Search results for ""author luke""

The application of biocatalysis in organic synthesis is rapidly gaining popularity amongst chemists. Compared to traditional synthetic methodologies biocatalysis offers a number of advantages in terms of enhanced selectivity (chemo-, regio-, stereo-), reduced environmental impact and lower cost of starting materials. Together these advantages can contribute to more sustainable manufacturing processes across a wide range of industries ranging from pharmaceuticals to biofuels. The biocatalytic toolbox has expanded significantly in the past five years and given the current rate of development of new engineered biocatalysts it is likely that the number of available biocatalysts will double in the next few years. This textbook gives a comprehensive overview of the current biocatalytic toolbox and also establishes new guidelines or rules for “biocatalytic retrosynthesis”. Retrosynthesis is a well known and commonly used technique whereby organic chemists start with the structure of their target molecule and generate potential starting materials and intermediates through a series of retrosynthetic disconnections. These disconnections are then used to devise a forward synthesis, in this case using biocatalytic transformations in some of the key steps. Target molecules are disconnected with consideration for applying biocatalysts, as well as chemical reagents and chemocatalysts, in the forward synthesis direction. Using this textbook, students will be able to place biocatalysis within the context of other synthetic transformations that they have learned earlier in their studies. This additional awareness of biocatalysis will equip students for the modern world of organic synthesis where biocatalysts play an increasingly important role. In addition to guidelines for identifying where biocatalysts can be applied in organic synthesis, this textbook also provides examples of current applications of biocatalysis using worked examples and case studies. Tutorials enable the reader to practice disconnecting target molecules to find the ‘hidden’ biocatalytic reactions which can be applied in the synthetic direction. The book contains a complete description of the current biocatalyst classes that are available for use and also suggests areas where new enzymes are likely to be developed in the next few years. This textbook is an essential resource for lecturers and students studying synthetic organic chemistry. It also serves as a handy reference for practicing chemists who wish to embed biocatalysis into their synthetic toolbox.

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Prompted by the overt omission of Muncie's black community from the famous community study by Robert S. Lynd and Helen Merrell Lynd, Middletown: A Study in Modern American Culture, the authors initiated this project to reveal the unrecorded historical and contemporary life of Middletown, a well-known pseudonym for the Midwestern city of Muncie, Indiana. As a collaboration of community and campus, this book recounts the early efforts of Hurley Goodall to develop a community history and archive that told the story of the African American community, and rectify the representation of small town America as exclusively white. The authors designed and implemented a collaborative ethnographic field project that involved intensive interviews, research, and writing between community organizations, local experts, ethnographers, and teams of college students. This book is a unique model for collaborative research, easily accessible to students. It will be a valuable resource for instructors in anthropology, creative writing, sociology, community research, and African American studies.

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Pirate Percy loves his parrot, Polly. Find out what happens when One-eyed Jack steals Polly and won't give her back. Books with short chapters are a great way for children who are beginning to read independently to extend reading stamina and progress to the next step of their reading journey. This Read with Oxford Stage 5 book has short chapters, an engaging story and exciting colour illustrations. Tips for parents and fun after-reading activities help you to get the most out of the story. Featuring much-loved characters, great authors, engaging storylines and fun activities, Read with Oxford offers an exciting range of carefully levelled reading books to build your child's reading confidence. Find practical advice, free eBooks and fun activities to help your child progress on oxfordowl.co.uk. Let's get them flying!

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Succinct, highly readable and thought provoking, this important new text is designed to raise awareness of the potential economic impact of companion animals in the UK. It discusses the potential benefits and costs of companion animals to the economy and highlights the need for this matter to be thoroughly researched, given the potential scale of impact and the potential costs of ignoring this matter. The book includes: - case studies to illustrate the savings to the NHS that might be associated with companion animal ownership; - links to up-to-date tables and content that might form templates for use in other countries; and - highly readable information written by expert authors and key opinion leaders in the field. Inspired by the seminal Council for Science and Society (CSS) Report, Companion Animals in Society (1988), this work updates and extends its evaluation of the economic impact of companion animals on society and lays a benchmark for future development. This pivotal new book is important for policy makers at national and international levels and all those involved in animal welfare.

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From 1935 until 1975, just about every junkie busted for dope went to the Narcotic Farm. Equal parts federal prison, treatment center, farm, and research laboratory, the Farm was designed to rehabilitate addicts and help researchers discover a cure for drug addiction. Although it began as a bold and ambitious public works project, and became famous as a rehabilitation center frequented by great jazz musicians among others, the Farm was shut down forty years after it opened amid scandal over its drug-testing program, which involved experiments where inmates were being used as human guinea pigs and rewarded with heroin and cocaine for their efforts.Published to coincide with a documentary to be aired on PBS, The Narcotic Farm includes rare and unpublished photographs, film stills, newspaper and magazine clippings, government documents, as well as interviews, writings, and anecdotes from the prisoners, doctors, and guards that trace the Farm's noble rise and tumultuous fall, revealing the compelling story of what really happened inside the prison walls.

