Search results for ""Author Alfred""
John Beaufoy Publishing Ltd The Malay Archipelago
Book SynopsisAlfred Russel Wallace's The Malay Archipelago is a work of astounding breadth and originality that chronicles the British naturalist's scientific exploration of Malaysia, Singapore, Indonesia and New Guinea between 1854 and 1862. An intrepid explorer who earned his living by collecting bird skins, Wallace also catalogued the vast number of plant and animal species that inhabit this unique geographical area. In addition, he includes numerous observations on the people, their languages, and ways of living and social organization, as well as geological insights into the nature and activity of volcanoes and the destructive force of nature. Colourful personal anecdotes based on experiences during his travels also pepper the text. First published in 1869, The Malay Archipelago provided some of the initial evidence for the modern theory of evolution. Discursive, captivating, occasionally offensive, but always wonderfully descriptive, it remains one of the most extensive works of natural history ever compiled. The Earl of Cranbrook is an expert in the environmental biology of the Malaysian region, and has a special interest in the life and career of Alfred Russel Wallace. Stanfords Travel Classics feature some of the finest historical travel writing in the English language, with authors hailing from both sides of the Atlantic. Every title has been reset in a contemporary typeface to create a series that every lover of fine travel literature will want to collect and keep.
£14.24
Boydell & Brewer Ltd The Court of Richard II and Bohemian Culture:
Book SynopsisFirst detailed exploration of the role played by Bohemian tradition and customs in the court of Richard II. Bohemian culture exercised an important influence on the court of King Richard II, but it has been somewhat overlooked, with previous scholarship on its writers and artists generally confined to the role played by the French courtof King Charles V and the Italian city states of Milan and Florence. This book aims to fill that gap. It argues that Richard's marriage to Anne of Bohemia, daughter of the Holy Roman Emperor Charles IV, one of the greatest rulersand patrons of the age, exposed England to the full extent of this international court culture. Ricardian writers, including Chaucer, Gower and the Gawain-poet, wrote in their native language not because they felt "English" in the modern national sense but because they aspired to be part of a burgeoning vernacular European culture stretching from Paris to Prague and from Brabant to Brandenburg; thus, one of the major periods of English literature can only be properly understood in relation to this larger European context.Trade ReviewContinuing his two-decades-long exploration of medieval and early modern Anglo-Bohemian relations, Thomas, in his latest study, convincingly demonstrates the significant cultural and political ramifications of King Richard II;s marriage to Anne of Bohemia in 1382. -- Nathanial B. Smith * Renaissance Quarterly *Table of ContentsRichard II and the Luxembourg Court The Familiar Patron: Collaboration and Conflict in Chaucer and Late Medieval European Courtly Writing Scandals at Court: Pride and Penitence in Sir Gawain and the Green Knight and the Alliterative Morte Arthur Pearl in its Setting: Piety and Politics at the Luxembourg and Ricardian Courts Conclusion: The End of the Ricardian Court Culture Bibliography
£72.00
Bloomsbury Publishing PLC The Interpreter From Java
Book Synopsis'What a great novel, its language and storytelling so light but also raw and lyrical. A tremendous writer. Read this book' ADRIAAN VAN DIS. Alan Noland discovers his father's memoirs and learns the truth about the violent man he despised. In this unsparing family history, Alan distils his father's life in the Dutch East Indies into one furious utterance. He reads about his work as an interpreter during the war with Japan, his life as an assassin, and his decision to murder Indonesians in the service of the Dutch without any conscience. How he fled to the Netherlands to escape being executed as a traitor and met Alan's mother soon after. As he reads his father's story Alan begins to understand how war transformed his father into the monster he knew. Birney exposes a crucial chapter in Dutch and European history that was deliberately concealed behind the ideological facade of postwar optimism. Readers of this superb novel will find that it reverberates long afterwards in their memory.Trade ReviewA masterly novel about the violence of colonialism, the war of decolonisation, the repatriation of the collaborators and the consequences all of this has had on the families of those involved * De Groener Amsterdammer *Birney mercilessly exposes a crucial part of Dutch history. This masterful novel will echo in the minds of its readers * De Volkskrant *What a great novel, its language and storytelling so light but also raw and lyrical. A tremendous writer. Read this book -- Adriaan van Dis, author of My Father's War and BetrayalA work of unbridled, incensed storytelling: an assault on the lazy assumptions of parochial, colonial history and a personal quest for redemption * South China Morning Post *
£9.49
Usborne Verlag StickerWissen Natur Tierspuren
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£7.71
The New York Review of Books, Inc End of Me
Book SynopsisA moving tale about middle age, divorce, modern love, and returning home by one of the great American storytellers.Asher’s career as a Hollywood screenwriter has come to a humiliating end; so has his latest marriage. Returning to New York, where he grew up, he takes a room at a hotel and wonders what, well into middle age as he is, he should do next. It’s not a question of money; it’s a question of purpose, maybe of pride. In the company of the arch young poet Michael, Asher revisits the streets and tenements of the Lower East Side where he spent his childhood, though little remains of the past. Michael introduces Asher to Aurora, perhaps his girlfriend, who, to Asher’s surprise, seems bent on pursuing him, too. Soon the older man and his edgy young companions are caught up in a slow, strange, almost ritualized dance of deceit and desire. The End of Me, a successor to Hayes’s In Love and My Face for the World to See, can be seen as the final panel of a triptych in which Alfred Hayes anatomizes, with a cool precision and laconic lyricism that are all his own, the failure of modern love. The last scene is the starkest of all.
