Search results for ""imperial college press""

This book represents a collection of papers from one of the founders of the new Philosophy of Chemistry. It is only the second single-author collection of papers on the Philosophy of Chemistry.The author is the editor-in-chief of Foundations of Chemistry, the leading journal in the field. He has recently gained worldwide success with his book on the periodic table of the elements titled The Periodic Table: Its Story and Its Significance. This volume provides an in-depth examination of his more philosophical and historical work in this area and further afield.

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This is perhaps the first book containing biographical information of Sir James Lighthill and his major scientific contributions to the different areas of fluid mechanics, applied mathematics, aerodynamics, linear and nonlinear waves in fluids, geophysical fluid dynamics, biofluiddynamics, aeroelasticity, boundary layer theory, generalized functions, and Fourier series and integrals. Special efforts is made to present Lighthill's scientific work in a simple and concise manner, and generally intelligible to readers who have some introduction to fluid mechanics. The book also includes a list of Lighthill's significant papers.Written for the mathematically literate reader, this book also provides a glimpse of Sir James' serious attempt to stimulate interest in mathematics and its diverse applications among the general public of the world, his profound influence on teaching of mathematics and science with newer applications, and his deep and enduring concern on enormous loss of human lives, economic and marine resources by natural hazards. By providing detailed background information and knowledge, sufficient to start interdisciplinary research, it is intended to serve as a ready reference guide for readers interested in advanced study and research in modern fluid mechanics.

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In this Completely Revised and Extended Edition with a significantly enhanced content, all Chapters have been updated considering relevant literature and recent developments until 2016 together with application oriented examples with a focus on Industrial Biocatalysis. Newly treated topics comprise among others systems metabolic engineering approaches, metagenome screening, new tools for pathway engineering, and de-novo computational design as actual research areas in biocatalysis. Information about different aspects of RNA technologies, and completely new Chapters on 'Fluorescent Proteins' and 'Biocatalysis and Nanotechnology' are also included.

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Precipitating atmospheric convection is fundamental to the Earth's weather and climate. It plays a leading role in the heat, moisture and momentum budgets. Appropriate modelling of convection is thus a prerequisite for reliable numerical weather prediction and climate modelling. The current standard approach is to represent it by subgrid-scale convection parameterization.Parameterization of Atmospheric Convection provides, for the first time, a comprehensive presentation of this important topic. The two-volume set equips readers with a firm grasp of the wide range of important issues, and thorough coverage is given of both the theoretical and practical aspects. This makes the parameterization problem accessible to a wider range of scientists than before. At the same time, by providing a solid bottom-up presentation of convection parameterization, this set is the definitive reference point for atmospheric scientists and modellers working on such problems.Volume 1 of this two-volume set focuses on the basic principles: introductions to atmospheric convection and tropical dynamics, explanations and discussions of key parameterization concepts, and a thorough and critical exploration of the mass-flux parameterization framework, which underlies the methods currently used in almost all operational models and at major climate modelling centres. Volume 2 focuses on the practice, which also leads to some more advanced fundamental issues. It includes: perspectives on operational implementations and model performance, tailored verification approaches, the role and representation of cloud microphysics, alternative parameterization approaches, stochasticity, criticality, and symmetry constraints.

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This textbook is an introduction and guide to undergraduate surgery. It has been a bestseller since its first edition in 2001.The philosophy of this book is to focus on the level of knowledge and the approach that would be expected of the better students reaching the end of their undergraduate training. Avoiding a book that is too cumbersome, we have tried to make this volume readable and enjoyable, using various techniques to help the reader remember key facts: the text has been deliberately written in a tutorial-like story format as opposed to a set of lists, since this makes it easier to understand and remember.In addition to general surgery, the book contains sections on trauma, orthopaedics, urology and ENT, making it the only comprehensive textbook for medical students wishing to learn top tips in surgery.Subjects that are poorly covered in other main texts — such as fluid balance management and minor surgical procedures — are dealt with in a tutorial fashion in this book, and there is a section on how to problem-solve even in the context of areas unknown to the student.This book is useful for medical students and also for junior doctors during their day-to-day working lives, as well as those coming up to postgraduate exams.Each chapter is written by an authoritative author, alongside the book editors, and they have ensured it remains in the spirit of the bestselling previous editions.

