Search results for ""author leon""

Leon Logothetis, host of the popular discovery+ series The Kindness Diaries and author of Go Be Kind, returns with a brand-new set of adventures and a brand-new call to action: Go Be Brave!Bravery goes far beyond running into burning buildings. It’s what makes us human and what allows us to connect with others. It’s the foundation of a truly magnificent life—if only we’re vulnerable enough to embrace it.In his travels across the world, Leon Logothetis—“The Kindness Guy”—has met some of the kindest people around. What he discovered along the way was that bravery wasn’t what he thought it was. True bravery means being kind, making connections, and tapping into the deep fearlessness that defines us as human beings. Now, in Go Be Brave, Leon shares 24 (and ¾) new adventures for a fearless, wiser, and truly magnificent life. Bravery is a choice—the choice to reconnect to our humanity—and it’s one we can make every single day. Go Be Brave is a simple concept and a simple journal that will strengthen your being-human muscle and remind you how brave you truly are. With Leon cheering you on, you will:Go on a treasure hunt to find your very own Bravery BuddyBuild a strategy for love—to both offer and accept more of it Learn to say "yes" to adventure, and embrace saying "no" to things that don't serve you.Tackle your biggest fear—whether it’s spiders or having a difficult conversation with a loved oneBravely share your greatest dream with the world (or email it to Leon)Some of the adventures will be fun (ice cream sold separately), some will be serious, some will be hard, and a few will crack you up. But all of them will have the power to change your life, and the lives of those around you. So go out there, and #GoBeBrave.

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The notion of retrieving a bit of the past-by owning a material piece of it-has always appealed to humans. Often our most prized possessions are those that have had a long history before they came into our hands. Part of the pleasure we gain from the encounter with antiques stems from the palpable age and the assumed (sometimes imaginary) cultural resonances of the particular object. But precisely what is it about these objects that creates this attraction? What common characteristics do they share and why and how do these traits affect us as they do? In Antiques: The History of an Idea, Leon Rosenstein, a distinguished philosopher who has also been an antiques dealer for more than twenty years, offers a sweeping and lively account of the origin and development of the antique as both a cultural concept and an aesthetic category. He shows that the appeal of antiques is multifaceted: it concerns their value as commodities, their age and historical and cultural associations, their uniqueness, their sensuous and tactile values, their beauty. Exploring how the idea of antiques evolved over time, Rosenstein chronicles the history of antique collecting and connoisseurship. He describes changing conceptions of the past in different epochs as evidenced by preservations, restorations, and renascences; examines shifting attitudes toward foreign cultures as revealed in stylistic borrowings and the importation of artifacts; and investigates varying understandings of and meanings assigned to their traits and functions as historical objects. While relying on the past for his evidence, Rosenstein approaches antiques from an entirely original perspective, setting history within a philosophical framework. He begins by providing a working definition of antiques that distinguishes them from other artifacts in general and, more distinctly, both from works of fine art and from the collectible detritus of popular culture. He then establishes a novel set of criteria for determining when an artifact is an antique: ten traits that an object must possess in order to elicit the aesthetic response that is unique to antiques. Concluding with a provocative discussion of the relation between antiques and civilization, this engaging and thought-provoking book helps explain the enduring appeal of owning a piece of the past.

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Six authors, all of whom have been associated with the Center of International Studies at Princeton University, take the occasion of the twentyfifth anniversary of the United Nations to reexamine the UN's role and work in the world today and to anticipate its future. Chapters ranging from the theoretical to the detailed and practical include "The United Nations and the International System," by Oran R. Young; "The United Nations and the League," by Stanley Michalak; "An Inquiry into the Successes and Failures of the United Nations General Assembly," by Gabriella Rosner Lande; "International Organization and Internal Conflicts," by Linda Miller; "The United Nations and Economic and Social Change," by Leon Gordenker; and "The United Nations: Various Systems of Organization," by Richard A. Falk. Originally published in 1971. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

