Description

Book Synopsis
Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, a-synuclein and TDP-43) and in the extracellular compartments (e.g. ß-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel

Trade Review

“Overall, this textbook provides useful and systematic information on the basic mechanisms of neurodegenerative diseases. It will provide useful for resident trainees, neurologists and pathologists.” (Canadian Journal of Neurological Sciences, 1 November 2012)



Table of Contents
List of Contributors, viii

Preface, xii

List of Abbreviations, xiii

Part 1 Introduction: Basic Mechanisms of Neurodegeneration

1 Introduction to Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders, 3
Dennis W. Dickson

2 Cell Death and Neurodegeneration, 6
Violetta N. Pivtoraiko and Kevin A. Roth

3 Oxidative Stress and Balance in Neurodegenerative Diseases, 10
George Perry, Siddhartha Mondragón-Rodríguez, Akihiko Nunomura, Xiongwei Zhu, Paula I. Moreira and Mark A. Smith

4 Protein Aggregation in Neurodegeneration, 13
Adriano Aguzzi and Veronika Kana

5 Protein Degradation in Neurodegeneration: The Ubiquitin Pathway, 18
Lynn Bedford, Robert Layfi eld, Nooshin Rezvani, Simon Paine, James Lowe and R. John Mayer

6 Genetics of Neurodegeneration, 22
John Hardy

7 Transgenic Animal Models of Proteinopathies, 26
Naruhiko Sahara, Heather Melrose, Simon D'Alton and Jada Lewis

Part 2 Alzheimer's Disease and Aging

8 Clinical Aspects of Alzheimer's Disease, 39
David Knopman

9 Genetics of Alzheimer's Disease, 51
Lars Bertram and Rudolph E. Tanzi

10 Neuropathology of Alzheimer's Disease and its Variants, 62
Charles Duyckaerts and Dennis Dickson

11 Amyloid-ß Production, 92
Colin L. Masters and Konrad Beyreuther

12 Elimination of Amyloid ß from the Brain, its Failure in Alzheimer's Disease and Implications for Therapy, 97
Roy O. Weller, Seth Love and James A.R. Nicoll

Part 3 Tauopathies

13 Introduction to the Tauopathies, 105
Michel Goedert

14 Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17, 110
Bernardino Ghetti, Zbigniew K. Wszolek, Bradley F. Boeve, Salvatore Spina and Michel Goedert

15 Progressive Supranuclear Palsy and Corticobasal Degeneration, 135
Dennis W. Dickson, Jean-Jaques Hauw, Yves Agid and Irene Litvan

16 Pick's Disease, 156
David G. Munoz, