresponding objectivities. The book reveals a picture of the Royal Society as more sophisticated and unified than previously depicted, while simultaneously demonstrating how the fellows’ development of Bacon’s legacy ultimately pulled in different directions. Specular objects of knowledge privileged passive observation and justified an empiricist objectivity. Manipulated objects of art or manual objects emphasized an engaged, constructivist objectivity in which knowing is doing. And, a vision of underlying forms as generative objects of knowledge, which could be combined like letters of the alphabet to produce phenomena at will, defined a theoretical concept of objectivity. These components of Bacon’s method inform in varying ways the early publications of the Royal Society by John Evelyn, Robert Hooke, John Wilkins, Thomas Sprat, and John Graunt, which are examined in detail to demonstrate the collective negotiation of an ambitious inductive program employing hypotheses, active powers, and the disciplined use of analogy. Examining the Royal Society’s activity in the areas of horticulture, experimentation, language reform, cultural criticism, and political arithmetic, the author synthesizes philosophical and sociological approaches to science in developing a new understanding of the Royal Society and its legacy for science, culture, and politics.

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Awaken your healing power with The Chakra Fix, a contemporary guide to finding your flow, unlocking positive energy and living a high-vibe life. The chakras are connecting, radiating cores that map out the energy within us, and our potential. Focusing on the seven major chakras, this book shows you how to locate, nurture and activate these untapped sources for optimal wellbeing in your daily life. Find out what each chakra represents, how these connect with the emotional, physical and spiritual self – and follow simple but effective exercises to transform the health of each.Designed to answer everyday anxieties and concerns, author Juliette Thornbury offers cleansing meditations, healing rituals and nourishing practices to aid each chakra and enhance your self-care. Start by tuning into the chakras to ascertain how you feel, then discover the cause and find your fix for any number of problems, from combating fatigue and alleviating stress to sparking creativity and finding self-compassion. MASTER THE ESSENTIALS: study the significance of the chakras and demystify associated symbols, crystals, plants, essential oils and colours; SPARK ENERGY AND INSPIRATION: reignite your creativity with an empowering meditation; FIND PROTECTION AND COMFORT: try a root chakra crystal grid to help you feel safe and secure; BOOST JOY AND SUCCESS: develop the self-confidence and willpower to achieve your goals with an abundance ritual; EXPLORE LOVE AND RELATIONSHIPS: find compassion for yourself with a chest-opening yoga pose; IMPROVE COMMUNICATION: try a throat chakra herbal tea to master truthful communication and self-expression; DEVELOP KNOWLEDGE AND INSIGHT: use an essential oil blend to enhance your psychic ability and encourage vivid dreams; SEEK GUIDANCE AND CONNECTION: try a crown chakra balancing bath when you are going through a major life shift. Whether you’re a beginner or an experienced energy healer, The Chakra Fix offers you a renewed sense of self and harmonious energy to heal and flourish.

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Nicole Loraux has devoted much of her writing to charting the paths of the Greek "imaginary," revealing a collective masculine psyche fraught with ambivalence as it tries to grasp the differences between nature and culture, body and soul, woman and man. The Experiences of Tiresias, its title referring to the shepherd struck blind after glimpsing Athena's naked body, captures this ambivalence in exploring how the Greek male defines himself in relationship to the feminine. In these essays, Loraux disturbs the idea of virile men and feminine women, a distinction found in official discourse and aimed at protecting the ideals of male identity from any taint of the feminine. Turning to epic and to Socrates, however, she insists on a logic of an inclusiveness between the genders, which casts a shadow over their clear, officially defined borders. The emphasis falls on the body, often associated with feminine vulnerability and weakness, and often dissociated from the ideal of the brave, self-sacrificing male warrior. But heroes such as the Homeric Achilles, who fears yet fights bravely, and Socrates, who speaks of the soul through the language of the body, challenge these representations. The anatomy of pain, the heroics of childbirth, the sorrows of tears, the warrior's wounds, and the madness of the soul: all these experiences are shown to engage with both the masculine and the feminine in ways that do not denigrate the experiences for either gender. Originally published in 1995. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