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A Wall Street Legend Recounts His Fifty Years in the Stock Market, Hedge Funds, and PhilanthropyWall Street mogul Leon Cooperman provides a brilliant business memoir encompassing a quarter-century with Goldman Sachs and then the management of his own successful hedge fund, Omega Advisors. Cooperman traces his life story from his roots as the son of immigrant parents in the Bronx through his days as an undergraduate at Hunter College, his subsequent graduate studies at the Columbia Business School, and beyond, all the way to his current role as a subscriber to Warren Buffet’s “Giving Pledge” and a committed philanthropist engaged in giving away the entirety of his multi-billion-dollar fortune. Along the way, Cooperman also spells out his philosophies and “best practices” for stock research and investment, rooted in the classic value-investing approach originated by Benjamin Graham and David Dodd. Additionally, Cooperman makes an impassioned defense of capitalism as the best of all possible economic systems. Cooperman’s narrative also includes meditations on taxes in general (and a wealth tax in particular) and challenges the thinking of political progressives who espouse policies which Cooperman believes would unduly restrain the free market.

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Packed with physical facts and healthy hints - find out why healthy kids choose to understand puberty!Find out what happens to a body in puberty and why, and how these changes can affect your mental health. Whatever stage of maturity you''re facing, this book has something for everyone: from hormones and spots to emotional and relational health during puberty. And don''t forget about healthy eating - it is also key to managing puberty!The HEALTHY KIDS series encourages children aged 9-11 to make healthy lifestyle choices with knowledge that will benefit them throughout their lives. Discover positive, practical and to-the-point advice on everything from puberty and fitness, to staying safe and keeping clean.Books in the series:Healthy Kids: Eat Healthy FoodHealthy Kids: Exercise Your Body Healthy Kids: Keep Yourself Clean Healthy Kids: Keep Yourself SafeHealthy Kids: Understand Puberty

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This is the story of the defeats and triumphs of three Irish families.It is a powerful and stirring look at love and hate, both personal and political.Told through the simple lives of its people, this is an epic history of Ireland. From the famine of the 1840s to the 1916 Easter Rising, Trinity chronicles the terrible and beautiful drama of more than half a century.Leon Uris’s skill is in capturing a subject seemingly too big to handle and distilling the very essence of that struggle into passionate prose. Years after his death, he remains one of the most popular storytellers of the twentieth century – this is one of his most celebrated novels.

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At a time when the hottest issue in US immigration law is the proposed action by President Obama to protect from deportation as many as 5 million illegals in the United States, the 1972 John Lennon deportation case takes on special relevance today, notwithstanding the passage of forty years since he was placed in deportation proceedings. For the first time, noted New York immigration attorney Leon Wildes tells the incredible story of this landmark case - John Lennon vs. The U.S.A. - that set up a battle of wills between John Lennon, Yoko Ono, and President Richard Nixon. Although Wildes did not even know who John Lennon and Yoko Ono were when he was originally retained by them, he developed a close relationship with them both during the eventual five-year period while he represented them and thereafter. This is their incredible story.

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In a work that casts philosophical and theological reflections against a backdrop of personal experience, Leon Wiener Dow offers a learned discourse that elucidates the telos of Jewish law and the philosophical-theological commitments that animate it. To the reader gazing upon the halakha from the outside, this book offers a glimpse of its central, orienting concepts. To the reader who lives amidst the rigor of halakha, this book bestows an insightful glance at the law’s orienting ethos and higher aspirations that often remain opaque.

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The Philosopher's English King offers a close reading of the Henriad, presenting Shakespeare's teaching on political authority and contributing to the burgeoning scholarship on Shakespeare as a political thinker. This book on Shakespeare's Henriad studies the tetralogy as a work of political thought. Leon Harold Craig, author of two previous volumes on Shakespeare's political thought, argues that the four plays present Shakespeare'steaching on the problem of legitimacy, or who has the right to rule -- one of the perennial questions of political philosophy. Offering original interpretations of each of the plays, Craig discusses the demise of divine right inRichard II, political upheaval and disputed rule in Henry IV, Parts 1 and 2, and the attempt to reestablish legitimacy on a new basis in Henry V. While focusing especially on the plays' various interpretive puzzles,Craig shows how the four plays constitute one narrative, culminating in the rule of England's most famous warrior king, Henry V, whose brilliant achievements were undone by ill fortune. Craig concludes with an epilogue on what might have been had Henry lived to consolidate his conquest of France and unify it with England under a single crown. Supported by a wealth of scholarship, both historical and critical, The Philosopher's English King makes a major contribution to the burgeoning scholarship on Shakespeare as a political thinker, providing further evidence for why the poet deserves to be recognized as a philosopher in his own right. Leon Harold Craig is professor emeritus of political science at the University of Alberta.

