Search results for ""Author Philip Dawson""

It is commonly agreed that the history of France at the end of the eighteenth century was influenced powerfully, at times decisively, by collective interests and group actions. Yet, as Philip Dawson shows, this consensus has been the foundation of endless scholarly argument over the purposes of group actions and their effects on economic, political, and intellectual life, the accuracy of facts reported, the validity of different methods of analysis, and the significance of the whole topic for previous and subsequent human experience. In probing these questions, this monograph contributes research findings to the historical controversy over the political motives and conduct of the upper bourgeoisie during the French Revolution.Chosen for study is a well-defined occupational group near the pinnacle of the bourgeoisie, the 2700 judicial officeholders in the bailliages and sénéchaussées--royal courts from which appeals were taken to the parlements. These lower-court magistrates were generally well-to-do and esteemed personages in the provincial bourgeoisie, who could potentially be drawn to either side in a political struggle between nobility and bourgeoisie. They constituted more than 20 percent of the bourgeois representation in the Estates General of 1789. Revolutionary legislation abolished their offices, but many of them remained active in politics even under the revolutionary republic.Dawson makes use of a variety of manuscript materials pertinent to the magistrates as he treats their activities as members of corporate groups before 1790 and follows many of them as individuals through the revolutionary years to 1795. In part, the book is based on biographical data relating to 230 magistrates--all who were in office in the provinces of Burgundy and Poitou at the outbreak of the revolution. By the end of 1789, the author concludes, most of the magistrates came to accept revolutionary change because alternative courses of action had been made more unacceptable to them. It was their support that helped to make possible the revolutionary process itself. "They were not the leaders of the revolutionary bourgeoisie. Before 1789, they had been in the highest rank of the bourgeoisie and they remained a notable part of it, but most of them had come to support revolution hesitantly, cautiously, with moderation and many a backward glance."

Read more less

How to synthesize native and modified proteins in the test tube With contributions from a panel of experts representing a range of disciplines, Total Chemical Synthesis of Proteins presents a carefully curated collection of synthetic approaches and strategies for the total synthesis of native and modified proteins. Comprehensive in scope, this important reference explores the three main chemoselective ligation methods for assembling unprotected peptide segments, including native chemical ligation (NCL). It includes information on synthetic strategies for the complex polypeptides that constitute glycoproteins, sulfoproteins, and membrane proteins, as well as their characterization. In addition, important areas of application for total protein synthesis are detailed, such as protein crystallography, protein engineering, and biomedical research. The authors also discuss the synthetic challenges that remain to be addressed. This unmatched resource: Contains valuable insights from the pioneers in the field of chemical protein synthesis Presents proven synthetic approaches for a range of protein families Explores key applications of precisely controlled protein synthesis, including novel diagnostics and therapeutics Written for organic chemists, biochemists, biotechnologists, and molecular biologists, Total Chemical Synthesis of Proteins provides key knowledge for everyone venturing into the burgeoning field of protein design and synthetic biology.

Read more less

This timely, one-stop reference is the first on an emerging and interdisciplinary topic. Covering both established and recently developed ligation chemistries, the book is divided into two didactic parts: a section that focuses on the details of bioorthogonal and chemoselective ligation reactions at the level of fundamental organic chemistry, and a section that focuses on applications, particularly in the areas of chemical biology, biomaterials, and bioanalysis, highlighting the capabilities and benefits of the ligation reactions. With chapters authored by outstanding scientists who range from trailblazers in the field to young and emerging leaders, this book on a highly interdisciplinary topic will be of great interest for biochemists, biologists, materials scientists, pharmaceutical chemists, organic chemists, and many others.

Read more less