Search results for ""author matthew"

An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs. Valuable information includes: Comprehensive overviews of the major kinase families involved in oncology, integrating protein structure and function, and providing important tools to assist pharmaceutical researchers to understand and work in this dynamic area of cancer drug research Focus on small molecule inhibitors as well as other therapeutic modalities Discussion of kinase inhibitors that have entered clinical trials for the treatment of cancer, with an emphasis on molecules that have progressed to late stage clinical trials and, in a few cases, to market Providing a platform for further study, this important work reviews both the successes and challenges of kinase inhibitor therapy, and provides insight into future directions in the war against cancer.

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127 recipes for stovetop, oven, Instant Pot, and slow cooker, from the editor of the New York Times bestselling Fix-It and Forget-It series! You want to put a delicious home-cooked meal on the table but you don't have a lot of time. Welcome Home 30-Minute Cookbook has your back! Each of the 127 recipes take 30 minutes or less from prep to food on the table. Whether you prefer to use your stovetop, oven, Instant Pot, or slow cooker, there are plenty of options in this book for you. Find dishes such as: Berry-Topped Wheat Pancakes Easy Chicken Fajitas Broccoli Rabe and Sausage Soup Barbecue Chicken Pizza BLT Pasta Salad Easy Enchilada Chicken Creamy Broccoli Soup Maple-Glazed Salmon Chicken Alfredo And more! You can trust these recipes because they are collected from some of America’s best home cooks, tested in real-life settings, and carefully selected from thousands of recipes. This is the perfect cookbook for busy home chefs!

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Recreate the classic and nostalgic flavors of your youth with ice cream recipes for French vanilla, chocolate, strawberry, coffee, rocky road, and so much more! Ice cream sundaes have been pleasuring our collective senses ever since 1892, when an enterprising soda fountain proprietor in Ithaca, New York, accessorized a scoop of ice crea

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Watch wooden sailing ships being tossed on stormy seas and attacked by pirates. Learn how they are made and how their sails work. Sail on a racing yacht, go fishing for merlin and see a fishing boat trawling for fish. Find out about canoes, yachts, motor boats, speed boats, tug boats and submersibles, as well as huge container ships, cruise ships, aircraft carriers and oil tankers. Learn how to make a boat and how to tie different sailor’s knots.

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What if Anna and Elsa never knew each other? Following the unexpected death of her parents, Elsa finds herself the sole ruler of Arendelle and mysterious powers begin to reveal themselves.Elsa starts to remember fragments of her childhood that seem to have been erased - pieces that include a familiar-looking girl. Determined to fill the void she has always felt, Elsa must take a harrowing journey across her icy kingdom to undo a terrible curse... and find the missing Princess of Arendelle.This audiobook is an mp3-CD edition

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In 1934, the people of Inishmaan learn that the Hollywood director Robert Flaherty is coming to the neighbouring island to film his documentary Man of Aran. No one is more excited than Billy, an unloved and crippled boy whose chief occupation has been gazing at cows and yearning for a girl who wants no part of him. For Billy is determined to cross the sea and audition for the Yank. As news of his audacity ripples through his rumour-starved community, The Cripple of Inishmaan becomes a merciless portrayal of a world so comically cramped and mean-spirited that hope is an affront to its order. With this bleak yet uproariously funny play, Martin McDonagh fulfilled the promise of his award-winning The Beauty Queen of Leenane while confirming his place in a tradition that extends from Synge to O'Casey and Brendan Behan. This Student Edition, complete with plot summary and scholarly notes, is edited by Dr. P.J. Mathews of University College Dublin.

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After Urban Regeneration is a comprehensive study of contemporary trends in urban policy and planning. Focusing on the history and theory of community in urban policy, and including a unique set of case studies, the book will appeal to scholars and students in geography, urban studies, planning, sociology, law and art as well as policy makers and community workers.

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Forbidden love was a forbidden topic. Decorum was everything—in society, where Catholicism dictated the terms, and in literature, where a code of decency governed writers and readers alike. To women were left the pale love stories that conducted appropriate partners in proper settings to socially acceptable outcomes. So it was in Latin America well into the twentieth century. The stories in this volume announce a dramatic change, a transformation of the literature of love in Latin America, and of the role—even the nature—of women in this most “feminine” literary tradition. These stories, by exciting new writers as well as by the renowned, are “violations” of the most exhilarating sort, flouting conventions of language, behavior, subject matter, and style to remake and widen our once-narrow view of the literary landscape of Latin America. Here women writers from Mexico and Brazil, Colombia and Argentina, Cuba, Peru, and Uruguay break social, religious, political, and sexual barriers in fiction that is by turns erotic, satirical, shocking, tragic—and always, in its remapping of literary boundaries, deeply and richly entertaining.