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This book is designed to enable non-native English speakers to write science research for publication in English. It can also be used by English speakers and is a practical, user-friendly book intended as a fast, do-it-yourself guide for those whose English language proficiency is above intermediate. The approach is based on material developed from teaching graduate students at Imperial College London and has been extensively piloted. The book guides the reader through the process of writing science research and will also help with writing a Master's or Doctoral thesis in English.Science writing is much easier than it looks because the structure and language are conventional. The aim of this book is to help the reader discover a template or model for science research writing and then to provide the grammar and vocabulary tools needed to operate that model. There are five units: Introduction, Methodology, Results, Discussion/Conclusion and Abstract. The reader develops a model for each section of the research article through sample texts and exercises; this is followed by a Grammar and Writing Skills section designed to respond to frequently-asked questions as well as a Vocabulary list including examples of how the words and phrases are to be used.

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This book is intended for self-study or as a companion of lectures delivered to post-graduate students on the subject of the computational prediction of complex turbulent flows. There are several books in the extensive literature on turbulence that deal, in statistical terms, with the phenomenon itself, as well its many manifestations in the context of fluid dynamics. Statistical Turbulence Modelling for Fluid Dynamics — Demystified differs from these and focuses on the physical interpretation of a broad range of mathematical models used to represent the time-averaged effects of turbulence in computational prediction schemes for fluid flow and related transport processes in engineering and the natural environment. It dispenses with complex mathematical manipulations and instead gives physical and phenomenological explanations. This approach allows students to gain a 'feel' for the physical fabric represented by the mathematical structure that describes the effects of turbulence and the models embedded in most of the software currently used in practical fluid-flow predictions, thus counteracting the ill-informed black-box approach to turbulence modelling. This is done by taking readers through the physical arguments underpinning exact concepts, the rationale of approximations of processes that cannot be retained in their exact form, and essential calibration steps to which the resulting models are subjected by reference to theoretically established behaviour of, and experimental data for, key canonical flows.

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Advances in Earth Science outlines the latest developments and new research directions currently being made world-wide in the earth sciences. It contains invited and refereed articles by leading younger researchers on their cutting-edge research, but aimed at a general scientific audience.This exciting volume explains how powerful methodologies such as satellite remote sensing and supercomputing simulations are now profoundly changing research in the earth sciences; how the earth system is increasingly being viewed in a holistic way, linking the atmosphere, ocean and solid earth; and how the societal impact of the research in the earth sciences has never been more important.Published by Imperial College Press in collaboration with the Royal Society of London, the book features many articles originating from invited papers published in the Philosophical Transactions of the Royal Society. Eleven of the distinguished contributors hold prestigious Royal Society Research Fellowships.

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This important book deals with the modeling and design of higher-order single-stage delta-sigma modulators. It provides an overview of the architectures, the quantizer models, the design techniques and the implementation issues encountered in the study of the delta-sigma modulators. A number of applications are discussed, with emphasis on use in the design of analog-to-digital converters and in frequency synthesis. The book is education- rather than research-oriented, containing numerical examples and unsolved problems. It is aimed at introducing the final-year undergraduate, the graduate student or the electronic engineer to this field.

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This book provides the reader with an explanation of the origin and establishment of quantum mechanics, with the mathematics in a digestible form, together with a descriptive survey of later developments up to the present day. The mathematical treatment closely follows the original treatment, but in modern terms, using uniform symbolism as much as possible and with simplifications (e.g. the use of one dimension instead of three) to avoid unnecessarily complicated-looking mathematics.Containing an extensive bibliography and useful appendices as well as references to original works, reviews, and biographies, the reader is well-equipped to delve further into the subject. In addition to its importance for those studying physics, it is also valuable for those studying the history of science.

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Two recent major trends in today's complex and competitive high technology global society have underscored the importance for a textbook on strategic technology management. The first is the desire of major global corporations and high technology firms to hire graduates who are able to understand engineering and science, and make sound strategic business decisions. The second is the increasing interest among engineering and science students to take courses in business management.This invaluable book attempts to bridge business and scientific management practices so as to foster better understanding between the two entities. The second edition is updated with interesting case studies on biomedical and renewable technologies.

