Description
Book SynopsisT Lymphocyte Subpopulations in Immunotoxicology Edited by Ian Kimber ZENECA Pharmaceuticals, Central Toxicology Laboratory, Macclesfield, Cheshire, UK and Mary Jane K. Selgrade US Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, NC, USA Immunotoxicology is a diverse discipline that embraces the investigation of the adverse health effects that may result from the interaction of xenobiotics with the immune system. T lymphocytes orchestrate adaptive immune responses and are of central importance in the consideration of immunotoxicity. These cells and/or the tissue responsible for their functional maturation (the thymus) have been implicated as the primary or secondary targets for chemical insult. Moreover, T lymphocytes play pivotal roles in the induction and elicitation of chemical and protein allergy and in the pathogenesis of autoimmune disease. Classically, T lymphocytes have been divided into two main populations: CD4 helper T cells and
Table of ContentsT Lymphocyte Subpopulations in Immunotoxicology: An Introduction (I. Kimber & M. Selgrade).
Functional Subpopulations of CD4¯+ T Lymphocytes (L. Krishnan & T. Mosmann).
Functional Subpopulations of CD8¯+ T Lymphocytes (D. Kemeny, et al.).
T Lymphocyte Subpopulations and TCDD Immunotoxicity (N. Kerkvliet).
T Lymphocyte Subpopulations and Immunotoxicology of Drugs of Abuse (M. Holsapple, et al.).
Oxidative Stress and Heavy Metal Modification of T Lymphocyte Subsets (J. Krieger, et al.).
The Effect of UV Exposure on the Activation of T-Cell Subsets (S. Ullrich).
T Helper Cell Clones and In Vitro Assessment of Immunotoxicity (B. Lawrence & N. Kerkvliet).
Influence of the Sympathetic Nervous System on T Helper Cell Function (V. Sanders, et al.).
Endocrine Regulation of T Lymphocyte Subpopulations (G. Rook, et al.).
T Lymphocyte Subpopulations and Immune Responses to Chemical Allergens (I. Kimber & R. Dearman).
T Lymphocyte Subpopulations in Human Allergic Disease (M. Schuyler & J. Wilder).
Modulation of T Lymphocyte Responses by Air Pollutants (M. Gilmour & M. Selgrade).
T Lymphocyte Subpopulations in Autoimmune Responses to Chemicals and Drugs (D. Oliveira & J. Coleman).
Index.
