Description

Book Synopsis

Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe.

  • Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human application
  • Includes evaluation of vaccine efficacy and safety
  • Details clinical trial design, including regulatory requirements
  • Discusses the emerging field of active cellular immunotherapy

Vaccinology: Principles and Practice provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.



Trade Review

“Vaccinology provides an invaluable and authoritative resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.” (Sir Read A lot, 10 May 2012)



Table of Contents

List of Contributors viii

Preface xii

Part 1 Introduction

1 Concept and Scope of Modern Vaccines 3
D. Huw Davies, Clint S. Schmidt, & Nadeem A. Sheikh

Part 2 Principles of Vaccine Design

2 Strategies to Stimulate Innate Immunity for Designing Effective Vaccine Adjuvants 15
Heather L. Wilson, Scott Napper, George K. Mutwiri, Sylvia van Drunen Littel-van den Hurk, Hugh Townsend, Lorne A. Babiuk, Andrew A. Potter, & Volker Gerdts

3 Antigen Processing and Presentation by MHC Class I, II, and Nonclassical Molecules 29
Antony N. Antoniou, Izabela Lenart, David B. Guiliano, & Simon J. Powis

4 Understanding the Mucosal Immune System for Better Mucosal Vaccine Design 47
Janine Bilsborough & Joanne L. Viney

5 Immunologic Memory: T Cells in Humans 61
Maria Candela Iglesias, Victor Appay, & Arnaud Moris

6 Immunologic Memory: B cells 79
F. Eun-Hyung Lee & Iñaki Sanz

7 Utility of Mouse Models in Vaccine Design and Development 94
Catharine M. Bosio, Megan MacLeod, Philippa Marrack, & Ross M. Kedl

8 Utility of Nonhuman Primate Models for Vaccines 110
Preston A. Marx, Jr & Alexander F. Voevodin

Part 3 Antigen Discovery

9 Sequence-Based Computational Approaches to Vaccine Discovery and Design 133
Darrick Carter

10 Antigen Discovery for Vaccines Using High-throughput Proteomic Screening Technologies 150
D. Huw Davies

11 Phage Libraries 168
Aaron K. Sato

Part 4 Antigen Engineering

12 Attenuated Bacterial Vaccines 181
Richard W. Titball & Helen S. Atkins

13 Virus-like Particles as Antigen Scaffolds 196
Bryce Chackerian & John T. Schiller

14 Recombinant MVA vaccines: Optimization, Preclinical, and Product Development 209
Yper Hall & Miles W. Carroll

15 Recombinant Adenoviruses for Vaccination 224
Nelson Cesar Di Paolo, Dmitry Shayakhmetov, & André Lieber

16 Recombinant Avipoxviruses 237
Michael A. Skinner & Stephen M. Laidlaw

17 Intracellular Facultative Bacterial Vectors for Cancer Immunotherapy 255
Patrick Guirnalda, Laurence Wood, Matthew Seavey, & Yvonne Paterson

