Description
Book SynopsisParasitic Nematodes are amongst the most successful parasites on Earth. This fully-updated second edition constitutes a comprehensive volume that continues to discuss the molecular biology, biochemistry and immunology of nematode parasites of humans, domestic animals and plants. There is a strong focus on new advances including chapters on horizontal gene transfer, genetics of susceptibility in humans, nematode protein structures, role of bacterial symbionts, host immune system modulation, modulation of allergic and autoimmune diseases by parasitic nematodes and the use of these organisms or their products as therapeutics. This book will be of significant importance to advanced students and researchers in human and veterinary parasitology, plant nematology and pathogen immunology in general.
Table of ContentsPart 1: Evolution of parasitism and life history adaptations 1: The genome of Pristionchus and the evolution of parasitism 2: Life history placticity and responses to host defense 3: Horizontal gene transmission in plant parasites 4: Innate Immunity in Caenorhabditis elegans Part 2: Modulation of the host immune response 5: Nematodes and T regulatory cells 6: The alternatively activated macrophage 7: Modulation of autoimmune and allergic responses by defined nematode molecules 8: Tracking the host response in nematode immunity 9: Nematodes and regulation of the inflammatory response Part 3: Genetics of susceptibility and resistance 10: Susceptibility of humans to Ascaris 11: Genetics of resistance to hookworm 12: Population genetics and anthelmintic resistance to nematodes of domestic animals 13: Asthma, allergy and parasitic worm infections 14: Genetics of susceptibility - wild animals Part 4: Protection systems - Immune effectors, therapeutics, vaccines 15: Wolbachia as a therapeutic target 16: The Molecular Biology, Immunology and Chemotherapy of Wolbachia bacterial endosymbionts of filarial nematodes 17: Nematodes and human therapeutic trials 18: Vaccination against hookworms 19: Vaccination against filarial nematodes 20: Vaccination against nematodes of domestic animals 21: Immune regulation and multiple species infections 22: Effect of nematode infection on the immune response to other pathogens 23: Genetics of drug resistance in nematodes Part 5: Specialised and novel structures 24: Nervous system and neural communication molecules 25: Host cell and tissue modification 26: Cuticle synthesis and modification 27: Proteinases, from free-living to parasite 28: Nematode polyprotein structure"