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ICARDA International Center for Agricultural Research in the Dry Areas Address: P.O. Box 5466, Aleppo, Syria Telex: 331206 ICARDA SY, 331208 ICARDA SY Fax: 963-21-213490 Established in 1977, ICARDA is governed by an independent Board of Trustees. Based at Aleppo, Syria, it is one of 18 centres supported by the Consultative Group on International Agricultural Research (CGIAR), which is an international group of representatives of donor agencies, eminent agricultural scientists, and institutional administrators from developed and developing countries who guide and support its work. The CGIAR seeks to enhance and sustain food production and, at the same time, improve the socioeconomic conditions of people through strengthening national research systems in developing countries. ICARDA focuses its research efforts on areas with a dry summer, where precipitation in winter ranges from 200 mm to 600 mm. The Center has a global responsibility for the improvement of barley, lentil and faba bean, and a regional responsibility -- in West Asia and North Africa -- for the improvement of wheat, chickpea and pasture and forage crops and the associated farming systems. Much of ICARDA's research is carried out on a 948-hectare farm at its headquarters at Tel Hadya, about 35 km south-west of Aleppo. ICARDA also manages other sites where it tests material under a variety of agroecological conditions in Syria and Lebanon. However, the full scope of ICARDA's activities can be appreciated only when account is taken of the cooperative research carried out with many countries in West Asia and North Africa. The results of research are transferred through ICARDA's cooperation with national and regional research institutions, universities and ministries of agriculture, and through the technical assistance and training that the Center provides. A range of training programmes is offered, extending from residential courses for groups to advanced research opportunities for individuals. These efforts are supported by seminars and publications and by specialised information services.

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Over the past few years software radio has transitioned from an esoteric academic idea to a rapidly commercialising technology that in the coming decade will revolutionise the mobile telecommunications marketplace. Written for industry professionals in engineering and commercial roles, as well as those in academia and research, this book will provide a comprehensive context for all those already active in or entering the field. Walter Tuttlebee, himself a pioneer of software radio in Europe, has gathered contributions from many of the acknowledged world experts in software radio -leaders operating at the heart of the software radio world today - who share their experience and insight into the background, the present and the future evolution of the technology and the industry. Contributions from North America, Europe and Asia ensure a comprehensive overview of the global SDR scene. The structured approach ensures that the book comprehensively addresses the key issues in the title - the origins of software radio, what has been (and is) driving its commercialisation and what is happening on the international scene The book includes: a comprehensive review of the origins of software radio in the defence industry an insider's view of the origins, evolution, role and activities of the SDR Forum a summary of the MIT Sloan study into the drivers of global success in the mobile wireless marketplace a review of end user and mobile network operator perspectives of software radio and what the value it can offer insiders' summaries of recent SDR research activities in Europe and Japan coverage of the regulatory issues associated with SDR and the current approaches being taken in North America and Europe, with contributions from the regulators themselves a description of the first steps to SDR standards - the ETSI MExE standard descriptions of some of the first commercial software defined radio products, for both defence and commercial applications Endorsed with a foreword from Joseph Mitola III, 'the father of software radio'

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A counterintuitive and novel approach to the long-sought goal of subtyping schizophrenia and other psychotic disorders emerges from ongoing research.? Five psychosis associated anxiety and depressive subtypes each help define five corresponding psychosis diagnoses, their fixed false beliefs, and most importantly, their treatments. These anxiety and depressive comorbidities have long been long overlooked as an understandable hodgepodge of distressing symptoms caused by the pain of psychosis.? But these five comorbidities usually precede onset of the psychosis, and their treatment can significantly improve outcome. So, maybe, the causation is the other way around: maybe they are among the underlying contributors to schizophrenia and other psychotic disorders. The chapter authors expertly detail the data supporting this innovative approach.? They provide fictional case studies, DSM-5 diagnostic criteria, specific interviewing approaches for the five comorbidities in psychosis patients, and improved treatment options.? Other chapters explore psychoses related to substance use, medical illness and medical treatment, as well as other factors that contribute to psychotic disorders. This first-of-its-kind reference is a valuable clinical, educational, research and training resource for psychiatrists, psychologists, nurses, social workers, neurologists and anyone interested in the care and treatment of someone with a psychotic disorder. Reflects current research, diagnosis, and treatment options for: Schizophrenia with Voices and Panic Anxiety Obsessive-Compulsive Schizophrenia and Obsessive-Compulsive Disorder Persecutory Delusional Disorder and Social Anxiety Delusional Depression and Melancholic Depression Bipolar I Disorder and Atypical Depression Substance Use Psychoses Medical Illness and Iatrogenic Psychoses Covers treatment options and outcomes with medication and psychotherapy.? Includes sample patient interview approaches and/or biological tests for each diagnosis. Highlights symptoms, quasi-psychotic symptoms and secondary signs of the comorbidities when alone, and when in conjunction with psychosis. Reviews diagnosis-specific significance and contributory roles of neurotransmitters, hypofrontality, psychological trauma, and genetics. Enhanced eBook version allows access to entire book contents on most devices.? Included free with book purchase, or purchase separately.

