Search results for ""taylor francis""

Following in the tradition of its popular predecessor, the Manual of Geospatial Science and Technology, Second Edition continues to be the authoritative volume that covers all aspects of the field, both basic and applied, and includes a focus on initiating, planning, and managing GIS projects. This comprehensive resource, which contains contributions from 53 leading experts and professors in the areas of GIS, GPS, and remote sensing, reflects the very latest advances in the technology, applications, and usage of the geospatial sciences in many key disciplines, from natural resource analysis to transportation planning.Significantly updated and expanded, this reader-friendly manual introduces the fundamentals in mathematics and physics needed to perform area-wide mapping, inventory, data conversion, and analysis. The text maintains a focus on the practical aspects of these technologies and remains the only resource to cover the areas of GIS, GPS, and remote sensing with such breadth and clarity. An expanded index, new and revised figures, a color insert, and an easier to read format are among the many improvements to this edition. New to the Second Edition: Revised chapters reflecting the changes that have occurred in the technology, applications, and usage of geospacial science Coverage of GIS applications in automobile navigation and enterprise-wide applications A new chapter devoted to basic statistics and least squares solutions Expanded international scope that addresses the other Global Navigation Satellite Systems (GNSS), including the Russian Federation system (GLONASS), the Chinese system (COMPASS), and the European space agency system (GALILEO) A new chapter covering Light Detection and Ranging (LiDAR) A new chapter that addresses privacy issues, legal concerns, and the emerging field of public participation GIS (PPGIS) New material on the expanding field of geovisualization The text presents many real-world applications, including road map navigation using GPS, as well as problems associated with mapping, inventory of land parcels, and data analysis. Complete with helpful references, decision making tools, and many new case studies, this time-saving resource provides the practical understanding required to harness the potential of these dynamic technologies.

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The widespread availability of mobile devices coupled with recent advancements in networking capabilities make opportunistic networks one of the most promising technologies for next-generation mobile applications. Are you ready to make your mark? Featuring the contributions of prominent researchers from academia and industry, Mobile Opportunistic Networks: Architectures, Protocols and Applications introduces state-of-the-art research findings, technologies, tools, and innovations. From fundamentals to advanced concepts, the book provides the comprehensive technical coverage of this rapidly emerging communications technology you need to make contributions in this area. The first section focuses on modeling, networking architecture, and routing problems. The second section examines opportunistic networking technologies and applications. Presenting the latest in modeling opportunistic network connection structures and pairwise contacts, the text discusses the fundamentals of opportunistic routing. It reviews the most-popular routing protocols and introduces a routing protocol for delivering data with load balancing and reliable transmission capabilities. Details an approach to analyzing user behavior based on realistic data in opportunistic networks Presents analytical approaches for mobility and heterogeneous connections management in mobile opportunistic networks Compares credit-based incentive schemes for mobile wireless ad hoc networks and challenged networks Discusses the combined strengths of cache-based approaches and Infostation-based approaches Addressing key research challenges and open issues, this complete technical guide reports on the latest advancements in the deployment of stationary relay nodes on vehicular opportunistic networks. It also illustrates the use of the service location and planning (SLP) technique for resource utilization with

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Cardiology Science and Technology comprehensively deals with the science and biomedical engineering formulations of cardiology. As a textbook, it addresses the teaching, research, and clinical aspects of cardiovascular medical engineering and computational cardiology. The books consists of two sections. The first section deals with left ventricular (LV) wall stress, cardiac contractility, ventricular remodeling, active wall stress and systolic pressure generation, and vector cardiogram characteristics, with applications in cardiology. The second section covers ECG signal analysis for arrhythmias detection, LV pumping (intra-LV, aortic and coronary flow) characteristics, and coronary bypass surgery design, with applications in cardiology and cardiac surgery.This book is like an exciting train ride through the heart and into blood flows within its chamber, the coronary tree, the aorta, and finally into coronary flow and bypass grafting. The train starts from the heart’s central station and journeys through exciting places of heart wall stresses, cardiac contractility measures to characterize heart failure, and active stress generation to develop systolic heart pressure. We learn about cardiomyopathic heart remodeling and its surgical ventricular restoration, theory of ECG and vector cardiogram with medical applications, and heart rate variability signal processing to detect cardiac arrhythmias. In the heart chamber, we witness the amazing intricate intra-ventricular flow patterns. Then, we study pressure pulse wave propagation into the aorta, determination of pulse wave velocity and arterial elasticity as a measure of arteriosclerosis. We climb into the mountainous coronary terrain and look at the fascinating scenery of coronary flows and myocardial perfusion that governs cardiac contractility. Finally, we arrive at coronary bypass grafting and witness the new sequential anastomosis design for enhanced patency. This fascinating journey helps us to fully appreciate cardiology from the science, technology, engineering, and mathematics viewpoint. The book represents what can be termed as computational cardiology, and hence belongs to the emerging field of computational medicine.

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Based on research projects supported by the National Natural Science Foundation of China and Nanjing University of Aeronautics and Astronautics, Optimization of Regional Industrial Structures and Applications provides an authoritative introduction to and survey of the cutting-edge research and applications in industrial structure optimization. Employing grey systems theory as its method of analysis, it integrates grey systems theory with industrial structure optimization theory to provide dynamic and efficient methods of measurement, analysis, and decision making. The authors cover several models of grey regional industrial structure, including grey correlation priority analysis, industrial structure order degree measurement model, regional leading industries grey assessment model and turnpike model. The first part of the book clarifies basic theory. This section covers the production and development of industrial structure theory, evolution laws of industrial structure, rationalization and upgrading of industrial structures, factors of industrial structure upgrading, input–output analysis, and mathematical modeling of regional industrial structures. The second section introduces four case studies that illustrate real-world research and applications. It considers the approaches and measures taken in China’s industrial structure upgrade during the "eleventh five-year plan". The case studies examine measures of and strategies for Jiangsu province’s industrial structural adjustment.This section also presents the optimization and promotion study of the "eleventh five" industrial structure of another city in China. The models detailed in this book not only develop application fields of grey systems theory, but also enrich the theories of industrial structure optimization. All of the methods presented in the text are reviewed in the case studies to supply readers with a vivid and practical understanding.

