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Record your grandfather’s life story in this beautiful keepsake journal with 200 guided exercises and prompts that take him back through each stage of his life and its accompanying adventures. Whether called Papa, Grampie, Grandpa, or something else, grandfathers are a family’s most-prized treasure and whose patriarchal wisdom, love, and support are needed and appreciated by every member. Grandfathers have lived full lives that show that, even though times may change, most of life’s truths are timeless. With a compassionate ear always at the ready, their experiences have also gifted them with profound insight to share. In this second edition of My Grandfather’s Life featuring a new cover design, both thought-provoking and lighthearted writing prompts and guided exercises are organized into chapters based on your grandfather’s life stages to help him record his life’s memoir. Beginning with early childhood, questions like What are some family holiday traditions you remember? followed by early adulthood prompts such as Did a particular person inspire you in pursuing a job or career? and then moving to the wisdom he has learned and would like to share such as If you could change one thing about the world, what would it be and why?, the My Grandfather’s Life journal jump starts the reflective writing process to open your grandfather’s mind to dig deeper into who he is, where he started, and, most importantly, what he has learned. Complemented with poignant quotes about grandfathers throughout history, this beautifully designed journal will give your grandfather everything he needs to record his life’s experiences to not only shed light on the events that shaped him into the man he is today, but also to preserve his life’s memories and stories for you and your family to learn from, become inspired by, and cherish for future generations. With so much of our lives and contact going digital, the Creative Keepsakes journals offer an intimate way to nurture your connection with yourself and the people around you. An entertaining way to get off your screen, these guided and free-form journals are great for writers and artists alike. Each journal offers content around a different theme, including silly prompts for a laugh, random yet thoughtful questions, inspiration for art and composition, interactive prompts to learn about your heritage, and blank interiors on high-quality paper stock to use as your creative canvas. Beautifully designed and full of mindful prompts, channel your inspiration as you put pen (or pencil, or marker, or crayon!) to paper to learn more about yourself, your talents, and the people you love. Also in this Series: 3,001 Questions All About Me, 3,001 Would You Rather Questions, 3,001 This or That Questions, 301 Things to Draw, 301 Writing Ideas, Anti-Anxiety Journal, Complete the Drawing, Create a Poem, Create a Story, Create Comics: A Sketchbook, Design & Destroy, Forever Friends, Gratitude Journal, Inner Me, Inspired by Prayer, Internet Password Book, Mom & Me, My Family Story, My Father's Life, My Grandmother's Life, My Life Story, My Mother's Life, Our Love Story, Sermon Notes, Sketch - Large Black, Sketch - Large Kraft, Sketch - Medium Black, Sketch - Medium Kraft, This is Me, Write - Medium Black, Write - Medium Black

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The Global Medical Excellence Cluster (GMEC) and the New York Academy of Sciences, in collaboration with Imperial College London and King's College London, sponsored the conference "Animal Models and Their Value in Predicting Drug Efficacy and Toxicity." The goal was to provide a neutral forum to critically examine and discuss the traditional role of pre-clinical animal models in drug discovery, and how these models most effectively contribute to translational medicine and therapeutic development. International, multi-disciplinary clinical and basic science investigators convened to discuss and identify changes needed to increase the predictive power of various models for drug efficacy and toxicity in humans, and ways in which to further refine, reduce, and replace animal models in biomedical research in areas such as metabolic and cardiovascular disease, inflammation, pain. Other topics discussed included new technologies in bioimaging, biosimulation, bioinformatics, the generation of genetically modified animals, phenotype screening, alternatives to rodent models, the use of embryonic stem cells, patient-specific induced pluripotent stem cells, and humanized animal models. This volume presents a collection of short papers on some of the topics discussed at this important conference. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.1111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