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Fetal & Neonatal Physiology provides neonatologist fellows and physicians with the essential information they need to effectively diagnose, treat, and manage sick and premature infants. Fully comprehensive, this 2-volume resource continues to serve as an excellent reference tool, focusing on the basic science needed for exam preparation and the key information required for full-time practice. The 5th edition is the most substantially updated and revised edition ever. In the 5 years since the last edition published, there have been thousands of publications on various aspects of development of health and disease; Fetal and Neonatal Physiology synthesizes this knowledge into definitive guidance for today's busy practitioner. Offers definitive guidance on how to effectively manage the many health problems seen in newborn and premature infants. Chapters devoted to clinical correlation help explain the implications of fetal and neonatal physiology. Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices. Features a fantastic new 4-color design with 1,000 illustrations, 170+ chapters, and over 350 contributors. 16 new chapters cover such hot topics as Epigenetics; Placental Function in Intrauterine Growth Restriction; Regulation of Pulmonary Circulation; The Developing Microbiome of the Fetus and Newborn; Hereditary Contribution to Neonatal Hyperbilirubinemia; Mechanistic Aspects of Phototherapy for Neonatal Hyperbilirubinemia; Cerebellar Development; Pathophysiology of Neonatal Sepsis; Pathophysiology of Persistent Pulmonary Hypertension of the Newborn; Pathophysiology of Meconium Aspiration Syndrome; Pathophysiology of Ventilator Dependent Infants; Pathophysiology of Hypoxic-Ischemic Brain Injury; Pathophysiology of Neonatal White Matter Injury; Pathophysiology of Meningitis; Pathophysiology of Preeclampsia; and Pathophysiology of Chorioamnionitis. New Pathophysiology of Neonatal Diseases section highlights every process associated with a disease or injury, all in one place. In-depth information, combined with end-of-chapter summaries, enables deep or quick use of the text.

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Hamlet's Castle is both a theoretical and a practical examination of the interactions that take place in a literary classroom. The book traces the source of literature's power to the relationship between its illusional quality and its abstract meaning and relates these elements to the process by which a group, typically an academic class, forms a judgment about a literary work. In focusing on the importance of the exchange of ideas by readers, Gordon Mills reveals a new way of looking at literature as well as a different concept of the social function of the literary classroom and the possible application of this model to other human activities. The three fundamental elements that constitute Mills's schema are the relationship between a reader and the illusional quality of literature, the relationship between a reader and the meaning of a text, and the concept of social experience within the environment of a text. The roles of illusion and meaning in a text are explored in detail and are associated with areas outside literature, including science and jurisprudence. There is an examination of the way in which decisions are forced by peers upon one another during discussion of a literary work-an exchange of opinion which is commonly a source of pleasure and insight, sought for its own sake. In the course of his study, Mills shows that the act of apprehending a literary structure resembles that of apprehending a social structure. From this relationship, he derives the social function of the literary classroom. In combining a theoretical analysis with the practical objective of determining what value can be found in the study of literature by groups of people, Mills has produced a critical study of great significance. Hamlet's Castle will change concepts about the purpose of teaching literature, affect the way in which literature is taught, and become involved in the continuing discussion of the relationship of literary studies to other disciplines.

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For over half a century, Robert Schmuhl interviewed and wrote about Reverend Theodore M. Hesburgh, C.S.C., who served as the president of the University of Notre Dame from 1952 until 1987. Beginning as an undergraduate student during the 1960s, when he covered Hesburgh and Notre Dame for the Associated Press, to 2014 when he conducted his last visit with the frail ninety-seven-year-old priest, Schmuhl maintained a unique relationship with Father Hesburgh. Over time, Hesburgh’s meetings with Schmuhl evolved into a friendship, which is documented in this personal and warmhearted portrait of the man who was for decades considered the most influential priest in America. Fifty Years with Father Hesburgh: On and Off the Record contains excerpts and commentary from various interviews Schmuhl conducted with Father Hesburgh about his service as Notre Dame’s president, including the most difficult years of his presidency during the 1960s, when Notre Dame and other college campuses were in turmoil because of student protests against the Vietnam War and other issues. Knowing and working with four popes and nine U.S. presidents, Father Hesburgh was a moral force in virtually all major social issues of his day, including civil rights, peaceful uses of atomic energy, third-world development, and immigration reform. Schmuhl records Hesburgh’s candid reflections on the U.S. presidents with whom he worked and his assessment of the years after he left the university’s presidency and maintained an active life of service in retirement. Schmuhl expresses his devotion and respect in the chapters about Hesburgh’s twilight decades. He describes how Hesburgh dealt with macular degeneration and blindness in his later years, enlisting students to read the New York Times and other publications to him. During the 1990s and the first years of the twenty-first century, Father Ted was, as he liked to say, “everybody’s grandfather.” His open-door policy extended beyond students to faculty, staff, alumni, and campus visitors, and continued right up until the end of his life. Throughout the book, Schmuhl captures the essence, spirit, and humanity of a great leader.

