Search results for ""elsevier science""

This comprehensive handbook is a "one-stop-shop" for all researchers involved in the field of alcohol-related harm at the whole body or cellular level. Over 100 chapters provide abundant information of a wide range of topics that extend from the evolutionary aspects of alcohol consumption and the prevalence of alcohol misuse to programmed cell death. Each chapter is highly illustrated with tables and figures making this a valuable reference for students, clinicians and researchers alike.

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The new edition of Seeds contains new information on many topics discussed in the first edition, such as fruit/seed heteromorphism, breaking of physical dormancy and effects of inbreeding depression on germination. New topics have been added to each chapter, including dichotomous keys to types of seeds and kinds of dormancy; a hierarchical dormancy classification system; role of seed banks in restoration of plant communities; and seed germination in relation to parental effects, pollen competition, local adaption, climate change and karrikinolide in smoke from burning plants. The database for the world biogeography of seed dormancy has been expanded from 3,580 to about 13,600 species. New insights are presented on seed dormancy and germination ecology of species with specialized life cycles or habitat requirements such as orchids, parasitic, aquatics and halophytes. Information from various fields of science has been combined with seed dormancy data to increase our understanding of the evolutionary/phylogenetic origins and relationships of the various kinds of seed dormancy (and nondormancy) and the conditions under which each may have evolved. This comprehensive synthesis of information on the ecology, biogeography and evolution of seeds provides a thorough overview of whole-seed biology that will facilitate and help focus research efforts.

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The Encyclopedia of the Solar System, Third Edition—winner of the 2015 PROSE Award in Cosmology & Astronomy from the Association of American Publishers—provides a framework for understanding the origin and evolution of the solar system, historical discoveries, and details about planetary bodies and how they interact—with an astounding breadth of content and breathtaking visual impact. The encyclopedia includes the latest explorations and observations, hundreds of color digital images and illustrations, and over 1,000 pages. It stands alone as the definitive work in this field, and will serve as a modern messenger of scientific discovery and provide a look into the future of our solar system. New additions to the third edition reflect the latest progress and growth in the field, including past and present space missions to the terrestrial planets, the outer solar systems and space telescopes used to detect extrasolar planets.

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Since its first edition in 1982, the Paxinos and Watson rat brain atlas has become the most trusted source of accurate coordinates and anatomical information in laboratories throughout the world. It has been cited over 60,000 times, making it the most cited publication in neuroscience. The seventh edition incorporates new findings on developmental gene expression and presents the boundaries of neuromeres in sagittal sections.

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Advances in Catalysis, Volume 69 fills the gap between journal papers and textbooks across the diverse areas of catalysis research. For more than 60 years, this series has dedicated itself to record and present the latest progress in the field of catalysis, providing the scientific community with comprehensive and authoritative reviews. This series is an invaluable and comprehensive resource for chemical engineers and chemists working in the field of catalysis in both academia and industry, with this release focusing on solid acids, surface acidity and heterogeneous acid catalysis.

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Cognitive Systems and Signal Processing in Image Processing presents different frameworks and applications of cognitive signal processing methods in image processing. This book provides an overview of recent applications in image processing by cognitive signal processing methods in the context of Big Data and Cognitive AI. It presents the amalgamation of cognitive systems and signal processing in the context of image processing approaches in solving various real-word application domains. This book reports the latest progress in cognitive big data and sustainable computing. Various real-time case studies and implemented works are discussed for better understanding and more clarity to readers. The combined model of cognitive data intelligence with learning methods can be used to analyze emerging patterns, spot business opportunities, and take care of critical process-centric issues for computer vision in real-time.

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Fundamentals of Heat and Fluid Flow in High Temperature Fuel Cells introduces key-concepts relating to heat, fluid and mass transfer as applied to high temperature fuel cells. The book briefly covers different type of fuel cells and discusses solid oxide fuel cells in detail, presenting related mass, momentum, energy and species equation. It then examines real case studies of hydrogen- and methane-fed SOFC, as well as combined heat and power and hybrid energy systems. This comprehensive reference is a useful resource for those working in high temperature fuel cell modeling and development, including energy researchers, engineers and graduate students.

