Description
Book SynopsisOne of the biggest challenges faced in medical research had been to create accurate and relevant models of human disease. A number of good animal models have been developed to understand the pathophysiology. However, not all of them reflect the human disorder, a classic case being Usher's syndrome where the mutant mice do not have the same visual and auditory defects that patients face. There are others which have been even more difficult to model due to the multi-factorial nature of the condition and due to lack of discovery of a single causative gene such as age-related macular degeneration or Alzheimer's syndrome. Thus a more relevant and accurate system will allow us to make better predictions on relevant therapeutic approaches.
The discovery of human pluripotent stem cells in 1998 followed by the technological advances to reprogram somatic cells to pluripotent-stem cell-like cells in 2006 has completely revolutionized the way we can now think about modelling human develop
Table of Contents
- Human induced pluripotent stem cells: derivation
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- Human induced pluripotent stem cells: banking, and characterization
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- Genetic and Epigenetic considerations in iPSC technology
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- CRISPR-based genome engineering in human stem cells
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- Stem cells for Parkinson’s disease
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- Huntington’s Disease and Stem Cells
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- Applications of Pluripotent Stem Cells in the Therapy and Modeling of Diabetes and Metabolic Diseases
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- The Role of iPSCs in Disease Modeling: Gaucher Disease and Related Disorders
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- Role of induced pluripotent stem cells in urological disease modeling and repair
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- Induced Pluripotent Stem Cells – a Research Tool and a Potential Therapy for RPE-associated Blinding Eye Diseases
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- Modeling Neuro-Retinal Development and Disease in Stem Cells