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‘Essential reading.’ – ESQUIRE ‘Both absorbing and highly illuminating’ – THE BOOKSELLER ‘No one understands the intricacies of YouTube like Chris Stokel-Walker’ – THE ATLANTIC Two billion people watch YouTube and it reaches deep into everyday lives. Its creators start new trends, popularise new songs and games and make and break new products. Yet while they are famous to billions of mostly young people, they mostly remain a mystery to the general public and mainstream media. What is the secret of their appeal? How do they cope with being in front of the lens – and who is behind their success? More than 100 insiders spoke candidly to teach journalist Chris Stokel-Walker for this first in-depth independent book on YouTube. YouTubers is the only book you need to understand YouTube, its ownership by Google, its deal for stars and its ecosystem of talent managers, advertisers and marketers. It is a richly-layered deep dive into YouTube brimming with lively characters, engaging facts, and influencer case studies. It is an ideal guide for any media studies students, advertisers, brand managers and business people who need to understand YouTube professionally. And for any non-fiction reader interested in a gripping business and technology saga dripping with big money, ruthlessness, determination and ambition. YouTubers starts by charting the platform's launch in a boring 19-second video of the elephant enclosure at San Diego Zoo – which has now had 242 million views. YouTubers then moves onto the first oddball videos before the site found success by showing comedy clips from the TV show Saturday Night Live. YouTubers reveals how YouTube saw off its emerging rivals in the online video battle of the 2000s and was bought by the search engine specialist Google. With Google's billions and boosted by smartphones, YouTube became the dominant video platform. Bloggers started to create engaging, fast-cut videos that capitalised on the intimate relationship between creator and user – a 'parasocial' relationship stronger than the bond between TV presenter and viewer. By ceaselessly urging their followers to tap the like, comment and subscribe buttons, these creators helped YouTube's rise to global domination. YouTubers speaks to YouTube stars KSI, Hank and John Green and delves into the lives of child star MattyB, the training camp for aspiring teenage bloggers, the YouTube stunts that go wrong and the increasing efforts of creators to earn money from Patreon. And it tackles the platform's Muslim extremism, red-pilling, and its content guidelines and censorship. YouTubers asks how YouTube can take on the threat from other big platforms such as Instagram and Facebook. In short, YouTubers tells the riveting story of the exponential growth of YouTube from single home video to global tech phenomenon. It is the best and only book you need to read on YouTube. Extract Introduction One spring afternoon Casey Neistat uploaded a video lasting five minutes and twenty-two seconds to YouTube. In the style of so many YouTubers, he looked straight into the camera and aired his opinion on a matter of importance. As the elder statesman on the platform, Neistat’s words carry weight. He can make or break products and careers — and this video was no different. Seconds after he uploaded his video to YouTube via his superfast broadband at his creative headquarters in New York, it was available worldwide to four billion people: everyone on Earth with an internet connection. Millions of Neistat’s subscribers instantly received a notification telling them that one of YouTube’s most influential stars was again speaking directly to them. Across the world in apartment blocks, restaurants, bedrooms and bathrooms, phones pinged, buzzed and beeped. Hundreds of thousands of people instantly watched what Neistat had to say. Wearing dark glasses, his hair streaked blond, Neistat vented his frustration at the way the media was second-guessing the motivations of YouTubers; and he wanted to single out one journalist in particular. In the comments section underneath his video his fans began discussing the question he posed: did people post videos on YouTube for the fame and fortune — or just to express themselves? YouTube is a kaleidoscope of visual and audio content that mimics the richness, quirkiness, beauty and madness of human life. Every day its users upload videos on everything from pop music to politics, fashion to plumbing, and cars to fishing. The topics are as diverse (and as random) as the world itself. Want to watch racing pigeons, cut a perfect bob, discuss Che Guevara, speak Mandarin, or play guitar? YouTube can offer that, instantly. Want to relax while seeing boiled sweets made the old-fashioned way? Load up Lofty Pursuits. Have a hankering to watch a man meticulously scratch away the foil on 200 lottery playing cards to see if he can win back his outlay? Type ‘moorsey scratchcards’ into your search bar and reap the rewards. Whether giving sex advice, posting football clips or simply splicing together footage