Search results for ""author leonard"

This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important reference for research scientists and drug discovery companies.

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Grasp the basics of reliability techniques in engineering design With an emphasis on the problem of quantifying reliability in product design and testing, Reliability in Engineering Design provides a complete overview of the topic. Beginning with an introduction to reliability, the text then proceeds in a logical manner through related, relevant topics. Discussed at length are terms and measures used in reliability testing, static reliability models, probabilistic approaches to design reliability, analysis of complex systems, and obtaining reliability estimates from test data. To provide a connection between theory and practice, simple design examples are utilized to fully describe and illustrate design reliability methodologies, making the text an excellent resource for both experienced engineers and those new to these reliability techniques.

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The volumes in this continuing series provide a compilation of current techniques and ideas in inorganic synthetic chemistry. Includes inorganic polymer syntheses and preparation of important inorganic solids, syntheses used in the development of pharmacologically active inorganic compounds, small-molecule coordination complexes, and related compounds. Also contains valuable information on transition organometallic compounds including species with metal-metal cluster molecules. All syntheses presented here have been tested.

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From #Gamergate to the 2016 election, to the daily experiences of marginalized perspectives, gaming is entangled with mainstream cultures of systematic exploitation and oppression. Whether visible in the persistent color line that shapes the production, dissemination, and legitimization of dominant stereotypes within the industry itself, or in the dehumanizing representations often found within game spaces, many video games perpetuate injustice and mirror the inequities and violence that permeate society as a whole. Drawing from groundbreaking research on counter and oppositional gaming and from popular games such as World of Warcraft and Tomb Raider, Woke Gaming examines resistance to problematic spaces of violence, discrimination, and microaggressions in gaming culture. The contributors of these essays seek to identify strategies to detox gaming culture and orient players and gamers toward progressive ends. From Anna Anthropy’s Keep Me Occupied to Momo Pixel’s Hair Nah, video games can reveal the power and potential for marginalized communities to resist, and otherwise challenge dehumanizing representations inside and outside of game spaces. In a moment of #MeToo, #BlackLivesMatter, and efforts to transform current political realities, Woke Gaming illustrates the power and potential of video games to foster change and become a catalyst for social justice.

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With the increasing use of immune checkpoint inhibitors (ICI) across various cancers, the trends for indication at earlier stages, and the use of combination immunotherapy, the frequency of ICI-induced immune-related adverse events (irAE) is expected to grow substantially. Management of these irAE is challenging as it requires not only consideration of the toxicity but also risk-benefit ratios with respect to the primary cancer. Several rheumatic irAE have been reported with ICI therapy including arthritis, myositis, polymyalgia-like syndromes, sicca/Sjogren-like manifestations, and several other less common systemic autoimmune features commonly associated with connective tissue disease. This handbook provides clinicians with a comprehensive overview of the management of rheumatic irAE that develop from cancer immunotherapy. It focuses on the irAE seen with ICI, the most frequently used agents in treating cancer. It provides an overview of cancer immunology, immunotoxicity, and immunotherapies such as ICI, cytokine-based therapy, and CART. It examines the epidemiology, clinical manifestations, diagnosis, differential diagnosis, and treatment of a variety of rheumatic immune-related adverse events arising from these therapies. Chapters also cover cancer immunotherapy in patients with preexisting rheumatic diseases such as inflammatory arthritis and other connective tissue disorders. The book helps clinicians to distinguish the current types of cancer immunotherapy and general toxicity patterns, recognize and diagnose rheumatic clinical syndromes, understand the pathogenesis of irAE, and consider risk–benefit ratios when managing patients with rheumatic irAE.Rheumatic Diseases and Syndromes Induced by Cancer Immunotherapy is an essential resource for physicians and related professionals, residents, fellows, graduate students and nurses alike in rheumatology, clinical immunology, oncology, and internal medicine.

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Jake Ahn, burglar and jewel thief, gets involved in a burglary in Seattle that turns violent when his partner tries to doublecross him. Escaping to San Francisco, Jake looks up his brother, Eugene, and finds himself in the middle of Eugene's marital and career problems, while gradually becoming attracted to Eugene's wife, Rachel. The brothers' painful memories of their childhoods are awakened with this visit, while Jake eventually turns back to his criminal pursuits, and involves Rachel. Meanwhile, Jake's ex-partner continues his search for Jake, and the result is a violent convergence of events.

