Description
Book SynopsisAlzheimer''s disease (AD) and vascular dementia (VaD) are commonly viewed as the first and second most common types of dementia, respectively. The traditional paradigm has been to view and treat each illness as a separate entity with a separate pathophysiology. However, clinical and pathological studies suggest that the boundary separating AD and VaD, as well as their mild cognitive impairment (MCI) analogs, is not well defined. Thus, there is increased interest in viewing these diseases along a spectrum because of the significant overlap in the characterization and diagnosis of AD, VaD, and MCI. The focus of this edited volume is to examine how AD and VaD, as well as their MCI analogs, are best viewed as a heterogeneous, intersecting, if not a continuous disease state rather than separate, distinct entities. This book examines this approach by providing empirically based evidence, reviews of the literature, and chapters by key leaders in the field and will be of interest to clinical n
Trade ReviewA 'must-read,' very timely, comprehensive interdisciplinary overview illuminating the complexity of the dementia syndromes, particularly Vascular-Alzheimer spectrum disorders." -Sandra E. Black, Professor of Medicine (Neurology), Department of Medicine, Sunnybrook HSC and University of Toronto
This remarkable volume brings us the most current understanding on the undeniable role of vascular disease risk factors in both neurodegenerative and vascular dementias. Expert authors fittingly also focus on prodromal phases of the most common dementia types including mild cognitive impairment and vascular cognitive impairment. They highlight vascular disease that robustly influences relevant neuropsychological, neuroimaging as well as neuropathological substrates of dementia syndromes." -Raj Kalaria, Professor of Cerebrovascular Pathology (Neuropathology), Newcastle University
There is an increasing realization that the most common neuropathology underlying dementia and MCI is the combination of plaques, tangles, as well as alterations due to vascular disease. In this important book Libon, Lamar, Swenson, and Heilman have assembled an impressive set of contributors to describe the mechanisms, markers, and treatment implications of combined AD and vascular pathology commonly present in dementia and MCI. This endeavor stands to advance our knowledge and shift current research and clinical paradigms that study neurodegenerative illness." -Glenn Smith, Chair of Psychology, University of Florida
In this book, world-leaders in the area summarize current knowledge on the heterogeneity of Alzheimer's disease, vascular dementia, and mild cognitive impairment, and how these conditions are on a continuum and influence and shape the expression of each other. This book is a must for researchers, clinicians, and others interested in the heterogeneity and overlap of the most common forms of cognitive decline, and will be a standard reference for many years." -Ingmar Skoog, Professor, Institute of Neuroscience and Physiology and Director of the Centre for Ageing and Health, AgeCap, University of Gothenburg, Sweden
Table of ContentsPreface Part 1: Epidemiology and Neuropsychology Chapter 1: Vascular risk factors and their relationship to brain aging: Findings from the Framingham Heart Study Chapter 2: Neuropsychological Profiles in Alzheimer's/ Vascular Spectrum Dementia Chapter 3: Neuropsychological Diagnostic Criteria for Mild Cognitive Impairment due to Alzheimer's Disease Chapter 4: Vascular Cognitive Impairment Chapter 5: Decline in Everyday Functioning in MCI and Dementia: A Neuropsychological Perspective Chapter 6: Heterogeneity in Dementia and MCI: Using Statistical Modeling Techniques Chapter 7: Apraxic and Action-Intentional Disorders Associated With Vascular And Degenerative Dementing Diseases Part 2: Neuroimaging Chapter 8: Cerebral small vessel disease and the risk of dementia and cognition decline Chapter 9: Structural MRI in Alzheimer's disease: Are we measuring the right stuff Chapter 10: Advances in Multi-Modal Imaging Across the Spectrum of Normal to Pathological aging: Incorporating Vascular Comorbidities Common to Alzheimer's disease and Vascular Dementia Part 3: Blood-Brain-Barrier and Cardiogenic Mechanisms Chapter 11: The Blood-Brain Barrier in Cognitive Decline and Alzheimer's Disease Chapter 12: Arterial Stiffening and Cerebrovascular Resistance in Cognitive Decline and Alzheimer's Disease Chapter 13: Hemodynamics in Alzheimer's Disease and Vascular Cognitive Impairment & Dementia Part 4: Neuropathological and Neurophysiological Mechanisms Chapter 14: Neuropathology of AD/ VaD Dementia Chapter 15: Potential of blood- and CSF-based biomarkers for AD diagnostics Chapter 16: Unravelling the Role of Mitochondria in Alzheimer's disease: Toward Assembling the Puzzle Part 5: Treatment and Intervention Chapter 17: Dementia and Elective Surgeries: Considerations for Neuropsychologists Chapter 18: Management of Mild Cognitive Impairment