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The vector-borne Zika virus joins avian influenza, Ebola, and yellow fever as recent public health crises threatening pandemicity.By a combination of stochastic modeling and economic geography, this book proposes two key causes together explain the explosive spread of the worst of the vector-borne outbreaks.Ecosystems in which such pathogens are largely controlled by environmental stochasticity are being drastically streamlined by both agribusiness-led deforestation and deficits in public health and environmental sanitation.Consequently, a subset of infections that once burned out relatively quickly in local forests are now propagating across susceptible human populations whose vulnerability to infection is often exacerbated in structurally adjusted cities. The resulting outbreaks are characterized by greater global extent, duration, and momentum.As infectious diseases in an age of nation states and global health programs cannot, as much of the present modeling literature presumes, be described by interacting populations of host, vector, and pathogen alone, a series of control theory models is also introduced here. These models, useful to researchers and health officials alike, explicitly address interactions between government ministries and the pathogens they aim to control.

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Foresight has emerged as a key instrument for the development and implementation of research and innovation policy. The main focus of activity has been at the national level. Governments have sought to set priorities, to build networks between science and industry and, in some cases, to change their research system and administrative culture. Foresight has been used as a set of technical tools, or as a way to encourage more structured debate with wider participation leading to the shared understanding of long-term issues.In this comprehensive and critical Handbook, cross-cutting analytical chapters explore the emergence and positioning of foresight, common approaches and methods, organisational issues, and the scope for policy transfer and evaluation. Leading experts and practitioners contribute chapters analysing experiences in France, Germany, the United Kingdom, the USA, Japan, China, Latin America, small European nations, Nordic countries and selected developing countries. The book concludes with consideration of the future of foresight itself.This fascinating Handbook will appeal equally to those wishing to apply foresight to their policy or strategy-making activities, and to those studying the theory and practice of foresight. The Handbook will be vital reading for policymakers considering, commissioning, or using foresight, companies eager to use public foresight, as well as academics and researchers in foresight, futures and STI policy and management communities.

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The nation’s favourite annual guide to the short story, now in its tenth year.Best British Short Stories invites you to judge a book by its cover – or, more accurately, by its title. This new series aims to reprint the best short stories published in the previous calendar year by British writers, whether based in the UK or elsewhere. The editor’s brief is wide ranging, covering anthologies, collections, magazines, newspapers and web sites, looking for the best of the bunch to reprint all in one volume.Featuring: Richard Lawrence Bennett, Luke Brown, David Constantine, Tim Etchells, Nicola Freeman, Amanthi Harris, Andrew Hook, Sonia Hope, Hanif Kureishi, Helen Mort, Jeff Noon, Irenosen Okojie, KJ Orr, Bridget Penney, Diana Powell, David Rose, Sarah Schofield, Adrian Slatcher, NJ Stallard, Robert Stone, Stephen Thompson and Zakia Uddin.

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Customer Loyalty Isn't Enough—Grow Your Share of Wallet The Wallet Allocation Rule is a revolutionary, definitive guide for winning the battle for share of customers' hearts, minds, and wallets. Backed by rock-solid science published in the Harvard Business Review and MIT Sloan Management Review, this landmark book introduces a new and rigorously tested approach—the Wallet Allocation Rule—that is proven to link to the most important measure of customer loyalty: share of wallet. Companies currently spend billions of dollars each year measuring and managing metrics like customer satisfaction and Net Promoter Score (NPS) to improve customer loyalty. These metrics, however, have almost no correlation to share of wallet. As a result, the returns on investments designed to improve the customer experience are frequently near zero, even negative. With The Wallet Allocation Rule, managers finally have the missing link to business growth within their grasp—the ability to link their existing metrics to the share of spending that customers allocate to their brands. Learn why improving satisfaction (or NPS) does not improve share. Apply the Wallet Allocation Rule to discover what really drives customer spending. Uncover new metrics that really matter to achieve growth. By applying the Wallet Allocation Rule, managers get real insight into the money they currently get from their customers, the money available to be earned by them, and what it takes to get it. The Wallet Allocation Rule provides managers with a blueprint for sustainable long-term growth.