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Shaped by Quantum Theory, Technology, and the Genomics RevolutionThe integration of photonics, electronics, biomaterials, and nanotechnology holds great promise for the future of medicine. This topic has recently experienced an explosive growth due to the noninvasive or minimally invasive nature and the cost-effectiveness of photonic modalities in medical diagnostics and therapy. The second edition of the Biomedical Photonics Handbook presents recent fundamental developments as well as important applications of biomedical photonics of interest to scientists, engineers, manufacturers, teachers, students, and clinical providers. The third volume, Therapeutics and Advanced Biophotonics, focuses on therapeutic modalities, advanced biophotonic technologies, and future trends. Represents the Collective Work of over 150 Scientists, Engineers, and CliniciansDesigned to display the most recent advances in instrumentation and methods, as well as clinical applications in important areas of biomedical photonics to a broad audience, this three-volume handbook provides an inclusive forum that serves as an authoritative reference source for a broad audience involved in the research, teaching, learning, and practice of medical technologies. What’s New in This Edition:A wide variety of photonic biochemical sensing technologies has already been developed for clinical monitoring of early disease states and physiological parameters, such as blood pressure, blood chemistry, pH, temperature, and the presence of pathological organisms or biochemical species of clinical importance. Advanced photonic detection technologies integrating the latest knowledge of genomics, proteomics, and metabolomics allow sensing of early disease states, thus revolutionizing the medicine of the future. Nanobiotec

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These proceedings from the 2008 NSTI Nanotech conference provide the most prestigious forum in the world for leading nano scientists. The papers from the conference have been compiled into three volumes to create the most authoritative and comprehensive compendium available across all of nanotechnology. Including the latest information on industrial development, investments, and ventures, each volume explores cutting-edge research and applications. Volume III covers photonics, nanowires, lab-on-a-chip, nanofluidics, MEMS, and NEMS. This volume also explores the modeling and simulation of microsystems, computational nanoscience, and compact modeling.

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Up to date and comprehensive in its coverage, Neutrinos in Particle Physics, Astrophysics and Cosmology reviews the whole landscape of neutrino physics, from state-of-the-art experiments to the latest phenomenological and theoretical developments to future advances.With contributions from internationally recognized leaders in the field, the book covers the basics of the standard model and neutrino phenomenology. It also discusses Big Bang cosmology, neutrino astrophysics, CP violation, leptogenesis, and solar neutrino physics, including the standard solar model. The contributors present experimental aspects of accelerator and reactor neutrino experiments as well as nuclear physics experiments that deal with neutrinoless double beta decay and tritium decay. They also focus on neutrino detectors, neutrino beams, and the neutrino factory.Drawn from the lectures of the Scottish Universities Summer Schools in Physics, this resource provides an essential foundation for anyone working in the exciting area of neutrino physics.

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During the past decade since the first edition of this practical work was published, global prevalence of obesity has increased by epic proportions, and physical fitness levels have continued to decline. Nutrition, Physical Activity, and Health in Early Life, Second Edition analyzes cutting-edge longitudinal and cross-sectional data on morphological, nutritional, and functional characteristics related to environmental factors to assess how the lifestyle choices we make when we’re young deeply impact overall health and wellness throughout our lives. Includes Step-by-Step Nutrition and Exercise PlansExtensively revised and updated, this definitive second edition synthesizes new, original research findings related to anthropometric and body composition data, dietary intake, cardiorespiratory function, motor and psychomotor skills, muscle strength, and biochemical and physiological parameters of preschool-age children. The book supplies ready-to-implement nutrition and exercise plans that are appropriate for children in this age group. Almost tripling the number of references, the text includes new chapters that address the role of genetic factors in addition to prevention techniques, consequences, and treatment of obesity. It also compares body mass index, body composition, and the shifts of adiposity rebound on an international scale.Nutrition, Physical Activity, and Health in Early Life, Second Edition emphasizes that to preserve a high-quality of life no matter your age, it is crucial that a foundation of healthy nutrition and optimal physical activity, which increases the level of physical fitness, be cemented early on. In effect, this book illustrates why early prevention always trumps a cure.

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High Speed Packet Access (HSPA) is a collection of two mobile telephony protocols, High Speed Downlink Packet Access (HSDPA) and High Speed Uplink Packet Access (HSUPA). Allowing networks based on the Universal Mobile Telecommunications System to achieve data rates of several megabits per second, these powerful protocols are ideal for applications ranging from file transfer to multimedia streaming.From basic concepts to research grade material, the HSDPA/HSUPA Handbook provides technical information on all aspects of HSDPA/HSUPA. With contributions from 30 experts from around the world, this comprehensive HSPA reference provides a global and authoritative perspective of this rapidly emerging technology. Investigates the relationship between HSDPA/HSUPA and UMTS Describes the benefits of HSPA and its technical enhancements Explains packet flows in HSDPA Explores migration issues associated with HSPA Considers receiver designs and multi-user extensions to MIMO HSDPA Presenting information in a well-structured manner for ease of reference, this book presents accurate and up-to-date information on the full spectrum of topics related to HSPA technology, including future directions. The ideal desk reference for designers and planners of contemporary wireless communication networks, this book can also be adopted as a textbook for graduate and research-oriented courses that deal with HSPA.

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Military supply chains are unique because what is supplied to the end user is routinely returned to the supply chain for maintenance, repair, and overhaul (MRO). Offering a blueprint for transforming military depot workload and processes into those of high-performance commercial facilities, Enterprise Sustainability: Enhancing the Military’s Ability to Perform its Mission provides a powerful system of concepts and tools for enhancing the ability of the military to perform MRO on its weapon systems. These concepts and tools are applicable to any enterprise, military or commercial, that is concerned about sustainability.The text focuses on five abilities that must be considered to achieve efficient, cost-saving operations: Availability of required parts, facilities, tools, and manpower Dependability of the weapon systems Capability of the enterprise to perform the mission Affordability and improving the life cycle cost (LCC) of a system or project Marketability of concepts and motivating decision makers Aging weapons systems, an aging workforce, limited financial resources, new technologies, and an increased military operational tempo demand that the military develop an aggressive transformation plan for its sustainability. This book follows An Architecture for a Lean Transformation, the first in a series dedicated to the sustainment of an enterprise. In this second volume, the authors continue to provide an analysis of, and prescription for, the strategies, principles, and technologies that are necessary to sustain an enterprise like the military and the weapons system it develops and utilizes.

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All too often the assessment of structural vulnerability is thought of only in terms of security upgrades, guards, and entrance barriers. However, in order to fully ensure that a building is secure, the process of design and construction must also be considered. Building Vulnerability Assessments: Industrial Hygiene and Engineering Concepts focuses on the range of vulnerabilities that can and should be addressed from design implementation through securing a building from intrusion from all types of threats.Customized Recommendations for Individual StructuresThe book begins with an outline for vulnerability assessments conducted either in-house or in coordination with a third party. The text is presented in a way that facilitates modifications for an organization’s particular needs. The authors present summaries of regulations that are used to determine if chemicals create a risk to off-site locations or constitute a homeland security vulnerability. They also discuss physical security and chemical, biological, and radioactive (CBR) threat potentials. Highlights the Threat of Biological ContaminationThe remainder of the book discusses control systems to reduce vulnerabilities, emphasizing ventilation system controls. Since a building or facility which is already contaminated is easier to contaminate further, the authors put a heavy focus on new, latent, and residual chemical and biological contamination within building infrastructures. The book concludes by presenting basic emergency planning recommendations and offering recommendations for assessment programs and emergency drills.This volume, comprising the wisdom of scientists and engineers who have dealt in the past with building and site failures, assists future designers and operations and emergency planners in making decisions that may lessen the impact of emergencies and he

