Search results for ""taylor francis""

The costs associated with a drug’s clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans.Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairment examines some of the most popular and successful animal archetypes used in the context of drug discovery. It provides integrated coverage of the latest research concerning neuronal systems relevant to cognitive function and dysfunction, assimilating reviews of this research within the context of each chapter. This approach is unique in that it brings together molecular and neurochemical methodologies, behavioral applications in translational models, and clinical applications. The book comprehensively discusses a wide variety of animal models of cognitive impairment, including genetic, lesion, pharmacological, and aging related impairments. It also explores the significance of this research in regards to the treatment of various addictions and disorders such as stroke, autism, Alzheimer’s, schizophrenia, and ADHD. Edited by two renowned authorities in the field, Animal Models of Cognitive Impairment is a timely book that provides integrated coverage of cutting-edge research that concerns neuronal systems relevant to cognitive function and dysfunction.

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Scientists, health professionals, and consumers are increasingly interested in the relationships between food components and food-drug combinations as they strive to find more effective ways to prevent or treat chronic disease. As one of the first unified and in-depth sources in this emerging topic, Food-Drug Synergy and Safety explores the vast potential benefits of food and food-drug synergy. The book addresses the interaction of two or more components within a single food, between several foods, or between foods and drugs consumed together, in which the potential health benefit is greater than the effect of the single component, food, or drug. Each chapter follows a consistent framework and addresses the health benefits, mechanisms of action, and safety aspects pertaining to the food and food-drug synergies. Sections discuss food and food-drug synergies in the context of specific disease groups, such as cardiovascular disease, cancer, osteoporosis, inflammatory diseases, hypertension, and obesity, for easy reference in a clinical setting. A separate section focuses entirely on performance enhancers, including caffeine, creatine, and ephedrine/ephedra, and their potential to influence human health in addition to ergogenic applications.The final section provides scientists with a framework for designing experiments that elucidate the heath benefits and safety aspects of food and food-drug synergies. Food-Drug Synergy and Safety lays the essential foundation in this new direction of research as it gains momentum in the fields of food, nutrition, medicine, and pharmaceutical sciences.

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This book provides a broad base of knowledge of G-protein-coupled receptors. Useful at both the university and industrial levels, this book is of particular interest to those who are developing therapeutic approaches to diseases using drugs that influence receptor activation.

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Nutritional status is recognized as a major determinant in health and disease. Effective treatment of chronic conditions such as obesity or of diseases of the skin requires the integration of clinical and nutritional management. Nutritional and Clinical Management of Chronic Conditions and Diseases, like its predecessor, Nutritional Aspects and Clinical Management of Chronic Disorders and Diseases, is a comprehensive reference that helps clinicians successfully integrate nutritional management with clinical care. The book begins by discussing childhood obesity, adult obesity, and bariatric surgery. It then addresses nutritional concerns for the elderly, food allergies, and the nutritional and clinical management of pregnancy and lactation. A chapter also guides the clinician in facilitating and reinforcing patient behavior as well as behavioral changes with regard to food intake and diet. The second part of the book explains the nutritional management of specific disease conditions. Descriptions of genetic diseases and the management of errors of metabolism are followed by chapters on the immune system, chronic oral diseases, dermatology, upper gastrointestinal cancer, and of the cachexia of chronic illness. These chapters are characterized by detailed analyses of mechanisms. Written by experts that treat patients in a clinical setting, Nutritional and Clinical Management of Chronic Conditions and Diseases translates research results into practical approaches that allow the clinician to correlate nutrition with health.

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Hard drives and disk management receive scant attention from the industry press, yet recent surveys have identified disk failure as the #1 source of server downtime. Combine this fact with the skyrocketing TCO of data storage management, and it is apparent that server disk management is a subject deserving of much more scrutiny.Server Disk Management in a Windows Environment explains the basic elements of disks and disk architectures, and explores how to successfully manage and maintain functionality within a Windows environment. The author focuses on critical issues that are often ignored by other books on this subject, issues including disk quotas, fragmentation, optimization, hard drive reliability, asset management, software deployment, and system forensics.This book is a valuable resource for IT veterans and those who are less tech-savvy. Students and IT newcomers can access multiple definitions and examples of fundamentals such as disk organization, file systems, and basic maintenance actions. Chapters examining hardware and software management and industry trends provide further insight into how you can maintain and monitor disks, and have them perform at maximum efficiency.

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Written for the professional and the layman, the book provides the meanings of important and interesting acronyms in the broad area of computing and information science and technology. The acronyms and abbreviations contained in this book were created by the men and women of the computer and information age to save time and space and eliminate unnecessary repetition and wordage. The book is of value to engineers, scientists, technologists, executives and managers in technical fields, programmers, systems analysts, writers, and computer owners or potential buyers.

