Description

This publication explains the principles of the techniques used in disposition and metabolism studies in animals, in man, and in vitro. It includes methods for studying routes and rates of absorption, distribution, metabolism, and excretion of novel compounds and their metabolites. Relevant surgical, whole-body autoradiographic and pharmacokinetic procedures are discussed, together with techniques for separating and identifying metabolites and metabolic path-ways. Information on when the procedures are appropriate, and examples of what they represent, are presented in order to illustrate the value of such studies.

Xenobiotic Metabolism and Disposition: The Design of Studies on Novel Compounds

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Hardback by Harry P.A. Illing

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This publication explains the principles of the techniques used in disposition and metabolism studies in animals, in man, and in... Read more

    Publisher: Taylor & Francis Inc
    Publication Date: 28/02/1989
    ISBN13: 9780849361630, 978-0849361630
    ISBN10: 084936163X

    Number of Pages: 232

    Non Fiction , Education

    Description

    This publication explains the principles of the techniques used in disposition and metabolism studies in animals, in man, and in vitro. It includes methods for studying routes and rates of absorption, distribution, metabolism, and excretion of novel compounds and their metabolites. Relevant surgical, whole-body autoradiographic and pharmacokinetic procedures are discussed, together with techniques for separating and identifying metabolites and metabolic path-ways. Information on when the procedures are appropriate, and examples of what they represent, are presented in order to illustrate the value of such studies.

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