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Global warming, pollution, food and water shortage, cyberspace insecurity, over-population, land erosion, and an overburdened health care system are major issues facing the human race and our planet. These challenges have presented a mandate to develop “natural” or “green” technologies using nature and the living system as a guide to rationally design processes, devices, and systems. This approach has given rise to a new paradigm, one in which innovation goes hand-in-hand with less waste, less pollution, and less invasiveness to life on earth. Bioinspiration has also led to the development of technologies that mimic the hierarchical complexity of biological systems, leading to novel highly efficient, more reliable multifunctional materials, devices, and systems that can perform multiple tasks at one time. This multi-volume handbook focuses on the application of biomimetics and bioinspiration in medicine and engineering to produce miniaturized multi-functional materials, devices, and systems to perform complex tasks. Our understanding of complex biological systems at different length scales has increased dramatically as our ability to observe nature has expanded from macro to molecular scale, leading to the rational biologically-driven design to find solution to technological problems in medicine and engineering.The following three-volume set covers the fields of bioinspired materials, electromechanical systems developed from concepts inspired by nature, and tissue models respectively.The first volume focuses on the rational design of nano- and micro-structured hierarchical materials inspired by the relevant characteristics in living systems, such as the self-cleaning ability of lotus leaves and cicadas' wings; the superior walking ability of water striders; the anti-fogging function of mosquitoes' eyes; the water-collecting ability of Namib Desert Beetles and spider silk; the high adhesivity of geckos' feet and rose petals; the high adhesivity of mussels in wet aquatic environments; the anisotropic wetting of butterflies' wings; the anti-reflection capabilities of cicadas' wings; the self-cleaning functionality of fish scales; shape anisotropy of intracellular particles; the dielectric properties of muscles; the light spectral characteristics of plant leaves; the regeneration and self-healing ability of earthworms; the self-repairing ability of lotus leaves; the broadband reflectivity of moths' eyes; the multivalent binding, self-assembly and responsiveness of cellular systems; the biomineral formation in bacteria, plants, invertebrates, and vertebrates; the multi-layer structure of skin; the organization of tissue fibers; DNA structures with metal-mediated artificial base pairs; and the anisotropic microstructure of jellyfish mesogloea. In this volume, sensor and microfluidic technologies combined with surface patterning are explored for the diagnosis and monitoring of diseases. The high throughput combinatorial testing of biomaterials in regenerative medicine is also covered.The second volume presents nature-oriented studies and developments in the field of electromechanical devices and systems. These include actuators and robots based on the movement of muscles, algal antenna and photoreception; the non-imaging light sensing system of sea stars; the optical system of insect ocellus; smart nanochannels and pumps in cell membranes; neuromuscular and sensory devices that mimic the architecture of peripheral nervous system; olfaction-based odor sensing; cilia-mimetic microfluidic systems; the infrared sensory system of pyrophilous insects; ecologically inspired multizone temperature control systems; cochlea and surface acoustic wave resonators; crickets' cercal system and flow sensing abilities; locusts' wings and flapping micro air vehicles; the visual motion sensing of flying insects; hearing aid devices based on the human cochlea; the geometric perception of tortoises and pigeons; the organic matter sensing capability of cats and dogs; and the silent flight of rats. The third volume features engineered models of biological tissues. These include engineered matrices to mimic cancer stem cell niches; in vitro models for bone regeneration; models of muscle tissue that enable the study of cardiac infarction and myopathy; 3D models for the differentiation of embryonic stem cells; bioreactors for in vitro cultivation of mammalian cells; human lung, liver and heart tissue models; topographically-defined cell culture models; ECM mimetic tissue printing; biomimetic constructs for regeneration of soft tissues; and engineered constructs for the regeneration of musculoskeletal and corneal tissue.This three-volume set is a must-have for anyone keen to understand the complexity of biological systems and how that complexity can be mimicked to engineer novel materials, devices and systems to solve pressing technological challenges of the twenty-first century.Key Features:The only handbook that covers all aspects of biomimetics and bioinspiration, including materials, mechanics, signaling and informaticsContains 248 colored figures

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One-eyed Jack has a big ship and lots of treasure, but what he really wants, more than anything, is a parrot. Pirate Percy only has a small leaky ship and no treasure, but he does have a parrot called Polly. Percy loves Polly very much. But when one-eyed Jack steals Polly and tries to make her sit on his shoulder, Polly the mischievous parrot has other ideas ... Oxford Reading Tree Story Sparks is an emotionally-engaging fiction series that will fire children's imaginations. These 36 original stories will get children thinking, and develop and deepen their comprehension skills. The variety of authors and illustration styles broadens children's reading experience, with something to appeal to every child. All the books in the series are carefully levelled, so it's easy to match every child to the right book for them. They also contain inside cover notes, to enable parents and teachers to support children in their reading. Help with children's reading development is also available at www.oxfordowl.co.uk.