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For dynamic distributed systems modeled by partial differential equations, existing methods of sensor location in parameter estimation experiments are either limited to one-dimensional spatial domains or require large investments in software systems. With the expense of scanning and moving sensors, optimal placement presents a critical problem.Optimal Measurement Methods for Distributed Parameter System Identification discusses the characteristic features of the sensor placement problem, analyzes classical and recent approaches, and proposes a wide range of original solutions, culminating in the most comprehensive and timely treatment of the issue available. By presenting a step-by-step guide to theoretical aspects and to practical design methods, this book provides a sound understanding of sensor location techniques.Both researchers and practitioners will find the case studies, the proposed algorithms, and the numerical examples to be invaluable. This text also offers results that translate easily to MATLAB and to Maple. Assuming only a basic familiarity with partial differential equations, vector spaces, and probability and statistics, and avoiding too many technicalities, this is a superb resource for researchers and practitioners in the fields of applied mathematics, electrical, civil, geotechnical, mechanical, chemical, and environmental engineering.

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This seventh edition of a bestseller has been totally revised and updated, making this the most comprehensive rewrite in the book's long and distinguished history. It includes new chapters, new sections and section editors, and new contributors. Offering an interdisciplinary approach to pain management, the book delivers a scholarly presentation for those concerned with pedagogy, while still being accessible to those concerned with the immediate application of techniques.Here's what you get in the Seventh Edition:Tighter focus on discipline-specific approaches Expanded coverage of electrical and magnetic therapies New information on behavioral approaches Diagnostic tests and evaluations Updated information on legal and ethical issues

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Recent studies have raised concerns about the health effects of dietary exposure to trace elements. An estimated 40 percent of the world's population suffers from developmental and metabolic functional disorders due to trace element deficiencies. Conversely, there is an established link between excess intake of mineral components and diseases of the endocrine, kidney, liver, cardiovascular, and skeletal system. It has become crucial that food chemists understand the origin, function, bioavailability, and interactions of mineral components in food.Mineral Components in Foods presents the state of knowledge on the distribution, speciation, and interaction of mineral components and contaminants inherent in different raw materials and products, as well as acquired during processing, packaging, and handling. With contributions written by some of the foremost food researchers in the world, this book considers the analysis of mineral components in food, the recent advancements in analytical techniques including statistical multivariate approaches to confirm authenticity based on mineral composition, and the quality control practices that ensure consistent and accurate data. The functional role of a number of minerals is addressed along with the effects of their deficiency or excess on the body, their interactions with other minerals, and their changes during storage and processing. Specifically, the authors examine mineral distribution in certain animal and plant products including confections, honey, wine and beer. A considerable portion of the book is devoted to the contamination of foods and food supplements by metals, metalloids and radionuclides, from packaging containers as well as a variety of environmental pathways.With numerous tables and figures clearly expressing a wealth of detailed data, Mineral Components in Foods provides food chemists, quality control professionals, nutritionists, and students in these fields with an invaluable resource to t

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The study of buckling loads, which often hinges on numerical methods, is key in designing structural elements. But the need for analytical solutions in addition to numerical methods is what drove the creation of Exact Solutions for Buckling of Structural Members. It allows readers to assess the reliability and accuracy of solutions obtained by numerical methods. The author has attempted to gather and present as many exact buckling solutions as possible in one single volume for engineers and researchers. These buckling solutions of columns, beams, arches, ring plates, and shells should serve as benchmarks for checking the validity, convergence, and accuracy of numerical methods and solutions.Catalog Copy

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The outbreak of anthrax infections that followed September 11, 2001, showed all too clearly that while we can defend ourselves against bioterrorism, our defenses need improvement. What's most important is the ability to recognize the associated disease, and recognize them quickly. Yet, many in the medical world are unfamiliar with the characteristic signs and symptoms of bioterrorism agents and are unable to differentiate between diseases whose symptoms appear almost identical. While a plethora of information on such diseases is available, finding it is time consuming.Bioterrorism: Field Guide to Disease Identification and Initial Patient Management is an accessible resource that helps first-responders to quickly recognize the signs and symptoms caused by exposure to bioterrorism agents. It provides enough information to initiate treatment while a definitive diagnosis is being determined and presents measures for preventing contamination of those involved in the victims' medical management.A special quick-reference foldout chart features a matrix linking 180 symptoms to 17 diseases and 90 differential diagnosis. In bulleted format, the book includes for each pathogenic agent:A brief description Signs and symptoms Diagnostic features Lab tests and expected results Treatment (specific drug regimens) Prophylaxis (specific drug regimens) Precautionary measuresThis book is a potentially life-saving resource that can be thrown into a medical bag and kept there, hopefully forever unused. But if needed, it is a resource that can quickly provide information that will prevent secondary infections, improve site safety, and buy life-saving time for victims.

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Economic pressures have forced IT executives to demonstrate the immediate and calculable ROI of new technology deployments. Unfortunately, existing IT service delivery often drifts without serious thought as to how process improvements could lead to higher performance and customer satisfaction. The Hands-On Project Office: Guaranteeing ROI and On-Time Delivery offers the proven processes, techniques, and tools that IT managers can use to immediately improve the delivery of IT products and services. This compendium of best practices and practical recommendations details simple, deployable frameworks, practical tools, and time-tested best practices for successful IT service and project delivery management. Recognizing how your tech staff can do more with less, this practitioner's handbook describes how you can better coordinate work efforts, hold project teams accountable, and communicate and demonstrate the importance of IT services to your company as a whole. By explaining how to streamline the functions that capture and report information about IT delivery, this volume clarifies roles, responsibilities, customer expectations, and performance measures, resulting in improved service and efficiency.Emphasizing the establishment of processes that result in repeatable success, the book provides quickly implementable solutions for IT personnel faced with the daily management of large, complex systems.

