Search results for ""Author Volker""

Studies in bioequivalence are the commonly accepted method to demonstrate therapeutic equivalence between two medicinal products. Savings in time and cost are substantial when using bioequivalence as an established surrogate marker of therapeutic equivalence. For this reason the design, performance and evaluation of bioequivalence studies have received major attention from academia, the pharmaceutical industry and health authorities. Bioequivalence Studies in Drug Development focuses on the planning, conducting, analysing and reporting of bioequivalence studies, covering all aspects required by regulatory authorities. This text presents the required statistical methods, and with an outstanding practical emphasis, demonstrates their applications through numerous examples using real data from drug development. Includes all the necessary pharmacokinetic background information. Presents parametric and nonparametric statistical techniques. Describes adequate methods for power and sample size determination. Includes appropriate presentation of results from bioequivalence studies. Provides a practical overview of the design and analysis of bioequivalence studies. Presents the recent developments in methodology, including population and individual bioequivalence. Reviews the regulatory guidelines for such studies, and the existing global discrepancies. Discusses the designs and analyses of drug-drug and food-drug interaction studies. Bioequivalence Studies in Drug Development is written in an accessible style that makes it ideal for pharmaceutical scientists, clinical pharmacologists, and medical practitioners, as well as biometricians working in the pharmaceutical industry. It will also be of great value for professionals from regulatory bodies assessing bioequivalence studies.

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The collection at hand is a subjective, but representative selection of articles in German and English on the representation of bellicose acts in modern times. The wide range of wars treated in these essays begins with the Canudos Civil War in the Brazilian state of Bahia in 1896-97. The various articles include new perceptions and interpretations of the First World War, the Spanish Civil War of 1936-39, the Holocaust, the Second World War, the Korean War, the wars in the former Portuguese colonies of Africa, and the Balkan Wars of the last decade of the 20th century, and close with the current war in Afghanistan, which began in 2001. The wars discussed, although having different origins, such as national pride, territorial expansion, fanatic religiousness, ethnic and racial conflicts, great social differences, the process of decolonization, and terrorism, have one thing in common: their significant and constant repercussion in the print and broadcast media over a long period of time. These modern wars have therefore often been the object of new readings and reinterpretations until today. The history of these wars could not have been written without the development of journalism, the mass media, and new technologies of war reporting in the 20th century.

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New technological approaches in dermatologic diagnostics, such as surface microscopy and dermoscopy, are continuously advancing. Anatomical structures can be viewed like never before. Through these new techniques the necessity of a new terminology and a new set of dermoscopic criteria has come up. So far, many different and sometimes confusing terms have been used in designating these microscopic features. However, the daily challenge physicians face when evaluating skin lesions acquires immediate access to the current dermoscopic nomenclature and definition. This unique guide provides a comprehensive, current, and accurate A-Z encyclopaedia to clarify the meaning of surface microscopic and dermoscopic terminology including a broad range of both melanocytic and non-melanocytic skin lesions. It will support dermatologists, histopathologists and all other physicians in charge of a biopsy and excision decision.

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In-cell NMR spectroscopy is a relatively new field. Despite its short history, recent in-cell NMR-related publications in major journals indicate that this method is receiving significant general attention. This book provides the first informative work specifically focused on in-cell NMR. It details the historical background of in-cell NMR, host cells for in-cell NMR studies, methods for in-cell biological techniques and NMR spectroscopy, applications, and future perspectives. Researchers in biochemistry, biophysics, molecular biology, cell biology, structural biology as well as NMR analysts interested in biological applications will all find this book valuable reading.

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An accessible and comprehensive guide to all things acoustic bat detection. This highly illustrated handbook provides an in-depth understanding of acoustic detection principles, study planning, data handling, properties of bat calls, manual identification of species, automatic species recognition, analysis of results, quality assurance and the background physics of sound. No other method of detecting bats is so popular and widespread in the context of environmental assessment and voluntary work as acoustic detection, and its increased use has driven the development of a large number of sophisticated devices and analytical methods. Acoustic detection has become a standard approach for establishing the presence of bats, carrying out species identification and monitoring levels of activity. The resolution, accuracy and scale with which these tasks can be done has risen dramatically with the availability of automated real-time recording. But anyone interested in acoustic recording will quickly recognise that there are still quite a few open questions about the limits and possibilities of acoustic detection. Clear definitions of how to handle the data are usually missing, for example, and there are no clearly described activity indices. In response to the lack of thorough information on the underlying science of acoustic detection, the authors present this handbook.