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This book treats the Stark effect of a hydrogenic atom or ion in a homogeneous electric field. It begins with a thorough review of previous work in this field since 1926. After the Schrödinger equation has been separated with respect to time dependence, centre of mass motion and internal motion, followed by a discussion of its eigenfunctions, the exact development in time of the probability amplitude for a decaying state is obtained by means of a formula analogous to the Fock-Krylov theorem. From this formula one obtains by means of the phase-integral approximation generated from a particular base function non-relativistic formulas for profiles, energies and half-widths of the Stark levels. These formulas are then transformed into formulas expressed in terms of complete elliptic integrals. The formulas thus obtained are used for the calculation of energies and half-widths of 198 different Stark states, which are compared with the corresponding results obtained by other authors with the use of other methods. An analysis of this material indicates that the energy values obtained by the phase-integral method are at least as accurate as those obtained by other methods in more than half of the 198 cases. The book presents one of the most comprehensive asymptotic treatments of the Stark effect in atomic hydrogen that have been published.

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This book has been developed over many years from several popular courses taught to students at both Birmingham and London universities. It provides an important step in introducing principles and concepts within the field of toxicology. The underlying mechanisms of toxicity are highlighted through examples taken from gases, minerals, plants, fungi, bacteria, marine creatures, industrial chemicals and pharmacological agents.In this second edition, the text has been completely revised and expanded with the addition of six new chapters — carbon monoxide, hydrofluoric acid, lead, mushroom, toxins, paracetamol, paraquat and diquat. Each chapter is self-sufficient, enabling readers to dip into chapters of interest at random without any lack of understanding. The book is informative, with numerous clinical details, and will appeal to those who wish to delve into this fascinating subject.

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This unique book provides a unified and systematic account of internal, external and unsteady slow viscous flows, including the latest advances of the last decade, some of which are due to the author. The book shows how the method of eigenfunctions, in conjunction with least squares, can be used to solve problems of low Reynolds number flows, including three-dimensional internal and unsteady flows, which until recently were considered intractable. Although the methods used are quantitative, much stress is laid on understanding the qualitative nature of these intriguing flows. A secondary purpose of the book is to explain how the complex eigenfunction method can be used to solve problems in science and engineering.Although primarily aimed at graduate students, academics and research engineers in the areas of fluid mechanics and applied mathematics, care has been taken, through the use of numerous diagrams and much discussion, to explain to the non-specialist the qualitative features of these complex flows.

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This engaging book provides a state-of-the-art introduction to the rapidly evolving field of mechanical circulatory support therapy in the care of patients with advanced heart failure. It is aimed at healthcare teams around the world who are involved in patient care, research, and teaching of advanced heart failure; healthcare professionals in training; and interested lay persons.In particular, this book• serves as a comprehensive resource and practice guide on all aspects of mechanical circulatory support therapy, starting with an overview on heart failure management and then continuing with the referral and evaluation, the care before and after mechanical circulatory support implantation, the analysis of outcomes and complications, as well as a description of research and societal perspectives in the field of mechanical circulatory support therapy;• is founded on the expertise of Columbia University Medical Center (New York City), which has one of the most renowned heart failure, mechanical circulatory support, and heart transplantation programs in the world;• takes a multidisciplinary integrated healthcare team approach, including the perspectives of cardiologists, cardiac surgeons, nurses, coordinators, social workers, psychologists, physical therapists, financial experts, and bioethicists; and• provides in a unique way the complementary viewpoints from the expert healthcare team's as well as the patient's and family's perspectives, with patient vignettes interspersed throughout the entire text.

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Although textbooks on the physics of condensed matter consider non-covalent interactions in detail, their application for analysis of protein properties is often poorly presented or omitted. On the other hand, books on biochemistry, molecular modeling or molecular simulation introduce these interactions in the context of the corresponding topic, which sometimes results in superficial explanations of their nature. This book succeeds in uniting comprehensive considerations of non-covalent interactions with the specificity of their application in protein sciences.The ideal aid for students of physics or chemistry, with interests in biology and biophysics, the book can also be useful for students of biology, biochemistry, or biomedicine who want to extend their knowledge of how protein properties are described at the molecular level.

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This book adopts a “show and tell” approach to guiding readers in the area of industrial wastewater treatment and the facilities associated with such treatment. It assumes the reader is familiar with wastewater treatment theory but may be unfamiliar with the reasons why certain unit processes or equipment are included in practice, how these work, and why they fail therein. Industrial wastewaters are extremely varied and this complicates their treatment and discussion. Numerous tables showing industrial wastewater characteristics and photographs of facilities are provided so that the reader can better appreciate industrial wastewater treatment and its “culture” in Asia, and gain a degree of familiarity with the subject unachievable if only text descriptions were used. The book aims to provide a link between theory and practice. It does not only cover typical textbook material but also includes much information that would usually be accessible only to persons who have handled wastewaters and treatment facilities personally. The numerous examples provided have been drawn from the author's own field experience over two decades in Asia.