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Summarizing our present knowledge of the structures and chemistry of small organic cations in the gas phase, Assigning Structures to Ions in Mass Spectrometry presents the methods necessary for determining gas-phase ion structures. It is a comprehensive resource of background material that is essential for the interpretation and understanding of organic mass spectra.Following a historical introduction of chief discoveries, the book surveys current experimental methods for ion production and separation as well as those designed to reveal qualitative and quantitative aspects of gas-phase ions. It also examines the computational chemistry and theoretical calculations that provide complementary thermochemical, structural, and mechanistic information. Five selected case studies illustrate specific challenges associated with ion structure assignment and thermochemical problems. The last major section of the book contains the data for describing or identifying all ions containing C alone and C with H, O, N, S, P, halogens, and small organic cations. Presenting material written by leading researchers in the field, Assigning Structures to Ions in Mass Spectrometry underscores the importance of understanding the behavior of small organic ions and gas-phase ion chemistry for making new ion structure assignments

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Enhancing LAN Performance, Fourth Edition explains how to connect geographically separated LANs with appropriate bandwidth, the issues to consider when weighing the use of multiport or dualport devices, how to estimate traffic for new networks, the effects of configuration changes on the performance of Ethernet and Token Ring networks, the design of switch-based networks that prevent traffic bottlenecks, and other critical topics. It provides the tools to address these issues in relation to specific network requirements. This volume develops mathematical models of various LAN performance issues, enabling LAN managers to determine the answers that are right for their organizations.

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This guide contains over 20,000 entries completely cross-indexed and quoted in context to provide readers with instant access to every noun, phrase, and concept used by the Drug Enforcement Administration and U.S. Food and Drug Administration.

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Presenting the latest research in glial cell function gleaned from new techniques in imaging and molecular biology, The Role of Glia in Neurotoxicity, Second Edition covers multiple aspects of glial cells, including morphology, physiology, pharmacology, biochemistry, pathology, and their involvement in the pathophysiology of neurological diseases. The book is structured to examine the interactions between glial cells and neurons during development, adulthood, and senescence, followed by specific examples of directly mediated glial neurotoxicity. The book also covers miscellaneous topics in glial physiology/biochemistry such as signaling and edema. The book includes coverage of advances in our knowledge and understanding of glial physiology and biochemistry. Discover what's new in the Second Edition:Neuronal-glia metabolic interactionsNeuronal-glia interactions (glutamate homeostasis)Zinc transporters in gliaEnergy deprivation/mitochondrial dysfunction - unique astrocyte susceptibilitiesAstrocytes and MPTP neurotoxicityAstroglia and food toxinsCurrent understanding of the importance of glia has caused a boom in published information. Yet while many of the published textbooks are multifaceted and multidisciplinary, none includes the role of glia in neurotoxicity. Written by leaders in the field of glial research, this text fills this missing gap in the literature. Broader in scope than the first edition, including contributions from internationally known researchers, this is still the only book dedicated to exploring the role of glial cells in mediating neurotoxicology.FeaturesSummarizes the latest research in glial cell function gleaned from new techniques in imaging and molecular biology Contains tables and figures that give you quick and easy access to precise data Includes a contemporary summary of literature that puts information useful for grant submissions at your fingertips

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Provides Insight into How Cytokine Action Impacts the Physiology and Pathology of the CNS.As with the first edition of Cytokines and the CNS, this completely updated and revised edition introduces neurobiologists to cytokine biology and immunologists to the unique functions of cytokines in CNS physiology. The dramatically accelerating interest in cytokines and cytokine/chemokine signaling over the past several years has encouraged an explosion of literature on cytokines. The similarity between factors involved in inflammation or immunity, and those implicated in neural development, physiology, and repair has become so apparent that familiarity with cytokines must now be considered an essential element in the neurobiologist’s cognitive tool-kit. Conversely, for immunobiologists, the concepts elaborated by neurobiologists to understand developmental patterning and networked organ function continue to evolve in such a way that comprehension of cytokine action in the CNS can only enhance a further understanding of immune system function. Cytokines and the CNS, Second Edition is patterned after the first edition; however, the wealth of knowledge now available adds a tremendous amount of insight and new implications. To guarantee a fresh perspective, the editors made a conscious choice to utilize an entirely new set of contributors, all experts in various aspects of cytokine research. Cytokines and the CNS, Second Edition starts with a chapter on the CNS, focusing on pathological reactions to insult. Next, come three chapters on cytokine biology, followed by four chapters that integrate cytokine biology into basic CNS processes (development; inflammation; immunity; degeneration/repair), after which five chapters apply this body of knowledge to disease or pathology. The book closes with a look at the application of cytokine biology to the treatment of disease, a brand new area of research.