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The journal Put', or The Way, was one of the major vehicles for philosophical and religious discussion among Russian émigrés in Paris from 1925 until the beginning of World War II. This Russian language journal, edited by Nicholas Berdyaev among others, has been called one of the most erudite in all Russian intellectual history; however, it remained little known in France and the USSR until the early 1990s. This is the first sustained study of the Russian émigré theologians and other intellectuals in Paris who were associated with The Way and of their writings, as published in The Way. Although there have been studies of individual members of that group, this book places the entire generation in a broad historical and intellectual context. Antoine Arjakovsky provides assessments of leading religious figures such as Berdyaev, Bulgakov, Florovsky, Nicholas and Vladimir Lossky, Mother Maria Skobtsova, and Afanasiev, and compares and contrasts their philosophical agreements and conflicts in the pages of The Way. He examines their intense commitment to freedom, their often contentious struggles to bring the Christian tradition as experienced in the Eastern Church into conversation with Christians of the West, and their distinctive contributions to Western theology and ecumenism from the perspective of their Russian Orthodox experience. He also traces the influence of these extraordinary intellectuals in present-day Russia, Western Europe, and the United States. Throughout this comprehensive study, Arjakovsky presents a wealth of arguments, from debates over "Russian exceptionalism" to the possibilities of a Christian and Orthodox version of socialist politics, the degree to which the church could allow its agenda to be shaped by both local and global political realities, and controversies about the distinctively Russian theology of Divine Wisdom, Sophia. Arjakovsky also maps out the relationships these émigré thinkers established with significant Western theologians such as Jacques Maritain, Yves-Marie Congar, Henri de Lubac, and Jean Daniélou, who provided the intellectual underpinnings of Vatican II.

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Virginia Dwan is one of the most influential figures in the history of twentieth-century American art. Her eponymously named galleries, the first established in a Los Angeles storefront in 1959, followed by a second in New York in 1965, became a beacon for influential postwar American and European artists. She sponsored the debut show for Yves Klein in the United States, and she championed such artists as Franz Kline, Robert Rauschenberg, Claes Oldenburg, Sol LeWitt, and Ad Reinhardt. Her Los Angeles gallery featured abstract expressionism, neo-dada, and pop, while the New York branch became associated with the emerging movements of minimalism and conceptualism. At the same time, the gallery's influence expanded to remote locations in Nevada, Utah, and Arizona, where Dwan sponsored such iconic earthworks as Robert Smithson's Spiral Jetty, Michael Heizer's Double Negative, and Walter De Maria's Lightning Field. Though Dwan was a major force in the art world of the sixties and seventies, her story and the history of her gallery have been largely unexplored until now. Published to coincide with an exhibition at the National Gallery of Art celebrating Dwan's gift to the Gallery of her extraordinary personal collection, From Los Angeles to New York: The Dwan Gallery, 1959 1971 explores her remarkable career. Alongside lush full-color images of one hundred leading artworks, the book deepens our understanding of the artistic exchanges Dwan facilitated during this age of mobility, when air travel and the interstate highway system linked the two coasts and transformed the making of art and the sites of its exhibition. James Meyer, the curator of the exhibition and the foremost authority on minimal art, contributes a essay that is a sophisticated and broad-ranging analysis of Dawn's legacy. Honoring Dwan's significant influence and impact on postwar art, From Los Angeles to New York is a rich and informative collection that will be treasured by fans of contemporary art.