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Gigantism and Acromegaly brings together pituitary experts, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches. This book serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable as it provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as recommended approaches to evaluation and management. Acromegaly is a rare pituitary disorder that slowly changes its adult victim’s appearance over time: larger hands and feet, bigger jaw, forehead, nose, and lips. Generally, a benign pituitary tumor is the cause and symptoms of acromegaly can vary from patient to patient, making a diagnosis difficult and prolonging suffering for years. Early detection is key in the management of acromegaly as the pathologic effects of increased growth hormone (GH) production are progressive and can be life-threatening as the result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies.

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Cell and Tissue Destruction: Mechanisms, Protection, and Disorders provides an overview of the main mechanisms responsible for degradation in human beings and summarizes important strategies to counter these mechanisms. This book details the properties and limits of protective mechanisms, along with disturbances to systematic physiological functions. It provides examples of disease states resulting from the limits of protective systems. Three sections consider the physical and chemical reasons for destruction in living systems, protection against cytotoxic components, and the development of pathologic states. This book provides neuroscientists, cancer researchers and physicians with robust, overall coverage of the interrelated processes involved in cell and tissue destruction in living structures, and concomitant protective mechanisms and their limitations.

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Atlas of the Morphology of the Human Cerebral Cortex on the Average MNI Brain provides a comprehensive identification of the sulci and gyri of the human brain on a series of coronal sections of the average MNI brain and identifies the likely location of the cytoarchitectonic areas of the cerebral cortex. Presentation in MNI Stereotaxic Space enables the atlas to serve as a useful working tool for structural/functional neuroimagers attempting to identify the sulcus or gyrus and the likely cytoarchitectonic area within which a functional activation or a structural change has occurred. A brief introductory section discusses the history and current state of studies of the sulcal and gyral morphology and cytoarchitecture of the human cerebral cortex.

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The classic textbook on fluid mechanics is revised and updated by Dr. David Dowling to better illustrate this important subject for modern students. With topics and concepts presented in a clear and accessible way, Fluid Mechanics guides students from the fundamentals to the analysis and application of fluid mechanics, including compressible flow and such diverse applications as aerodynamics and geophysical fluid mechanics. Its broad and deep coverage is ideal for both a first or second course in fluid dynamics at the graduate or advanced undergraduate level, and is well-suited to the needs of modern scientists, engineers, mathematicians, and others seeking fluid mechanics knowledge.

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Advanced Topics in Forensic DNA Typing: Interpretation builds upon the previous two editions of John Butler’s internationally acclaimed Forensic DNA Typing textbook with forensic DNA analysts as its primary audience. Intended as a third-edition companion to the Fundamentals of Forensic DNA Typing volume published in 2010 and Advanced Topics in Forensic DNA Typing: Methodology published in 2012, this book contains 16 chapters with 4 appendices providing up-to-date coverage of essential topics in this important field. Over 80 % of the content of this book is new compared to previous editions.

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In the forensic context it is quite common for nonhuman bones to be confused with human remains and end up in the medical examiner or coroner system. It is also quite common for skeletal remains (both human and nonhuman) to be discovered in archaeological contexts. While the difference between human and nonhuman bones is often very striking, it can also be quite subtle. Fragmentation only compounds the problem. The ability to differentiate between human and nonhuman bones is dependent on the training of the analyst and the available reference and/or comparative material. Comparative Osteology is a photographic atlas of common North American animal bones designed for use as a laboratory and field guide by the forensic scientist or archaeologist. The intent of the guide is not to be inclusive of all animals, but rather to present some of the most common species which also have the highest likelihood of being potentially confused with human remains.