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Recent advances not only in the creation of new polymers but also in their processing and production have ushered in huge strides in a variety of biomedical and clinical areas. Orthopedics and dentistry are two such areas that benefit immensely from developments in polymer science and technology. Polymers for Dental and Orthopedic Applications examines the most current topics in this expanding field with an emphasis on technological evolution and clinical impacts.Surveying major progress in polymer science and technology for dental, maxillofacial, and orthopedic applications, this book provides a unique illustration of the conceptual development of novel biomaterials and processes designed to meet targeted clinical needs. Two preeminent scientists lead a close-knit team of international experts with extensive experience in product development, bioengineering, education, and clinical applications. Ranging from polymeric materials for dental and maxillofacial application to joint repair and replacement, polymeric composites, and tissue engineering, the book also examines topics that are common to both dental and orthopedic fields, such as osseointegration and infection management. Explore the current status and future possibilities of polymeric biomaterials in Polymers for Dental and Orthopedic Applications. A unique blend of technical information and practical insight, this reference fosters the continued growth of a critically important field.

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Interest in biodegradable and absorbable polymers is growing rapidly in large part because of their biomedical implant and drug delivery applications. This text illustrates creative approaches to custom designing unique, fiber-forming materials for equally unique applications. It includes an example of the development and application of a new absorbable system, a condensed encyclopedia on novel PEG-based copolyesters, and the first comprehensive discussion of a novel class of absorbable tissue adhesives. The book also provides up-to-date information on important tissue engineering technologies and approaches to utilizing these technologies for long awaited practical applications.

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Containing over 150 original photomicrographs accompanied by protocol information, Atlas of Cell Organelles Fluorescence delineates organelles’ structures, interaction, and organization into complexes. It provides a collection that shows living cells under physiopathological conditions and in the context of treatment with carcinogens, xenobiotics, and chemotherapeutic drugs as well as photosensitizers. A guide for therapeutic, diagnostic, or prognostic interpretation of images, and for further research, the atlas helps you identify critical points of attack and suggests possible strategies for investigation.Each section provides a brief introduction and the technical details of the staining methods used. The text identifies the organelles and gives explanations of unusual appearances and the cytochemical reactions when necessary. Additional text is provided where appropriate for extension and implementation of methods being utilized to generate similar results. In all cases the normal and pathological markers and content are presented. The atlas includes a color insert that illustrates characteristic organelle features, microcompartmentalization, and alterations as investigated by one or more probes simultaneously. The book, an exhaustive list of cellular events observed using microfluorometry, supplies a compilation of information spread throughout the literature of the last 30 years. Atlas of Cell Organelles Fluorescence brings the information together and puts it in an easily accessible format.

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DID YOU KNOW?While organizational entities cannot be sent to prison, they can be heavily fined, ordered to make restitution, placed on probation, forced to forfeit property, suffer public and stakeholder recriminations, and can be forced out of business. Avoid these unnecessary repercussions with Occupational Crime: Deterrence, Investigation, and Reporting in Compliance with Federal Guidelines. Whether you are starting from scratch or you wish to benchmark an existing program against another framework, this book takes you from legal mandates and program design to implementation and maintenance to help you develop an effective Employee Security-Awareness Program that accommodates the compliance needs specific to your organization.DON'T LET YOUR COMPANY BE THE NEXT STATISTICWe all watched it happen: the demise of a powerhouse corporation caused by the irreverent and illegal actions of a handful of employees and executives. If it wasn't clear before the Enron/Arthur Andersen fiasco, it's painfully obvious now: Not only do we have to worry about our employees committing crimes against us as employers, we may even be held accountable for their actions! From governmental entities to partnerships to non-profit establishments - organizations can be indicted, criminally charged, prosecuted, and found guilty of criminal conduct. If you haven't yet heard of the US Sentencing Commission, and more specifically Chapter Eight, Sentencing of Organizations, of the United States Sentencing Guidelines, it's time to learn.Occupational Crime: Deterrence, Investigation, and Reporting in Compliance with Federal Guidelines clearly explains how Chapter Eight sets forth punishment for organizations convicted of federal crimes, including felonies and Class A misdemeanors, and describes an effective compliance program and other incentives that can mitigate sanctions. It begins by defining the problem of organizational crime and puts into perspective the abusive employee behavior problem. Then the book examines the price that businesses, institutions, individuals, and the nation pays for organizational crime and shows how to calculate those costs. Thirdly, it provides the tools for the solution of the problem - through the implementation and maintenance of a customized Employee Security-Awareness Program. Finally, the book provides supplemental materials you can use for program planning, records, and communications media.In every venue, societal and governmental, abusive employee behavior and occupational crime is a costly and intricate issue demanding vigilant management attention and diverse remedies. Considering the uniqueness of each company, there is no "one size fits all" formula for an effective compliance program. Written by a 25-year veteran of corporate internal security and a certified fraud examiner, Occupational Crime helps you customize, no matter the size or type of company, a compliance program that will meet and exceed federal guidelines. With its step-by-step presentation, you will learn how to prevent, detect, and report crimes committed by employees on behalf of or against your organization.

