Description
Book SynopsisThe second edition of Structure in Protein Chemistry showcases the latest developments and innovations in the field of protein structure analysis and prediction. The book begins by explaining how proteins are purified and describes methods for elucidating their sequences of amino acids and defining their posttranslational modifications. Comprehensive explanations of crystallography and of noncovalent forces-ionic interactions, hydrogen bonding, and the hydrophobic effect-act as a prelude to an exhaustive description of the atomic details of the structures of proteins. The resulting understanding of protein molecular structure forms the basis for discussions of the evolution of proteins, the symmetry of the oligomeric associations that produce them, and the chemical, mathematical, and physical basis of the techniques used to study their structures. The latter include image reconstruction, nuclear magnetic resonance spectroscopy, proton exchange, optical spectroscopy, electro
Table of Contents
1. Purification
2. Electronic Structure
3. Sequences of Polymers
4. Crystallographic Molecular Models
5. Noncovalent Forces
6. Atomic Details
7. Evolution
8. Counting Polypeptides
9. Symmetry
10. Chemical Probes of Structure
11. Immunochemical Probes of Structure
12. Physical Measurements of Structure
13. Folding and Assembly
14. Membranes