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The Birmingham City Miscellany – a book on the Blues like no other, packed with facts, stats, trivia, stories and legend. Delve deep to find out all about the events and people who have shaped the club into what it is today. Featured here are a plethora of stories on this charismatic football club ranging from how the club was formed, to little-known facts about players and managers. Here you will find player feats, individual records and plenty of weird and wonderful trivia. Rivalry with Villa, favourite managers, quotes ranging from the profound to the downright bizarre and cult heroes from yesteryear – a book no true Birmingham City fan should be without.

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Welcome to the imaginary world of a most unusual painter, Guiseppe Arcimboldo, who created highly original still life portraits that are, in fact, full of life! Using your ‘magic’ torch, explore the strange and surprising details of his Renaissance paintings: a head made of flowers and a body made of leaves, a mushroom mouth and a courgette nose, peach cheeks and cherry lips. Each spread more spectacular than the last! This title is part of the My First Discovery paperback series – a unique collection of beautifully illustrated information books for children aged 4 to 7, with simple language to aid learning and realistic artwork to inspire young minds. This edition contains a paper torch at the back of the book, revealing hidden secrets on the 4 darkened transparent pages and making the story come alive – one detail at a time. With free access to a brand new audio app, children can listen and read along at their own pace, page by page.

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A translation of Fernand Braudel's "Ecrits sur l'histoire", published in 1969. The main themes of the work are: the importance of a "rapprochement" between history and the social sciences; the inseparability of study of past and present; the dubious value of the narrative techniques; and the liberating effect of approaching the human past with eyes firmly fixed upon the "longue duree".

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This is a faery tarot with a difference, uncompromising in its portrayal of faeries as they really are: sly, frequently cruel, cleverer than humans and full of secrets, rather than the whimsical, sweet-natured creatures beloved of the Victorians and the New Age. It's the world of Christina Rossetti's Goblin Market, a place where all denizens of the Otherworld come to buy and sell, to mingle and exchange gossip. It is a place unsafe for humans. But imagine if you could look through a window onto the scene, as Christina Rossetti does in her poem? Imagine the beings you would see there ... Here is a tarot of wit and wickedness, of challenge and uncertainty, of wonder and truth. This 80-card deck with 176-page guidebook offers as the Major Arcana a gallery of strange and wonderful creatures, from the Faery Queen to the Wiseman, plus intriguing motifs from the poem, such as the Secret Way and the Fallen Tree. Minor suits represent magical implements, fruits, flowers and elements. Enter a haunted, magical world – an enchanting landscape of falling towers, crumbling walls and tangled woods, of streams tumbling amongst mossy stones, of fallen trees and bones threaded with vines and spiked roses. Prepare to be enspelled ... and to discover the answers to your questions and dilemmas.

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Twins cause trouble in this classic Shakespeare comedy! With notes on Shakespeare and the Globe Theatre and Appearance in Twefth Night. The tales have been retold using accessible language and with the help of Tony Ross's engaging black-and-white illustrations, each play is vividly brought to life allowing these culturally enriching stories to be shared with as wide an audience as possible.Have you read all of The Shakespeare Stories books? Available in this series: A Midsummer Night's Dream, Macbeth, Romeo and Juliet, The Tempest, Hamlet, Twelfth Night, Antony and Cleopatra, Much Ado About Nothing, The Merchant of Venice, Henry V, Julius Caesar, As You Like It, Othello, The Taming of the Shrew, Richard III, and King Lear.

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A wonderful retelling of Shakespeare's thrilling tale of love torn apart by history. With notes on Shakespeare and the Globe theatre and Love and Death in Anthony and Cleopatra. The tales have been retold using accessible language and with the help of Tony Ross's engaging black-and-white illustrations, each play is vividly brought to life allowing these culturally enriching stories to be shared with as wide an audience as possible.Have you read all of The Shakespeare Stories books? Available in this series: A Midsummer Night's Dream, Macbeth, Romeo and Juliet, The Tempest, Hamlet, Twelfth Night, Antony and Cleopatra, Much Ado About Nothing, The Merchant of Venice, Henry V, Julius Caesar, As You Like It, Othello, The Taming of the Shrew, Richard III, and King Lear.