£12.74
Alfred Music Alfreds Easy Piano Songs Standards Jazz
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£20.79
Duke University Press An Other Tongue
Book SynopsisTrade Review"The essays in this volume are well-written, powerfully argued, and provocative critical introductions to issues such as nation and national languages and heteroglossia and interlingualism. With its focus on multilingualism in the U. S., the Caribbean, India, and Ireland, the volume is essential reading for those interested in the remapping of World Literature."—José David Saldívar, University of California, Santa CruzTable of ContentsAcknowledgments ix Introduction: The Here, the Now / Alfred Artega 1 An Other Tongue / Alfred Artega 9 Colonialism and the Politics of Translation / Tejaswini Niranjana 35 Adulteration and the Nation: Monologic Nationalism and the Colonial Hybrid / David Lloyd 53 Seeing with Another I: Our Search for Other Worlds / Eugene C. Eoyang 93 Cut Throat Sun / Jean-Luc Nancy 113 Conjugating Subjects: The Heteroglossia of Essence and Resistance / Norma Alarcon 125 The Ruins of Representation: Shadow Survivance and the Literature of Dominance / Gerald Vizenor 139 A Rhetoric of Obliquity in African and Caribbean Women Writers / Michael G. Cooke 169 Differance and the Discourse of "Community" in Writings by and about the Ethnic Other(s) / Cordelia Chavez Candelaria 185 Dialogism and Schizophrenia / Tzvetan Todorov 203 Bilingualism and Dialogism: Another Reading of Lorna Dee Cervantes's Poetry / Ada Savin 215 Dialogical Strategies, Monological Goals: Chicano Literature / Bruce-Novoa 225 Bilingualism as Satire in Nineteenth-Century Chicano Poetry / Luis A. Torres 247 Nacer en Espagnol / Edmundo Desnoes 263 Bonding in Difference / Gayatri Chakravorty Spivak 273 Contributors 287 Index 291
£73.95
Quarto Publishing PLC The Southern Fells
Book SynopsisThe Southern Fells include the highest, roughest, grandest fells in Lakeland including the highest mountain in England, Scafell Pike. Wainwright – a fell-walking legend in his own lifetime – knew the terrain and conveyed its grandeur and beauty like nobody else. In this unique Pictorial Guide, he writes of the glorious curves and simple grandeur of Great Langdale; of Wasdale, 'an emerald amongst sombre hills'; of enchanting Borrowdale; of the sparkling radiance of the Duddon; and of the most delectable valley of all – Eskdale, 'sanctuary of peace and solitude'. This is the original Pictorial Guide to the Southern Fells of Lakeland, freshly reproduced from Wainwright's original pages. These popular Pictorial Guides have been treasured by generations of walkers and are as enchanting and inspiring now as when they were written, half a century ago.
£13.59
John Wiley & Sons Inc Signal Analysis
Book SynopsisSignal analysis gives an insight into the properties of signals and stochastic processes by methodology. Linear transforms are integral to the continuing growth of signal processes as they characterize and classify signals. In particular, those transforms that provide time-frequency signal analysis are attracting greater numbers of researchers and are becoming an area of considerable importance. The key characteristic of these transforms, along with a certain time-frequency localization called the wavelet transform and various types of multirate filter banks, is their high computational efficiency. It is this computational efficiently which accounts for their increased application. This book provides a complete overview and introduction to signal analysis. It presents classical and modern signal analysis methods in a sequential structure starting with the background to signal theory. Progressing through the book the author introduces more advanced topics in an easy to understand style.Trade Review"...excellent and interesting reading for digital signal processing engineers and designers and for postgraduate students in electrical and computer faculties." (Mathematical Reviews, 2002d)Table of ContentsSignals and Signal Spaces. Integral Signal Representations. Discrete Signal Representations. Examples of Discrete Transforms. Transforms and Filters for Stochastic Processes. Filter Banks. Short-Time Fourier Analysis. Wavelet Transform. Non-Linear Time-Frequency Distributions. Bibliography. Index.