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This textbook provides the first systematic presentation of the theory of stochastic differential equations with Markovian switching. It presents the basic principles at an introductory level but emphasizes current advanced level research trends. The material takes into account all the features of Ito equations, Markovian switching, interval systems and time-lag. The theory developed is applicable in different and complicated situations in many branches of science and industry.

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This unique book describes the science and technology of silicon carbide (SiC) microelectromechanical systems (MEMS), from the creation of SiC material to the formation of final system, through various expert contributions by several leading key figures in the field. The book contains high-quality up-to-date scientific information concerning SiC MEMS for harsh environments summarized concisely for students, academics, engineers and researchers in the field of SiC MEMS.This is the only book that addresses in a comprehensive manner the main advantages of SiC as a MEMS material for applications in high temperature and harsh environments, as well as approaches to the relevant technologies, with a view progressing towards the final product.

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The Human Genome Project has spawned a Renaissance of research faced with the daunting expectation of personalized medicine for individuals with sickle cell disease in the Genome Era. This book offers a comprehensive and timeless account of emerging concepts in clinical and basic science research, and community concerns of health disparity to educate professionals, students and the general public about meeting this challenging expectation. Contributions from physicians, research scientists, scientific administrators and community workers make Renaissance of Sickle Cell Disease Research in the Genome Era unique among the catalogue of books on this genetic disorder.Part 1 offers detailed review of the National Heart Lung and Blood Institute's leadership role in funding sickle cell research, as well as developing progressive research initiatives and the predicted impact of the Human Genome Project. Part 2 gives an account of several clinical research perspectives based on the Cooperative Study of Sickle Cell Disease. These include recommendations for newborn screening, pain management, stroke, transfusion therapy and pediatric and adult healthcare. Part 3 offers novel insights into basic science research progress and the impact of the Human Genome Project on the direction of hemoglobinopathy research, including hemoglobin switching, bone marrow transplantation and gene therapy. Part 4 engages the reader in a culture-based discussion of the stigma attached to sickle cell disease in the African American community and the apprehensions about genetic research in this community. It concludes with a global perspective on sickle cell disease from African, European and American experiences. For readers seeking a definitive account of sickle cell disease appropriate for students, researchers and community workers, this collaborative effort is an ideal textbook.

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The CCN Proteins are thought to play key roles in the biology of normal cell, tissue, organ, and body, and altered expression of CCN proteins is associated with several pathologies, including fibrosis and cancer. Because of its importance, the CCN field is expanding at a fast pace. Research articles in this field have recently increased logarithmically, and a book that is up-to-date, comprehensive, authoritative and affords insights into the biological roles of CCN proteins, is timely.CCN Protein: A New Family of Cell Growth and Differentiation Regulators presents the most recent progress in the field of CCN proteins, a new family of secretory signaling molecules that are involved in several fundamental biological progress. These proteins share a unique multimodular organization and present a partial identity with four families of regulatory proteins controling growth and development. The book covers the roles of CCN proteins in the control of cell proliferation and differentiation during normal development, wound repair, chondrogenesis and bone development, angiogenesis, tissue regeneration, fibrosis, renal diseases and cancer development.

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This book discusses issues associated with the quantum mechanical formulation of dissipative systems. It begins with an introductory review of phenomenological damping forces, and the construction of the Lagrangian and Hamiltonian for the damped motion. It is shown, in addition to these methods, that classical dissipative forces can also be derived from solvable many-body problems. A detailed discussion of these derived forces and their dependence on dynamical variables is also presented. The second part of this book investigates the use of classical formulation in the quantization of dynamical systems under the influence of dissipative forces. The results show that, while a satisfactory solution to the problem cannot be found, different formulations represent different approximations to the complete solution of two interacting systems. The third and final part of the book focuses on the problem of dissipation in interacting quantum mechanical systems, as well as the connection of some of these models to their classical counterparts. A number of important applications, such as the theory of heavy-ion scattering and the motion of a radiating electron, are also discussed.

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Cosmology is an unusual science with an unusual history. This book examines the formative years of modern cosmology from the perspective of its interaction with religious thought. As the first study of its kind, it reveals how closely associated the development of cosmology has been with considerations of a philosophical and religious nature. From nineteenth-century thermodynamics to the pioneering cosmological works of Georges Lemaître and Arthur E Milne, religion has shaped parts of modern cosmological theory. By taking the religious component seriously, a new and richer history of cosmology emerges.