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Advances in Feedstock Conversion Technologies for Alternative Fuels and Bioproducts: New Technologies, Challenges and Opportunities highlights the novel applications of, and new methodologies for, the advancement of biological, biochemical, thermochemical and chemical conversion systems that are required for biofuels production. The book addresses the environmental impact of value added bio-products and agricultural modernization, along with the risk assessment of industrial scaling. The book also stresses the urgency in finding creative, efficient and sustainable solutions for environmentally conscious biofuels, while underlining pertinent technical, environmental, economic, regulatory and social issues. Users will find a basis for technology assessments, current research capability, progress, and advances, as well as the challenges associated with biofuels at an industrial scale, with insights towards forthcoming developments in the industry.

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EEG Brain Signal Classification for Epileptic Seizure Disorder Detection provides the knowledge necessary to classify EEG brain signals to detect epileptic seizures using machine learning techniques. Chapters present an overview of machine learning techniques and the tools available, discuss previous studies, present empirical studies on the performance of the NN and SVM classifiers, discuss RBF neural networks trained with an improved PSO algorithm for epilepsy identification, and cover ABC algorithm optimized RBFNN for classification of EEG signal. Final chapter present future developments in the field. This book is a valuable source for bioinformaticians, medical doctors and other members of the biomedical field who need the most recent and promising automated techniques for EEG classification.

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Advances in Nanosensors for Biological and Environmental Analysis presents the current state-of-art in nanosensors for biological and environmental analysis, also covering commercial aspects. Broadly, the book provides detailed information on the emergence of different types of nanomaterials as transduction platforms used in the development of nanosensors. These include carbon nanotubes, graphene, 2-D transition metal dichalcogenides, conducting polymers and metal organic frameworks. Additional topics include sections on the way nanosensors have inspired new product development in various types of biological and environmental applications that are currently available and on the horizon.

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Advances in Food and Nutrition Research, Volume 87 provides updated information on nutrients in foods and how to avoid deficiency, especially the essential nutrients that should be present in the diet to reduce disease risk and optimize health. The book provides the latest advances on the identification and characterization of emerging bioactive compounds with putative health benefits. Chapters in this new release include discussions of the function and application of bioactive peptides from corn gluten meal, Dietary fatty acids and metabolic syndrome, the Microbial ecology of plant-based fermented foods and current knowledge on their impact on human health, and much more.

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Nanocrystalline Titanium discusses the features of nanocrystalline titanium production by various SPD methods, also comparing their microstructure and properties. The authors characterize the physical, chemical and mechanical properties of ultrafine grained titanium, indicating which are crucial for their application. Titanium alloys are characterized by high specific strength combined with excellent corrosion resistance, whereas the mechanical properties of pure (or commercial purity - CP) titanium are much lower. SPD methods are proving to be an effective way to increase strength, even to a level typical for structural titanium alloys. This book is useful for academics and professionals studying the behavior of metallic materials.

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Nanomaterials in Plants, Algae and Microorganisms: Concepts and Controversies: Volume One discusses the vast amount of nanomaterials that have been released into the environment in a relatively short amount of time. There is a need to understand what the implications to the health of our biota and ecosystems are as the earth is increasingly inundated with these materials. Not all of the effects are negative, but their impacts are increasing exponentially due to their size, quantity and other factors.

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Mathematica by Example, Sixth Edition is an essential resource for the Mathematica user, providing step-by-step instructions on achieving results from this powerful software tool. The book fully accounts for the changes to functionality and visualization capabilities and accomodates the full array of new extensions in the types of data and problems that Mathematica can immediately handle, including cloud services and systems, geographic and geometric computation, dynamic visualization, interactive applications and other improvements. It is an ideal text for scientific students, researchers, and aspiring programmers seeking further understanding of Mathematica. Written by seasoned practitioners with a view to practical implementation and problem-solving, the book's pedagogy is delivered clearly and without jargon using representative biological, physical and engineering problems. Code is provided on an ancillary website to support the use of Mathematica across diverse applications and subject areas.