£181.76
John Wiley & Sons Inc Limbo
Book SynopsisAward-winning journalist Alfred Lubrano takes an incisive look at the estimated 65 million Americans who straddle the line between the middle-class communities in which they grew up and the upper-class corporate world they inhabit from nine to five.Table of ContentsIntroduction. 1. Bricklayer’s Son: The Birth and Clash of Values. 2. Crawling Out of the Black Hole: The Pain of Transition. 3. The Shock of Education: How College Corrupts. 4. Culture Conflicts: First Encounters with the Upper Classes. 5. Going Home: An Identity Changed Forever. 6. Office Politics: The Blue-Collar Way. 7. Class, Love and Progeny: The Ultimate Battle. 8. Duality: The Never-Ending Struggle with Identity. Conclusion. Endnotes. Source Notes. Acknowledgments. Index.
£16.15
John Wiley & Sons Inc Small Ring Heterocycles Volume 42 Part 1
Book SynopsisThe Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects properties, synthesis, reactions, physiological and industrial significance of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.Table of Contents1. Azwdines 1James A. Deymp 2. Azirines 215Vasu Nair 3. Three-Membered Rings Containing Sulfur 333Uri Zoller Author Index 631 Subject Index 673
£460.76
University of Washington Press Shopping at Giant Foods
Book SynopsisA fascinating study of the rise and fall of Chinese American supermarketsTrade Review"This book provides a revealing insight into a remarkable chapter of American and Chinese American economic history . . . a valuable source on this thread of Chinese American economic and social history." -- Benedikt Kohler * China Information *"The unlikely venue of the modern supermarket enables readers to catch glimpses of how Chinese Americans carved out an economic niche for themselves amidst overt and covert discrimination." * The Journal of American History *"Yee's accessible study provides rare insights into the business practices and relationships of Chinese-American enterprises, and their historical legacy. As someone who spent fifteen years in the industry, his passion about the subject, first-hand knowledge, and personal contacts made him uniquely qualified to write this study." * Left History *"Yee's ability to bring to the fore differing and often competing perspectives about the supermarket industry makes this work rich and engaging." * Ameriasia Journal *Table of ContentsPreface Acknowledgments Introduction Supermarkets Community, Employment, and Enterprise Beginnings Golden Times Decline and Passing Employees and Salesmen Chinese Management and Labor Unions Stop-N-Shop Conclusion Appendix Notes Bibliography Index
£21.59
Columbia University Press Democratic Transition in the Muslim World
Book SynopsisThis book convenes leading scholars to consider the implications of democratic success in Tunisia and failure in Egypt in comparative perspective. Contributors analyze similarities and differences among democratizing countries with large Muslim populations, considering universal challenges as well as each nation’s particular obstacles.Trade ReviewIn the age of ISIS and growing anti-Muslim bigotry embodied in the rise of Donald Trump, the claim that Islam and Muslim societies are essentially and enduringly antidemocratic has again become mainstream. This book forcefully and convincingly repudiates this proposition. Focusing on the fascinating case of Tunisia and drawing up his vast erudition on the study of democracy, Alfred Stepan makes an important and unique contribution in understanding the relationship between religion and democracy in Muslim societies. -- Nader Hashemi, the University of DenverAl Stepan was our leading theorist of how to get and keep democracy around the world. His work on the Middle East revealed great subtlety and depth of understanding, made all the more remarkable by the fact that his primary region of study was Latin America. This carefully curated volume demonstrates the influence that Stepan’s thinking has had (and will have) on generations of Middle East scholars. -- Tarek Masoud, John F. Kennedy School of Government, Harvard UniversityAl Stepan was a giant in the field of comparative politics. His contributions to our understanding of the complicated processes of liberalization and democratization are unrivaled. The invaluable essays contained in this volume reflect Stepan’s broad intellectual range and his rich legacy as a teacher to a generation of scholars. -- Steven A. Cook, Eni Enrico Mattei Senior Fellow for Middle East and Africa Studies, Council on Foreign RelationsStepan (Columbia) presents an edited volume that focuses on successful democratic transition in the Muslim word, a question so far neglected in comparative politics literature....Highly recommended. * Choice *An important and often original work. * Foreign Affairs *Table of ContentsForeword by Monica MarksAcknowledgmentsIntroduction by Alfred StepanPart I. Why Different Democratization Outcomes in Tunisia and Egypt? Cross-Ideological Accommodations, Constitutions, Militaries, and the Content of International Assistance1. Ennahda’s Democratic Commitments and