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A Fascinating Glimpse into the World of the New Testament Transported two thousand years into the past, readers are introduced to Antipas, a Roman civic leader who has encountered the writings of the biblical author Luke. Luke's history sparks Antipas's interest, and they begin corresponding. While the account is fictional, the author is a highly respected New Testament scholar who weaves reliable historical information into a fascinating story, offering a fresh, engaging, and creative way to learn about the New Testament world. The first edition has been widely used in the classroom (over 30,000 copies sold). This updated edition, now with improved readability and narrative flow, will bring the social and political world of Jesus and his first followers to life for many more students of the Bible.

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This book asks whether the decision to lock down the world was justified in proportion to the potential harms and risks generated by the Covid-19 virus. Drawing on global, empirical data, it explores and exposes the social harms induced by lockdowns, many of which are 'hidden', including joblessness, mental health problems and an intensification of societal inequalities and divisions. It offers data-driven case studies on harms such as domestic violence, child abuse, the distress of being ordered to stay at home, and the numerous harms associated with the new wealth industries. It explores why some people weren't compliant with lockdown restrictions and examines the already vulnerable social groups who were disproportionally affected by lockdown including those who were locked in (care home residents), locked up (prisoners), and locked out (migrant workers, refugees). The book closes with a brief discussion on what the future might look like as we enter a post-Covid world, drawing on cutting-edge social theory.

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As the United States approaches its 50th year of mass incarceration, more children than ever before have experienced the incarceration of a parent. The vast majority of incarceration occurs in locally operated jails and disproportionately impacts families of color, those experiencing poverty, and rural households. However, we are only beginning to understand the various ways in which children cope with the incarceration of a parent – particularly the coping of young children who are most at risk for the adversity and also the most detrimentally impacted. When Are You Coming Home? helps answer questions about how young ones are faring when a parent is incarcerated in jail. Situated within a resilience model of development, the book presents findings related to children’s stress, family relationships, health, home environments, and visit experiences through the eyes of the children and families. This humanizing, social justice-oriented approach discusses the paramount need to support children and their families before, during, and after a parent’s incarceration while the country simultaneously grapples with strategies of reform and decarceration.

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An original graphic novel based on the IVF stories of its husband-and-wife authors and the 1-in-50 couples around the world like them. Conrad and Joanne met in their final year of university and have been virtually inseparable since then. For a while, it felt like they had all the time in the world. Yet now, when they are finally ready to have kids, they find that getting pregnant isn’t always so easy. Ahead of them lies a difficult, expensive, and emotional journey into the world of assisted fertility, where each ‘successful’ implantation is followed by a two-week wait to see if the pregnancy takes. Join Joanne and Conrad, their friends, their family, their coworkers, and a stream of expert medical practitioners as they experience the highs and the lows, the tears and the laughter in this sensitive but unflinching portrayal of the hope and heartbreak offered to so many by modern medicine.

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Meet Hilda – explorer, adventurer, avid sketchbook-keeper and friend to every creature in the valley! Well … almost every creature. We rejoin our favourite blue-haired heroine to find her warding off the nightmarish Marra, rescuing weather spirits and searching for the elusive black hound … and she's still got to make it to the Sparrow Scout badge ceremony on time! There is no shortage of unexpected twists, turns and new friends in this latest instalment of the Hilda fiction series.

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"The most important thing about being a dad is to be an example." Mark Wahlberg Welcome to The Father Hood. Where we celebrate the growing tribe of hands-on dads who are discovering that becoming a father is the greatest opportunity a man can have to be better than he's ever been before; stronger, wiser and more compassionate. But there is no instruction manual or benchmark for modern dads aside from one golden rule: keep showing up. With a mix of celebrity interviews - from Hugh Jackman, David Beckham, Osher Gunsberg and many more - as well as quotes and stats that capture the rise of the hands-on dad, The Father Hood is the guide to helping modern dads thrive and survive in the only job that really counts.

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Providing detailed and comprehensive coverage of the transitional justice field, this Research Handbook brings together leading scholars and practitioners to explore how societies deal with mass atrocities after periods of dictatorship or conflict. Situating the development of transitional justice in its historical context, social and political context, it analyses the legal instruments that have emerged. The Research Handbook is extensive in scope, with chapters discussing the concepts, actors, mechanisms and practices of transitional justice. They address the challenges of implementing a range of transitional justice mechanisms, including methods of truth recovery, criminal trials and reparation and lustration programmes. Going a step further, this book also expands the gaze of transitional justice to include underexplored areas, such as art and transitional justice, media and transitional justice and unique international case studies, such as Cambodia and Palestine. Timely and thought provoking, the Research Handbook on Transitional Justice will be of interest to both scholars and students, particularly those working in the areas of transitional justice and peace-building. It will also prove a valuable reference tool for practitioners of transitional justice and international criminal justice, helping to inform best practice.Contributors: A. Breslin, B.C. Browne, A. Davidian, S. Dezalay, P.J. Dixon, A. Fichtelberg, L.E. Fletcher J. Gallen, T. Hadden, T.O. Hansen, C. Harwood, R. Hodzic, C.M. Horne, E. Kenney, R. Killean, C. Lawther, P. McAuliffe, F. Mégret, L. Moffett, C. O'Rourke, J.R. Quinn, N. Roht-Arriaza, M. Schkolne, D.N. Sharp, L. Stan, D. Tolbert, C. Turner, R. Vagliano, H. van der Merwe, H.M. Weinstein