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Rome's greatest general, Julius Caesar, returns to the city celebrating a glorious victory. But among the cheering crowds a group of conspirators are determined to prevent Caesar becoming king... With Notes on Shakespeare and the Globe Theatre and Liberty and Power in Julius Caesar.The tales have been retold using accessible language and with the help of Tony Ross's engaging black-and-white illustrations, each play is vividly brought to life allowing these culturally enriching stories to be shared with as wide an audience as possible.Have you read all of The Shakespeare Stories books? Available in this series: A Midsummer Night's Dream, Macbeth, Romeo and Juliet, The Tempest, Hamlet, Twelfth Night, Antony and Cleopatra, Much Ado About Nothing, The Merchant of Venice, Henry V, Julius Caesar, As You Like It, Othello, The Taming of the Shrew, Richard III, and King Lear.

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Lovely Bianca has a queue of admirers anxious to marry her. But her older sister, Katharina, must get married first. Katharina has such a fiery temper she is known as 'the shrew', and no man is brave enough to propose. Can Petruchio tame her with his outrageous behaviour? With Notes on Shakespeare and the Globe Theatre and Love and Marriage in The Taming of the Shrew. The tales have been retold using accessible language and with the help of Tony Ross's engaging black-and-white illustrations, each play is vividly brought to life allowing these culturally enriching stories to be shared with as wide an audience as possible.Have you read all of The Shakespeare Stories books? Available in this series: A Midsummer Night's Dream, Macbeth, Romeo and Juliet, The Tempest, Hamlet, Twelfth Night, Antony and Cleopatra, Much Ado About Nothing, The Merchant of Venice, Henry V, Julius Caesar, As You Like It, Othello, The Taming of the Shrew, Richard III, and King Lear.

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Foolish and bad-tempered, King Lear divides the kingdom between his two wicked daughters, disowns his honest youngest daughter and banishes his friends. As the kingdom falls apart and Lear's humiliation turns him mad, will he finally realise what he has done? With Notes on Shakespeare and the Globe Theatre and Chaos and Old Age in King Lear.The tales have been retold using accessible language and with the help of Tony Ross's engaging black-and-white illustrations, each play is vividly brought to life allowing these culturally enriching stories to be shared with as wide an audience as possible.Have you read all of The Shakespeare Stories books? Available in this series: A Midsummer Night's Dream, Macbeth, Romeo and Juliet, The Tempest, Hamlet, Twelfth Night, Antony and Cleopatra, Much Ado About Nothing, The Merchant of Venice, Henry V, Julius Caesar, As You Like It, Othello, The Taming of the Shrew, Richard III, and King Lear.

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Relive the decade when Reading's music scene turned itself up to 11 and really started to rock. This hugely well-informed and entertaining account of live music in Reading between 1966 and 1976 charts the journey from the emergence of psychedelia to the dawn of punk, and brings into focus the many musicians and bands - from The Amboy Dukes to The Who - that played at venues around the town. Read about the early years of the Reading Festival, lost and much missed music venues, and local musical heroes. Includes a foreword by Mike Cooper.

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Psychologists have discovered that one of the best ways of being mentally healthy is to understand and talk about your feelings. Taking care of your mental health is as important as being physically fit and healthy. Try to recognise your feelings. Learn to use the right words and phrases to talk about your mental health. It can be just as normal and easy as talking about your hobbies or favourite foods! Let's Talk About It: A Guide to Your Mental Health is part of the Reading Planet Cosmos range of books from Hodder Education. Cosmos provides a vibrant collection of fiction and non-fiction books that will widen children's reading horizons. Reading Planet books have been carefully levelled to support children in becoming fluent and confident readers. Each book features useful notes and questions to support reading at home and develop comprehension skills. Reading age: 8-9 years

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This book features over 570 colour photographs, including stunning plant directories, inspirational plantings, and practical step-by-step techniques. Providing all the essential gardening know-how, it shows how to create a fabulous garden with lasting impact, year-round colour and delicious scent. It teaches how to use scented bulbs, annuals, shrubs and trees to create a welcoming and relaxing outdoor environment. Here, is the ultimate inspirational guide to planning, creating and maintaining bountiful borders of beautiful blooms all year round. This is a book for the enthusiastic and practical as well as the aspirational gardener. It shows how to make best use of a plant's features to create a particular style of garden, and how to keep your garden looking good all year round. Packed with essential information, hints and professional tips, this is the perfect planting guide and practical handbook.