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The liturgical drama arose in a period of rapidly integrating feudalism. Christians experienced contradiction between a Church that offered salvation and a Church that, through its large landholdings, exploited a large number of peasants. This study examines the attempts made by clergy to revitalize faith by creating new theology, new music, new prayers, tropes, new rituals, and the drama.

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A longtime leader among liberal Catholics lays out a practical program for democratizing and opening up the Church from the local parish and diocese level up, drawing on the unrealized potential of models and reforms through history. As background he especially focuses on the Enlightenment reform movement in 19th-century Germany that presaged the reforms proposed by Vatican Council II, many of which are still unfulfilled or even reversed. He also discusses the remarkably democratic and lay-involving practices of the Catholic Church in early America. He concludes with a draft constitution for parishes and dioceses to adapt.

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This text explains in common-sense terms, the fastest, most effective ways to sharpen your woodworking tools, from chisels to drill bits. You'll get better edges than on most razor blades, and you'll learn how to shape them to cut better and stay sharp longer.

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Since its famed introduction of the “boiled bunny,” Fatal Attraction (1987) established itself as one of American cinema’s most controversial films. This insightful new book surveys the film's formal features and its ideological impact, paying special attention to the film’s signature mix of sexuality, fear, and family values. Features detailed breakdowns of the formal techniques the film employs to create suspense, such as turning ordinary household objects into agents of terror Considers the film’s mixed-genre status as a thriller, melodrama, horror picture, and film noir Offers an explanation and analysis of the cultural storm ignited by the film, especially due to its treatment of single career women Investigates the film’s handling of extramarital sexuality, pregnancy, birth control, and AIDS Discusses the film’s lasting role in shaping American gender politics

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Defining and changing perceptions of ethnic identity

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This is the story of loss – and what happens afterwards… When Emma gets home after work one evening, she calls hello to her husband Jay, as she always does. Stepping into the kitchen, she sees he has done the shopping, as she had reminded him to; remembered to buy peppercorns; has bought her flowers. Everything is neatly put away. But Jay is not there. A photographer, all Jay has left behind is his camera containing five photographs, which are unlike his other work. Emma follows the images to Cornwall, beginning a journey in which old relationships are re-written and new ones are formed. As the visual mystery of each photograph unfolds, Emma finds herself unravelling and perilously close to breaking point. But could her unlikely salvation lie in the sea, a small community of swimmers and the promise of something Emma thought she didn’t want? ‘Truly beautiful’ Debbie Johnson 'A stunning story about love, longing and learning to live again after loss. Utterly immersive, and brimming with exquisite prose, AFTERWARDS is a thought-provoking and powerful debut with a message of hope at its heart. Emma's journey is guaranteed to stay with you long after you turn the final page' Holly Miller 'A delicately crafted literary novel, capturing in pin-sharp prose the myriad of emotions that grief can cause and how even in the darkest of circumstances, we can learn to live again' Living Magazines 'I've already given this debut novel to my mum and my best friend. It's a raw and very human account of what happens "afterwards"' Back Story

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A text/reference on analysis of structures that deform in use. Presents a new, integrated approach to analytical dynamics, structural dynamics and control theory and goes beyond classical dynamics of rigid bodies to incorporate analysis of flexibility of structures. Includes real-world examples of applications such as robotics, precision machinery and aircraft structures.

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"If this isn't the best analysis of the professional sports business ever written, I'd like to see the book that beats it. . . . Should be read by every sports fan or -- for that matter -- social critic." --From a five-star review, West Coast Review of Books. "Explores its subject so thoroughly and demolishes so many commonly held assumptions that after reading it even the most knowledgeable fans (and some journalists) should feel like drunks who have suddenly been forced to sober up." -- Chicago Tribune "Required reading for anyone who calls himself a fan." -- Chicago Sun-Times "An invaluable contribution to sports literature." -- Howard Cosell

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