Description
Book SynopsisDespite many encouraging developments in the field of animal-free technologies, well-defined animal models are still needed to study fundamental properties of human diseases and to develop new prophylactic and therapeutic treatments against human diseases. Non-human primates (NHP) make up only a small, but important, part of the total number of animals used in biomedical and preclinical research. Due to their close phylogenetic relationship and the shared susceptibility to many human diseases, NHP can provide important research models to study these diseases and, as such, play a critical role in the advancement of various areas in the medical field. Studies in NHP have contributed to our understanding of various diseases and fundamental biological phenomena and they continue to be important in the development of new therapies, treatments, drugs and vaccines. Moreover, NHP models also contribute to our general knowledge of the processes that underlie non-disease and disease conditions. Important areas where NHP can provide important information include (emerging) infectious diseases, organ transplantation, neurological and aging-related disorders. Although not covered in this book due to time constraints, the need for, and benefits of, NHP models has been demonstrated most recently in the SARS-CoV-2 pandemic. The present book is the second of two volumes and covers important disease areas where NHP are used as model species. This volume includes different chapters on NHP models in infectious diseases, aging, neurodegenerative disorders, organ transplantation and cancer.
Table of ContentsPreface; Viral Diseases in NHPs; NHP Models for Influenza; Modelling Malaria in Non-Human Primates between 1900 and 2020; Aging Research in Nonhuman Primates; Nonhuman Primate Models of Human Autoimmune Diseases; NHP Models in Neurodegenerative Disorders Research; Nonhuman Primate Models of Parkinsons Disease: Improvement in the Understanding of PD Progress and Development of Novel Therapy; Nonhuman Primate Models for Beta Cell Replacement in Diabetes Research; The Nonhuman Primate as a Unique Model to Understand the Pathogenesis of Human Endometriosis; Nonhuman Primate Models in Organ Transplantation; Nonhuman Primate (NHP) Models in Lung Transplantation; NHP Models of Cardio-Cerebrovascular Diseases Research; NHP Models of Cancers; Index.