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Addressing the most dynamic areas of the ever-changing telecommunications landscape, the second edition of the bestselling CRC Handbook of Modern Telecommunications once again brings together the top minds and industry pioneers in wireless communication networks, protocols, and devices. In addition to new discussions of radio frequency identification (RFID) and wireless sensor networks, including cognitive radio networks, this important reference systematically addresses network management and administration, as well as network organization and governance, topics that have evolved since the development of the first edition. Extensively updated and expanded, this second edition provides new information on: Wireless sensor networks RFID Architectures Intelligent Support Systems Service delivery integration with the Internet Information life cycle and service level management Management of emerging technologies Web performance management Business intelligence and analytics The text details the latest in voice communication techniques, advanced communication concepts, network organization, governance, traffic management, and emerging trends. This comprehensive handbook provides telecommunications professionals across all fields with ready access to the knowledge they require and arms them with the understanding of the role that evolving technologies will play in the development of the telecommunications systems of tomorrow.

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These are exciting times for the field of optical imaging of brain function. Rapid developments in theory and technology continue to considerably advance understanding of brain function. Reflecting changes in the field during the past five years, the second edition of In Vivo Optical Imaging of Brain Function describes state-of-the-art techniques and their applications for the growing field of functional imaging in the live brain using optical imaging techniques.New in the Second Edition: Voltage-sensitive dyes imaging in awake behaving animals Imaging based on genetically encoded probes Imaging of mitochondrial auto-fluorescence as a tool for cortical mapping Using pH-sensitive dyes for functional mapping Modulated imaging Calcium imaging of neuronal activity using 2-photon microscopy Fourier approach to optical imaging Fully updated chapters from the first edition Leading Authorities Explore the Latest Techniques Updated to reflect continuous development in this emerging research area, this new edition, as with the original, reaches across disciplines to review a variety of non-invasive optical techniques used to study activity in the living brain. Leading authorities from such diverse areas as biophysics, neuroscience, and cognitive science present a host of perspectives that range from a single neuron to large assemblies of millions of neurons, captured at various temporal and spatial resolutions. Introducing techniques that were not available just a few years ago, the authors describe the theory, setup, analytical methods, and examples that highlight the advantages of each particular method.

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Many bottom-up and top-down techniques for nanomaterial and nanostructure generation have enabled the development of applications in nanoelectronics and nanophotonics. Handbook of Nanophysics: Nanoelectronics and Nanophotonics explores important recent applications of nanophysics in the areas of electronics and photonics. Each peer-reviewed chapter contains a broad-based introduction and enhances understanding of the state-of-the-art scientific content through fundamental equations and illustrations, some in color.This volume discusses how different nanomaterials, such as quantum dots and nanotubes, are used in quantum computing, capacitors, and transistors. Leading international experts review the potential of the novel patterning techniques in molecular electronics as well as nanolithography approaches for producing semiconductor circuits. They also describe optical properties of nanostructures, nanowires, nanorods, and clusters, including cathodoluminescence, photoluminescence, and polarization-sensitivity. In addition, the book covers nanophotonic devices and nanolasers. Nanophysics brings together multiple disciplines to determine the structural, electronic, optical, and thermal behavior of nanomaterials; electrical and thermal conductivity; the forces between nanoscale objects; and the transition between classical and quantum behavior. Facilitating communication across many disciplines, this landmark publication encourages scientists with disparate interests to collaborate on interdisciplinary projects and incorporate the theory and methodology of other areas into their work.

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A Thorough Overview of the Next Generation in ComputingPoised to follow in the footsteps of the Internet, grid computing is on the verge of becoming more robust and accessible to the public in the near future. Focusing on this novel, yet already powerful, technology, Introduction to Grid Computing explores state-of-the-art grid projects, core grid technologies, and applications of the grid.After comparing the grid with other distributed systems, the book covers two important aspects of a grid system: scheduling of jobs and resource discovery and monitoring in grid. It then discusses existing and emerging security technologies, such as WS-Security and OGSA security, as well as the functions of grid middleware at a conceptual level. The authors also describe famous grid projects, demonstrate the pricing of European options through the use of the Monte Carlo method on grids, and highlight different parallelization possibilities on the grid.Taking a tutorial approach, this concise book provides a complete introduction to the components of the grid architecture and applications of grid computing. It expertly shows how grid computing can be used in various areas, from computational mechanics to risk management in financial institutions.

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Consisting of papers that have appeared recently in International Geology Review, Middle American Terranes, Potential Correlatives, and Orogenic Processes focuses on Middle American terranes in which tectonic processes, including flat-slab subduction, for orogenic development are examined at various times since the late Mesoproterozoic: at 1 Ga, through the Paleozoic, and into the Cenozoic. Many papers relate the evolution of the Middle American terranes over the past billion years to global scale events, and a second theme running through the book relates to the supercontinents, Rodinia and Pangea, the geometry of their amalgamation and breakup, and the processes responsible.Highlights include: · An update on the geographic record, tectonic setting, and provenance of these terranes · Documentation of allocthonous nature and position peripheral to Amazonia of the ~1 Ga basement of southern Mexico · Data demonstrating that the basement rocks were involved in several Phanerozoic tectonic events · An examination of new evidence of a Late Paleozoic event associated with the amalgamation of Pangea overprinting the ~1 Ga basement and the Paleozoic units lying chiefly to the west and south of it · An exploration of the following potential correlatives: (1) events in Europe on the northern margin of Gondwana; (2) the Late Silurian-Devonian Acadian orogeny in the Appalachian, which is inferred to have resulted from flat-slab subduction related to overriding a plume; and (3) Mesozoic-Cenozoic events along the western margin of Laurentia · A discussion of possible mechanisms for the initiation of orogeny, flat-slab subduction in the Laramide orogeny, and hypotheses relating to the amalgamation and breakup of supercontine

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From the development of polymers that make cars lighter to fuels that make them run cleaner, the chemist’s role in the automotive industry has evolved to be one that is more outside the laboratory than in it. Drawing on the author’s 20 years of experience in vehicle design and laboratory experience, The Role of the Chemist in Automotive Design elucidates how the skills of chemists are put to use in the automotive industry and their effect on all phases of design. A glance through the table of contents provides an overview of the issues commonly encountered by chemists in the automotive industry. The author discusses fuels cells, lithium ion batteries, carbon nanotubes, and nickel metal hydride technology, all of which require the technical knowledge of a chemist but cross the lines of various disciplines. He also covers future technology including items such as battery technology, fuel cell membranes, and environmentally friendly plastics such as nylons that use castor oil as a primary component. The book examines environmental concerns such as CARB legislation and how the industry plans to deal with the new legislation with strategies such as Ozone Reduction Catalyst.The increasing technological, environmental, and economic issues facing the auto industry underscores the need for a basic reference that covers technologies that can be used to make vehicle more fuel efficient, environmentally friendly, and cost efficient. Exploring the expanding role chemists will play in future automotive design and technology, this book delineates the areas and technologies that require the technical knowledge of a chemist but that cross the lines of many disciplines.