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In this rich and diverse collection, 28 writers describe what positive experiences they have had as an autistic person, and show how the most unexpected subject areas can be a source of the positive. They demonstrate that individuals can, and do, experience life in positive ways, sometimes in the face of adversity. Sharing both dark and joyful moments with unreserved honesty, their insights are moving, often hilarious, creative, and highly intelligent, and usually surprising. From hair-raising travelling experiences to parenting with verve, volunteering to teaching, running a marathon to taking on a PhD, they show that autism need not limit life. Introduced by Luke Beardon and Dean Worton, their stories challenge stereotypes surrounding autism, empower, and entertain.

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The laugh-out-loud new adventure featuring Jamie McFlair, from comedy duo Luke and Sean. Packed full of illustrations, this is perfect for 8+ readers and fans of Kid Normal and The Great Dream Robbery.Welcome to a new adventure starring our courageous young heroine Jamie McFlair, who so successfully thwarted her nasty uncle's monstrous plans a few months ago. But as we rejoin her, Jamie McFlair is ... sad. HUH!? Well, she just found out that she and her best friends - Daisy, Mel, and Jenners - are being split up and sent to different schools. Not one to admit defeat, Jamie discovers a way out of this unpleasant situation: Rubbsling's Academy for Creators, a school for famous kids. Because of their antics stopping the evil mastermind Barry Bigtime, Jamie and her friends have attracted some fans. It's enough to get them accepted into the school - they can stay together!But the school is ... weird. Located on a remote island, with strange teachers who give out punishments for NOT having your phone out in class, it all seems geared towards building the students' social media profiles. Though Daisy enjoys the attention, Jamie is suspicious that something isn't right. What is really going on at this school?Poor Jamie. What she's about to discover is that Barry Bigtime is bigtime back. Fallen from grace, outcast by society, and determined for revenge on Jamie, the school is the secret hiding place for his new plan...A plan to control the brains of all the children at the school, to make them do what he wants. A plan that is the first step towards controlling EVERY BRAIN ON THE PLANET!What questionable science is this!? How will this madness end?! Can Jamie rescue her friends and defeat Barry Bigtime once more, or will she become victim to THE ULTIMATE BRAIN HACK?

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In this world of challenges, we all need a hero … and here comes Bryson the Brave Bison! In the face of a big storm, Bryson shows his crew and the entire herd, that you can get through anything with a little bravery and self-confidence.Follow one brave bison as he leads his herd to face a challenge and overcome it in this original rhyming story. Combined with dynamic artwork from New York Times bestselling artist Richard Cowdrey, this legend comes alive!Bryson the Brave Bison: is written in lyrical rhyme perfect for read-alouds features unique vintage style artwork from NYT bestselling artist Richard Cowdrey highlights positive character traits such as bravery, courage, and trust is an ideal gift for any time of year From debut authors Nate Davenport and Luke Freshwater, Bryson the Brave Bison teaches children positive character traits such as bravery, honesty, and perseverance and shows them that with courage they can face the storms in life. Nate and Luke are good friends, intentional fathers, and business leaders who frequently speak about bravery and courage with their children and in business. Bryson the Brave Bison was inspired by Luke’s service as a firefighter in Idaho and as an Army bomb squad leader in the war in Afghanistan.

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MRCP Part 2: 450 BOFs, Second Edition offers a comprehensive selection of practice questions for trainees preparing for the MRCP Part 2 exam. Chapters are arranged by specialty and the weighting of questions is proportional to the exam. Thoroughly updated and featuring a wealth of practice questions that will test your ability to apply clinical understanding and make clinical judgements, this book is an essential revision tool to maximise the chances of exam success. Key points Gives practical advice on how to approach revision and useful tips to help improve exam technique Contains questions that accurately reflect the format and the range of difficulty in the exam Includes image interpretation questions in full colour

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Learn how to use managerial economics to diagnose and solve business problems with Froeb/McCann/Ward/Shor's MANAGERIAL ECONOMICS: A PROBLEM SOLVING APPROACH, 6E. This breakthrough text, designed specifically for upper-level and M.B.A. students like you, offers a succinct and fast-paced, yet challenging, approach full of invaluable insights. This edition incorporates less math and fewer technical models, graphs and figures than traditional managerial economics texts, while emphasizing the real decisions that today's managers face daily. The authors use models only to help you determine why mistakes are made and how to fix them. The latest economic updates introduce the most recent economic developments and current economic challenges worldwide. You learn how to apply economic theory to even the most formidable business challenges as interactive applications and MindTap digital resources reinforce understanding. Meaningful insights make this learning guide useful now and throughout your business career.

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'Luke is someone I trust implicitly with my hair.' Victoria Beckham'From the moment Luke Hersheson cut off my long locks ... I finally began to undersand my own hair ... My friend Lauren Laverne began to call Hershesons "The Happy Place".' Sali Hughes'Full of his amazing advice. Only person who could convince me to take the plunge and cut it all off.' Alice LevineWe all know the secret to happiness is a good hair day. It’s OK to take your hair seriously, because it’s more than just hair ­– it’s about confidence, it’s about self-expression, it’s all about feeling good in your own skin. This book will show you how.Practical, inspirational, products tested, myths-busted, all occasions covered. This book offers all the expert styling advice and hair dos and don’ts you will ever need from acclaimed fashion and A-list hairstylist Luke Hersheson, the man behind the iconic cuts and styles seen on runways for Missoni and Armani, in the pages of Vogue and i-D and worn by Keira Knightley, Sienna Miller, Emma Watson and Claudia Schiffer, among others.Foreword by beauty journalist Sali Hughes, bestselling author of Pretty Honest and Pretty Iconic. Chapters include:What’s Your Hair Type?It All Starts with a Good HaircutWhat You Need, What You Don’tYour Hair RoutineRules are There to Be BrokenHair at All AgesHair Goals Five Looks That Always WorkHair WoesGreat Hair From The Inside OutHair and Clothes, Hair Icons, Special Occasion Hair AND MORE!

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A NEW SCIENCE FICTION EPIC FROM THE MIND OF STAN LEE!From the mind of legendary comics creator Stan Lee, the architect of the Marvel Universe, comes Alliances: Orphans, a brand-new original graphic novel set in the New York Times best-selling Alliances universe, co-written by Lee with Luke Lieberman (Red Sonja) and Ryan Silbert (The Coldest Case). This cosmic adventure features fully painted artwork by Bill Sienkiewicz, who handles the prologue and cover, and Szymon Kudranski. Orphans blasts readers into the heart of our galaxy alongside William Ackerson, a man lost in space on a quest to find the source of his uncanny abilities. As gravity waves ripple across reality, warping time and space, he meets the Orphans. They are each the last of their kind, all their kin having been wiped outby the alien Hive: Little Boy, their giant childlike leader; Haze, a caustic creature of pure vapor; Rascal, a self-loathing zealot with dark secrets; and Critter, a being that's equal parts monster and puppy.This ragtag group find themselves in over their heads when their space-heist is hijacked. They have a stowaway with her own agenda: Samsi, the fearsome survivor of a civilization that once ruled the galaxy.Orphans is a fast-paced, intergalactic treasure hunt that explodes the Alliances universe into the cosmos. It introduces an extraordinary band of lone survivors, that must become a family to save the very fabric of reality.

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A new mystery has rolled onto Penfurzy island and the Rebel Bicycle Club are ready to investigate! Nessa, Demelza and Captain Honkers set-off to explore a travelling fun-fair when things begin to get strange. With new friends and a new legend to uncover, the bestfriends do what they do best: SAVE THE DAY FROM A FATE WORSE THAN HOMEWORK. A mysterious adventure with twists, turns and gross-out caravan invaders guaranteed to make you laugh!

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In addition to their invaluable role in the fight against infection, Toll-Like Receptors (TLRs) in an under- or over-active state can lead to the pathogenesis of disease, making these receptors a key focal point for many research laboratories. In Toll-Like Receptors: Methods and Protocols, experts in the field contribute techniques currently used to study TLRs, their downstream signalling pathways, and their role in the pathogenesis of disease, with sections examining TLR expression and the application of genetic techniques and microarray analysis to TLR research. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and Notes sections highlighting tips on troubleshooting and avoiding known pitfalls. Versatile and cutting-edge, Toll-Like Receptors: Methods and Protocols provides an ideal manual for a wide range of biologists and medical researchers studying these vital components of the immune system.