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Differential Equations with Mathematica, Fifth Edition uses the fundamental concepts of the popular platform to solve (analytically, numerically, and/or graphically) differential equations of interest to students, instructors, and scientists. Mathematica’s diversity makes it particularly well suited to performing calculations encountered when solving many ordinary and partial differential equations. In some cases, Mathematica’s built-in functions can immediately solve a differential equation by providing an explicit, implicit, or numerical solution. In other cases, Mathematica can be used to perform the calculations encountered when solving a differential equation. Because one goal of elementary differential equations courses is to introduce students to basic methods and algorithms so that they gain proficiency in them, nearly every topic covered this book introduces basic commands, also including typical examples of their application. A study of differential equations relies on concepts from calculus and linear algebra, so this text also includes discussions of relevant commands useful in those areas. In many cases, seeing a solution graphically is most meaningful, so the book relies heavily on Mathematica’s outstanding graphics capabilities.

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Diagnosis and Treatment of Traumatic Brain Injury will improve readers’ understanding of the complexities of diagnosis and management of traumatic brain injuries. Featuring chapters on drug delivery, different treatments, and rehabilitation, this volume discusses in detail the impact early diagnosis and effective management has on the long-term prognosis of these injuries and the lives of those affected. This book will be relevant for neuroscientists, neurologists, clinicians, and anyone working to better understand these injuries.

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Elementary Linear Algebra, Sixth Edition provides a solid introduction to both the computational and theoretical aspects of linear algebra, covering many important real-world applications, including graph theory, circuit theory, Markov chains, elementary coding theory, least-squares polynomials and least-squares solutions for inconsistent systems, differential equations, computer graphics and quadratic forms. In addition, many computational techniques in linear algebra are presented, including iterative methods for solving linear systems, LDU Decomposition, the Power Method for finding eigenvalues, QR Decomposition, and Singular Value Decomposition and its usefulness in digital imaging.

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Applied Numerical Methods for Chemical Engineers emphasizes the derivation of a variety of numerical methods and their application to the solution of engineering problems, with special attention to problems in the chemical engineering field. These algorithms encompass linear and nonlinear algebraic equations, eigenvalue problems, finite difference methods, interpolation, differentiation and integration, ordinary differential equations, boundary value problems, partial differential equations, and linear and nonlinear regression analysis. MATLAB is adopted as the calculation environment throughout the book because of its ability to perform all the calculations in matrix form, its large library of built-in functions, its strong structural language, and its rich graphical visualization tools. Through this book, students and other users will learn about the basic features, advantages and disadvantages of various numerical methods, learn and practice many useful m-files developed for different numerical methods in addition to the MATLAB built-in solvers, develop and set up mathematical models for problems commonly encountered in chemical engineering, and solve chemical engineering related problems through examples and after-chapter problems with MATLAB by creating application m-files.

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Wetzel’s Limnology: Lake and River Ecosystems, Fourth Edition, presents a fully updated revision of the classic textbook Limnology: Lake and River Ecosystems - last published in 2001. The coverage has been thoroughly updated with recent research and theoretical developments. Each chapter of this edited volume has been written by an expert, or team of experts, providing a comprehensive and global perspective, with the editors working closely with the authors to maintain continuity within and between the chapters. This is not only an essential textbook for undergraduate and graduate students in limnology but also a standard reference book for seasoned limnologists and other scientists.

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Mitochondrial Diseases, Volume 194 presents the most common clinical manifestations, providing an up-to-date summaries on the clinical presentations, diagnostic processes, genetic counseling and treatment options in mitochondrial diseases. Contents include specialist biochemical analyses and targeted molecular genetic testing, as well as first-line genome-wide sequencing to accelerate speed of diagnosis while avoiding time-consuming, expensive and invasive investigations. Establishing a genetic diagnosis allows patients with mitochondrial diseases to have reproductive options, all of which are covered within. This book is intended for neurologists to help them recognize and manage patients with mitochondrial diseases.