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Research data is expensive and precious, yet it is seldom fully utilized due to our ability of comprehension. Graphical display is desirable, if not absolutely necessary, for fully understanding large data sets with complex interconnectedness and interactions. The newly developed GGE biplot methodology is a superior approach to the graphical analysis of research data and may revolutionize the way researchers analyze data. GGE Biplot Analysis: A Graphical Tool for Breeders, Geneticists, and Agronomists introduces the theory of the GGE biplot methodology and describes its applications in visual analysis of multi-environment trial (MET) data and other types of research data. The text includes three parts: I) Genotype by environment interaction and stability analysis, II) GGE biplot and multi-environment trial (MET) data analysis, and III) GGE biplot software and applications in analyzing other types of two-way data. Part I presents a comprehensive but succinct treatment of genotype-by-environment (G x E) interaction in order to provide an overall picture of the entire G x E issue and to show how GGE biplot methodology fits in. Part II describes and demonstrates the numerous utilities of a GGE biplot in visualizing MET data. Part III describes the "GGE biplot" software and extends its application to the analysis of genotype by trait data, QTL mapping data, diallel cross data, and host by pathogen data. Altogether, this book demonstrates that the GGE biplot methodology is a superior data-visualization tool and allows the researcher to graphically extract and utilize the information from MET data and other types of two-way data to the fullest extent. GGE Biplot Analysis makes this useful technology accessible on a wider scale to plant and animal breeders, geneticists, agronomists, ecologists, and students in these and other related research areas. The information presented here will greatly enhance researchers' ability to understand their data and will mak

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The remarkable work of a brilliant botanist and linguist, this unparalleled critically acclaimed lexicon offers an indispensable guide for all those involved with plants and gardens whether they are growing, studying, or writing about them. Detailing approximately 800 generic names and thousands of species of grasses, including cereals and forages, this 3-volume set lists all relevant properties related to the main and secondary uses of the grasses, as well as detailed descriptions and geographical distribution. Entries include genus, synonyms, and etymology, as well as vernacular and rejected names, and orthographic variants. It provides a huge amount of obscure sources of nearly impossible to find information.

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Opto-mechatronics-the fusion of optical and mechatronic technologies-has been integral in the evolution of machines, systems, and products that are smaller and more precise, more intelligent, and more autonomous. For the technology to reach its full potential, however, engineers and researchers from many disciplines must learn to work together through every phase of system development. To date, little effort has been expended, either in practice or in the literature, to eliminate the boundaries that exist between the optics and mechatronics communities.The Opto-Mechatronics Systems Handbook is the first step in that direction. Richly illustrated and featuring contributions from an international panel of experts, it meets three essential objectives:Ö Present the definitions, fundamentals, and applications of the technologyÖ Provide a multidisciplinary perspective that shows how optical systems and devices can be integrated with mechatronic systems at all stages, from conceptualization to design and manufacturingÖ Demonstrate the roles and synergistic effects of optical systems in overall system performanceAlong with his fresh approach and systems perspective, the editor has taken care to address real cutting-edge technologies, including precision opto-mechatronic systems, intelligent robots, and opto-microsensors. Ultimately, the Opto-Mechatronics Systems Handbook provides readers with the technological foundation for developing further innovative products and systems.

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Written in a simple, straightforward manner, this book will help today's criminal justice student better understand con law issues as well as the complicated development of constitutional rights and law. In its simple, easy to understand format, this book is a must for both current criminal justice professionals and students studying to enter the profession.Constitutional Law for the Criminal Justice Professional covers search and seizure, arrest and civil rights as well as the judiciary, first amendment, due process and the judicial system. By an author with more than ten years experience as a police officer, another seven years as an attorney (both prosecuting and defending criminal cases), and more than seven years teaching law, this book is a valuable source of knowledge and understanding. It helps today's criminal justice student and professional be better prepared for tomorrow's needs.

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The concept of customer relationship management (CRM) has grown from the loosely defined methodology of using customer transactions for developing profiles on customers to the well-defined business process of using sophisticated tools and analytical processes for managing each customer on an individual basis. CRM integrates e-mail and the PDA with the day planner, electronic scheduler, client database, and a number of other business management tools so you can create a single point from which to manage customer relationships.The Customer Relationship Management Systems Handbook provides a complete and detailed analysis of CRM, its origins, rationale, implementation strategies, core technologies, and benefits. The author takes readers through the evolution of CRM- from its early beginning as a tool for better managing and utilizing vast amounts of customer transaction data acquired in day-to-day transactions to today's sophisticated data warehouse-based systems. The text was researched, formatted, and written for IS professionals who need a full understanding of what is involved in the successful development and implementation of a CRM. To highlight the significant benefits of implementing CRM strategies, the book provides examples of successful CRM implementations from a broad range of business sectors. These implementations, presented in a case study format, demonstrate implementation processes, appropriate technologies, and vendor solutions that work. Wherever possible, illustrations are used to enhance the textual presentation. The complete analysis of CRM provided in the Customer Relationship Management Systems Handbook will enable you to accomplish what many businesses fail to do-put the customer first.