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The fast and easy way to start and run an online business Starting an online business is no longer a novelty. It's a fact of life for individuals and established companies alike. The good news is that e-commerce and the practice of selling goods and services through a Web site and is not only here to stay, but it's thriving. More good news is that the steps required to conduct commerce online are well within the reach of ordinary people, even if you have no business experience. All you need is a good idea, a bit of start-up cash, computer equipment, and a little help from the practical, hands-on information in Starting and Running an Online Business For Dummies. With strategies to help you identify your market, design your website, choose services, trade securely, boost sales, and stay ahead of the competition; Starting and Running an Online Business For Dummies is just what you need to succeed. You'll discover how to open an online business in ten easy steps, how to select the right web host and design tools, why giving your e-business site structure and style is vital, techniques on attracting and keeping customers, and much more. Advice on how to get your business on the Web quickly and economically Completely revised and updated Includes the latest information on web hosting, search engine optimization, pay-per-click advertising, harnessing the power of social media marketing, and more Whether you're a budding entrepreneur or a small business owner looking to expand your business online, this up-to-date and easy-to-follow guide covers all the essentials you need to know to get on the Web quickly and economically, without all the technical jargon and hype bogging you down.

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Empower your students as they reimagine the world around them through mathematics Culturally relevant mathematics teaching engages students by helping them learn and understand math more deeply, and make connections to themselves, their communities, and the world around them. The mathematics task provides opportunities for a direct pathway to this goal. But many teachers ask, how can you find, adapt, and implement math tasks that build powerful learners? Engaging in Culturally Relevant Math Tasks helps teachers to design and refine inspiring mathematics learning experiences driven by the kind of high-quality and culturally relevant mathematics tasks that connect students to their world. With the goal of inspiring all students to see themselves as doers of mathematics, this book provides intensive, in-the-moment guidance and practical classroom tools that empower educators to shape culturally relevant experiences while systematically building tasks that are standards-based. It includes A pathway for moving through the process of asking, imagining, planning, creating, and improving culturally relevant math tasks. Tools and strategies for designing culturally relevant math tasks that preservice, novice, and veteran teachers can use to grow their practice day by day. Research-based teaching practices seen through the lens of culturally relevant instruction that help students develop deep conceptual understanding, procedural knowledge, fluency, and application in 6-12 mathematical content. Examples, milestones, opportunities for reflection, and discussion questions guide educators to strengthen their classroom practices, and to reimagine math instruction in response. This book is for any educator who wants to teach mathematics in a more authentic, inclusive, and meaningful way, and it is especially beneficial for teachers whose students are culturally different from them.

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Reporting the findings of a series of in-depth studies based on diverse groups of students, including early school-leavers, men, Maori, teachers, nurses, midcareer students, and retirees, this book examines these students' patterns of study, their employment status, their motivations, and the decisions they make. It examines how they experience university, how they see their futures, and how educational institutions might better plan, promote, process, and deliver courses to this growing group of older students.

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Short, clear chapters each focus on a single topic, presenting necessary information thoroughly and clearly, in a manner that’s easy for students to graspLarge number of musical examples allows students to better understand techniques by seeing them in multiple contexts Companion website provides video demonstrations that help students understand techniques in action

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This book presents a full decade of Sartre's work, from the publication of the Critique of Dialectical Reason in 1960, the basic philosophical turning-point in his postwar development, to the inception of his major study on Flaubert, the first volumes of which appeared in 1971. The essays and interviews collected here form a vivid panorama of the range and unity of Sartre's interests, since his deliberate attempt to wed his original existentialism to a rethought Marxism.A long and brilliant autobiographical interview, given to New Left Review in 1969, constitutes the best single overview of Sartre's whole intellectual evolution. Three analytic texts on the US war in Vietnam, the Soviet invasion of Czechoslovakia, and the lessons of the May Revolt in France, define his political positions as a revolutionary socialist. Questions of philosophy and aesthetics are explored in essays on Kierkegaard, Mallarme and Tintoretto. Another section of the collection explores Sartre's critical attitude to orthodox psychoanalysis as a therapy, and is accompanied by rejoinders from colleagues on his journal Les Temps Modernes. The volume concludes with a prolonged reflection on the nature and role of intellectuals and writers in advanced capitalism, and their relationship to the struggles of the exploited and oppressed classes. Between Existentialism and Marxism is an impressive demonstration of the breadth and vitality of Sartre's thought, and its capacity to respond to political and cultural changes in the contemporary world.

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The types of plants and animals that live on seashores in temperate regions are similar around the globe, but many of the individual species in south-eastern Australia are found only in this region.Field Guide to the Seashores of South-Eastern Australia features colour photographs, descriptions and ecological notes for around 240 species of the more common plants and animals found on rocky, sandy and muddy shores along the coastline from Port Lincoln, South Australia, to the Hawkesbury River, New South Wales, and Tasmania.This guide will allow beachgoers to learn interesting details about the plants and animals they come across, while also having sufficient scientific detail for natural history enthusiasts and biology students to develop their understanding of these shore ecosystems.

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Discover all about ladybirds and also about the whole teeming world of ants, beetles, and grasshoppers.