18 Nucleic Acid Vaccination 275
Britta Wahren & Margaret A. Liu

19 Artificial Antigen-presenting Cells: Large Multivalent Immunogens 286
Matthew F. Mescher & Julie M. Curtsinger

Part 5 Delivery Systems

20 Transcutaneous Immunization via Vaccine Patch Delivery System 303
Robert C. Seid, Jr & Gregory M. Glenn

21 Needle-free Jet Injection for Vaccine Administration 324
Brian R. Sloat, Hoi K. Tran, & Zhengrong Cui

22 Oral Vaccines: An Old Need and Some New Possibilities 336
Amit A. Lugade, Kalathil Suresh, & Yasmin Thanavala

23 Adjuvants: From Serendipity to Rational Discovery 348
Derek T. O’Hagan & Andreas Wack

24 Immunostimulatory Properties of Biodegradable Microparticles 361
Fiona A. Sharp & Ed C. Lavelle

25 Co-administration of Co-stimulatory Moieties 375
Carolina Arancibia-Cárcamo & Yvette Latchman

26 Toll Receptors in Relation to Adjuvant Effects 393
Dipshikha Chakravortty, Amit Lahiri, & Priyanka Das

Part 6 Regulatory Considerations

27 Regulatory Issues (FDA and EMA) 403
Murrium Ahmad, Victoria Byers, & Peter Wilson

Part 7 Evaluating Vaccine Efficacy

28 Immune Monitoring Design within the Developmental Pipeline for an Immunotherapeutic or Preventive Vaccine 419
Sylvia Janetzki, Pedro Romero, Mario Roederer, Diane L. Bolton, & Camilla Jandus

29 Clinical Development Strategy: Nuts and Bolts 441
Candida Fratazzi & Claudio Carini

30 Current Approaches to Identify and Evaluate Cancer Biomarkers for Patient Stratification 452
Robert Rees, Stephanie Laversin, Cliff Murray, & Graham Ball

Part 8 Implementing Immunizations/Therapies

31 Mass Immunization Strategies 467
David L. Heymann, R. Bruce Aylward, & Rudolf H. Tangermann

32 The Role of Mathematical Models in Vaccine Development and Public Health Decision Making 480
Marie-Claude Boily, Marc Brisson, Benoit Mâsse, & Roy M. Anderson

33 Vaccine Safety 509
John Iskander, Claudia Vellozzi, Jane Gidudu, & Robert T. Chen

Index 525

Vaccinology

    Product form

    £118.76

    Includes FREE delivery

    RRP £131.95 – you save £13.19 (9%)

    Order before 4pm today for delivery by Thu 2 Jul 2026.

    A Hardback by W. John W. Morrow, Nadeem A. Sheikh, Clint S. Schmidt

      Trusted by thousands of customers. See 2,385+ Customer Reviews

      View other formats and editions of Vaccinology by W. John W. Morrow

      Publisher: John Wiley and Sons Ltd
      Publication Date: 10/08/2012
      ISBN13: 9781405185745, 978-1405185745
      ISBN10: 1405185740
      Also in:
      Public health and preventive medicine

      Description

      Book Synopsis

      Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe.

      • Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human application
      • Includes evaluation of vaccine efficacy and safety
      • Details clinical trial design, including regulatory requirements
      • Discusses the emerging field of active cellular immunotherapy

      Vaccinology: Principles and Practice provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.



      Trade Review

      “Vaccinology provides an invaluable and authoritative resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.” (Sir Read A lot, 10 May 2012)



      Table of Contents

      List of Contributors viii

      Preface xii

      Part 1 Introduction

      1 Concept and Scope of Modern Vaccines 3
      D. Huw Davies, Clint S. Schmidt, & Nadeem A. Sheikh

      Part 2 Principles of Vaccine Design

      2 Strategies to Stimulate Innate Immunity for Designing Effective Vaccine Adjuvants 15
      Heather L. Wilson, Scott Napper, George K. Mutwiri, Sylvia van Drunen Littel-van den Hurk, Hugh Townsend, Lorne A. Babiuk, Andrew A. Potter, & Volker Gerdts

      3 Antigen Processing and Presentation by MHC Class I, II, and Nonclassical Molecules 29
      Antony N. Antoniou, Izabela Lenart, David B. Guiliano, & Simon J. Powis

      4 Understanding the Mucosal Immune System for Better Mucosal Vaccine Design 47
      Janine Bilsborough & Joanne L. Viney

      5 Immunologic Memory: T Cells in Humans 61
      Maria Candela Iglesias, Victor Appay, & Arnaud Moris

      6 Immunologic Memory: B cells 79
      F. Eun-Hyung Lee & Iñaki Sanz

      7 Utility of Mouse Models in Vaccine Design and Development 94
      Catharine M. Bosio, Megan MacLeod, Philippa Marrack, & Ross M. Kedl