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Flexible and efficient, VMware ESX is the tool of choice for enterprise data centers looking to make the most of the latest virtualization methods. However, to date, no single manual provides users with a systematic way to understand and take full advantage of all its features and options.Novel Solutions for Every Level of the IT ChainVMware ESX Essentials in the Virtual Data Center answers that need. Written by pioneers and established experts in the field of virtualization with years of hands-on experience, it details the product and outlines innovative ways to use virtualization within the organization. With novel solutions for every level of the IT chain, this text is a complete guide to the design, operation, and management of the ESX product.Featuring technical information, best practices, and technology breakdowns needed to answer real business challenges, this succinct volume – Shows how to install ESX, either manually or using an automated method, detailing the various key performance optimizations that can make installation more efficient Describes ways to further automate and enhance the ESX environment, and make it more extensible with APIs, SDKs, programming extensions, and VirtualCenter plug-ins Explains the latest ESX features fully Details the architecture and background of ESX through the use of diagrams Uses Real-World Experience to Slash Costs and Increase EfficiencyThis text covers VMware VI3, the most widely distributed server virtualization product on the market, from 3.0 to 3.5, and the most recently announced embedded version of ESXi. It will enable IT organizations to save hardware costs and make server deployments, provisioning, and management more efficient. Able to make use of the full benefits of virtualization, they will gain the flexibility to create solutions and the freedom that comes with not being locked into a single vendor’s hardware solution.

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Until recently, innate immunity was regarded as a relatively nonspecific system designed to engulf and destroy pathogens. However, new studies show that the innate immune system is highly developed in its ability to discriminate between self and foreign entities. Understanding this mechanism can lead to therapeutic strategies based on manipulation of this previously unexploited branch of the immune system.Drawing on the research of leading experts, Nucleic Acids in Innate Immunity provides insight in this new area of immunology. The book begins by explaining the roles of nucleic acids in immunity, describing the mechanism of discrimination based on pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs), Nod-like receptors (NLR), and RIG-I-like receptors (RLR). Chapters discuss how these PRRs recognize and respond to pathogen-associated molecular patterns (PAMPs) by activating specific signaling pathways.The second section focuses on the therapeutic applications of immunomodulatory DNA by manipulating released pathogenic nucleic acids as immune system stimulants. The book introduces novel therapeutics developed to prevent or treat infectious diseases, allergic disorders, and cancer, as well as clearing unnecessary or abnormal host molecules.The final section addresses how the immune system discriminates self and non-self RNA. Recent findings that host (self) nucleic acids are not inert in the immune system beg the question of exactly what elements within DNA or RNA are recognized by the innate immune system. Contributions review recent advances to understand innate immune recognition of nucleic acids and describe the resulting immune modulation.Providing a comprehensive review of nucleic acid recognition and regulation by the innate immune system, this seminal work reveals new directions for future research in immune modulation.

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With growing consumer demand for ready-to-eat (RTE) foods that are wholesome and require less handling and preparation, the production of RTE foods has increased and their variety has expanded considerably, spanning from bagged spinach to pre-packaged school lunches. But since RTE foods are normally consumed directly without cooking — a step that kills pathogenic microorganisms that may be present in the food products — concerns exist with regard to their safety. Several severe and high-profile outbreaks of food-borne illness linked to the consumption of RTE foods have prompted the USDA and FDA to issue stringent rules and regulations governing the manufacturing of RTE foods. Ready-to-Eat Foods: Microbial Concerns and Control Measures comprehensively reviews individual common RTE food and their specific safety-related aspects. This text explores the extensive research conducted by the food industry, academia, and research institutes that examines the potential health risk of contaminated RTE foods, investigates the growth behavior of common contaminating foodborne pathogens, and develops intervention technologies and control measures. The book supplies an overview of food safety of RTE foods and various categories into which they fall. It also addresses the microorganisms of concern, the effect of processing on the survival of pathogenic and spoilage microorganisms, food safety, practical control measures, and intervention strategies. Ready-to-Eat Foods: Microbial Concerns and Control Measures is a critical reference for scientists and professionals working on the forefront of food safety and RTE food manufacturing.

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Completely revised text that reflects to emergent trends and cutting-edge advances in pharmaceutical biotechnology, this Third Edition provides a well-balanced framework for understanding every major aspect of pharmaceutical biotechnology, including drug development, production, dosage forms, administration, and therapeutic developments. New chapters cover evolving areas regarding biopharmaceuticals, including oligonucleotides, siRNA and various monoclonal antibodies, immunogenicity, gene therapy, and the regulatory issues factoring into the biopharmaceutical approval process

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Many health professionals today seem to approach sports nutrition and physical activity recommendations with a "one size fits all" approach. Surprisingly, little consideration goes into addressing the changing needs of athletes as they progress in age. Nutrition and Exercise Concerns of Middle Age addresses the specific nutritional and physical activity needs of active individuals thirty to sixty years old. Judy A. Driskell, one of the world’s leading experts in the field of sports nutrition, brings together cutting-edge research on the nutritional needs and exercise recommendations for this quickly growing age group.Internationally acclaimed experts on nutrition and kinesiology unveil their research in sports nutrition, endurance and strength training, age-related disorders, and nutrition and exercise recommendations of health organizations. They also explore the role of diet and physical activity in reducing the risk of and in treating age-related diseases such as cancer and cardiovascular disease.Nutrition and Exercise Concerns of Middle Age is a valuable resource for nutritionists, physicians, dieticians, and researchers looking to access authoritative information on exercise and sports nutrition recommendations for middle-age adults.

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Energy efficiency, environmental protection, and processing waste management continue to attract increased attention in the food processing industry. As with other industrial sectors, reducing costs while also reducing environmental impact and improving overall sustainability is becoming an important part of the business process. Providing practical guidance, Energy Efficiency and Management in Food Processing Facilities explores energy efficiency technologies, emerging energy efficient processes, and methods for converting food processing wastes into energy. Organized around five central themes, the book explores: Fundamentals of energy conservation, analysis, and management Energy conservation technologies as applied to the food processing industry Energy efficiency and conservations in current food processing systems Emerging systems Energy conversion technologies for utilization of food processing wastes Conservation Techniques that Improve the Bottom LineThe lack of information on energy conservation and conversion technologies has been a major barrier to energy efficiency improvement and the utilization of processing wastes in the food processing industry. With coverage ranging from basic theory to traditional and alternative energy, this book provides the required skill set for the increased energy conservation and reduced consumption that will positively impact the bottom line in food processing facilities.