to create an action-packed vlog, video makers want to communicate with and be seen by YouTube’s 1.9 billion registered users. Some hope that, like Casey Neistat, they too will one day set off pings across the world. For a few, notifications mean that millions of fans are watching them and their view counters are whirring upwards, along with their bank balances. Elite influencers are creative and dynamic and get to do what they want all day long. Unsurprisingly, becoming a YouTuber is the job children most covet. They understand the platform’s extraordinary growth. YouTube is expanding so fast that outsiders can’t accurately measure its size. An estimated 576,000 hours of video are added daily to YouTube – vastly more than the new releases on Netflix. In October, November and December 2018, Netflix added 781 hours of original content, while 53 million hours of footage likely went onto YouTube. It would take you 35 days to watch the new Netflix content non-stop. You’d still be watching the YouTube uploads in the year 8069. YouTube’s rise has been swift. In little more than a decade, it has moved from an oddity broadcast on bulky grey computer monitors to mass media entertainment viewed on ultra-thin, wall-mounted 55-inch televisions. In the past five years, YouTube viewing has rocketed from 100 million hours a day to one billion hours a day. Buy the book and carry one reading

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This book aims to reflect the digital transformation of Chinese education toward smart education comprehensively and accurately. It is the first systematic summary of the progress of smart education in China. The book believes that smart education is a new education form in the digital era and is essentially distinct from education forms in the industrial era. This new education form is innovative in five dimensions. First is the new core concept. Smart education is not only a concrete action concerning people’s well-being, but also a vital strategy concerning national plans. Through technology empowerment and data drive, it empowers educational reform in all aspects, systematically constructs a new relationship between education and society, provides suitable education for each learner, and makes the aptitude-based teaching that we have been dreaming of for thousands of years a reality. For the first time in history, smart education helps to reach the full alignment between individual development and societal development. Second is the new system structure. Smart education will break through the boundaries of school education, drive the diversified combination of various education types, resources, and elements, promote the collaboration of school, family, and society in education, and build a high-quality, individualized lifelong learning system that is available for anyone anywhere anytime. Third is the new teaching paradigm. Smart education will integrate physical, social, and digital spaces to create new learning scenarios and promote human–technology integration, and cultivate cross-grade, cross-class, and cross-discipline learning communities across time and space to organically combine large-scale education with individualized cultivation. Fourth is the new educational content. Smart education will focus on developing all-round education, establishing digital knowledge graphs based on systematic logics of knowledge points, and innovating content presentation methods to make learning a wonderful experience and help learners develop higher-order thinking skills, comprehensive innovation capability, and lifelong learning ability. Fifth is the new education governance. With data governance at the core and digital intelligence technology as the driver, smart education will boost the holistic reengineering of education administration and business processes and enhance the modernization of the education governance system and governance capacity. This book is intended for teachers, education administrators, education policymakers, education researchers, and parents concerned about education innovation and development, as well as people from all walks of life who have aspirations for the education industry. It can also serve as a reference for international organizations and education research institutions of all countries to promote the joint exploration of the development path of smart education and create a better future for the world’s mutual development through educational reform.

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Radiofrequency catheter ablation is a safe and presently a routine method for the treatment of arrhythmias. This practical atlas presents illustrative cases aiming to inform practitioners and aid in the management of their patients. This essential text is written by an international array of experts in this field and organized by the Reunion of European countries for the Treatment of Arrythmias in Cardiology (RETAC).