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In this book, the issues regarding the theory of optics and quantum optics of spherical multilayered systems are studied. In such systems the spatial scale of layers becomes comparable with the wavelength of radiation, which complicates the analysis of important quantities such as reflectivity and transmission. Often, a large amount of time is spent on performing numerical calculations and simulation to elucidate the behavior of such electromagnetic properties. The author has written down the calculation details of important properties of multilayered microspheres in a more comprehensive manner, so that undergraduates and practitioners can follow them freely.From a skill-oriented point of view the book covers the following: electrodynamics of multilayered environments in the spherical geometry; methods of calculating both reflection and transmission coefficients from an alternating stack; calculations of eigenfrequencies and quality factors of electromagnetic oscillations; radial distribution of the electromagnetic field in a spherical cavity; computer methods of calculations with C++ as basic languages and construction of the graphic user interface (GUI); the object-oriented approach as a basis of the modern methods of calculation.

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This is a collection of 43 essays about the economics and management of information technology markets. The first part of the book focuses on events, notable birth dates and longstanding trends. The unifying theme revolves around the role of human economic behavior in the face of uncertainty and confusion. The contributors' intent is to explain, educate and entertain — to go beyond the obvious.The next part contains writing about the Internet. It discusses the development of the online commercial world, and analyzes the macroeconomic side of the investment boom and bust related to Internet activities. It also focuses on the measurement of economic activity in the digital economy.In addition, the book deals with how computers get used in organizations and discusses the Microsoft antitrust case. Finally, there are two long essays about economic constraints on strategic behavior in markets where standards and platforms matter.

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Engineering represents an ordered activity of creative design and inventive manufacture of ingenious devices. Its practitioners have thereby stimulated individuals, enlivened communities, enriched civilizations, and contributed to the shaping of cultures.The authors of this innovative text develop a systematic framework for engineering in time, making extensive use of adaptive heterogeneous progressions. When combined with considerations of feedback, feedforward, recursion, and branching, an evolving and comprehensive characterization of engineering becomes evident. It is in this blending of chronology, emerging theory, and professional practice that engineering finds its foundational role in innovative design, device reliability, intellectual property, technology risks, public safety, professional ethics, material accounting, and other recurring themes relevant to contemporary engineering. Engineering clearly emerges as a complex and increasingly important profession.The authors introduce concepts and methods — including a critical definition of engineering -and selectively adapt symbolic-mathematical relations. The technical level of analysis is suitable for the undergraduate curriculum commonly encountered in colleges of engineering.

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This book presents a practical guide to the analysis of materials and includes a thorough description of the underlying theories and instrumental aberrations caused by real experiments. The main emphasis concerns the analysis of thin films and multilayers, primarily semiconductors, although the techniques are very general. Semiconductors can be very perfect composite crystals and therefore their study can lead to the largest volume of information, since X-ray scattering can assess the deviation from perfection.The description is intentionally conceptual so that the reader can grasp the real processes involved. In this way the analysis becomes significantly easier, making the reader aware of misleading artifacts and assisting in the determination of a more complete and reliable analysis. The theory of scattering is very important and is covered in such a way that the assumptions are clear. Greatest emphasis is placed on the dynamical diffraction theory including new developments extending its applicability to reciprocal space mapping and modelling samples with relaxed and distorted interfaces.A practical guide to the measurement of diffraction patterns, including the smearing effects introduced to the measurement, is also presented.

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Fully updated, this revised edition describes the statistical aspects of both the design and analysis of trials, with particular emphasis on the more recent methods of analysis.About 8000 clinical trials are undertaken annually in all areas of medicine, from the treatment of acne to the prevention of cancer. Correct interpretation of the data from such trials depends largely on adequate design and on performing the appropriate statistical analyses. This book provides a useful guide to medical statisticians and others faced with the often difficult problems of designing and analysing clinical trials.

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This book describes a search for geological evidence of meteorite impact structures in Britain. The statistics of impact structures indicate that Britain should have Phanerozoic impact structures up to tens of kilometres in diameter. A constant theme is the importance of atmospheric break-up of small asteroids and comets. These fragmenting bodies produce anomalously shallow craters with low rims and central peaks; three British structures of this type are identified.Analysis of fireball statistics implies that damaging fireball explosions occur over the British Isles on a time-scale of decades. On a time-scale of millennia, however, more damage is done by Atlantic impact tsunami.