Capabilities: Major Evolutionary Moments and Choices, by Rached Ghannouchi2. The Challenges of Democratization in the Arab World: Some Reflections on the Egyptian Case, by Carrie Rosefsky Wickham3. Mutual Accommodation: Islamic and Secular Parties and Tunisia’s Democratic Transition, by Alfred Stepan4. The Roots of Egypt’s Constitutional Catastrophe: The Necessity of Marrying an Analysis of Context, Process, and Text, by Nathan J. Brown5. Purists and Pluralists: Cross-Ideological Coalition Building in Tunisia’s Democratic Transition, by Monica Marks6. Patterns of Civil-Military Relations and Their Legacies for Democratization: Egypt Versus Tunisia, by Hicham Bou Nassif7. The Failure of the International Community to Support Tunisia, by Radwan MasmoudiPart II. Rethinking Other Democracies with Large Muslim Populations: What Policies Helped in Indonesia and India?8. Crafting Indonesian Democracy: Inclusion-Moderation and the Sacralizing of the Postcolonial State, by Jeremy Menchik9. Indian Democracy and the World’s Largest Muslim Minority, by Hilal Ahmed and Sudipta KavirajSelected BibliographyContributorsIndex
£70.40
Alfred Publishing Co Inc.,U.S. Suzuki Cello School Cello 3
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£14.20
Nova Science Publishers Inc The Cost of Prescription Drugs
Book SynopsisThe prescription drug delivery system -- how a drug gets from the manufacturer to the patients -- is complicated. Over 4.4 billion prescriptions are written for drugs each year for Americans who then pick up these prescriptions at 60,000 drugstores or receive them from doctors or hospitals or online pharmacies. Chapter 1 is about how Americans pay for prescription drugs and where that money goes. Chapter 2 is about the process, beginning with the manufacturer's development of a drug, the different steps through which the drug travels before arriving in a patient's hands, how this is paid for, and what the costs are at each step along the way.Table of ContentsPreface; The Cost of Prescription Drugs: How the Drug Delivery System Affects What Patients Pay; The Cost of Prescription Drugs: How the Drug Delivery System Affects What Patients Pay, Part II; Index.
£163.19
Collector's Guide Publishing Rocket Science 1947-1952: The Journal of the
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£27.99
Quarto Publishing PLC The Western Fells Readers Edition A Pictorial
Book SynopsisThe original Pictorial Guide to the Western Fells of Lakeland â freshly reproduced from Wainwright's original pages.
£13.49
Alfred Publishing Co Inc.,U.S. Suzuki Cello School 1 Piano Accompaniment
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£14.20
Penguin Books Ltd The Girl on the Via Flaminia
Book SynopsisA dark love story set in wartime Rome from the author of In Love and Your Face for the World to SeeRome, 1944. Robert is a lonely American soldier looking for a girl. Lisa is cold and hungry, obliged to seek work at Mamma Pulcini''s house on the Via Flaminia. Their lives come together in what should be a simple exchange, a temporary arrangement without love or complication. But in a city broken by war, its people defeated, nothing is simple. Based on Alfred Hayes''own experiences of wartime Italy, this spare, searing novel exposes the dark complexities of the relationship between men and women, victor and vanquished. ''Hayes has done for bruised men what Jean Rhys does for bruised women, and they both write heartbreakingly beautiful sentences'' Paul Bailey, Guardian''Rings true as gold ... every single character in the book is sharp with the infallible stroke of art'' Daily MailTrade ReviewA superb short novel ... The Hemingway influence is clear, but Hayes is his own man, a master of irony and ambiguity ... An enthralling narrative, and art of a high order * Kirkus Reviews *It is a bigger story than it seems to be, for it has implications that spread through the city and the world * The New York Times *Hayes has done for bruised men what Jean Rhys does for bruised women, and they both write heartbreakingly beautiful sentences * Guardian *A sensitive and gorgeously wrought study of connections and misconnections, this masterpiece of the period perfectly captures a short, but unique, period in history * Mostly Fiction *Hayes balances a bitter depiction of an unforgiving world with sympathy for the sad evasive manoeuvres of the human psyche... His novels perfectly capture the texture of midcentury American life ... His work must come back to us in all its brutal honesty * Los Angeles Review of Books *
£9.49
Orion Publishing Co The Demolished Man
Book SynopsisIn the year 2301, guns are only museum pieces and benign telepaths sweep the minds of the populace to detect crimes before they happen. In 2301 murder is virtually impossible, but one man is about to change that ...Ben Reich, a psychopathic business magnate, has devised the ultimate scheme to eliminate the competition and destroy the order of his society. The Demolished Man is a masterpiece of imaginative suspense, set in a superbly imagined world in which everything has changed except the ancient instinct for murder.