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This book shows why mindful leadership is the key element for supportive management and leadership in the 21st century. It highlights the fundamentals of mindful leadership in philosophy and history in different cultural traditions and shows latest research on mindfulness and digitalization, technology, social networking, and leading-self concepts. The book bridges the past and the future. By combining a range of research perspectives, it connects mindfulness to serving leadership concepts and describes resilience for both individuals and organizations. In addition, it presents theoretical aspects and practical recommendations on how to implement mindful leadership and supportive environments in organizational cultures. The book encompasses history, present leadership challenges and future management perspectives and enables the implementation of models of good practice into daily working life. It includes contributions from researchers of different continents, and offers an international overview of state-of-the art leadership research.This book is of interest to professionals and researchers working on leadership, from the perspective of positive psychology, organizational studies, and wellbeing studies.

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This handbook shares profound insights into the main principles and concepts of integrated care. It offers a multi-disciplinary perspective with a focus on patient orientation, efficiency, and quality by applying widely recognized management approaches to the field of healthcare. The handbook also highlights international best practices and shows how integrated care can work in various health systems. In the majority of health systems around the world, the delivery of healthcare and social care is characterised by fragmentation and complexity. Consequently, much of the recent international discussion in the fields of health policy and health management has focused on the topic of integrated care. “Integrated” acknowledges the complexity of patients’ needs and aims to meet them by taking into account both health and social care aspects. Changing and improving processes in a coordinated way is at the heart of this approach. The second edition offers new chapters on people-centredness, complexity theories and evaluation methods, additional management tools and a wealth of experiences from different countries and localities. It is essential reading both for health policymakers seeking inspiration for legislation and for practitioners involved in the management of public health services who want to learn from good practice.

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With the new contribution of Dr. Volker Fintelmann, Weiss's classic text on Herbal Medicine has been expanded and refocused to meet the needs of practicing physicians, residents, students, and other clinicians. Arranged by organ system, the book's clear structure and scientific orientation make the topic of herbal medicine accessible to even the most traditional medical doctor. You will benefit from the newest research, clinical studies, and the pivotal findings of the German Commission E on the efficacy of herbs. Special features include: In-depth coverage of the state-of-the-art of phytotherapy Key prescription information highlighted in each chapter Superb color photographs throughout the text Two new quick reference sections that maximize your access to the material -- by herbs and the disorder they are used for, and by disorder and the herbs used in its treatment

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In Love With Photography is a unique treasure in the history of photography, lifted from the archives of Volker Hinz, one of the most important and indefatigable photographers of our time. A treasure, amassed in almost 50 years by a passionate collector of portraits and presented here for the first time. Volker Hinz photographed those who normally remain hidden behind their cameras. Whenever and wherever he encountered them: at work, at home, in public or private moments. This is how a unique collection of the most renowned photographers of the second half of the 20th and the early 21st centuries came about. He got everybody in front of his camera: from Muhammad Ali to Richard Avedon, from Jeff Koons to Karl Lagerfeld, from Annie Leibowitz to Robert Mapplethorpe, from Helmut Newton to Irving Penn, from Sebastiao Salgado to Andy Warhol - the list is endless.

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Die 1945 zu weiten Teilen zerstörte Stadt Mainz wollten die französischen Besatzer unmittelbar nach Kriegsende zu einem französisch geprägten Mayence aufbauen. Für diese Aufgabe wurde Marcel Lods berufen, Verfechter einer funktionalistischen Moderne, dessen deutsch-französisches Architektenteam auch Überlegungen aus der Zeit vor 1945 in den Aufbauplan einfließen ließ. Als Antwort auf die ablehnende Haltung der lokalen Bevölkerung – aber auch einiger französischer Militärs – beauftragte die Stadt Mainz Paul Schmitthenner mit einem Projekt, das den historischen Charakter der Stadt stärker bewahren sollte. Beide Projekte scheiterten zwar, doch blieb Mainz bis weit in die 1950er Jahre Schauplatz einer exemplarischen Konfrontation zweier sich unversöhnlich bekämpfender Tendenzen innerhalb der europäischen Architektur des 20. Jahrhunderts, wie sie an keinem anderen Ort in dieser Schärfe und mit dieser fachlichen Kompetenz ausgetragen wurde. Als Ergebnis jahrzehntelanger Forschungen bietet dieses Buch erstmalig eine systematische Aufarbeitung dieser umfassenden Planungen und ihrer zeitgeschichtlichen Hintergründe.