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In the competitive business arena companies must continually strive to create new and better products faster, more efficiently, and more cost effectively than their competitors to gain and keep the competitive advantage. Computer-aided design (CAD), computer-aided engineering (CAE), and computer-aided manufacturing (CAM) are now the industry standard. These seven volumes give the reader a comprehensive treatment of the techniques and applications of CAD, CAE, and CAM.

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The updated second edition of the popular Inorganic Materials Chemistry Desk Reference remains a valuable resource in the preparation of solid-state inorganic materials by chemical processing techniques. It also expands upon new chemical precursors available to materials scientists, the applications of those materials, and existing or emerging topics where materials chemistry plays an important role, such as in microelectronics, surface science, and nanotechnology. This edition places additional emphasis on additives, characterization techniques and structure-property relationships, and materials classifications based on type and applications, including electronics, biomaterials, thin films, and coatings. Other new topics include combinatorial chemistry, nanostructures and technology, surface materials chemistry, biomimetic processing, and novel forms of carbon. The authors discuss the role of materials chemistry in micro- and nano-fabrication, self-assembly, scanning probe microscopy, and carbon fullerenes. The new edition adds forty black and white figures, over 200 new definitions, and 50% more new chemical precursors and their properties. With a new and improved reference format, Inorganic Materials Chemistry Desk Reference continues to be a constructive resource to specialists conducting research in materials chemistry.

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The responsibilities of the system engineer are many and varied, especially as they relate to facility design and construction. Successful execution of these responsibilities requires an understanding of the underlying technologies, the applicable quality standards, and the proper methods for achieving them. The Communications Facility Design Handbook is dedicated to providing and supporting that understanding. It examines the tasks and functions of the system engineer and establishes a foundation for designing, installing, operating, and maintaining audio, video, computer, and radio frequency systems and facilities.Unique in its scope and its approach, The Communications Facility Design Handbook describes the important steps required to take a project from basic design to installation and completion. From the fundamental principles of electronics to details on wiring, from budget analysis to safety considerations, this is your one-stop reference for planning, building, renovating, and operating all types of electronics facilities.

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The fruit of a conference that gathered seven very active researchers in the field, Combinatorial Design and their Applications presents a wide but representative range of topics on the non-geometrical aspects of design theory. By concentrating on a few important areas, the authors succeed in providing greater detail in these areas in a more complete and accessible form. Through their contributions to this collection, they help fill a gap in the available combinatorics literature.The papers included in this volume cover recent developments in areas of current interest, such as difference sets, cryptography, and optimal linear codes. Researchers in combinatorics and other areas of pure mathematics, along with researchers in statistics and computer design will find in-depth, up-to-date discussions of design theory and the application of the theory to statistical design, codes, and cryptography.

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Analogous to other infections, evidence suggests that improved micronutrient intake may reduce HIV transmission and progression, as well as morbidity from common and opportunistic infections. This is important information, considering many in the world's HIV-infected population do not yet have access to anti-retroviral drugs. Micronutrients and HIV Infection presents current knowledge on the role of micronutrients in HIV and other infections - knowledge that can be used to improve case management and public health interventions.The book provides a comprehensive overview of micronutrients and HIV infection through a review of recently published human studies and intervention trials and other important epidemiology based literature. It begins by introducing the malnutrition-infection complex, Nutritionally Acquired Immune Deficiency Syndrome, and the role of oxidative stress in infection. Then the book covers the history, biochemistry, biological functions, and food sources of individual micronutrients, and reviews their roles in host defense and resistance to infections in general, and HIV in particular. Finally, the book discusses how this information can be applied for the benefit of individuals with HIV and countries where HIV is widespread and treatment unavailable. Most of the world's 35 million people living with HIV are micronutrient deficient and have little access to HIV testing, counseling, and care. In addition to covering specific micronutrients, Micronutrients and HIV Infection presents a critical review of how existing micronutrient interventions can be promoted, expanded, and modified to reduce the magnitude and impact of the HIV pandemic.

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Bacterial surface or secreted polysaccharides are molecules that can function as barriers to protect bacterial cells against environmental stresses, as well as act as adhesins or recognition molecules. In some cases, these molecules are immunodominant antigens eliciting a vigorous immune response, while in other cases the expression of polysaccharides camouflages the bacteria from the immune system. Until recently, most studies on the enzymatic steps and regulation of these molecules were performed on the enteric gram negative bacteria Escherichia coli and Salmonella typhimurium. With the advent of modern bacterial genetics, techniques such as construction and characterization of polysaccharide mutants, cloning of genes and complementation of these mutations, and expression of polysaccharides in heterologous bacterial hosts has prompted investigations into the roles and functions of these molecules for many different bacteria.Here, we present the genetic analysis of polysaccharides from a number of bacteria pathogenic to humans and one symbiotic with plants in hopes that similarities in the experimental approaches as well as finding s from such investigations may lead to a general understanding of polysaccharide synthesis and regulation in various bacteria. Features

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There is a general consensus that deep-seated changes are reshaping the way production and work are organized, the way employees, employers and their representatives deal with each other, and the way governments seek to shape society. In this work a group of leading scholars take stock of the evidence and implications of the new workplace. Drawing on examples from a variety of national contexts, they seek to characterize the nature of contemporary workplace change, and assess its implications for the organization of work for workers, for employment relations and for public policy.