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Sarah Calhoun has taken her father’s throne and ascended into her goddess’s presence in Unfallen Eden, as her father never did. And now young Sarah Calhoun is dying. Her uncle Thomas Penn isn’t done with her. Armed with new powers conferred upon him by the Necromancer and with new allies won via his impending marriage, Penn aims to remove Sarah from her throne—and from the world of the living. In the meantime, Sarah has fallen out with one of her best allies. Against Sarah’s advice, her brother Nathaniel heads into Imperial Philadelphia with the reckless and likely impossible aim of healing the Emperor Thomas. On the shores of the northern seas, agents of Franklin’s Conventicle with an unlikely connection to the Emperor struggle to win allies among the pole-dwelling giants, who are torn between seizing land covertly from the Firstborn of the Ohio and entering the war openly on the side of Simon Sword. In the west, the Heron King rides an explosive storm into war, crushing the mortal kingdoms in his path and bearing down on Sarah’s Cahokia. To survive—and to gain the strength she needs to fight this impossible war—Sarah must unite the Moundbuilder kings to enact an ancient rite that will propel her beyond mortality. To do so, she must not only win over doubters among the Firstborn kings, but she must also beat back a rebellion among the Handmaids of her goddess—for there are some of the goddess’s priestesses who long for the dark days of human sacrifice, and who are willing to throw Sarah herself upon the altar. Praise for Witchy Winter: “Butler follows Witchy Eye with a satisfying second tale of a magic-filled early America. . . . Deep and old magic influences both places and characters, and the story is tightly focused on the determined Sarah . . . Fans of epic and alternate historical fantasy will savor this tale of witchery and intrigue.”—Publishers Weekly “For readers who love history-based fantasy, steampunk, or urban fantasy . . . this series that gives the genre a new twist.”—Booklist Praise for Witchy Eye and D.J. Butler: “ . . . [Y]ou can’t stop yourself from taking another bite . . . and another . . . and another . . . I didn’t want to stop reading . . . Kudos!”—R.A. Salvatore “Excellent book. I am impressed by the creativity and the depth of the world building. Dave Butler is a great storyteller.”—Larry Correia “Witchy Eye is an intricate and imaginative alternate history with a cast of characters and quirky situations that would make a Dickens novel proud.” —Kevin J. Anderson “Butler’s fantasy is by turns sardonic and lighthearted; ghoulish shadows claw into the most remote areas and heroism bursts out of the most unlikely people. Sarah is the epitome of the downtrodden hero who refuses to give up until she gets what she needs, and her story will appeal to fantasy readers of all stripes.”—Publishers Weekly “David's a pro storyteller, and you're in for a great ride.”—Larry Dixon “ . . . [A] fascinating, grittily-flavored world of living legends. Hurry up and write the next one, Dave.”—Cat Rambo “This is enchanting! I'd love to see more.”—Mercedes Lackey “Goblin Market meets Magical Musketpunk . . . A great ride that also manages to cover some serious cultural terrain.”—Charles E. Gannon “Witchy Eye is a brilliant blend of historical acumen and imagination, a tour-de-force that is at once full of surprises and ultimately heart-warming. This is your chance to discover one of the finest new stars writing today!”—David Farland “A gritty, engrossing mash-up of history, fantasy, and magic. Desperate characters careen from plot twist to plot twist until few are left standing.”—Mario Acevedo “Captivating characters. Superb world-building. Awesome magic. Butler fuses fantasy and history effortlessly, creating a fascinating new American epic. Not to be missed!”—Christopher Husberg “[A] unique alternative-history that is heavily influence by urban and traditional fantasy and steeped in the folklore of the Appalachians. . . . Fans of urban fantasy looking to take a chance on something with a twist on a historical setting may find this novel worth their time.”—Booklist

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ONE FAMILY’S REVOLT AGAINST EVERYDAY POLLUTION When a beanbag sent thousands of polystyrene balls flying through her garden, Kate Hughes decided to make a break with the throwaway society. She and her husband transformed the lives of their ordinary family of four. They ditched plastic, shunned supermarkets, cooked all meals from scratch, bought only second-hand clothes, and made their own cleaning agents. Then they went deeper – greening every aspect of their home life, from their gas and electricity to their car, from their money to their IT. The Hugheses have achieved the ‘zero waste’ goal of sending nothing to landfill. Now they are going even further… Told with refreshing humility and humour, this eye-opening story shows that a well-lived life doesn’t have to come wrapped in plastic. Packed with handy tips, it reveals much about what makes a fulfilling modern family – and how readers can empower themselves to preserve the climate, forests and seas. And, heart-warmingly, how that can lead to a more relaxing life. Extract Cooking our own meals Wrestling out of the firm grip of the supermarkets has had other, unexpected benefits, too. It’s undoubtedly cheaper to cook from