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The discovery of superconductivity at 30 K by Bednorz and Müller in 1986 ignited an explosion of interest in high temperature superconductivity. The initial development rapidly evolved into an intensive worldwide research effort — which still persists after more than a decade — to understand the phenomenon of cuprate superconductivity, to search for ways to raise the transition temperature and to produce materials which have the potential for technological applications.During the past decade of research on this subject, significant progress has been made on both the fundamental science and technological application fronts. A great deal of experimental data is now available on the cuprates, and various properties have been well characterized using high quality single crystals and thin films. Despite this enormous research effort, however, the underlying mechanisms responsible for superconductivity in the cuprates are still open to question.This book offers an understanding from the phase transition point of view, surveys and identifies thermal and quantum fluctuation effects, identifies material-independent universal properties and provides constraints for the microscopic description of the various phenomena. The text is presented in a format suitable for use in a graduate level course.

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Atomic force microscopy (AFM) is part of a range of emerging microscopic methods for biologists which offer the magnification range of both the light and electron microscope, but allow imaging under the 'natural' conditions usually associated with the light microscope. To biologists AFM offers the prospect of high resolution images of biological material, images of molecules and their interactions even under physiological conditions, and the study of molecular processes in living systems. This book provides a realistic appreciation of the advantages and limitations of the technique and the present and future potential for improving the understanding of biological systems.

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This is a unique book about natural catastrophes, focusing on the mathematical aspects of these phenomena. Although academic in style and didactic in purpose, it is practical in the treatment of the diverse issues covered, which range from hazard warning and forecasting to engineering design criteria and insurance loss estimation. Addressing as it does many mathematical topics not found together in a single volume, the book should be of value to all those with a quantitative educational interest in or professional concern for natural catastrophes.

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The fact that the World Health Organization has declared tuberculosis a “global emergency” indicates the serious inadequacy of the ways in which the control methods at our disposal are used. Several books on tuberculosis have been published in recent years, but none have taken a deep and detailed look at the “holistic” aspects of global tuberculosis control, even though international agencies are increasingly aware of the importance of the numerous factors other than the design and efficacy of therapeutic drug regimens. This unique book fills that gap. Although it deals specifically with tuberculosis, the principles outlined and discussed are relevant to many other areas of global medicine, including the ever-growing problem of HIV/AIDS.The book is aimed principally at those involved in the design, establishment and management of disease control programmes at international, national and local levels, and also at a more general readership of epidemiologists, public health officers, community psychologists, and others interested in understanding the human dimension of disease control.

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Venous diseases are among the most commonly encountered problems at primary care level, yet they are poorly understood and often mismanaged. This concise, highly illustrated book will fill the need of all primary care staff and trainees for clear information on the diagnosis and management of the different conditions and their complications.

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This book offers a comprehensive overview of the most recent developments in both total oxidation and combustion and also in selective oxidation. For each topic, fundamental aspects are paralleled with industrial applications. The book covers oxidation catalysis, one of the major areas of industrial chemistry, outlining recent achievements, current challenges and future opportunities. One distinguishing feature of the book is the selection of arguments which are emblematic of current trends in the chemical industry, such as miniaturization, use of alternative, greener oxidants, and innovative systems for pollutant abatement. Topics outlined are described in terms of both catalyst and reaction chemistry, and also reactor and process technology.

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Current research in genomics and pharmacogenomics is increasingly highlighting the need to move towards stratified disease descriptions and individualized treatment plans. This book explains how a confluence of recent biological, technological and methodological developments is making it possible to provide personalized diagnoses and treatments.By virtue of treating each person's condition as unique, personal genomics and personalized medicine require health professionals to understand the nature of the data, its health implications, and its limitations.This book provides a detailed scientific treatment of the emerging disciplines of personal genomics and personalized medicine. It also includes a comprehensive treatment of both the promises and challenges of personal genomics and medicine from technological, societal and medical perspectives. It offers a wide-ranging review of the state of the art across all aspects of a highly multi-disciplinary subject. This book will be immensely useful for practicing health professionals and researchers, as well as senior undergraduates and graduate students in biomedical sciences.