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Text in English & German. The way we sit simultaneously defines privileges, social status, power, and taboos. Parallel to the presentation of China as the guest of honour at the Frankfurt Book Fair 2009, the Museum für Angewandte Kunst in Frankfurt presents a panorama of Chinese sitting culture through a period of five centuries. Exclusive, noble Ming chairs stand side by side with chairs of the 18th and 19th century used by the middle class of that time. Limited sitting sculptures by renowned artist designers such as Shao Fan, Freeman Lau, Kenneth Cobonpue, XYZ-Design and Ji Liwei, who is also in charge of the interior design of the Chinese pavilion at the book fair, are confronted with the bourgeois sofas and sitting of the Chinese middle class of today. The "Bastard Chairs" of migrant workers and the homeless, day-to-day seats improvised out of pure need and made of trash and leftover materials, are commented in the sitting contexts of celebrities: emperors and courtesans, politicians and pop stars, athletes and students of product design show how sitting was done formerly and is done today. It ranges from a man of letters from the Ming era to the Qianglong emperor on the throne to Mao and Nixon in characteristic armchairs in Mao's best room. The most famous contemporary Chinese artist, Ai Weiwei, will also be represented with an excerpt of his grandiose chair performance at the Dokumenta XII. Of course, product piracy, which -- as the typical Chinese dipping figure "Shanzhai" -- has mean-while adopted characteristics that define society, is also dealt with.

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„Lebensspuren im Stein“ bietet spannende Einblicke in längst vergangene Lebenswelten Mitteleuropas. Jedes Hauptkapitel ist einer Periode der Erdgeschichte zugeordnet und gibt neben einem Überblick über die Geologie einen fundierten Einblick in die jeweiligen Lebensformen und ihre Überreste, die bis heute unsere Landschaft formen, als Rohstoffe genutzt werden und Fossiliensammler begeistern. So erfahren wir, dass die Ostseeküsten teilweise aus den Überresten von Kalkalgen bestehen, wo die ersten Säugetiere unterwegs waren, welche phantastischen Riesenformen das Karbon bevölkerten, wie die Urpferde aussahen und wo heute noch versteinerte Wälder zu sehen sind. Exkurse zu Massenaussterben, Eiszeiten und der Entstehung des Menschen ergänzen das Werk, eine fundierte Einführung ermöglicht es auch Einsteigern, die „Lebensspuren im Stein“ zu verstehen. Das Buch basiert auf einer erfolgreichen Serie des Magazins „Biologie in unserer Zeit“, an der viele bekannte Wissenschaftler mitgearbeitet haben. Es ist sowohl eine ideale Einführung für Studenten als auch ein fachkundiger Begleiter für alle von der Paläontologie Begeisterten – ob Forscher, Mitarbeiter in Museen oder Interessierte anderer Fachbereiche.

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The American West - where such landmarks as the Golden Gate Bridge rival wild landscapes in popularity and iconic significance - has been viewed as a frontier of technological innovation. Where Minds and Matters Meet calls attention to the convergence of Western history and the history of technology, showing that the region's politics and culture have shaped seemingly placeless, global technological practices and institutions. Drawing on political and social history as well as art history, the book's essays take the cultural measure of the region's great technological milestones, including San Diego's Panama-California Exposition, the building of the Hetch Hetchy Dam in the Sierras, and traffic planning in Los Angeles. Contributors: Amy Bix, Louise Nelson Dyble, Patrick McCray, Linda Nash, Peter Neushul, Matthew W Roth, Bruce Sinclair, L Chase Smith, Carlene Stephens, Aristotle Tympas, Jason Weems, Peter Westwick, and, Stephanie Young.

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Die Herausgeber, anerkannte Spezialisten und aktiv in der Interdisziplinären Arbeitsgruppe Weichteilsarkome (IAWS) der Deutschen Krebsgesellschaft, stehen für fundiertes Fachwissen. Das Werk zeichnet sich durch eine praxisorientierte und übersichtliche Darstellung aller bei Weichteilsarkomen klinisch relevanten Themen aus. Ausführlich wird auf Diagnostik, Klassifikation, Stadieneinteilung wie auch molekulare und genetische Aspekte als Grundlage therapeutischer Entscheidungen eingegangen. Ein weiteres zentrales Thema ist die interdisziplinäre Behandlung (Chirurgie, Strahlentherapie, medikamentöse Therapie) und deren Sequenz für die zahlreichen, unterschiedlichen Entitäten von Weichteilsarkomen. Auch spezielle Therapieverfahren, wie Extremitätenperfusion und Hyperthermie werden besprochen. Ärzte in Klinik und Praxis erhalten mit diesem Buch kompetente Unterstützung für die optimale Betreuung von Patienten mit Weichteilsarkomen.