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To provide the right supports for struggling students in grades pre-K to 12, your school team needs a thorough understanding of the skills that contribute to learning—and a systematic way to help students with a wide range of learning difficulties. This innovative planning guide is your key to identifying and prioritizing the essential skills that students with and without learning difficulties need to succeed.This book presents 11 key domains of learning—divided into neurological, developmental, and educational domains—and gives your team a complete, collaborative plan for pinpointing where students need help and adapting your supports to meet those needs. For each of the 11 domains, the authors offer a logical framework that consists of critical skill sets and skills your students need for learning success. Every domain gets a dedicated chapter that helps you: Understand why the domain is essential to learning in both special and general education Learn about the research and resources used to develop the framework for that domain Take a deep dive and master key terms and definitions Discover how the skills associated with each domain develop in typical learners Find students who are struggling by making good observations, and by identifying missing or underdeveloped skills Identify your students’ strengths so you can help them build and expand on their skills Clearly communicate your observations to all team members Build better intervention plans and IEPs using the specific educational objectives, teaching strategies, and accommodations suggested in each chapter PRACTICAL MATERIALS: Each chapter offers an in-depth Case Study example, a Skills Observation Sheet for notetaking during student observations, and a Skills Framework for use as a quick reference on skills when making observations and developing IEPs. Two practical appendices walk school professionals and team leaders through the collaborative process of putting the frameworks in the book into practice.Support students in 11 domains of learning: Vision Skills Hearing Skills Motor Skills Formal Language Skills Pragmatic Language Skills Social Skills Executive Skills Affect and Self-Regulation Skills Reading Skills Writing Skills Math Skills

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Fides quaerens intellectum is the idea that living faith naturally seeks a more complete understanding of God in relation to his creation. It has motivated Christian education from the very start. Although Ars quaerens intellectum--“art seeking understanding”--is by contrast a contemporary locution, in the Christian context of this volume it is a parallel to the more familiar phrase. “Art” here includes human making of the sort associated with any craft; this volume focuses on those usually called “fine” arts, namely poetry, painting, sculpture, and musical composition. The contributors to Art Seeking Understanding contend that art in almost any medium is typically born of a desire for some kind of understanding--perhaps of the potential in their medium, an aspect of the external world, or of the artist’s own compulsion to create. An artwork may be prompted by a desire for greater understanding of transcendent realities. A distinctive value of the collaboration represented in this book is thus the reflection of artists themselves set alongside remarks by philosophers, theologians, literary critics, art historians, and musicologists. Together, these authors argue that there is a tacit if not explicit theological dimension to art-making that reveals itself readily in religious art but also in works that may have no such conscious motivation. The artist, like all human creatures, is made in the image of God (imago Dei), but as both Scripture and tradition suggest, may in fact realize more intensively than the rest of us an aspect of the divine Maker. In turn, those who appreciate art may come to acquire an understanding of the nature of the Original Artist indirectly through allowing the works of gifted artists to spark their imaginative reflection. In this way, art “speaks” to us theologically in ways that substantially enrich our knowledge of our Creator and his creation. This volume invites readers to consider how God speaks, his characteristic poetic voice, and the influence of that voice on our knowledge of the holy.

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Transcendence and History is an analysis of what philosopher Eric Voegelin described as 'the decisive problem of philosophy': the dilemma of the discovery of transcendent meaning and the impact of this discovery on human self-understanding. The explicit recognition and symbolization of transcendent meaning originally occurred in a few advanced civilizations worldwide during the first millennium. The world's major religious and wisdom traditions are built upon the recognition of transcendent meaning, and our own cultural and linguistic heritage has long since absorbed the postcosmological division of reality into the two dimensions of 'transcendence' and 'immanence.' But the last three centuries in the West have seen a growing resistance to the idea of transcendent meaning; contemporary and 'postmodern' interpretations of the human situation - both popular and intellectual - indicate a widespread eclipse of confidence in the truth of transcendence.In Transcendence and History, Glenn Hughes contributes to the understanding of transcendent meaning and the problems associated with it and assists in the philosophical recovery of the legitimacy of the notion of transcendence. Depending primarily on the treatments of transcendence found in the writings of twentieth-century philosophers Eric Voegelin and Bernard Lonergan, Hughes explores the historical discovery of transcendent meaning and then examines what it indicates about the structure of history. Hughes's main focus, however, is on clarifying the problem of transcendence in relation to historical existence. Addressing both layreaders and scholars, Hughes applies the insights and analyses of Voegelin and Lonergan to considerable advantage.Transcendence and History will be of particular value to those who have grappled with the notion of transcendence in the study of philosophy, comparative religion, political theory, history, philosophical anthropology, and art or poetry. By examining transcendent meaning as the key factor in the search for ultimate meaning from ancient societies to the present, the book demonstrates how 'the decisive problem of philosophy' both illuminates and presents a vital challenge to contemporary intellectual discourse.