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This book compiles a collection of original scientific articles written by Professor Sir Alan Fersht over 40 years of his scientific career. A long-standing icon in the fields of enzymology, protein folding, and protein engineering, Sir Alan Fersht is also one of the world's greatest protein chemists, whose work has been extensively recognized by countless international awards in both chemistry and molecular biology. He has produced a number of classic papers that are cited regularly because of the originality of his work and his insightful analysis. The study of his work on the fusion of physical chemistry and molecular biology provides a course on how to approach the analysis of complex systems in a simple logical manner. His papers are models of clarity, benefitting students of protein chemistry in their understanding of the subject.The beginning of Sir Alan Fersht's career coincided with the birth of modern protein science based on structural biology, which started in earnest momentum in the 1960s. He worked in the then Mecca of molecular biology, the MRC Laboratory of Molecular Biology, and was one of the first protein chemists to exploit the new area of structural biology. The papers are interlaced with personal comments on how each article was important in his career and how he was influenced by the galaxy of legendary scientists in the MRC.

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In terms of structural complexity, the natural world presents innumerable examples of stunning beauty and high functionality, usually with the minimum of material and energy expenditure. Materials chemists can harness these amazing structures as ready-made scaffolds on which to grow inorganic phases which replicate the underlying complexity, thereby producing materials with greatly enhanced physical properties. This book comprehensively describes the entire range of natural materials that have been used in this way and the inorganic phases which result from them. The book covers simple molecules such as cellulose and chitin, to large biological constructs such as bacterial proteins, viruses and pollen. Practically every inorganic material has been synthesized using biotemplating methods and the book reflects this, ranging from simple oxides and carbonates such as silica and calcite, to complex semi- and superconducting materials. The book also discusses the formation of these materials from a mechanistic point of view, thereby enabling the reader to better understand the processes involved in biotemplated mineralization.

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This book is an impressive compilation of contributions on the hot topic of cardiac stem cell therapy from leading groups all over the world. In the assembly of chapters, a structured approach is adopted; starting from the clinician's perspective, all developments in both the experimental and clinical research areas are covered. This journey will take the reader from the bench-top to the bedside, with all chapters written by leading authorities in their respective fields, including data still in press with medical journals.So, beyond being excellent as an overall update for scientists in the field of cardiac stem cell therapy, this book will likely prove an indispensable tool for every budding scientist considering a research project within this field.

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The year 2007 marked not only the centenary of Imperial College London but also the 50th anniversary of the late Nobel Laureate Professor Abdus Salam's arrival at the College. Accordingly, a conference entitled “Salam + 50” organized by the Theoretical Physics Group was held at Imperial College on 7 July 2007.Many distinguished guests attended and paid their respects to the great man. Their contributions recorded in these proceedings are divided into three sections, designed to reflect the three dimensions of Salam's character: 1) Salam the Scientist, 2) Salam the Humanitarian, and 3) Salam the Man.

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As the first in the “Clinical Talk” series, the philosophy of this book is to have a set of question-based sections to help a final-year medical student prepare for exams. These sections include multiple choice questions (MCQs), extended matching questions (EMQs) and case studies. The idea is to have not just a “test yourself” book, but one which students can work through as a learning exercise as well as for revision purposes. For that reason, the answers and explanations provided here are just as important as the questions themselves.Stansby and Goldberg have structured this book such that it complements one of their bestselling textbooks, Surgical Talk: Revision in Surgery.

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This textbook introduces the tools and language of modern geometric mechanics to advanced undergraduate and beginning graduate students in mathematics, physics, and engineering. It treats the dynamics of rotating, spinning and rolling rigid bodies from a geometric viewpoint, by formulating their solutions as coadjoint motions generated by Lie groups. The only prerequisites are linear algebra, multivariable calculus and some familiarity with Euler-Lagrange variational principles and canonical Poisson brackets in classical mechanics at the beginning undergraduate level.Variational calculus on tangent spaces of Lie groups is explained in the context of familiar concrete examples. Through these examples, the student develops skills in performing computational manipulations, starting from vectors and matrices, working through the theory of quaternions to understand rotations, and then transferring these skills to the computation of more abstract adjoint and coadjoint motions, Lie-Poisson Hamiltonian formulations, momentum maps and finally dynamics with nonholonomic constraints.The 120 Exercises and 55 Worked Answers help the student to grasp the essential aspects of the subject, and to develop proficiency in using the powerful methods of geometric mechanics. In addition, all theorems are stated and proved explicitly. The book's many examples and worked exercises make it ideal for both classroom use and self-study.

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In this Completely Revised and Extended Edition with a significantly enhanced content, all Chapters have been updated considering relevant literature and recent developments until 2016 together with application oriented examples with a focus on Industrial Biocatalysis. Newly treated topics comprise among others systems metabolic engineering approaches, metagenome screening, new tools for pathway engineering, and de-novo computational design as actual research areas in biocatalysis. Information about different aspects of RNA technologies, and completely new Chapters on 'Fluorescent Proteins' and 'Biocatalysis and Nanotechnology' are also included.