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Mozart's Sonatas for Pianoforte are published as part of ABRSM's 'Signature' Series - a series of authoritative performing editions of standard keyboard works, prepared from original sources by leading scholars. Includes informative introductions and performance notes.

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If you are looking for the intersection of past practices, current thinking, and future insights into the ever-expanding world of entrepreneurship education, then you will want to read and explore the fourth edition of the Annals of Entrepreneurship Education and Pedagogy. Prepared under the auspices of the United States Association for Small Business and Entrepreneurship (USASBE), this edited volume covers a broad range of scholarly, practical, and thoughtful perspectives on a compelling range of entrepreneurship education issues.The fourth edition spans topics ranging from innovative practices in facilitating entrepreneurship teaching and learning inside and outside the classroom, learning innovation, model programs, to the latest research from top programs and thought leaders in entrepreneurship. Moreover, the fourth edition builds on previous editions as it continues to investigate critical issues in designing, implementing and assessing experiential learning techniques in the field of entrepreneurship. This contemporary volume provides insights and challenges in the development of entrepreneurship education for students, educators, mentors, community leaders, and more. Annals of Entrepreneurship Education and Pedagogy - 2021 is a must-have book for any entrepreneurship professor, scholar or program director dedicated to advancing entrepreneurship education in the U.S. and around the world.

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The importance of the Law of Treasure is largely the result of the spectacular growth in the activity of metal detecting which, starting in the 1960’s, has grown so much in popularity that it now brings to our knowledge each year more than a thousand objects of historical, cultural or archaeological interest. The nature and volume of these finds has in turn led to a greater public concern to ensure that measures exist which will be conducive to the retention and effective preservation of the more important of those objects. It is, of course, essential that facilities exist for the physical examination and conservation of finds and that those facilities should be accessible and adequate. But the law has an important part to play in this process by ensuring that finds of substantial value or importance should be preserved for the nation and made available to the public in museums. For many hundreds of years, the Law of Treasure was the common law of treasure trove. Today it is essentially based on the Treasure Act 1996. Although the Act is a great improvement on the common law it is nevertheless not always rational and the meaning of some of its provisions is sometimes obscure. This book aims to provide a reliable guide to the Law of Treasure in England, Wales and Northern Ireland and also to explain the role played by legal institutions, such as the Coroner, in that process. This book will be of interest to archaeologists, museums, coroner’s offices, finds liaison officers, farmers and landlords’ associations. It will also be of interest and utility to metal detectorists since, in addition to explaining what objects are considered to be treasure by the law, it explains the legal restrictions on searching for artefacts, the duty to report finds of treasure and the structure of the valuation process and rewards.

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127 recipes for stovetop, oven, Instant Pot, and slow cooker, from the editor of the New York Times bestselling Fix-It and Forget-It series! Anyone cooking for kids wants recipes that don't require a lot of dishes, have simple and budget-friendly ingredient lists, are reasonably healthy, and will please a variety of taste buds. Hope Comerford has you covered with Welcome Home Family Favorites. Whether you prefer to use your stovetop, oven, Instant Pot, or slow cooker, there are plenty of options in this book for you. Find dishes such as: Meatball Tortellini Soup Quick and Easy Chili Taco Bean Soup Easy Chicken Fajitas Barbecue Chicken Pizza Fresh Veggie Lasagna Sloppy Joes Country Gal's Chicken Pot Pie Super Creamy Macaroni and Cheese And many more! You can trust these recipes because they are collected from some of America’s best home cooks, tested in real-life settings, and carefully selected from thousands of recipes. Finally, a cookbook that makes dinnertime stress-free and fun!

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What if you could prepare holiday feasts for friends and family without spending hours in the kitchen? Now you can. Take your slow cooker out of the pantry and put away the stress of holiday cooking and baking this year. Here are 150 slow cooker recipes that will wow your guests and free you up to spend quality time with loved ones. From Sweet Potato Stuffing to Raspberry Glazed Ham, Slow Cooker Turkey and Stuffing to Pear Butter, there are recipes here to indulge every palate and gorgeous full-color photographs to inspire any menu planner. Phyllis Good is beloved for providing recipes that are simple and made with ingredients you can find easily—if you don't already have them in your cupboard. Who has time to search for obscure, gourmet ingredients around the holidays? Holiday cooking has never been easier—or more delicious. Learn what size slow cooker to purchase, discover tips for easy prep and cleanup, and find scrumptious recipes such as: Dried Cranberry Pudding Holiday Wild Rice Christmas Apple Date Pudding Pork Roast with Applesauce Cheesy Sausage Dip Gingerbread Pudding Cake And many more!

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