£7.64
Llanerch Press Ancient Stone Crosses of England
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£9.90
£14.44
St Martin's Press A Terrible Revenge
£18.89
Classiques Garnier Stello
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£21.57
NOVA MD ein edler Charakter ein höheres Bewusstsein
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£21.25
NOVA MD Die Macht der Dankbarkeit
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£23.80
Les Belles Lettres Plaute, Comedies: Tome VII: Trinummus -
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£30.00
Les Belles Lettres Plaute, Comedies: Tome II: Bacchides - Captivi -
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£29.00
Ohio University Press Revisiting U.S. Trade Policy Decisions in
Book SynopsisIn trade policy, as in many other areas of public policy, decision makers often confront present and future problems with little understanding of how similar disputes were resolved in the past. Too often, busy public officials had no time to write or record negotiating histories. Revisiting U.S.
£40.02
University of the West Indies Press Selected Writings of Alfred H. Mendes
Book SynopsisAlfred Hubert Mendes (1897–1991) was a member of the influential Beacon group of artists, writers and intellectuals in Trinidad in the 1930s. In common with other Beacon writers, including C.L.R. James and Ralph de Boissière, he set out to create a Trinidad-centred literature, and his extensive output of poetry, short stories, novels and journalism bears witness to his dedication to this goal. Selected Writings is an anthology of poetry, short fiction and journalism from the 1920s, 1930s and 1940s which places Mendes’s literary development in the context of his life. It is accompanied by an introduction, appendices containing early letters to Mendes from C.L.R. James, Claude McKay, and the Canadian writer Hulbert Footner, explanatory notes, and a brief glossary of Trinidadian words and phrases. The sheer vitality of Mendes’s writing and the huge scope of his interests will attract both scholars and general readers keen to understand what life really was like in the early decades of the twentieth century, especially now, as Trinidad celebrates fifty years of independent self-government. Whereas Mendes’s poems and short stories tellingly illustrate the stresses of social life under colonial rule, the journalism contains much thought-provoking discussion of the development of a national identity and political maturity through his intensive examination of Trinidad’s cultural life.
£32.21
Forgotten Books A Theory of Time and Space Classic Reprint
£18.96
Forgotten Books The Doane Family Classic Reprint
£15.48
LEGARE STREET PR Beside the Fire
£25.60
Legare Street Press Principia Mathematica
£30.35
Cosimo Classics The Principle of Relativity
£20.99
Cosimo Classics The Concept of Nature
£17.18
Yesterday's Classics Stories from the Greek Tragedians (Yesterday's Classics)
£13.31
Yesterday's Classics Stories from Livy
£13.31
Cosimo Classics The Economics of Welfare: Volume I
£34.99
Cambridge University Press Nature and Life
Book SynopsisFirst published as part of the Cambridge Miscellany series in 1934, this book presents the content of two lectures delivered by Alfred North Whitehead at the University of Chicago in October 1933. The volume concerns itself chiefly with the complex relationship between nature, philosophy and science.Table of ContentsLecture I; Lecture II.
£22.99
Cambridge University Press The Struggle for the Eurasian Borderlands
Book SynopsisA major new account of the Eurasian borderlands as 'shatter zones' where the Habsburg, Russian, Ottoman, Iranian and Qing Empires competed for hegemony. Alfred Rieber charts the rise and expansion of these multicultural, conquest empires from the late medieval period through to their collapse in the early twentieth century.Trade Review'A compelling demonstration of the central importance of borderlands and frontier disputes in Eurasian states. Its broad comparative sweep provides insights not only into the sources on international conflict, but also into the dynamics of internal reform enacted to bring borderlands more effectively under central control.'3 Richard S. Wortman, Bryce Professor Emeritus of European Legal History, Columbia University'This volume is an impressive feat of dedicated scholarship. Employing a mode of analysis that he calls 'geo-cultural', Alfred J. Rieber interprets the political and social history of Eurasia as a story in which certain frontiers play an absolutely essential, indeed informative role. It is safe to say that people who read this book will never see frontiers in the same way as before.' Ilya Vinkovetsky, Associate Professor of History, Simon Fraser University'No-one who reads this book can fail to gain new