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A new but timeless strategy and mindset that should greatly help investors lower downside risk while achieving market outperformance In The 52-Week Low Formula: A Contrarian Strategy that Lowers Risk, Beats the Market, and Overcomes Human Emotion, wealth manager Luke L. Wiley, CFP examines the principles behind selecting the outstanding companies and great investment opportunities that are being overlooked. Along the way, Wiley offers a melding of the strategies used by such investment giants as Warren Buffett, Howard Marks, Michael Porter, Seth Klarman, and Pat Dorsey. His proven formula helps investors get the upper hand by identifying solid companies that are poised for growth but have fallen out of the spotlight. Shows you how to investigate companies and identify opportunities Includes detailed discussions of competitive advantage, purchase value, return on invested capital, and debt levels Presents several case studies to examine companies that have overcome obstacles by trading around their 52-week lows The 52-Week Low Formula is a must-read for investors and financial advisors who want to break through conventional strategies and avoid common mistakes.

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Free yourself from cosmological tyranny! Everything started in a Big Bang? Invisible dark matter? Black holes? Why accept such a weird cosmos? For all those who wonder about this bizarre universe, and those who want to overthrow the Big Bang, this handbook gives you 'just the facts': the observations that have shaped these ideas and theories. While the Big Bang holds the attention of scientists, it isn't perfect. The authors pull back the curtains, and show how cosmology really works. With this, you will know your enemy, cosmic revolutionary - arm yourself for the scientific arena where ideas must fight for survival! This uniquely-framed tour of modern cosmology gives a deeper understanding of the inner workings of this fascinating field. The portrait painted is realistic and raw, not idealized and airbrushed - it is science in all its messy detail, which doesn't pretend to have all the answers.

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Borders harm all of us: they must be abolished.Borders divide workers and families, fuel racial division, and reinforce global disparities. They encourage the expansion of technologies of surveillance and control, which impact migrants and citizens both.Bradley and de Noronha tell what should by now be a simple truth: borders are not only at the edges of national territory, in airports, or at border walls. Borders are everyday and everywhere; they follow people around and get between us, and disrupt our collective safety, freedom and flourishing. is a passionate manifesto for border abolition, arguing that we must transform society and our relationships to one another, and build a world in which everyone has the freedom to move and to stay.

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100 Questions (and Answers) About Action Research identifies and answers the essential questions on the process of systematically approaching your practice from an inquiry-oriented perspective, with a focus on improving that practice. This unique text offers progressive instructors an alternative to the research status quo and serves as a reference for readers to improve their practice as advocates for those they serve. The Question and Answer format makes this an ideal supplementary text for traditional research methods courses, and also a helpful guide for practitioners in education, social work, criminal justice, health, business, and other applied disciplines.

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Featuring contributed chapters from experts in the field, Handbook of Asian American Families provides readers with a developmental systems-based approach to understanding contemporary Asian American families. The book examines the intricacies of family relationships and dynamics within Asian American families and the structural factors that hinder or promote family functioning and the well-being of Asian immigrants and their descendants.The chapters present theoretical, conceptual, empirical, and practical discussion on the interworking of Asian American families with each focusing on key aspects of family relationships. Opening chapters introduce readers to the developmental systems-based perspective of the book, discuss the effects of immigration on Asian American families, and explore specific relationship dynamics, including motherhood, intimate relationships, coparenting, and multigenerational and intergenerational relationships. Readers learn about the dynamics of divorced families, stepfamilies, adoption, and multiracial families. Additional chapters cover the acculturation gap in Asian American families, mental health, racial-ethnic socialization, religion and interfaith relationships, and combating stereotypes, microagressions, racism, and the model minority myth. The closing chapter looks to the future, discussing opportunities for further research, theories, practices, and policies. Handbook of Asian American Families is part of the Cognella Series on Families and Social Justice, a collection of textbooks that support core curriculum within family-related disciplines with emphasis on issues related to social justice, diversity, and equity.

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Combining informative, meticulously crafted prose with more than 4,000 high-quality images, Osborn's Brain, third edition, is a comprehensive, easy to understand, and visually stunning learning curriculum from highly esteemed author Dr. Anne G. Osborn. This fully revised edition provides a solid framework for understanding the complex subject of brain imaging, integrating relevant information from Dr. Osborn's entire career of accumulated knowledge, experience, and interest in neuropathology, neurosurgery, and clinical neurosciences. While neuroradiologists will find intriguing, thought-provoking insights included especially for them in every chapter, Osborn's Brain is an excellent review resource for physicians at all levels of expertise-from seasoned radiologists and neurosurgeons to new and senior residents or fellows. Combines essential anatomy with gross pathology and imaging, clearly demonstrating why and how diseases appear the way they do and helping readers think clearly about diagnoses, types of diagnoses, and the various pathologies that can affect the brain Guides readers through the "must know” aspects of neuroimaging and neuropathology (brain trauma, stroke, vascular lesions, etc.) before zeroing in on such topics as infections, demyelinating and inflammatory diseases, neoplasms, toxic-metabolic-degenerative disorders, and congenital brain malformations Provides state-of-the-art coverage on such topics as new brain tumor entities, the effects of emerging viral illness such as COVID-19 on the brain, and recently delineated/named diseases (e.g., HIV-associated CD8 encephalitis) Features more than 4,000 stunning, high-resolution radiologic images and 100+ detailed, full-color medical illustrations, all of which are annotated to describe the most clinically significant features; and includes robust, digital-only galleries that contain hundreds of additional images that further illustrate each chapter Includes up-to-date nomenclature based on the 5th edition of the WHO Classification of Tumors, Central Nervous System, including a complete revision, expansion, and updating of CNS neoplasms with new entities, revised grading criteria, diagnostic molecular pathology, and nomenclature Contains Dr. Osborn's trademark summary boxes for a quick review of essential facts, signature graphics with additional radiological and pathologic correlations, and up-to-the-minute literature references Includes an eBook version?that enables you to access all text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud