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Micellar Liquid Chromatography reviews the use of surfactant solutions at or above the critical micelle concentration as mobile phases in liquid chromatography. It employs a computer-assisted optimization methodology and integrates micellar liquid chromatography (MLC) with other chromatographic and electrophoretic techniques using surfactants. It also includes the MICHROM software package on CD-ROM to facilitate the application of equations and optimize efficiency of MLC systems.

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This theoretically and experientially grounded reference provides a complete overview of the principles and applications of government administration and management practices in the local public sector. Written by over 25 distinguished academics and professionals with substantial experience as practitioners and consultants of administrative operations to local governments, the book covers the effects of environmental conditions on local administrators and management techniques to administration in different types of local government. It helps readers reduce research time by presenting advanced materials on local government administration and management in a single source.

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"Discusses the fundamental design principles, capabilities, and applications of power hybrid microcircuits and modules--detailing the operation of power semiconductor and passive components, the properties of materials, design guidelines, thermal management, and manufacturing technologies."

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Based on the proceedings of the International Convocation on Immunology held recently at the State University of New York at Buffalo, this up-to-date resource provides a state-of-the-art examination of blood transfusion practice and its future possibilities.Explains the immunological effects of blood transfusion as well as its immunological and microbiological hazards and offers potential remedies!

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"Explains and summarizes the fundamental derivations, basic and advanced concepts, and equations central to the field of dynamics. Chapters stand as self-study guides-containing tables, summaries of relevant equations, cross references, and illustrative examples. Utilizes Kane's equations and associated methods for the study of large and complex multibody systems."

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How to integrate safety skills into job training through behavior modification and various instructional methods. The price is high for this compendium of training suggestions and techniques. Annotation copyright Book News, Inc. Portland, Or.

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This book contains the proceedings of the Eleventh Annual Basic Symposium sponsored by the Institute of Food Technologists and the International Union of Food Science and Technology. It discusses nutrition interactions in human and emphasizes research findings from human and animal studies.

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This handy, accessible single volume presents useful clinical information to expose the pathophysiology underlying major pulmonary diseases, and traces the steps of treatment, from establishing diagnosis to managing therapy.Contains more than 400 summary tables, radiographs, pathology specimens, and other illustrations that encapsulate information and highlight key points!A suggested reading list accompanies each chapter to facilitate further study!Written by over 55 internationally recognized experts who provide personal experiences, observations, and review statements, and recommend action based on their expertise dealing with patients, Medical Management of Pulmonary Diseases assesses new, efficient, cost-effective technologies for asthma and for the delivery of oxygen therapy evaluates new directions in the diagnosis and treatment of cystic fibrosis, lung cancer, occupational lung diseases, and diffuse interstitial lung disease describes the anatomy and physiology of the respiratory tract and includes examples of abnormalities drawn from common respiratory diseases discusses standard therapies for most pulmonary disease patients as well as targeted management for specific cases addresses common diagnostic and treatment dilemmas and suggests helpful algorithms for care spotlights asthma, chronic obstructive pulmonary disease, sleep-disordered breathing, tuberculosis, and other conditions that warrant careful management follows the progression of lung cancer from initial diagnosis through staging, and explores individualized therapy options considers special environments that may contribute to respiratory symptoms details the effect pregnancy and surgery have on pulmonary disease and more!Medical Management of Pulmonary Diseases serves as an excellent user-friendly guide ideal for primary care, internal medicine, and family practice physicians; pulmonologists and pulmonary disease specialists; clinical allergists; immunologists; respiratory therapists; thoracic surgeons; physiologists; and medical school students in these disciplines.

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Offering an authoritative and timely account by twenty-nine internationally recognized experts, Metal Ions in Biological Systems: Metal Complexes in Tumor Diagnosis and as Anticancer Agents is devoted solely to the vital research area concerning metal complexes in cancer diagnosis and therapy. In fourteen stimulating chapters, the book focuses on diagnostic tools such as magnetic resonance imaging (MRI), luminescent probes, and radiopharmaceuticals, including radiometallo-labeled peptides and assesses the role of metal ions, especially iron, in the action of antibiotics employed in anticancer chemotherapy.

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An in-depth review of important preparative methods for the synthesis and chemical modification of polymers, this authoritative second edition examines the advantages and limitations of various polymerization applications and procedures. It features new approaches and innovative strategies from the most prominent industry and academic laboratories, reflecting the burgeoning role of polymers in modern science and technology. The book analyzes biodegradable polymers for biomedical applications; investigates the use of polyolefins, polymeric dienes, aromatic polyethers, polymides, and metal-containing macromolecules; and covers polymers of acrylic acid, methacrylic acid, and maleic acid.