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Basic Statistics with R: Reaching Decisions with Data provides an understanding of the processes at work in using data for results. Sections cover data collection and discuss exploratory analyses, including visual graphs, numerical summaries, and relationships between variables - basic probability, and statistical inference - including hypothesis testing and confidence intervals. All topics are taught using real-data drawn from various fields, including economics, biology, political science and sports. Using this wide variety of motivating examples allows students to directly connect and make statistics essential to their field of interest, rather than seeing it as a separate and ancillary knowledge area. In addition to introducing students to statistical topics using real data, the book provides a gentle introduction to coding, having the students use the statistical language and software R. Students learn to load data, calculate summary statistics, create graphs and do statistical inference using R with either Windows or Macintosh machines.

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Machine Learning: A Bayesian and Optimization Perspective, 2nd edition, gives a unified perspective on machine learning by covering both pillars of supervised learning, namely regression and classification. The book starts with the basics, including mean square, least squares and maximum likelihood methods, ridge regression, Bayesian decision theory classification, logistic regression, and decision trees. It then progresses to more recent techniques, covering sparse modelling methods, learning in reproducing kernel Hilbert spaces and support vector machines, Bayesian inference with a focus on the EM algorithm and its approximate inference variational versions, Monte Carlo methods, probabilistic graphical models focusing on Bayesian networks, hidden Markov models and particle filtering. Dimensionality reduction and latent variables modelling are also considered in depth. This palette of techniques concludes with an extended chapter on neural networks and deep learning architectures. The book also covers the fundamentals of statistical parameter estimation, Wiener and Kalman filtering, convexity and convex optimization, including a chapter on stochastic approximation and the gradient descent family of algorithms, presenting related online learning techniques as well as concepts and algorithmic versions for distributed optimization. Focusing on the physical reasoning behind the mathematics, without sacrificing rigor, all the various methods and techniques are explained in depth, supported by examples and problems, giving an invaluable resource to the student and researcher for understanding and applying machine learning concepts. Most of the chapters include typical case studies and computer exercises, both in MATLAB and Python. The chapters are written to be as self-contained as possible, making the text suitable for different courses: pattern recognition, statistical/adaptive signal processing, statistical/Bayesian learning, as well as courses on sparse modeling, deep learning, and probabilistic graphical models. New to this edition: Complete re-write of the chapter on Neural Networks and Deep Learning to reflect the latest advances since the 1st edition. The chapter, starting from the basic perceptron and feed-forward neural networks concepts, now presents an in depth treatment of deep networks, including recent optimization algorithms, batch normalization, regularization techniques such as the dropout method, convolutional neural networks, recurrent neural networks, attention mechanisms, adversarial examples and training, capsule networks and generative architectures, such as restricted Boltzman machines (RBMs), variational autoencoders and generative adversarial networks (GANs). Expanded treatment of Bayesian learning to include nonparametric Bayesian methods, with a focus on the Chinese restaurant and the Indian buffet processes.

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The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is a comprehensive reference to the aspects, features and effects of depression. This book provides readers with the behavior and psychopathological effects of depression, linking anxiety, anger and PSTD to depression. Readers are provided with a detailed outline of the genetic aspects of depression including synaptic genes and the genome-wide association studies (GWAS) of depression, followed by a thorough analysis of the neurological and imaging techniques used to study depression. This book also includes three full sections on the various effects of depression, including diet, nutrition and molecular and cellular effects. The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is the only resource for researchers and practitioners studying depression.

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Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator’s fields. This book bridges the knowledge gaps that invariably lead to communication issues in a new scientist’s early career, providing a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development. It provides students, new industrial scientists, and academics with a basic understanding of the drug discovery and development process. The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles of in vivo pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process.