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It has become crucial for managers to be computer literate in today’s business environment. It is also important that those entering the field acquire the fundamental theories of information systems, the essential practical skills in computer applications, and the desire for life-long learning in information technology.Programming Languages for Business Problem Solving presents a working knowledge of the major programming languages, including COBOL, C++, Java, HTML, JavaScript, VB.NET, VBA, ASP.NET, Perl, PHP, XML, and SQL, used in the current business computing environment. The book examines the concepts shared by these languages and details the unique features of each. It also focuses on various programming techniques, including structured, object-oriented, client-side and server-side programming, as well as graphical user-interface and multi-media processing. Self-contained, the book provides hands-on examples, self-review questions, project requirements, report formats, and operational manuals of programming environments for use by both MIS students and professionals.

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During the past 10 years a large variety of new multiphase polymer-based materials have been studied from a morphological point of view. Simultaneously, huge progress has been achieved in microscopy. These circumstances underline the need for a reference that delineates the differences of various types of nanostructures in multiphase polymer-based materials. Multiphase Polymer-Based Materials: An Atlas of Phase Morphology at the Nano and Micro Scale presents up-to-date coverage of developments in this field in a practical and easy to use format. Illustrates Microscopic Tools for Phase Morphology Investigation The author sifted through an encyclopedic amount of information to provide a selection of more than 550 microscopy pictures resulting from the observation of multiphase polymer-based materials. These illustrations include micro and nanopolymer blends, micro and nanocomposites, micro and nano phases in copolymers, thermosets, and thermoplastic blends that were intensively developed over the past decade. Each picture includes a detailed explanation of how to attain these materials, how the samples were prepared, and how the observations were conducted. A Practical Straightforward Approach to Microscopic ObservationThe book examines the various microscopic tools employed for the investigation of the phase morphology, highlighting the advantages and disadvantages of each. It provides a practical, straightforward approach for dealing with the microscopic observation of phase morphology in multicomponent polymer blends and nanocomposites.

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With the recent discovery of JAK2 mutations in myeloproliferative disorders, medical science has taken a revolutionary stride forward toward understanding the pathogenesis of these diseases. This new advancement translates not only to a more rapid and reliable diagnosis, but also allows groundbreaking research into the development of new therapeutics. Written in an easy-to-follow text myeloproliferative disorders gives the practicing clinician a single source answer to classification, diagnosis, management, and recent advances in this disorder.

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Written by experienced process improvement professionals who have developed and implemented computer based systems in organizations around the world, Interpreting the CMMI®: A Process Improvement Approach, Second Edition provides you with specific techniques for performing process improvement.Employing everyday language and supported by real world examples, the authors describe the fundamental concepts of the CMMI model, covering goals, practices, architecture, and definitions, and provide a structured approach for implementing the concepts of the CMMI into any organization. They discuss getting started in the process improvement effort, as well as how to continue on to high maturity. They walk you through the myriad of charts and graphs involved in statistical process control and offer practical recommendations. They also provide information on blending different process improvement initiatives into organizational programs (including agile development), and in this edition include more in-depth information. The authors distill the knowledge gained in their combined 70 years of experience in project management, software engineering, systems engineering, metrics, quality assurance, appraisals, training, process improvement, and team building. Whether you are new to process improvement or an experienced professional, this volume will save you time wasted on false starts, false promises by marketers, and failed deadlines. The authors have been responsible for successfully implementing process improvement in several different organizations. This book is based on real-life experience, not on academic theories. It provides workable solutions to inherent challenges such as appropriate roles and responsibility, resistance to change, and meaningful documentation, thus transforming CMMI concepts into practical applications.

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The concept of medical treatment from a distance (in absentia care) is actually quite ancient, dating back to tribal days where smoke signals were used to warn of serious disease in a community. Nowadays, telemedicine is used to facilitate treatment in rural areas, where the nearest doctor is miles away, through various forms of information technology, including videoconferencing and digital imaging. It can also be used to conveniently monitor chronically ill patients through electronic devices so that they can enjoy a better quality of life. But despite the strides that have been made in utilizing the telemedicine technology, there remain a number of limitations and weaknesses that must be overcome before this treatment paradigm can reach its full potential.In Mobile Telemedicine: A Computing and Network Perspective, noted computer scientists Yang Xiao and Hui Chen examine those computing and networking dilemmas arising from wireless and mobile telemedicine. Comprised of the contributions of many prominent international researchers, the book discusses the relative merits and limitations of the existing technology and sheds light on future developments. It begins with a discussion of patient care and monitoring through items such as personal alarm systems. It then reviews the current methods available to monitor cardiac and diabetic patients, analyzes the security and privacy considerations that arise with respect to the transmission of sensitive information, and examines issues relating to networking support. Finally, it concludes with a section on the opportunities and challenges faced by those involved at this intersection of healthcare and communications. By bridging the fields of medicine and information technology, this volume serves as a useful springboard for those pioneering IT researchers looking for a comprehensive reference. The book also provides information for those involved with either communications or healthcare who want to learn about the current state and potential use of this technology.

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Although ending world hunger remains the most important goal, increasingly the focus is on simultaneously improving world malnutrition. Paradoxically, nutritionally important trace elements essential for human health are both deficient and over-abundant in soils in many regions of the world. Using a multidisciplinary approach, Development and Uses of Biofortified Agricultural Products provides new strategies and techniques for the production of biofortified agricultural products from different soils.Seventeen contributors from twelve countries explore the effects of environmental and biological factors on the accumulation and speciation of nutritionally important trace elements in agricultural products. They explore novel strategies regarding the functional foods and animal feed and other forms of biofortified agricultural products. The text addresses alternative biosources and bioproducts produced from phytoremediation processes as well as the bioavailability and the effects of bioproduct compounds.The editors comprehensively synthesize the ever-mounting body of new information on biofortification, including theoretical, practical, and practiced agricultural-based strategies in micronutrient management and improvement in different types of soils. The book provides a unique and useful platform to further the understanding of nutritionally important trace elements in the context of biogeochemistry, food chain transfer, and health-related issues.

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The growth in the world’s nuclear industry, motivated by peaking world oil supplies, concerns about the greenhouse effect, and domestic needs for energy independence, has resulted in a heightened focus on the need for next-generation nuclear fuel-cycle technologies. Ion Exchange and Solvent Extraction: A Series of Advances, Volume 19 provides a comprehensive look at the state of the science underlying solvent extraction in its role as the most powerful separation technique for the reprocessing of commercial spent nuclear fuel. Capturing the current technology and scientific progress as it exists today and looking ahead to potential developments, the book examines the overall state of solvent extraction in reprocessing, new molecules for increased selectivity and performance, methods for predicting extractant properties, and actinide-lanthanide group separation. The contributors also explore the simultaneous extraction of radionuclides by mixing extractants, the cause and nature of third-phase formation, the effects of radiation on the solvent and its performance, analytical techniques for measuring process concentrations, new centrifugal contactors for more efficient processing, and new chemistry using novel media.The long-term vision of many professionals in the field entails a proliferation-free nuclear energy economy in which little or no waste is stored or released into the environment and all potential energy values in spent nuclear fuel are recycled. This text opens a window on that possibility, offering insight from world leaders on the cutting edge of nuclear research.