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In the 18th century the idea of the landscape garden, which had originated in England, spread all over Europe. The geometry of the Baroque park was abandoned in favour of a 'natural' design. At the same time the garden became "The land of illusion": Chinese pagodas, Egyptian tombs, and Turkish mosques, along with Gothic stables and Greek and Roman temples, formed a miniature world in which distance mingled with the past. The keen interest in a fairy-tale China, which was manifested not only in the gardens but also in the chinoiseries of the Rococo, abated in the 19th century. The increasing expansion of the European colonial powers was reflected in new exotic fashions. While in England it was primarily the conquest of the Indian subcontinent that captured the imagination, for France the occupation of Algiers triggered an Orient-inspired fashion that spread from Paris to encompass the entire Continent, and found its expression in paintings, novels, operas, and buildings. This 'Orient', which could not be clearly defined geographically, was characterised by Islamic culture: It extended around the Mediterranean Sea from Constantinople to Granada. There, it was the Alhambra that fascinated writers and architects. The Islamic styles seemed especially appropriate for "buildings of a secular and cheerful character". In contrast to ancient Egyptian building forms, which, being severe and monumental, were preferably used for cemetery buildings, prisons or libraries, they promised earthly sensuous pleasures. The promise of happiness associated with an Orient staged by architectural means was intended to guarantee the commercial success of coffee houses and music halls, amusement parks, and steam baths. But even extravagant summer residences and middle-class villas were often built in faux-Oriental styles: In Brighton, the Prince Regent George (George IV after 1820) built himself an Indian palace; in Bad Cannstatt near Stuttgart, a 'Moorish' refuge was erected for Württemberg's King Wilhelm I; and the French town of Tourcoing was the site of the Palais du Congo, a bombastic villa in the Indian Moghul style that belonged to a wealthy perfume and soap manufacturer.

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By 1300, England and other West-European countries had undergone a significant degree of commercialisation. More and more communities, both urban and rural, depended on an efficient network of local markets to obtain the goods they needed, in particular for their food. Yet in spite of this, some landed lords and, most notably, monasteries and convents continued to rely on the produce of their own estates, even though there were significant costs and risks associated with the production, transportation and storage of their own food. Philip Slavin sets out to account for this puzzling situation through an in-depth study of the changing patterns and fortunes of the provisioning of Norwich Cathedral Priory between c.1260 and 1536. Close analysis of contemporary archival sources reveals that the Priory made a deliberate choice, dictated by various economic, social and environmental factors and which, altogether, made isolation from the market a profitable, and very rational, option.This is a new sort of estate study that considers questions of both production and consumption as well as health issues, including the problems of overeating and obesity occurring in late-medieval monastic populations. Particular attention is given to the production, transportation, storage and consumption by the Priory household of grain-based products. In the late-medieval period, grains were the single most important component in the daily diet, for both commoners and the higher echelons, accounting for between 50 and 80 per cent of total calorific intake. Although focusing on one specific region, this is more than just a regional study, analysing as it does a microcosm of the late-medieval English economy and society at a time of political, socio-economic and biological shocks and crises, including years of bad weather, famine, pestilence (both human and bovine), warfare and revolts. The study of the food supply of late-medieval conventual households sheds much light on the wider process of decline and eventual collapse of direct demesne management in particular, and feudalism in general, in the post-Black Death era.

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This book presents the latest research in the field of machine learning, discussing the real-world application problems associated with new innovative renewable energy methodologies as well as cutting edge technologies in the transport industry. The requirements and demands of problem solving have been increasing exponentially, and new artificial intelligence and machine learning technologies have reduced the scope of data coverage worldwide. Recent advances in data technology (DT) have contributed to reducing the gaps in the coverage of domains around the globe. Attention to clean energy in recent decades has been growing exponentially. This is mainly due to a decrease in the cost of both installed capacity of converters and a decrease in the cost of generated energy. Such successes were achieved thanks to the improvement of modern technologies for the production of converters, an increase in the efficiency of using incoming energy, optimisation of the operation of converters and analysis of data obtained during the operation of systems with the possibility of planning production. The use of clean energy plays an important role in the transportation industry, where technologies are also being improved from year to year - the transportation industry is growing, and machinery and systems are becoming more autonomous and robotic, where it is no longer possible to do without complex intelligent computing, machine learning optimisation, planning and working with large amounts of data. The book is a valuable reference work for researchers in the fields of renewable energy, computer science and engineering with a particular focus on machine learning and intelligent optimization as well as for postgraduates, managers, economists and decision makers, policy makers, government officials, industrialists and practicing scientists and engineers as well compassionate global decision makers. Topics include: Machine learning, Quantum Optimization, Modern Technology in Transport Industry, Innovative Technologies in Transport Education, Systems Based on Renewable Energy Conversion, Business Process Models and Applications in Renewable Energy, Clean Energy, and Climate Change.