      8 Utility of Nonhuman Primate Models for Vaccines 110
      Preston A. Marx, Jr & Alexander F. Voevodin

      Part 3 Antigen Discovery

      9 Sequence-Based Computational Approaches to Vaccine Discovery and Design 133
      Darrick Carter

      10 Antigen Discovery for Vaccines Using High-throughput Proteomic Screening Technologies 150
      D. Huw Davies

      11 Phage Libraries 168
      Aaron K. Sato

      Part 4 Antigen Engineering

      12 Attenuated Bacterial Vaccines 181
      Richard W. Titball & Helen S. Atkins

      13 Virus-like Particles as Antigen Scaffolds 196
      Bryce Chackerian & John T. Schiller

      14 Recombinant MVA vaccines: Optimization, Preclinical, and Product Development 209
      Yper Hall & Miles W. Carroll

      15 Recombinant Adenoviruses for Vaccination 224
      Nelson Cesar Di Paolo, Dmitry Shayakhmetov, & André Lieber

      16 Recombinant Avipoxviruses 237
      Michael A. Skinner & Stephen M. Laidlaw

      17 Intracellular Facultative Bacterial Vectors for Cancer Immunotherapy 255
      Patrick Guirnalda, Laurence Wood, Matthew Seavey, & Yvonne Paterson

      18 Nucleic Acid Vaccination 275
      Britta Wahren & Margaret A. Liu

      19 Artificial Antigen-presenting Cells: Large Multivalent Immunogens 286
      Matthew F. Mescher & Julie M. Curtsinger

      Part 5 Delivery Systems

      20 Transcutaneous Immunization via Vaccine Patch Delivery System 303
      Robert C. Seid, Jr & Gregory M. Glenn

      21 Needle-free Jet Injection for Vaccine Administration 324
      Brian R. Sloat, Hoi K. Tran, & Zhengrong Cui

      22 Oral Vaccines: An Old Need and Some New Possibilities 336
      Amit A. Lugade, Kalathil Suresh, & Yasmin Thanavala

      23 Adjuvants: From Serendipity to Rational Discovery 348
      Derek T. O’Hagan & Andreas Wack

      24 Immunostimulatory Properties of Biodegradable Microparticles 361
      Fiona A. Sharp & Ed C. Lavelle

      25 Co-administration of Co-stimulatory Moieties 375
      Carolina Arancibia-Cárcamo & Yvette Latchman

      26 Toll Receptors in Relation to Adjuvant Effects 393
      Dipshikha Chakravortty, Amit Lahiri, & Priyanka Das

      Part 6 Regulatory Considerations

      27 Regulatory Issues (FDA and EMA) 403
      Murrium Ahmad, Victoria Byers, & Peter Wilson

      Part 7 Evaluating Vaccine Efficacy

      28 Immune Monitoring Design within the Developmental Pipeline for an Immunotherapeutic or Preventive Vaccine 419
      Sylvia Janetzki, Pedro Romero, Mario Roederer, Diane L. Bolton, & Camilla Jandus

      29 Clinical Development Strategy: Nuts and Bolts 441
      Candida Fratazzi & Claudio Carini

      30 Current Approaches to Identify and Evaluate Cancer Biomarkers for Patient Stratification 452
      Robert Rees, Stephanie Laversin, Cliff Murray, & Graham Ball

      Part 8 Implementing Immunizations/Therapies

      31 Mass Immunization Strategies 467
      David L. Heymann, R. Bruce Aylward, & Rudolf H. Tangermann

      32 The Role of Mathematical Models in Vaccine Development and Public Health Decision Making 480
      Marie-Claude Boily, Marc Brisson, Benoit Mâsse, & Roy M. Anderson

      33 Vaccine Safety 509
      John Iskander, Claudia Vellozzi, Jane Gidudu, & Robert T. Chen

      Index 525

      Recently viewed products

      © 2026 Book Curl

        • American Express
        • Apple Pay
        • Diners Club
        • Discover
        • Google Pay
        • Maestro
        • Mastercard
        • PayPal
        • Shop Pay
        • Union Pay
        • Visa

        Login

        Forgot your password?

        Don't have an account yet?
        Create account