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The Basal ganglia, to adopt a phrase of Churchill's, are "a riddle wrapped in a mystery, inside an enigma." And although there is a wealth of information available on them, this research field remains controversial due in part to the diverse number of disciplines involved. A Theory of the Basal Ganglia and Their Disorders provides a clear, coherent view of basal ganglia that integrates evidence from the basic neurosciences, neurology, and psychiatry. The author explores the basal ganglia within a context of the function of the mammalian forebrain as a whole.Divided into two parts, the book explores the basic framework in which normal functions of the basal ganglia can be understood, and then moves on to discuss major disorders. It explains, as far as possible, symptoms and related clinical facts in terms of the underlying pathology and pathophysiology. With this goal in mind, the author includes only disorders of the basal ganglia for which there are already clear ideas about the underlying neuropathology or pathophysiology. He also conveys the human experience of these disorders as well as their scientific basis. While many books cover cutting-edge research, none have addressed large-scale questions about the role of the basal ganglia as a whole. Until now. This is arguably the only book published in the last 50 years that has attempted to provide an overall theory of the basal ganglia, as well as relevant areas of neurology and psychiatry. It concisely presents the theory, rather than comprehensively covering all the literature, and places the essential clinical facts within a framework formulated for normal operations of the basal ganglia. Presenting a unified view, the book takes several steps toward unraveling the riddle that is basal ganglia.

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Students preparing to work with mechatronics, particularly with highly precise and smart actuators, face the challenge of designing and analyzing devices without formal and practical guidance in computer techniques. Finally there is a textbook that is as practical as it is authoritative: Kenji Uchino's FEM and Micromechatronics with ATILA Software.Ideal for Today's Computer-Based CurriculaEvery aspect of this book reflects its focus on being easy to use, easy to teach from, and above all, easy to implement. The first half of the text outlines the theory needed to develop and design smart actuators and transducers, while the second half walks students step-by-step through the software implementation using seven extensive examples. Even the book's lay-flat binding makes it easy for students to follow the text while working simultaneously at a computer. The downloadable resources supply a free educational version of ATILA-Light.Unified Coverage for Integrated TechnologiesCovering the myriad challenges posed by smart transducers, the author introduces the fundamentals of piezoelectric and magnetostrictive devices, practical materials, device designs, drive and control techniques, and typical applications. Numerous problems and examples give students ample opportunity to put the concepts into practice.Outlining a complete treatment in 30 convenient 75 minute lessons, FEM and Micromechatronics with ATILA Software is a unique classroom text that students will continue to use throughout their entire careers.

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The goal of Unlicensed Mobile Access (UMA) is to provide seamless access to GSM and GPRS mobile service networks via unlicensed spectrum technologies, including Bluetooth, WiMAX, and Wi-Fi. Expanding on the level of knowledge in this growing field, Unlicensed Mobile Access Technology: Protocols, Architectures, Security, Standards, and Applications presents the first complete cross-referenced resource exploring UMA and UMA-relevant technologies. When operating successfully, the technology supporting dual-mode enabled mobile terminals allows subscribers to roam freely and seamlessly between cellular networks. However, various technical challenges still occasionally impede clear communication. This book explores the complex issue of mobility management and emphasizes the need for intelligently designed vertical and horizontal handoff algorithms that will improve adaptability in heterogeneous wireless environments. In addition, it reviews the various strategies to guarantee Quality-of-Service (QoS) during movement and handoff. The first chapters introduce the basic technology of these systems and discuss QoS, resource management, mobility management, and security issues in UMA technology. The middle section concentrates on protocols and security challenges in UMA-related technologies, which include Bluetooth, WirelessPAN, Wi-Fi (IEEE 802.11) and WiMAX (IEEE 802.16). The final chapters present standard specifications and various applications. Comprised of contributions from world-wide experts, this book is a complete reference, offering guidance on all aspects of the technical and practical issues in UMA technology.

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The final quality of a food product is impacted heavily by preservation technologies, such as chilling, freezing, and freeze-drying, as well as the numerous pretreatments that are routinely applied to foods. Adequate design and implementation of each of these treatments are critical to ensuring the integrity of the final food product, the productivity of the equipment, and reduced operation costs. Operations in Food Refrigeration explores the fundamental issues involved in heat and mass transfer in food refrigeration and examines aspects of other operations applied to chilled or frozen foods.Following an overview of basic concepts and general calculation procedures involved in cooling, freezing, thawing, and freeze-drying, the book discusses: Sizing, peeling, cutting, sorting, and blanching fruits and vegetables Pretreatments for meats, including tenderization, electrical stimulation, portioning, curing, and smoking Pretreatments for fish and other seafood Processing of poultry Air and osmotic partial dehydration, infusion of special nutrients, and the concentration of juices Traditional chilling and freezing methods Special precooling and freezing techniques The effects of thawing on food, factors that influence the choice and design of thawing processes, and various thawing methods Freeze-drying equipment Each chapter is written by a recognized specialist and can serve as a stand-alone resource for the particular topic. Several chapters present case studies that can be used for developing processes or in teaching applications. Processors, researchers, and educators in the food industry will find this volume to be an invaluable reference for a host of food operations.

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Extracted from the Drug Abuse Handbook, 2nd edition, to give you just the information you need at an affordable price.Addiction and the Medical Complications of Drug Abuse explores the physiological and psychological phenomenon of addiction including the nature of dependence, the dependence potential of drugs, and the importance of motivation. Contributions analyze the practice of substitute prescribing and detail the immediate and long term benefits of their use in maintenance or controlled withdrawal from opioids, stimulants, and benzodiazepines. It considers the use of methadone, buprenorphine, adrenergic agonists, and naltrexone for detoxification. Practitioners will benefit from the expert instruction on the management of common comorbidities, including diagnosis and pharmaceutical treatment of psychological disorders. Additional information covers the physiological effects of each drug and the emergency management of several drug related disorders such as psychosis, seizures, stroke, hyperthermia, and cardiac crisis. With 29 tables and figures, expert data and extensive references, this is an indispensable book for anyone in the field of addiction or emergency medicine.