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The third edition of this popular core textbook provides wide-ranging coverage of the structure, internal working, policies and performance of international organizations such as the UN, EU, IMF and World Bank. Such organizations have never been so important in addressing the challenges that face our increasingly globalised world. This book introduces students to theories with which to approach international organizations, their history, and their ability to respond to contemporary issues in world politics from nuclear disarmament, climate change and human rights protection, to trade, monetary and financial relations, and international development. Underpinning the text is the authors' unique model that views international organizations as actual organizations. Reacting to world events, political actors provide the 'inputs' which are converted by the political systems of these organizations (through various decision-making procedures) into 'outputs' that achieve varying levels of real-world impact and effectiveness. This is the perfect text for undergraduate and postgraduate students of politics and international relations taking courses on International organization and global governance, as well as essential reading for those studying the UN, the EU and Globalization. New to this Edition: - Draws on the most recent research in the field and considers some of the significant world events of the last decade to ensure that the book is completely up to date. - Two separate chapters considering Trade and Development, and Finance and Monetary Relations respectively. - Fully accounts for the challenges to international organizations by the emerging powers, the Trump administration and Brexit

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Comprehensive resource covering all in-space manufacturing and planetary resource exploration endeavors. The space economy is developing quickly, and pivotal events have brought us to a strong inflection point. This unique book includes fundamental and ground-breaking innovations in the field and is meant to quickly get readers up to speed on many different facets of space and planetary resource exploration, such as: Space health & medicine Space biology & space farming Space chemistry & space mining Space construction & advanced materials production Space policy, law & economics Presenting a snapshot of the expanding space economy and manufacturing applications in low-Earth orbit, along with resource utilization capabilities in development for Moon and Mars missions, this an indispensable source for all researchers and commercial companies working on space and planetary resource exploration.

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The influence of political developments on the evolution of economic thought is the main theme behind this book. As the authors reveal throughout the book, history has shown many times that political events can trigger the formulation of new economic conceptions that in turn influence the future economic development of a country. The papers are arranged into five main areas of interest: monetary theory and policy economic crisis in France and the emergence of the physiocratic school the co-evolution of political ideas and economic thought in different countries and periods in Europe continuity and discontinuity in Russian economic thought attempted economic solutions to the problems posed by the Great Depression and the associated political transformation. Political Events and Economic Ideas will hold great appeal and interest for researchers and scholars of political thought, as well as historians of economic thought worldwide.

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This book contains an Open Access chapter The COVID-19 pandemic disrupted economies and society globally. In addressing the crisis, the Internet proved incredibly important in enabling many to shift physical work, education, and social activities online and facilitating the tracking of the progress of the pandemic. Beyond the Pandemic? is the first edited collection to concentrate on the dynamic and complex relationship between the Internet and the role it played in responding to the pandemic. Covid-19 accelerated the digital economy transformation, changing the way work, education, and social engagement is organized, potentially permanently. The collection of international scholars who contributed to this volume offer insightful perspectives on how the Internet ecosystem responded and was changed as a consequence of Covid-19; the sectoral consequences of shifting activity online that the Internet enabled for many, but not for all; and the implications for regulatory policies. Given how central digital technologies are to all aspects of business, society, and government, Beyond the Pandemic? is integral to the exploration of the sectoral consequences of the Internet for business managers, policymakers and researchers engaged in planning and study for the digital economy future and planning for future pandemics.

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The joint forces of digital and analogue allow for a myriad of different worlds for us to live in. In German they are called Parallelwelten (= parallel worlds). This book investigates these parallel worlds from different angles: technological, corporate, scientific, cultural, economic and political.

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Televion's Nature Nut, John Acorn, teams up with nature illustrator Ian Sheldon to craft a witty and personable book about the myriad insects and arachnids found throughout the diverse habitats of Northern California.

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Dieses Buch stellt neue Geschäftsmodelle und Methoden vor, mit denen Dienstleistungsinnovationen durch den Einsatz digitaler Technologien erfolgreich umgesetzt werden.Ein Schwerpunkt des zweiten Bandes sind neue Methoden für die digitale Transformation von Dienstleistungsprozessen in der Industrie, Logistik und Gesundheitsbranche. Das Buch stellt dabei auch besondere Herausforderungen und Lösungen für die digitale Transformation kleiner und mittlerer Unternehmen (KMU) vor und zeigt, wie dort neue Geschäftsmodelle umgesetzt werden. Die Entwicklung und Nutzung digitaler Plattformen stellt abschließend eine spezifische Perspektive auf neue Kooperationsformen in Wertschöpfungsnetzwerken dar. Zahlreiche Umsetzungsbeispiele zeigen konkret und praxisnah auf, wie Unternehmen digitale Geschäftsmodelle selbst entwickeln, neue Methoden sicher anwenden und Dienstleistungsinnovationen erfolgreich realisieren können.

