Description
Book SynopsisStatistical Testing Strategies in the Health Sciences provides a compendium of statistical approaches for decision making, ranging from graphical methods and classical procedures through computationally intensive bootstrap strategies to advanced empirical likelihood techniques. It bridges the gap between theoretical statistical methods and practical procedures applied to the planning and analysis of health-related experiments.
The book is organized primarily based on the type of questions to be answered by inference procedures or according to the general type of mathematical derivation. It establishes the theoretical framework for each method, with a substantial amount of chapter notes included for additional reference. It then focuses on the practical application for each concept, providing real-world examples that can be easily implemented using corresponding statistical software code in R and SAS. The book also explains the basic elements and methods
Trade Review
"This book covers a wide range of statistical approaches to hypothesis testing for decision-making in various health science research fields. It provides not only refreshing information on many routinely used statistical methods but also a good review of more advanced methods such as empirical likelihood (EL) methods… For clinicians or medical researchers with some training in statistics, many chapters can serve as references. For research statisticians, the book provides important properties and theoretical elaborations for the methods. For pharmaceutical drug trial statisticians in particular, the book on one hand offers a systematic account of many methods and on another hand exposes them to the methods used in some related research fields (e.g., diagnosis identification and testing) that lead one to see the interrelations across such research fields. Throughout the book, the authors transfer the statistical concepts and methods to real-world applications, with emphasis on implementing the methods in R and SAS program code and on interpreting the results…Another great feature of the book is that the authors provide supplemental materials on the evolution of the methodology with additional research notes in each chapter. These give research-oriented statisticians a comprehensive list of references which would be quite helpful for their research. The supplemental materials are also entertaining for the general readers to learn the chronology of statistical theory and methods."
—X. Daniel Jia, published in Journal of Biopharmaceutical Statistics, April 2017
"With techniques spanning robust statistical methods to more computationally intensive approaches, this book shows how to apply correct and efficient testing mechanisms to various problems encountered in medical and epidemiological studies, including clinical trials."
—TLT Magazine, September 2016
"This comprehensive book takes the reader from the underpinnings of statistical inference through to cutting-edge modern analytical techniques. Along the way, the authors explore graphical representations of data, a key component of any data analysis; standard procedures such as the t-test and tests for independence; and modern methods, including the bootstrap and empirical likelihood method. The presentation focuses on practical applications interwoven with theoretical rationale, with an emphasis on how to carry out procedures and interpret the results. Numerous software examples (R and SAS) are provided, such that the readers should be able to reproduce plots and other analyses on their own. A wealth of examples from real data sets, web resources, supplemental notes, and plentiful references are provided, which round out the materials."
—From the Foreword by Nicole Lazar, Department of Statistics, University of Georgia
Table of ContentsPreliminaries: Welcome to the Statistical Inference Club: Some Basic Concepts in Experimental Decision Making. Statistical Software: R and SAS. Statistical Graphics. A Brief Ode to Parametric Likelihood. Tests on Means of Continuous Data. Empirical Likelihood. Bayes Factor–Based Test Statistics. The Fundamentals of Receiver Operating Characteristic Curve Analyses. Nonparametric Comparisons of Distributions. Dependence and Independence: Structures, Testing, and Measuring. Goodness-of-Fit Tests (Tests for Normality). Statistical Change-Point Analysis. A Brief Review of Sequential Testing Methods. A Brief Review of Multiple Testing Problems in Clinical Experiments. Some Statistical Procedures for Biomarker Measurements Subject to Instrumental Limitations. Calculating Critical Values and p-Values for Exact Tests. Bootstrap and Permutation Methods. References. Index.