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Biomedical Engineering Design presents the design processes and practices used in academic and industry medical device design projects. The first two chapters are an overview of the design process, project management and working on technical teams. Further chapters follow the general order of a design sequence in biomedical engineering, from problem identification to validation and verification testing. The first seven chapters, or parts of them, can be used for first-year and sophomore design classes. The next six chapters are primarily for upper-level students and include in-depth discussions of detailed design, testing, standards, regulatory requirements and ethics. The last two chapters summarize the various activities that industry engineers might be involved in to commercialize a medical device.

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Paxinos and Franklin's The Mouse Brain in Stereotaxic Coordinates, Compact Fifth Edition, is the compact version of the most widely used and cited atlas of the mouse brain in print. It emulates in design and accuracy Paxinos and Watson’s The Rat Brain in Stereotaxic Coordinates, the most cited publication in neuroscience. The compact edition provides the coronal plates and diagrams of the full mouse atlas in a smaller, more convenient spiral format and at a student friendly price. High resolution digital photographs of the coronal plane of section from the full 5th edition complement the coronal drawings. Unique to the compact, it includes an introduction to the use of the atlas in stereotaxic surgery.

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Encyclopedia of Caves, Third Edition, provides detailed background information to anyone with a serious interest in caves. This includes students, both undergraduate and graduate, in the earth, biological and environmental sciences, and consultants, environmental scientists, land managers and government agency staff whose work requires them to know something about caves and the biota that inhabit them. Caves touch on many scientific interests in geology, climate science, biology, hydrology, archaeology, and paleontology, as well as more popular interests in sport caving and cave exploration. Case studies and descriptions of specific caves selected for their special features and public interest are also included. This book will appeal to these audiences by providing in-depth essays written by expert authors chosen for their expertise in their assigned subject.

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Malignant Pleural Mesothelioma: A Guide for Clinicians is a practical book developed to assist clinicians, pathologist and molecular biologist in the management of malignant pleural mesothelioma (MPM). MPM represents a challenge in terms of diagnosis, staging and treatment, and to date, the optimal management of MPM patients has not yet been clearly defined – and this book is intended to be an efficient tool for these cases. The book encompasses topics such as epidemiology and surveillance evidence, multimodality imaging assessment of MPM, pathology, molecular mechanisms and treatment of such disease. Additionally, it discusses the standard operative procedures and the future directions for the management of MPM from experts’ experiences. Malignant Pleural Mesothelioma: A Guide for Clinicians is a valuable source for oncologists, pathologist, cancer researchers, thoracic specialists and several members of biomedical field who needs to learn more from experts about the diagnosis, operative procedures and treatment of malignant pleural mesothelioma.

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The Autoimmune Diseases, Sixth Edition, emphasizes the "3 P’s" of 21st Century medicine: precision, prediction and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. Chapters emphasize the immunologic basis of the disease as well as the use of immunologic diagnostic methods and treatments. The book also covers several cross-cutting issues related to the recognition and treatment of autoimmune diseases, including chapters on the measurement of autoantibodies and T cells, the use of biomarkers as early predictors of disease, and new methods of treatment.

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Veterinary Toxicology, Basic and Clinical Principles, Third Edition, is a unique, single reference that teaches the basic principles of veterinary toxicology to any student at the DVM, MS or PhD level. While comparable texts are primarily directed on the field of human toxicology, this text thoroughly prepares toxicologists and students on the newest approaches for diagnosing chemical and plant poisoning cases in animals. Many chapters on topics not covered in any previous books are provided, such as target organ toxicity, radiation and radioactive materials, FDA regulatory issues, and ethics in veterinary toxicology. Completely revised and updated to include the most recent developments in the field, including new toxins, methods and regions, this book is an essential resource for advanced students and researchers in toxicology, practicing veterinary toxicologists, poison control centers, marine biologists, environmentalists and animal scientists.