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This book adopts collaborative autoethnography as its methodology, and presents the collective witnessing of experiences of the COVID-19 pandemic within the higher education sector. Through the presentation of staff and student experiences and what was learnt from them, the authors examine the global phenomenon that is the COVID-19 pandemic through the purposeful exploration of their own experiences. This book presents an overall argument about the state of higher education in the middle of the pandemic and highlights academic issues and region-specific challenges. The reflections presented in this book offer insights for other staff and students, as well as academic policy-makers, regarding the pandemic experiences of those within academia. It also offers practical suggestions as to how we as a global community can move forward post-pandemic.

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Part of the renowned Braunwald family of references, Hypertension: A Companion to Braunwald’s Heart Disease provides today’s clinicians with clear, authoritative guidance on every aspect of managing and treating patients who suffer from hypertensive disorders. An invaluable resource for cardiologists, endocrinologists, and nephrologists, this one-stop reference covers all the latest developments from basic science to clinical trials and guidelines related to the treatment of common to complex hypertension. Now fully updated from cover to cover, the 4th Edition offers unparalleled coverage of hypertension in an accessible and user-friendly manner. Thoroughly covers new treatment guidelines related to recent research and the latest physiologic understanding for a wide range of patients with hypertension and related co-morbidities. Includes new chapters on Hypertension in Women, Mineralocorticoid Receptor Antagonists, Exercise and Hypertension, and Telemedicine/Digital Health. Contains new or expanded content on epidemiology, pathophysiology, immunology, clinical findings, laboratory testing, invasive and non-invasive testing, risk stratification, clinical decision-making, prognosis, and management. Provides new chapter summaries and a new focus on clinical and actionable content using a streamlined, narrative format. Covers behavior management and prevention as an integral part of hypertensive and pre-hypertensive treatment plans. Highlights combination drug therapies and management of chronic complications of hypertension. Offers expert guidance from worldwide experts in cardiology, endocrinology, and nephrology, and integrates the most recent guidelines from leading organizations around the world. An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date.

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The late Navjot Sodhi conceived this book as a way of bringing to the forefront of our conservation planning for the tropics the views of people who were actually working and living there. In its 31 chapters, 55 authors present their views on the conservation problems they face and how they deal with them. Effective long term conservation in the tropics requires the full participation of local people, organizations and governments. The human population of tropical countries is expected to grow by more than 2.5 billion people over the next several decades, with expectations of increased consumption levels growing even more rapidly than population levels; clearly there will be a need for more trained conservationists and biologists. Significant levels of local involvement are essential to conservation success, with the rights of local people fully recognized, protected and fostered by governmental and international assistance. Overarching conservation plans are necessary, but cannot in themselves lead to success. The individual experiences presented in the pages of this book will provide useful models that may serve to build better and more sustainable lives for the people who live in the tropics and lead to the continued survival of as many species and functioning ecosystems as possible.

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As featured on BBC RADIO 4's Start the Week: a dazzling look at modern videogame worlds seen through an architectural lens, utilizing maps, diagrams and graphic illustrations to offer new perspectives on the art of virtual world building. Videogame Atlas presents a journey through twelve well-known videogame worlds via panoramic maps, intricate exploded diagrams and detailed illustrations. The book offers a playful new way of seeing these beloved virtual worlds using the practices and academic rigour that underpins real-world architectural theory. Titles such as Minecraft, Assassin’s Creed Unity and Final Fantasy VII are explored in exhaustive detail through over 200 detailed illustrations of the micro and macro, each with supporting commentary and architectural theory. Taking influence from high-end architectural monographs, the book is carefully designed to the smallest of details and its production is intricately executed. This book, printed in five colours, with neon ink throughout, is a culmination of Luke and Sandra’s work, which includes founding the Videogame Urbanism studio at the Bartlett School of Architecture, UCL that promotes the use of game technologies in architectural education.

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