perspectives on much of modern history, not to mention the constant crises of both Europe and Asia today.' The Times Literary Supplement'Borderlands are back. From the Baltic to the Balkans, from Ukraine and the Caucasus through Central Asia, old fault lines from old empires have once again taken on political relevance in world politics. Alfred J. Rieber's ambitious book looks at their formation and interaction with five imperial centers over five centuries through a study of the Habsburg, Ottoman, Russian, Iranian, and Chinese empires.' Thomas J. Barfield, American Historical Review'[Rieber] has produced an encyclopedic political history of mid-fifteenth- through twentieth-century Eastern Europe and much of Asia (except for the Arab and Indian worlds), with many forays into the Middle Ages and an emphasis on the period since 1815. The book includes an imposing wealth of factual material and comparisons, and a vast array of footnotes covering secondary literature in many languages on practically every important question related to the rise and decline of empires.' Seymour Becker, Ab Imperio'What is new about this book is a holistic vision of patterns of conflict determined by the existence of complex, interconnected and fluid frontiers … In its broad territorial and chronological span as well as its rich tapestry of historical detail, the book is written in the worthy tradition of the École des Annales … This should become a standard work, equally insightful for the academic specialist and for students of history.' Irina Marin, The English Historical Review'This is an impressive, complex, and comprehensive work that reflects a lifetime of scholarly study. It is also a study that focuses on borderlands within continental empires that, at least in the historiography of the modern era, tend to play a subordinate role to European overseas empires. For this reason alone, it is a refreshing approach to the broader subject of empire and borderlands.' Jonathan E. Gumz, Journal of Modern HistoryTable of ContentsIntroduction; 1. Imperial space; 2. Imperial ideologies: cultural practices; 3. Imperial institutions: armies, bureaucracies and elites; 4. Imperial frontier encounters; 5. Imperial crises; 6. Imperial legacies; Conclusion: transition.
£108.58
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG General Pharmacology
Book SynopsisThe author's general aim has been to survey as wide a field of evidence as possible and this had involved excursions into subjects of which he has little first hand knowledge. This width of range also has necessitated a somewhat arbitrary selection of evidence and has prevented full discussion of any indi- vidual problem. The author trusts that he has not misrepresented anyone's results or opinions, and if this has occurred, he can only plead in excuse the peculiar difficulty of giving a brief and yet accurate account of evidence of such a wide variety. The diagrams reproduced in the article have all been redrawn and in many cases the original figures or diagrams have been modified as, for instance, by recalculating dosage on the logarithmic scale. The original authors therefore have no direct responsibility for the diagrams in their present form. The author desires to thank Messrs Arnold and Co. for permitting the repro- duction of Figs. 9 and 23 from similar figures which appeared in his book "The Mode of Action of Drugs on Cells"; portions of other figures from this book also have been reproduced in modified form. The author also desires to thank Dr. J. M. ROBSON for help in correction of the proofs. Edinburgh, July, 1937. A. J. CLARK. Contents.Table of Contents1: Methods of General Pharmacology.- General Considerations p. 4. — Selection of Material p. 5. — Employment of Physico-chemical Methods p. 5. — The Mathematical Interpretation of Biological Data p. 6. — Favourable Factors in Pharmacological Measurements p. 7. — Curves Relating Exposure to Drugs with Biological Effect p. 7. — Classes of Curves p. 8. — Discussion p. 9.- 2: The Cell as a Physico-chemical System.- The Structure of Protoplasm p. 10. — The Cell Surface p. 12. — Cell Permeability p. 12. — Structure of Plasmatic Membrane p. 14. — Cell Organisation p. 15.- 3: General Characteristics of the Cell-Drug System.- Dimensions of Molecules and Cells p. 17. — The Number of Molecules in Single Cells p. 19. — The Number of Enzyme Molecules per Cell p. 19. — Lethal Doses of Drugs per Cell p. 20. — Effective Doses of Drugs per Cell p. 21. — Minimum Active Doses of Drugs per Organism p. 22. — Minimum Active Dilutions of Drugs p. 22. — Intracellular Administration of Drugs p. 23. — Types of Action of Drugs on Cells p. 25. — Discussion p. 25.- 4: Reactions between Drugs and Active Proteins.