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A True Insider’s Guide to the Field – Then and Now Until now, there has not been a book that effectively addresses the historical basis of protein discovery. Featuring contributions from a distinguished international panel of experts, Protein Discovery Technologies elucidates the principles, techniques, strategies, and broad range of applications of protein discovery by documenting the often untold stories and personal accounts of the contributors’ past scientific achievements.Incorporates Short, Personal Discovery Vignettes Rather than an exhaustive field analysis, this globally pertinent resource presents in-depth discussions of various methods for protein discovery, including bioinformatics, interaction cloning, protein purification, phage display, non-primate models, and chemical targeting. It also explores biological themes through the examination of cell death, angiogenesis, hemostasis, development, signal transduction, transcriptional control, cell cycle control, neurobiology, and quality control.This readily accessible resource discusses an array of interesting topics, including: Tumor necrosis factors The origin of interferon as an angiogenesis inhibitor In vivo combinatorial mapping of vascular zip codes Extracellular matrix degradome as regulators of angiogenesis and tumor growth A matricellular protein prototype The use of RING finger proteins as E3 Ubiquitin Ligases Whereas most books tend to be more specialized, this book contains a broad view of the protein discoveries in many different fields, making Protein Discovery Technologies a valuable reference for today’s researchers, both the new and more seasoned, who are seeking a newfound perspective or a deeper understanding of this exciting field.

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It was once assumed that mitochondrial diseases were rare and that few people were affected. As knowledge has grown about these organelles and their function, it became clear that mitochondrial malfunction could be linked to several chronic diseases. Diabetes has been associated with DNA mutation and can cause mutation itself. This text discusses findings involving the effects of disease on mitochondrial number, mitogenesis, and the base sequence of mitochondrial DNA. Experts discuss their study of mitochondria and what happens when it malfunctions. This book also explores the idea that mutated mitochondrial DNA can result in disease, and vice versa.

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When designing switch-mode power supplies (SMPSs), engineers need much more than simple "recipes" for analysis. Such plug-and-go instructions are not at all helpful for simulating larger and more complex circuits and systems. Offering more than merely a "cookbook," Practical Computer Analysis of Switch Mode Power Supplies provides a thorough understanding of the essential requirements for analyzing SMPS performance characteristics. It demonstrates the power of the circuit averaging technique when used with powerful computer circuit simulation programs.The book begins with SMPS fundamentals and the basics of circuit averaging models, reviewing most basic topologies and explaining all of their various modes of operation and control. The author then discusses the general analysis requirements of power supplies and how to develop the general types of SMPS models, demonstrating the use of SPICE for analysis. He examines the basic first-order analyses generally associated with SMPS performance along with more practical and detailed methods for developing SMPS and component models. The final chapter features the circuit-averaging macromodel of the integrated circuit PWM controller illustrated through analyses of three power supplies.Practical Computer Analysis of Switch Mode Power Supplies builds a strong foundation on the principles of SMPS analysis, enabling further development and advancement of the techniques while supplying meaningful insight into the process.

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Polymer Processing Instabilities: Control and Understanding offers a practical understanding of the various flows that occur during the processing of polymer melts. The book pays particular attention to flow instabilities that affect the rate of production and the methods used to prevent and eliminate flow instabilities in order to increase production rates and enhance manufacturing efficiency. Polymer Processing Instabilities: Control and Understanding summarizes experimental observations of flow instabilities that occur in numerous processing operations such as extrusion, injection molding, fiber spinning, film casting, and film blowing for a wide range of materials, including most commodity polymers that are processed as melts at temperatures above their melting point or as concentrated solutions at lower temperatures. The book first presents the fundamental principles in rheology and flow instabilities. It relates the operating conditions with flow curves, the critical wall shear stress for the onset of the instabilities, and new visualization techniques with numerical modeling and molecular structure. It reviews one-dimensional phenomenological relaxation/oscillation models describing the experimental pressure and flow rate oscillations, analyzes the gross melt fracture (GMF) instability, and examines how traditional and non-traditional processing aids eliminate melt fracture and improve polymer processability. It supplies a numerical approach for the investigation of the linear viscoelastic stability behavior of simplified injection molding flows and examines a newly discovered family of instabilities that occur in co-extrusion.Polymer Processing Instabilities: Control and Understanding is unique in that it fills a gap in the polymer processing literature where polymer flow instabilities are not treated in-depth in any book. It summarizes state-of-the-art developments in the field, particularly those of the last ten years, and contains significant data based on this research.

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Ranging from fundamental theoretical concepts to advanced device technologies, this reference/text explores the engineering, characteristics, and performance of specific semiconductor lasers. It defines key principles in electromagnetics, optoelectronics, and laser implementation for novel applications in optical communications, storage, processing, measurement, and sensing. This text prepares students for advanced experimental and theoretical research in semiconductor laser technology and provides the only comprehensive, systematic, and concise description of semiconductor lasers available for an understanding of the physics and parameters of laser operation and function.

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