scratch, especially if you can batch cook and fill every available space in your oven to reduce energy costs. The need to become the more organised, list-writing type of shoppers has also helped dramatically cut our food waste. We’re lucky that we can and do buy our raw ingredients from small, independent retailers that source from nearby suppliers and growers and pass on our questions about sustainability, sometimes even with enthusiasm. But what we hadn’t anticipated were the indirect effects of a brand vacuum. If you ever pop round to ours and start randomly opening our kitchen cupboards, fridge or freezer they would probably remind you of a blind taste test or an episode of the BBC’s Eat Well for Less. There’s definitely food in there, but it’s all in label-less jars, paper bags or sometimes even sacks for bulk items like bread flour and oats. At first, visitors find the lack of familiar packaging quite unsettling. We get a lot of questions that start: ‘Is this proper/real/like…?’ as guests hold jars up to the light with badly disguised scepticism. On the plus side, our children now have zero pester power. We don’t need to navigate the snack shuffle at the supermarket checkout because they have no hope of deploying the ‘It’s not the one I like’ argument at mealtimes. Nor, for that matter, have the adults. ... But we were starting to realise that making the journey was leading to more questions than answers, more grey areas, misinformation and conflicts of interest than we ever imagined – and that was just about food. We hadn’t even got started on anything else that came into our home yet. Take a single, uncontroversial ingredient, let’s say peppers. Should we buy them grown in a UK hothouse or ones trucked in from Spain? What if the Spanish ones are organic? Or the only UK option is wrapped in plastic? Which is better for the environment? Or at least less harmful? If we ever want to eat peppers again without negatively impacting the planet in some way are we going to have to grow our own? Because self-sufficiency wasn’t really part of the plan.... All we could do was dive in and hope we didn’t drown in the detail as we swam around looking for food that worked for us and the planet. We started with the problem of transport because food mileage was a well established measure that meant we could actually make some decisions based on numbers for once. Or, at least, we thought we could. Three quarters of all the fruit and veg now eaten in the UK is imported. Almost all the fruit we eat has been grown overseas, and soft fruit in particular is flown in. It turns out that the UK only produces half of all the food that is consumed on these shores – which is somewhat patriotically disconcerting as well as practically unsustainable. Global sourcing is not a new approach to feeding a nation. One of our family stories is the recollection of the first banana my great uncle ever tasted after the Second World War, shipped from the other side of the world and unloaded onto the Liverpool docks. We were very aware that bananas came from overseas. But the fact that such a vast proportion of the apples eaten in Britain are imported from South Africa, or at best France, when the fruit grows very well in the miles of orchards you can see from the motorway near our house seemed to be absurd. The obvious solution appeared to be only to buy food produced not just in the UK but as close to our immediate vicinity as possible. That immediately threw up two questions. The first we were becoming increasingly familiar with. Were we really prepared to give up things we took great pleasure in for the sake of an unquantifiable, but undoubtedly minuscule effect? Or even just to settle for not adding to the runaway levels of damage that our disconnected food shop was causing each and every day? We are children of the 90s. We grew up safe in the knowledge that the world’s produce was at our fingertips at any time of the year. When we were kids, cuisine was regularly valued on the exoticism of its ingredients. Even if your palate was resolutely British, a Sunday roast at an ageing auntie’s always included the smug mention that the family was consuming lamb imported from the other side of the world. Even in our twenties, the craze for exotic bottled water shipped, plastic encased, in vast quantities from tropical islands thousands of miles away, packed a serious economic punch. And then there’s the avocado – a native of Mexico and now all but a dictionary definition of the British Millennial. We had come of age and then brought our children into the world on the assumption that it was normal to buy exotic food cheaply all year round. Things were clearly going to have to change, starting with my obsession with avocado on toast. But the second question was whether a straightforward food mile approach was even a worthwhile aim. When I put the question of food miles to Riverford Organic Farmers, the sustainably produced veg box people, they told me that for most of the year our carbon impact would be smaller if we bought organic tomatoes trucked in from Spain than those heated thanks to fossil fuels in a UK hothouse. That means the answer has to be to eat food grown in the UK at the time of year it is traditionally produced. We finally arrived at a robust solution – seasonal, native eating. Buy the book to find out how they tackled this!

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