- Symplex Compounds p. 26. — Combination of Haemoglobin with Oxygen and Carbon Monoxide p. 27. — Antagonism of Oxygen and Carbon Monoxide p. 29. — Discussion p. 30.- 5: The Action of Drugs on Catalysts and Enzymes.- Poisoning of Inorganic Catalysts p. 31. — General Characters of Enzymes p. 33. — Enzyme Activity p. 34. — General Characters of the Poisoning of Enzymes p. 34. — Diphasic Actions of Enzyme Poisons p. 36. — The Rate of Action of Enzyme Poisons p. 37. — Relation between Concentration of Poison and Inhibitien of Enzyme p. 37. — Discussion p. 40.- 6: Action of Heavy Metals on Enzymes in vitro and in vivo.- Action of Heavy Metals on Saccharase p. 40. — Concentration-action Relations of Heavy Metals and Enzymes p. 42. — The Action of Metals on Living Cells p. 44. — Relation between Metal Concentration and Action on Cells p. 44. — Minimum Lethal Concentrations of Heavy Metals p. 44. — Relative Toxicity of Metals p. 46. — Course of Reaction between Metals and Cells p. 47. — Diphasic Actions of Metals on Cells p. 48. — Discussion p. 49.- 7: Action of Various Enzyme Poisons in vitro and in vivo.- The Action of Dyes on Enzymes p. 50. — Action of Quinine on Enzymes p. 51. — Action of Quinine on Cells p. 52. — Action of Cyanide on Enzymes and Cells p. 52. — Diphasic Actions of Cyanide p. 55. — Phenol Compounds p. 55. — The Action of Narcotics p. 56. — Action of Narcotics on Enzymes p. 56. — Action of Narcotics on Cells p. 59. — Theories of Narcotic Action p. 60. — Discussion p. 61.- 8: Concentration-action Relations I.- (1) Classification of Concentration-action Curves.- Relations Depending on Mass-action p. 63. — All-or-None Effects p. 64.- (2) Concentration-action Relations Attributable to Mass-action Laws.- The Mode of Action of Acetylcholine p. 66. — Amount of Acetylcholine Acting on Cells p. 69. — Individual Variation p. 70. — Site of Action of Acetylcholine p. 70. — Influence of Temperature on Acetylcholine Response p. 72. — Specificity of Acetylcholine Action p. 72. — Possible Nature of Acetylcholine Receptors p. 73. — Acetylcholine Esterase p. 74. — Concentration-action Relations of Adrenaline p. 74. — Dosage of Adrenaline p. 75. — Concentration-action Relations Found with Various Hormones p. 76. — Insulin p. 76. — Thyroxin p. 77. — Posterior Pituitary Principles p. 77. — Sex Hormones p. 77. — Various Alkaloids p. 78. — Nicotine p. 78. — Physostigmine p. 79. — Other Alkaloids p. 79.- 9: Concentration-action Relations II.- (3) Linear Relations; Action of Narcotics.- (4) All-or-None Responses.- Instrumental Errors p. 83. — Distortion by the Cell of some Chemical Relation p. 83. — Obligatory All-or-None effects p. 84. — All-or-None Cellular Responses p. 85. — Concentration-action Curves with Guinea Pig’s Uterus p. 86. — Drugs Producing All-or-None Effects p. 87. — Discussion p. 89.- 10: Quantitative Pharmacology and the Theory of Humoral Transmission.- p. 90. — Quantitative Data p. 91. — Rate of Action p. 92. — Concentration-action Relations p. 93. — Specific Antagonisms p. 95. — Discussion p. 96.- 11: Kinetics of Drug Action.- Sources of Error in Kinetic Measurements.- (1) Kinetics of Reactions in Heterogenous Systems.- (2) Kinetics of Cell Reaction.- Delays in Drug Action Due to Diffusion to Cell Surface p. 98. — Penetration of Cells p. 100. — Delay in Biological Response p. 102.- (3) Maximum Rate of Drug Action.- 12: The Rate of Action of Drugs on Cells.- (1) Curves Relating Time and Graded Action.- The Shapes of Time-action Curves p. 107.- (2) Curves Relating Time and All-or-None Effects.- Kinetics of Protein Precipitation p.110. — Precipitation of Protein by Phenol p. 111.- (3) Time Action Curves as Expressions of Variation.- Calculation of Time-action Curves p. 114. — Time Relations of Toxic Action of Copper on Algae p. 115.- (4) Implications of Monomolecular Theory.- Quantitative Measurements of Drug Uptake p. 118. — Drug Actions as Chain Processes p. 119.- (5) Mortality Curves.- (6) Action of Radiations.- Discussion p. 122.- 13: Time-concentrations Curves.- (1) Form of Curves and Possible Significance.- (2) Time-concentration Curves of Nerve Paralysis.- (3) Time-concentration Curves with Various Drugs.- (4) Time-concentration Relations in Disinfection.- (5) Toxic Vapours.- Deviation of Narcotics p. 139. — Time-concentration Curves of Anaesthetics p. 140. — Time-concentration Curves of Hydrocyanic Acid p. 141. — Irritant Gases p. 141. — Discussion p. 142.- 14: Individual Variation of Response to Drugs.- Methods of Measurement of Individual Variation p. 142. — Skew Variation in Biological Material p. 144. — Normal Equivalent Deviation p. 146. — Errors in Construction of Characteristic Curves p. 148. — Uniformity of Population p. 148. — Errors of Sampling p. 149.- 15: Relation between Various Types of Curves Expressing Response of Cells to Drugs.- (1) Concentration-action Curves as Expressions of Individual Variation.