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Hereditary Gynecologic Cancer: Risk, Prevention and Management fills the need that exists for a book addressing highly relevant clinical issues associated with the new field of hereditary gynecologic cancers. Written with the clinician in mind, the authors will cover a broad range of topics, beginning with an overview discussing clinical relevance of hereditary ovarian and hereditary endometrial cancers. Succeeding sections will provide in-depth analyses of Hereditary Breast Ovarian Cancer Syndrome, Lynch Syndrome, and other syndromes with gynecologic cancer components, and genetic risk assessment.Hereditary Gynecologic Cancer: Risk, Prevention and Management: is the first clinically focused reference detailing gynecologic patient management issues of BRCA1 and BRCA2 mutation carriers includes a practical section on genetic risk assessment and genetic testing examines case studies to demonstrate management techniques and decision-making provides detailed discussion of ovarian cancer screening, prevention and risk reducing surgery

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Touted as the new darling of the chemical industry, alkyl polyglycosides are gaining in popularity due to the fact that they are readily biodegradable, low-toxic, and made from renewable resources. Sugar-Based Surfactants compiles the most recent and relevant aspects of sugar-based surfactants, including self-association, phase behavior, and interfacial properties. Focusing on both colloidal and interfacial science, the book deals with the adsorption of surfactants in both the air-liquid and solid-liquid interfaces. It also covers new advances in surfactant science, such as the development of a family of potent surface active agents that are non-toxic, and thus usable in ubiquitous consumer products

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In the current, increasingly aggressive business environment, crucial decisions about product design often involve significant uncertainty. Highlighting the competitive advantage available from using risk-based reliability design, Engineering Design Reliability Applications: For the Aerospace, Automotive, and Ship Industries provides an overview of how to apply probabilistic approaches and reliability methods to practical engineering problems using real life engineering applications. A one-step resource, the book demonstrates the latest technology, how others have used it to increase their competitiveness, and how you can use it to do the same.The book makes the case for accurate assessment of the reliability of engineering systems, simple, complex, or large-scale. It presents two computer programs for reliability analysis and demonstrates these programs on aircraft engines, structures used for testing explosives, medical and automotive systems. The focus then shifts to aircraft and space systems, including lap joints, gas turbines, and actively controlled space structures. The editors provide analytical tools for reliability analysis, design optimization, and sensitivity analysis of automotive systems. They include a general methodology for reliability assessment of ship structures and highlight reliability analysis of composite materials and structures.Delineating generic tools and computer programs applicable to any situation, the book shows you how to quantify, understand, and control uncertainties, reduce risk, and increase reliability using real-life examples. Engineers from the industry and national labs as well as university researchers present success stories and quantify the benefits of reliability design for their organizations. They demonstrate how to convince colleagues and management of the potential benefits of these approaches in allowing their organizations to gain significant benefits and dramatically increase their competitiveness.

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The games that human societies devised over the centuries can be considered one of the most comprehensive and fertile symbolic systems ever created by human ingenuity. In all societies, members feel compelled to interact and communicate with each other as much as possible. As linguistic creatures, humans use language to establish social and interpersonal contacts. Games are a device to enable such connections.Robert Perinbanayagam examines how players value games. He assesses games as systems that embody metaphysics and pragmatic action. He then examines various religious ideas and how participants reference respective approaches to game playing.Perinbanayagam argues that games are forms of activity in which the human agent as an actor engages with others in various interactional situations. Such engagement creates dramas in which agents assume identities, give play to emotions and enrich their selves. He also examines the issue of game writing, particularly how selected writers have used game structures as narrative devices in their work.

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The problems and issues arising from globalization are difficult to resolve, in part because our ways of conceptualizing the conflicts and responding to them are inadequate. This book fills this gap, conceiving of globalization as a consequence of economic, political, technological, scientific, and cultural changes. A. Pablo Iannone provides a taxonomy of globalization processes, investigates the consequences of each, and formulates a comprehensive approach for dealing with them.While his emphasis is philosophical, this is not a single-discipline book. Rather, it belongs at the intersection of philosophy, economics, political science, and technology. Its discussions address issues concerning globalization and correlate the processes of fragmentation and dislocation in a realistic manner.Iannone focuses on concrete and current cases, from the global economic and financial issues posed by the multi-centered nature of contemporary business and technology, through the pressures of ever increasing information overload across the planet. He explores the environmental and social challenges associated with current Amazonian development and its significance to weather patterns on Earth. He considers the issues surrounding the use of robots in war from Pakistan through Mexico, and the militarization of space. In short, the approach, while based on theoretical concerns, is solidly grounded in highly practical applications, which are global in their implications.

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The Natural Law of Cycles assembles scientific work from different disciplines to show how research on angular momentum and rotational symmetry can be used to develop a law of energy cycles as a local and global influence. Angular momentum regulates small-scale rotational cycles such as the swimming of fish in water, the running of animals on land, and the flight of birds in air. Also, it regulates large-scale rotation cycles such as global currents of wind and water.James H. Bunn introduces concepts of symmetry, balance, and angular momentum, showing how together they shape the mobile symmetries of animals. Chapter 1 studies the configurations of animals as they move in a head-first direction. Chapter 2 shows how sea animals follow currents and tides generated by the rotational cycles of the earth. In chapter 3, Bunn explores the biomechanical pace of walking as a partial cycle of rotating limbs. On a large scale, angular momentum governs balanced shifts in plate tectonics.Chapter 4 begins with an examination of rotational wind patterns in terms of the counter-balancing forces of angular momentum. The author shows how these winds augment the flights of birds during migrations. A final chapter centres on the conservation of energy as the most basic principle of science. Bunn argues that in the nineteenth century the unity of nature was seen in the emergent concept of energy, not matter, as the source of power, including the movements of animals and machines. In each chapter Bunn features environmental writers who celebrate mobile symmetries. This book will interest students, naturalists, and advocates of the environmental movement.

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After World War II, communes and cooperative communities became internationally oriented in their membership and networking began to develop. Unlike earlier such enterprises, these groups shared an openness to international relationships. This was evident both in the groups' social composition, and in the extension of networks beyond their own country. Such globalization opened up the possibility of comparative analysis, which has become a trend in research since the 1950s.The dynamism and speed with which voluntary communities have spread throughout the world is impressive. In the 1950s there were only a few hundred such societies, but by the end of the last century there were thousands. These have taken a variety of forms. There are religious and secular communes, intentional communities, ecological communities, co-housing projects, various types of Christian communities, communities of Eastern religions, and spiritual communities inspired by New Age thought.Yaacov Oved shows that such societies maintain a community based on cooperation and expand their influence through newspapers, television, and the Internet. Their chief characteristic is their openness to the outside world, and their search for a way to move beyond a world of individualism and competitiveness. To accomplish this, they embrace all the tools of the modern world. Oved observes that those who predicted the failure of communes and intentional communities failed to appreciate the extent to which people in today's society aspire to communal life. This book answers the doubters and does so with a sense of deep historical understanding.