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A great breakfast or brunch has always been at the heart of the Leon experience and this irresistible compact collection of naturally fast recipes will make your tastebuds sing. From a Breakfasty Banana Split and a Mini Knickerbocker Glory to luxurious wheat-free Saturday Pancakes, every day will get off to a fabulously energetic Leon-style start.

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This volume includes five chapters dealing with some of the latest advances in medicine and biology. Chapter One pontificates on the impact of the sequencing of the human genome on the search for life in the universe. Chapter Two summarizes current understanding of how to assess endothelial dysfunction, main risk factors, mechanisms underlying its development, prognostic implications, and biomarkers. Chapter Three assesses the effects of the hormone irisin on glucose metabolism. Chapter Four highlights the common disorders that need to be considered as a differential diagnosis for neuromyelitis optica spectrum disorder and features that help in their differentiation. Finally, Chapter Five deals with tapered modular femoral components in revision total hip arthroplasty.

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This edited manuscript includes six chapters, each describing recent advancements in medicine and biology. Chapter One investigates the impact on psychopathology of adding lurasidone to clozapine for people with treatment-resistant schizophrenia. Chapter Two reviews some intestinal protozoa and their diseases in immunodeficient patients. Chapter Three addresses the general role of inflammasomes and reviews current knowledge of potential therapeutic application of inflammasomes in neurological disorders. Chapter Four looks at the role of ion channel activation and downstream signal transduction in modulating Sertoli cell behaviour to a final physiological response and its potential impact on spermatogenesis. Chapter Five includes a comprehensive view on sulphur-containing saponins and their mode of actions. Lastly, Chapter Six assesses the pathophysiological impacts of Spironucleus salmonis infection on the seawater adaptability of juvenile chum salmon.

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This monograph consists of six chapters, each describing recent advancements in medicine and biology. Chapter One details the use of radiology as an imaging method in diagnosis and risk-assessment of osteoporosis. Chapter Two describes research that aims to better understand the mechanisms involved in the onset of extrapyramidal side effects following treatment with antipsychotics. Chapter Three deals with issues related to endoscopic submucosal dissection (ESD), including diagnosis, endoknives, procedure, traction method, management of complications, and more. Chapter Four discusses ESD in the context of colorectal neoplasia. Chapter Five discusses estrogen receptor mutations that have been described in the ligand binding domain as well as the proposed treatments for patients with breast cancer ESR1 mutant-bearing tumors. Finally, Chapter Six discusses the role of estradiol in the regulation of the immune response of the host during parasitic infections and how estradiol affects parasite physiology.

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This monograph contains six chapters, each of which provides details about recent advancements in the field of medicine and biology. Chapter One describes the discovery of AZQ, a drug specifically designed to shut off genes that cause brain cancer. Chapter Two analyses the structure, stability, adaptation to extreme environments and the catalytic mechanism of α-helical membrane proteins. Chapter Three provides an up-to-date overview of artificial intelligence (AI) in assisted reproductive treatment (ART) clinics and explores how AI learns and develops a dataset to provide clinical guidance. Chapter Four consists of a study focused on the etiopathogenesis of primary open angle glaucoma using laboratory mice. Chapter Five presents and comments on the current evidence regarding diagnostics in patients with metastatic breast cancer based on circulating tumour cells (CTCs). Lastly, Chapter Six reviews the pathogenetic and clinical features of inner ear involvement in congenital cytomegalovirus (cCMV), the most frequent non-genetic cause of permanent sensorineural hearing loss in childhood.