- Virus Infections p. 151. — Discussion p. 153.- (2) Characteristic Curves as Expressions of Chemical Processes.- (3) Correlation between Concentration-action Curves and Characteristic Curves.- Examples of Skewed Characteristic Curves p. 156. — All-or-None Effects p. 161. — Discussion p. 162.- (4) Drug Responses and Individual Variation.- 16: Special Problems Relating to Variation of Populations.- Uniformity of Population p. 165. — Influence of Sex, Age and Weight on Response to Drugs p. 166. — Seasonal Variations in Sensitivity p. 169. — Variation in Human Populations p. 169. — Hypersensitivity and Idiosyncrasy p. 171. — Margin of Safety with Massive Doses p. 173. — Disinfection, etc. p. 175.- 17: Quantitative Aspects of Drug Antagonism and of Drug Synergism.- p. 176. — The antagonism of cyanides by narcotics p. 177. — Selective Antagonisms with Haemoglobin p. 180. — Antagonism in Enzyme Poisoning p. 181. — Acetyl Choline-Atropine Antagonism p. 184. — AdrenalineErgotoxine Antagonism p. 186. — Synergists of Adrenaline p. 187. — Comparison of Antagonisms found with Enzymes and with Hormones p. 188.- 18: Qualitative Aspects of Drug Antagonism.- p. 190. — Antagonism of Adrenaline p. 191. — Chemical Structure of Acetyl Choline Antagonists p. 191. — Acetyl Choline Antagonism in Different Tissues p. 193. — Analysis of Drug Actions by Drug Antagonisms p. 196. — General Theory of Drug Antagonisms p. 198.- 19: Alternative Theories of Drug Action.- Monomolecular Theory p. 199. — The Potential Theory of Drug Action p. 200. — Phasic response of cells p. 201. — Arndt-Schulz Law p. 204. — Drug Responses as Expression of Individual Variation p. 204. — Weber-Fechner Law p. 205. — Discussion p. 205.- 20: Quantitative Aspects of Chemotherapy.- p. 206. — Action of Metallic Compounds p. 207. — Action of Non-metallic Compounds p. 212. — Drug-resistance p. 213. — Discussion p. 214.- 21: Conclusion.- Index of Authors.- Index of Subjects.
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Pearson Education Data Structures and Algorithms
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Double 9 Books The Confession of a Child of the Century -
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Cambridge University Press Ecological Imperialism
Book SynopsisPeople of European descent form the bulk of the population in most of the temperate zones of the world - North America, Australia and New Zealand. The military successes of European imperialism are easy to explain; in many cases they were a matter of firearms against spears. But as Alfred W. Crosby maintains in this highly original and fascinating book, the Europeans'' displacement and replacement of the native peoples in the temperate zones was more a matter of biology than of military conquest. European organisms had certain decisive advantages over their New World and Australian counterparts. The spread of European disease, flora and fauna went hand in hand with the growth of populations. Consequently, these imperialists became proprietors of the most important agricultural lands in the world. In the second edition, Crosby revisits his now classic work and again evaluates the global historical importance of European ecological expansion.Trade ReviewReview of previous edition: 'Crosby has unfolded with great power the wider biopolitics of our civilization.' NatureReview of previous edition: '[This] book is important, and required reading for politicians worldwide … Nuclear war may be spectacular and a valid focus for our exertions, but ecological insouciance is even more dangerous because it is unspectacular, and it merits efforts to combat it as strenuous and urgent.' The GuardianReview of previous edition: 'The biological bases of radically changing historical ecosystems must never be forgotten - and Crosby has made them intelligible as well as memorable.' Natural HistoryReview of previous edition: 'Crosby argues his case with vigour, authority and panache, summoning up examples and illustrations that are often as startling in their character as in their implications. Ecological Imperialism could not ask for a more lucid and stylish exponent.' The Times Literary SupplementReview of previous edition: 'In telling his very readable story, Mr Crosby combines a historian's taste for colorful detail with a scientist's hunger for unifying and testable generalization … [He] shows that there is more to history than kings and battles, and more to ecology than fruits and nuts.' The Wall Street JournalTable of Contents1. Prologue; 2. Pangaea revisited, the Neolithic reconsidered; 3. The Norse and the Crusaders; 4. The Fortunate Isles; 5. Winds; 6. Within reach, beyond grasp; 7. Weeds; 8. Animals; 9. Ills; 10. New Zealand; 11. Explanations; 12. Conclusion.
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