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Warren Zevon and Philosophy is a collection of chapters on Zevon’s life and music, authored by philosophers who are also Zevon fans, providing new and exciting insights into Zevon’s thinking, his cynical lyrics, and the cruel ironies of his roller-coaster life and career.Since his death in 2003 at the age of fifty-six, Warren Zevon’s following has grown, and seven books on Zevon have appeared in the last few years, with more in the works. The Zevon legend continues to attract attention both because of the outstanding quality of his best songs and because of the poignant trajectory of his life. According to the novelist Carl Hiaasen, Zevon “left behind a wildly intelligent and captivating body of music.” Warren Zevon was an American rock’n’roll singer-songwriter, born in Chicago, though associated with the music scene in Los Angeles. His early albums, Warren Zevon (1976) and Excitable Boy (1978) attracted a loyal fan following and ecstatic praise from critics. As a special talent to watch, the teenage Zevon was introduced to several notable people, including even Igor Stravinsky.Zevon’s descent into alcoholism and other addictions, along with his debauchery and erratic behavior, took its toll and his performances suffered, an aspect disturbingly captured in the memoir by his ex-wife Crystal Zevon, I’ll Sleep When I’m Dead: The Dirty Life and Times of Warren Zevon (2008).In the last few years of his life, Zevon rehabilitated somewhat, and his work returned to an impressive level of quality. His remarkable final albums, Life’ll Kill Ya (2000), My Ride’s Here (2002), and The Wind (2003) have made a lasting impact. The last of these was given the Grammy Award for Best Contemporary Folk Album, while the song “Disorder in the House,” performed by Zevon with Bruce Springsteen, won Best Rock Vocal Performance. John MacKinnon teaches philosophy at Saint Mary’s University, Halifax, Nova Scotia. He has published scholarly articles on aesthetics and philosophy of literature.

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Sickle cell disease is one of the most common monogenic diseases globally, and the first disease where the genetic etiology was defined. It is common in sub Saharan Africa, the Middle East and India. This collection explores the advantages of newborn screening for sickle cell disease. Following this, the authors assess the costs of using continuous subcutaneous insulin infusion therapy for type 1 diabetes treatment. Scientific evidence has shown improvement in glycated hemoglobin levels, and in the reduction of glycemic oscillations and hypoglycemia episodes when compared to multiple-dose insulin therapy. Also assessed in this compilation are different analysis techniques, including spectrometry, chromatography and electrochemistry, used quantitatively and qualitatively to determine tadalafil pharmaceutical dosage forms. The authors discuss different risk factors pertaining to eye drop instillation and manipulation in glaucoma patients' daily tasks, analyzing the different classes of hypotensive ocular agents. Prostatic inflammation, or prostatitis, is the most common prostatic disease in men and it can progress to more serious conditions, such as benign prostatic hyperplasia and/or prostate cancer. As such, factors that could be related to inflammatory process in prostate, particularly the endocrine components, are addressed. Indocyanine green video angiography has been used for several medical applications in the recent decades. As a result, the authors describe the main neurosurgical applications and surgical results obtained by a senior vascular neurosurgeon. In one study, the antidepressant effects of three dosages forms of Guduchi are assessed using a behavioral despair test in depression. A statistical analysis was carried out via one-way ANOVA test followed by Tucky and Kramer multiple comparison tests. The penultimate study was conducted among 611 pregnant women who satisfy inclusion criteria in Bahir Dar town, northwest Ethiopia, wherein a multivariate analysis was employed to identify factors associated with dietary practices and nutrition status. The concluding chapter addresses current issues in direct-to-consumer marketing of behavioral health care services and offers several recommendations for its application.