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Today, people in different situations and contexts face intercultural challenges. These are a result of increasing mobility. Sometimes such challenges are brought about by crisis situations and an international labor market. However, people also come in contact with each other through forms of new technology such as the Internet, and through literature and film. In these multicultural encounters, misunderstandings and sometimes clashes are experienced. This volume presents studies in culture, communication, and language, all of which strive, through a variety of theoretical perspectives, to develop understanding of such challenges and perhaps offer practical solutions.Encountering otherness may evoke fears, negative attitudes, and a corresponding will to dismiss the otherness in front of us—either consciously or unconsciously. This denial of otherness may also be subtle. Thinking about otherness, as described in this volume, also raises questions about how otherness is represented and mediated and about the possible role of third parties in facilitating communication in such situations. Sometimes a third party can play a crucial role in facilitating the communication process and serve as a channel of communication.Trust in humanity as a bridge to community requires a subtle balance between representations of self and other. Various problems arise in intercultural mediation, which may be caused by cultural and political differences, and these are sometimes used to validate stereotypical beliefs and images. The editors argue that in both academic and art circles, European perspectives have widely been understood as universal.

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In a stunning work combining historical memory, legal ambiguity, and profound issues of justice, J. Kenneth Brody provides a picture of France in World War II that continues to haunt the present. Architect in 1940 of Marshal Petain's Vichy French regime and its prime minister from April 1942 to August 1944, at war's end Pierre Laval was promptly arrested on charges of treason. This book tells the story of his trial. Did he betray France, or did he serve France under terrible circumstances? What was the truth of "collaboration"? This book considers the pretrial proceedings, or lack thereof, the evidence, and the arguments of the prosecution, as well as Laval's vigorous defense in the early days of the trial.Because of irregularities in the preliminary proceedings, Laval's defense counsel declined from the outset to participate in the trial. For those reasons and because of the prejudicial conduct of the prosecution, on the third day of the trial, Pierre Laval also declined to participate further. What his defense might have been in a normal pre-trial proceeding and in a fair trial are matters of conjecture. What remains clear is that political trials are a unique form of law and moral judgment.Trials and history share a common goal-the truth. Trial, judgment, and appeal are intended to produce finality. History, on the other hand, is never final. After its performance in the trial of Pierre Laval, the government of France continued its policy of concealment, even though the truth could no longer determine the outcome of the trial. Slowly, by persistence, courage, and loyalty, history's claims to truth were established. This book presents the defense that might have been presented and then relates the final judgment, its grisly execution only eleven days after the trial opened, and its aftermath.

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Language is the species-specific human version of the animal system of communication. In contrast to non-human animals, language enables humans to invent a plurality of possible worlds; reflect upon signs; be responsible for our actions; gain conscious awareness of our inevitable mutual involvement in the network of life on this planet; and be responsibly involved in the destiny of the planet.The author looks at semiotics, the study of signs, symbols, and communication as developing sequentially rather than successively, more synchronically than diachronically. She discusses the contemporary phenomenon that people in today's society have witnessed and participated in, as part of the development of semiotics. Although there is a long history preceding semiotics, in a sense the field is, as a phenomenon, more "of our time" than of any time past. Its leading figures, whom Petrilli examines, belong to the twentieth and twenty-first century.Semiotics is associated with a capacity for listening. This capacity is also the condition for reconnecting to and recovering the ancient vocation of semiotics as that branch of medical science relating to the interpretation of signs or symptoms. The pragmatic aspect of global semiotics studies the impact of language or signs on those who use them, and looks for consequences in actual practice. In this respect, Petrilli theorizes that the task for semiotics in the era of globalization is nothing less than to take responsibility for life in its totality.

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One of the significant developments in scholarship in the latter half of the twentieth century was the awareness among historians of ideas, historians of theology, and medievalists of the importance of the Christian scriptures in the Latin Middle Ages. In contrast to an earlier generation of scholars who considered the medieval period as a ’Bible-free zone’, recent investigations have shown the central role of scripture in literature, art, law, liturgy, and formal religious education. Indeed, to understand the Latin Middle Ages one must understand the value they placed upon the Bible, how they related to it, and how they studied it. However, despite the new emphasis on the Bible’s role and the place of exegesis in medieval thought, our detailed understanding is all too meagre - and generalisations, often imagined as valid for a period of close to a millennium, abound. How the Scriptures were used in one pursuit (formal theology for example relied heavily on ’allegory’) was often very different to the way they were used in another (e.g. in history writing was interested in literal meanings), and exegesis differed over time and with cultures. Similarly, while most medieval writers were agreed that there were several ’senses’ within the text, the number and nature varied greatly as did the strategies for accessing those meanings. This collection of fifteen articles, concentrating on the early Latin middle ages, explores this variety and highlights just how patchy has been our understanding of medieval exegesis. We now may be aware of the importance of the Bible, but the task of studying that phenomenon is in its infancy.

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The work of mid-twentieth century art theorist Anton Ehrenzweig is explored in this original and timely study. An analysis of the dynamic and invigorating intellectual influences, institutional framework and legacy of his work, Between Art Practice and Psychoanalysis reveals the context within which Ehrenzweig worked, how that influenced him and those artists with whom he worked closely. Beth Williamson looks to the writing of Melanie Klein, Marion Milner, Adrian Stokes and others to elaborate Ehrenzweig’s theory of art, a theory that extends beyond the visual arts to music. In this first full-length study on his work, including an inventory of his library, previously unexamined archival material and unseen artworks sit at the heart of a book that examines Ehrenzweig’s working relationships with important British artists such as Bridget Riley, Eduardo Paolozzi and other members of the Independent Group in London in the 1950s and 1960s. In Ehrenzweig’s second book The Hidden Order of Art (1967) his thinking on Jackson Pollock is important too. It was this book that inspired American artists Robert Smithson and Robert Morris when they deployed his concept of ’dedifferentiation’. Here Williamson offers new readings of process art c. 1970 showing how Ehrenzweig’s aesthetic retains relevance beyond the immediate post-war era.

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Forensic science evidence and expert witness testimony play an increasingly prominent role in modern criminal proceedings. Science produces powerful evidence of criminal offending, but has also courted controversy and sometimes contributed towards miscarriages of justice. The twenty-six articles and essays reproduced in this volume explore the theoretical foundations of modern scientific proof and critically consider the practical issues to which expert evidence gives rise in contemporary criminal trials. The essays are prefaced by a substantial new introduction which provides an overview and incisive commentary contextualising the key debates. The volume begins by placing ’forensic science’ in interdisciplinary focus, with contributions from historical, sociological, Science and Technology Studies (STS), philosophical and jurisprudential perspectives. This is followed by closer examination of the role of forensic science and other expert evidence in criminal proceedings, exposing enduring tensions and addressing recent controversies in the relationship between science and criminal law. A third set of contributions considers the practical challenges of interpreting and communicating forensic science evidence. This perennial battle continues to be fought at the intersection between the logic of scientific inference and the psychology of the fact-finder’s ’common sense’ reasoning. Finally, the volume’s fourth group of essays evaluates the (limited) success of existing procedural reforms aimed at improving the reception of expert testimony in criminal adjudication, and considers future prospects for institutional renewal - with a keen eye to comparative law models and experiences, success stories and cautionary tales.

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