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Dieses praktische Handbuch leistet einen Beitrag zur Professionalisierung der Human Resources in Unternehmen. Auf mehr als 2.000 Seiten finden Personalverantwortliche alles, was sie aus Management und Recht für ein erfolgreiches​ Personalwesen wissen müssen. Das Werk orientiert sich am Aufbau des Betriebsverfassungsgesetzes, wobei die Regelungen nicht nur kommentiert, sondern im Kontext des betrieblichen Alltags behandelt werden. Mit aktuellen Themen wie Personalplanung, demografischer Wandel, Leistungsbeurteilung, Restrukturierung, Compliance sowie Corporate Governance dient das Handbuch als wertvoller Ratgeber in der modernen Personalarbeit.

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This groundbreaking volume offers a historical comparison between the events leading up to World War I and current global tensions related to the economical and political rise of Asia. What are the risks that the desire of the new super power China and great powers like India to be recognized by the West could set off a chain of events resulting in the nightmare of a great power war? Assessing the similarities as well as differences between the build-up of World War I and today, it is argued that we need to understand the driving forces behind the scene of global politics: The conflict between rising, established, and disintegrating powers and the desire of recognition on all sides. Carefully dissecting the current power dynamics in play, the authors hope to contribute to a better understanding of world events in order to ensure that history will not repeat itself.

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Reopened in 2010, having been closed since 1939, the world-famous Berlin Etruscan collection, one of the largest outside Italy, is now on permanent display again. This companion volume to the new exhibition in the Altes Museum provides exciting insights into this still fascinating culture of early Italy on the basis of the Berlin holdings - complete grave findings and excellent testimonies of Etruscan art production: history, architecture, sculpture and cabaret, cult and myth as well as writing and reception are presented in informative and richly illustrated articles.

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The Self-Propelled Island is the first unabridged English translation of Jules Verne’s original story featuring a famous French string quartet that is abducted by an American businessman and taken to Standard Island to perform for its millionaire inhabitants. The quartet soon discovers that Standard Island is not an island at all, but an immense, futuristic ship possessing all the features of an idyllic haven. Equipped with the most opulent amenities, Standard Island travels the Pacific Ocean, traversing the south archipelagos and stopping at many “sister” islands for the pleasure of its well-heeled inhabitants. These inhabitants soon meet with the danger, in its various forms, that is inherent in ocean travel. Meanwhile, the French quartet is witness to the rivalry that exists between the two most powerful families onboard, a rivalry that keeps the future of the island balancing on the edge of a knife. First published in English in 1896, the novel was originally censored in translation. Dozens of pages were cut from the story because English translators felt they were too critical of Americans as well as the British. Here, for the first time, readers have the pleasure of reading The Self-Propelled Island as Verne intended it.

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Intraoperative imaging technologies have taken an ever-increasing role in the daily practice of neurosurgeons and the increasing attention and interest necessitated international interaction and collaboration. The Intraoperative Imaging Society was formed in 2007. This book brings together highlights from the second meeting of the Intraoperative Imaging Society, which took place in Istanbul-Turkey from June 14 to 17, 2009. Included within the contents of the book is an overview of the emergence and development of the intraoperative imaging technology as well as a glimpse on where the technology is heading. This is followed by in detail coverage of intraoperative MRI technology and sections on intraoperative CT and ultrasonography. There are also sections on multimodality integration, intraoperative robotics and other intraoperative technologies. We believe that this book will provide an up-to date and comprehensive general overview of the current intraoperative imaging technology as well as detailed discussions on individual techniques and clinical results.

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The Tai Lü are a Tai-speaking group closely related to the Khon Müang or Tai Yuan, the dominant ethnic group in Northern Thailand. According to their own historical tradition, the ancestors of the Tai Lü migrated from what is now northwestern Vietnam into the southern part of Yunnan, where they founded their own kingdom in the twelfth century. Today, the Tai Lü are the most important population group within the so-called "Economic Quadrangle" of the Upper Mekong, which plays an increasingly important economic and geopolitical role. Chronicle of Sipsòng Panna offers the first English translation of four different versions of the Chronicle of Moeng Lü (also known as Sipsòng Panna) based on the oldest extant manuscripts. The volume provides a comprehensive analysis of Tai Lü historical sources and a valuable introduction to the history and society of the Upper Mekong region.

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