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Atrial fibrillation is initiated by triggers in combination with underlying atrial substrate. Horizons in World Cardiovascular Research. Volume 17 discusses how innovations in cardiac magnetic resonance imaging techniques, especially late gadolinium enhancement imaging, have advanced our ability to better understand and accurately identify fibrosis in the atrial myocardium of atrial fibrillation patients. According to the nephron number hypothesis, individuals born with kidneys with fewer nephrons would be at increased risk for hypertension and renal disease later in life. Evidence supporting a role for preterm birth itself as a programming risk factor come from observations demonstrating that the degree of prematurity impacts the severity of hypertension or renal dysfunction observed later in life, indicating a dose-response effect of preterm birth. As such, the authors review this effect in the context of consequences for the mother after pregnancy as well as individuals born during premature labor. This compilation goes on to discuss venous thromboembolism, a spectrum of disease that includes both deep venous thrombosis and pulmonary embolism. Venous thromboembolism affects 950,000 patients every year and is associated with significant morbidity and mortality. Superior mesenteric artery syndrome is a rare clinical entity resulting in partial or complete duodenal obstruction due to compression of the third part of the duodenum. Symptoms will vary depending on the severity, but can be very debilitating. The authors discuss the diagnosis of this rare condition, as well as treatment options. Next, the surgical anatomy of the superior mesenteric artery is schematized through a subdivision in three segments, each with a different method for surgical dissection, for a better understanding of its surgical anatomy. The final chapter focuses on the current development of zebrafish models for the screening for cardiotoxic and cardioprotective agents. The administration of endocrine disruptors, cigarette smoke, acrylamide, phthalates and phosphate, heavy metals, inoculation infectious agent, alcohol, surgery and laser light radiations are the major cause of cardiotoxicity in zebrafish.

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Learn how free software became open source and how you can sell open source software. This book provides a historical context of how open source has thoroughly transformed how we write software, how we cooperate, how we communicate, how we organize, and, ultimately, how we think about business values. This fully updated second edition includes an entire chapter on legal considerations such as trademarks and the latest happenings in open source licensing. It also expands on open hardware trends such as RISC-V, open governance, and the difference between community projects and commercial products, especially as seen through the lens of security. You’ll look at project and community examples including Linux, BSD, Apache, and Kubernetes, understand the open source development model, and how open source has influenced approaches more broadly, even within proprietary software, such as open betas. You'll also examine the flipside, the "Second Machine Age," and the challenges of open source-based business models. Today, open source serves as shorthand for much broader trends and behaviors. It’s not just about a free (in all senses of the word) alternative to commercial software. It increasingly is the new commercial software. How Open Source Ate Software, second edition reveals how open source has much in common, and is often closely allied, with many other trends in business and society. You'll see how it enables projects that go beyond any individual company. That makes open source not just a story about software, but a story about almost everything. What You'll Learn The opportunities that open source creates and the challenges that come with them The ways in which companies can create business models to successfully sell "free" software How the open source development model works from creating communities to selling commercial products The important issues associated with open source project and product governance and licensing How open source principles can apply more broadly to DevOps and other organizational practices Who This Book Is For Anyone who is contemplating building a community and a business around open source software.

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"This is a very useful and practical resource that will help the reader create the structured approach essential to any successful action research project." Early Years Update Are you worried about doing your early years action research project? Does the thought of choosing the right research question feel daunting? Are you concerned about the challenges you might face? If you answer 'yes' to any of these questions, then this is the book for you!Written in a lively and accessible style, this is the essential step-by-step guide to conducting your own action research project. The book introduces and evaluates different approaches to action research and explores how they can be applied in early childhood settings to create positive change and to improve practice.Using varied illustrations and case studies of contemporary projects in diverse early childhood contexts, the book addresses specific issues and challenges that you might face when conducting action research in such settings.Each chapter offers gentle guidance and support at a specific stage of the research process, from choosing your initial topic to formulating your research question, through to sharing the lessons of your project.The book's key features include: 16 'Steps' that walk you through the process of conducting your action research project References to real life research projects to illustrate key ideas, themes, practices and debates Advice on creating an action research journal, with sample extracts 'Thinking Boxes' in each chapter to encourage you to review and reflect on the chapter's contents as you plan your research project Checklists in each chapter of key concepts, processes and themes, together with further resources The authors explore some difficult issues associated with action research, including ethics, rigour, validity, critical reflection, and social and professional change. They show that there is more than one 'right' way to perform an action research project and advise you how to choose an approach that is appropriate for your particular interests and circumstances.Doing Action Research in Early Childhood Studies is an essential resource for students and practitioners of early childhood studies.

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