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How to achieve unlimited, safe, clean and low-cost energy by laser- or beam-driven inertial nuclear fusion has preoccupied all winners of the Edward Teller Medal since its inception in 1991. This book presents their findings, meeting discussions, and personal insights from Edward Teller himself. Expect discussion of important advances anticipated in the future such as multi-billion dollar fusion research projects (NIF), and new schemes such as the petawatt-picosecond laser-plasma interactions evoking new physics and coupling mechanisms.For the first time, laser technology of the new century is providing the very short and extremely intense energetic pulses needed for fusion energy from next generation power stations, which produce energy at cost several times lower than any other source. The long-sought dream to directly ignite frozen heavy hydrogen for controlled use is close to being realized. Years of research on plasmas and lasers carried out worldwide in highly sophisticated experiments is summarized. The coverage begins with the work of John Nuckolls and Nobel Laureate Nikolai Basov and leads to the new scheme of plasma block acceleration via the nonlinear ponderomotive force. Edward Teller Lectures is one of the first guides to these new developments.

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This book provides a comprehensive introduction to the physics of the photovoltaic cell. It is suitable for undergraduates, graduate students, and researchers new to the field. It covers: basic physics of semiconductors in photovoltaic devices; physical models of solar cell operation; characteristics and design of common types of solar cell; and approaches to increasing solar cell efficiency. The text explains the terms and concepts of solar cell device physics and shows the reader how to formulate and solve relevant physical problems. Exercises and worked solutions are included.

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This book is designed to enable non-native English speakers to write science research for publication in English. It can also be used by English speakers and is a practical, user-friendly book intended as a fast, do-it-yourself guide for those whose English language proficiency is above intermediate. The approach is based on material developed from teaching graduate students at Imperial College London and has been extensively piloted. The book guides the reader through the process of writing science research and will also help with writing a Master's or Doctoral thesis in English.Science writing is much easier than it looks because the structure and language are conventional. The aim of this book is to help the reader discover a template or model for science research writing and then to provide the grammar and vocabulary tools needed to operate that model. There are five units: Introduction, Methodology, Results, Discussion/Conclusion and Abstract. The reader develops a model for each section of the research article through sample texts and exercises; this is followed by a Grammar and Writing Skills section designed to respond to frequently-asked questions as well as a Vocabulary list including examples of how the words and phrases are to be used.

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This book is a step by step illustrated guide to planning and writing dissertations and theses for undergraduate and graduate science students. Topics covered include advice on writing each section of a thesis as well as general discussions on collecting and organizing references, keeping records, presenting data, interacting with a supervisor and avoiding academic misconduct. Recommendations about how to use word processors and other software packages effectively are included, as well as advice on the use of other resources. A concise summary of important points of English grammar is given, along with appendices listing frequently confused words and wordy phrases to avoid. Further appendices are provided, including one on SI units. The aim is to provide an easy-to-read guide that gives students practical advice about all aspects of writing a science thesis or dissertation, starting from writing a thesis plan and finishing with the viva and corrections to the thesis.

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The two most wanted terrorists in Southeast Asia — a Malaysian and a Singaporean — are on the run in the Philippines, but they manage to keep their friends and family updated on Facebook. Filipinos connect with al-Qaeda-linked groups in Somalia and Yemen. The black flag — embedded in al-Qaeda lore — pops up on websites and Facebook pages from around the world, including the Philippines, Indonesia, the Middle East, Afghanistan, Australia, and North Africa. The black flag is believed to herald an apocalypse that brings Islam's triumph. These are a few of the signs that define terrorism's new battleground: the Internet and social media.In this groundbreaking work of investigative journalism, Maria Ressa traces the spread of terrorism from the training camps of Afghanistan to Southeast Asia and the Philippines. Through research done at the International Center for Political Violence & Terrorism Research in Singapore and sociograms created by the CORE Lab at the Naval Postgraduate School, the book examines the social networks which spread the virulent ideology that powered terrorist attacks in the past 10 years.Many of the stories here have never been told before, including details about the 10 days during which Ressa led the crisis team in the Ces Drilon kidnapping case by the Abu Sayyaf in 2008. The book forms the powerful narrative that glues together the social networks — both physical and virtual — which spread the jihadi virus from bin Laden to Facebook.

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