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Thorp and Covich’s Freshwater Invertebrates, Fourth Edition: Keys to Neotropical Hexapoda, Volume Three, provides a guide for identifying and evaluating a key subphylum, hexapoda, for Central America, South America and the Antarctic. This book is essential for anyone working in water quality management, conservation, ecology or related fields in this region, and is developed to be the most modern and consistent set of taxonomic keys available. It is part of a series that is designed to provide a highly comprehensive, current set of keys for a given bioregion, with all keys written in a consistent style. This series can be used for a full spectrum of interested readers, from students, to university professors and government agencies.

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Every species has to preserve the integrity of its genome to ensure faithful passage of genetic information to the progeny. At the same time, there are times during the life of the organism and population in general when a fine balance in genome stability and diversification has to be made to benefit the survival of the species. Genome Stability teaches the reader how various species maintain this fine balance in genome stability and genome diversification in response to their environments. Genome Stability covers a wide range of topics, including the genome stability of DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes and mammals. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability as well as changes in genome stability in response to aging. Finally, Genome Stability covers how epigenetic factors contribute to genome stability and how the species pass the memory of the encounters to the progeny, thus influencing the genome of the progeny in an indirect manner. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly-expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability.

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Boorman’s Pathology of the Rat: Reference and Atlas, Second Edition, continues its history as the most comprehensive pathology reference on rat strains for researchers across science and medicine using rat models in the laboratory. It offers readers an added emphasis on the Sprague-Dawley and Wistar rat strains that is consistent with current research across academia, government, and industry. In addition, the book provides standard diagnostic criteria, basic content on histology, histological changes that result from drug toxicity and neoplasm, pathology terminology, and four-color photographs from the NTP archive and database. With updated references and photographs, as well as coverage of all rat strains, this book is not only the standard in the field, but also an invaluable resource for toxicologists, biologists, and other scientists engaged in regulatory toxicology who must make the transition from pathology results to the promulgation of meaningful regulations.

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Volcanoes are unquestionably one of the most spectacular and awe-inspiring features of the physical world. Our paradoxical fascination with them stems from their majestic beauty and powerful, sometimes deadly, destructiveness. Notwithstanding the tremendous advances in volcanology since ancient times, some of the mystery surrounding volcanic eruptions remains today. The Encyclopedia of Volcanoes summarizes our present knowledge of volcanoes; it provides a comprehensive source of information on the causes of volcanic eruptions and both the destructive and beneficial effects. The early chapters focus on the science of volcanism (melting of source rocks, ascent of magma, eruption processes, extraterrestrial volcanism, etc.). Later chapters discuss human interface with volcanoes, including the history of volcanology, geothermal energy resources, interaction with the oceans and atmosphere, health aspects of volcanism, mitigation of volcanic disasters, post-eruption ecology, and the impact of eruptions on organismal biodiversity.

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Readers familiar with the first three editions of Ecology and Classification of North American Freshwater Invertebrates (edited by J.H. Thorp and A.P. Covich) will welcome the comprehensive revision and expansion of that trusted professional reference manual and educational textbook from a single North American tome into a developing multi-volume series covering inland water invertebrates of the world. The series entitled Thorp and Covich’s Freshwater Invertebrates (edited by J.H. Thorp) begins with the current Volume I: Ecology and General Biology (edited by J.H. Thorp and D.C. Rogers), which is designed as a companion volume for the remaining books in the series. Those following volumes provide taxonomic coverage for specific zoogeographic regions of the world, starting with Keys to Nearctic Fauna (Vol. II) and Keys to Palaearctic Fauna (Vol. III). Volume I maintains the ecological and general biological focus of the previous editions but now expands coverage globally in all chapters, includes more taxonomic groups (e.g., chapters on individual insect orders), and covers additional functional topics such as invasive species, economic impacts, and functional ecology. As in previous editions, the 4th edition of Ecology and Classification of North American Freshwater Invertebrates is designed for use by professionals in universities, government agencies, and private companies as well as by undergraduate and graduate students.

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