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Advances in Medicine and Biology. Volume 170 begins by presenting the latest evidence that Alzheimer's disease-related proteins and their genes play a role in post-ischemic brain damage, and that an ischemic episode is an essential and leading provider of Alzheimer's disease development. The authors go on to review the pathophysiology, symptoms, epidemiology, analysis, and treatment of Alzheimer's disease. Important issues when appraising and interpreting studies on fertility awareness methods used for avoiding pregnancy are described, and correct clinical applications of fertility awareness methods for contraception are also discussed. The basic molecular pathology of human cancers is discussed, as well as rising technologies for tumour characterization and the role of molecular profiling in identifying potential targets for individualised treatment. Additionally, an overview of the various modalities for assessing the liver functional reserve in patients undergoing hepatic resection is provided. Lastly, data on the linearization of somatic growth plots in humans and rats is discussed, showing the existence of at least two ontogenetic transitions: juvenile and pubertal.

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This compilation opens with a review of the current knowledge regarding the impact of endocrine disruptors on human health, as well as the mechanisms contributing to it. The authors emphasize the evidence of aquaporin modulation by hypoxia and erythropoietin, as these water channels are increasingly valued as potential biomarkers of disease, as well as pharmacological targets for the treatment of brain and renal injuries, cardiovascular disorders and cancer. Later, the safety and tolerability of adalimumab demonstrated in pivotal phase III clinical trials is examined, along with long-term follow up data from open-label extensions and the ESPRIT registry. Adalimumab for the treatment of ankylosing spondylitis and peripheral spondyloarthritis is also discussed. The authors go on to study the types, causes, effect and problems related to polycystic ovary syndrome. The closing study deals with the relationship between reactive oxygen species and male fertility, providing some futuristic approaches for better research in the field.

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Volume 165 first presents promising information about the essential goal of effective and safe medication for target patients with the appropriate genotypes. The authors explore the diverse causes of neonatal leukemoid reaction in premature infants proposed by Hill and Duncan in 1941, such as intrauterine infection and maternal steroid administration. This compilation also explores hjypoxia-inducible factor-1, a key gene regulator for cellular adaptation to hypoxia which leads to a transcriptional response under physiological as well as pathological conditions. From a historical perspective, Wilms' tumor treatment is assessed, focusing on the different approaches of the two main groups, the Children's Oncology Group and the International Society of Paediatric Oncology. The genetics and genomics of Plasmodium, which include multiple parameters and factors affecting disease transmission, are assessed in an effort to enhance our knowledge about the disease. Following this, whole slide imaging or virtual microscopy is used for the quantitative evaluation of liver biopsy specimens of patients with chronic hepatitis. The closing study examines data which reveals changes in the functioning of the ceruloplasmin/transferrin system, decreasing the content of toxic ions of Fe2+ in the plasma of patients with Parkinson's disease. These changes are a pathogenetically significant factor of Parkinson's disease at all stages.

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Advances in Medicine and Biology. Volume 157 opens with a study wherein the authors use guinea pig airway smooth muscle to demonstrate that testosterone blocks L type voltage dependent Ca2+ channels. Furthermore, in vivo experiments with sensitized guinea pigs show that bronchospasm induced by antigenic challenge was abolished by testosterone and its 5α and 5β-dihydrotestosterone metabolites. Following this, the authors evaluate the structural features of skeletal muscles in children and adults with various pathologies of the musculoskeletal system based on ultrasonography, considering periods of natural growth and involutive changes. An overview of the current state of research on fluoxetine for the treatment of anxiety alone or combined with depression is provided, along with its possible side effects. Also provided is scientific information is regarding the neurobiological bases of depression and therapeutic effects of fluoxetine during the different periods of menopause. This information could be useful in pharmacological strategies for the treatment of depression occurring in the menopausal women. One chapter focuses on how improved direct access to the liver protected inside the rib cage can be obtained in laparoscopic liver resection using its specific "Caudal approach", decreasing the risk of refractory ascites and liver failure, especially in hepatocellular carcinoma patients with chronic liver diseases. The nucleolus is packed with proteins involved in ribosome function and biogenesis, as well as other proteins involved in cell-cycle regulation, senescence and stress response. However, little is known about the molecular mechanism of protein turnover in the nucleolus. As such, the authors discuss the nucleolus-localized protein degradation pathway, which is essential to ribosome production and cell-cycle progression. The concluding chapter focuses on the dye Congo red, which is used as a stain in microscopy to detect an abnormal material called amyloid. Amyloid consists of misfolded proteins that form fibrils which bind molecules of Congo red and orientate the molecules parallel to the long axis of the fibrils.

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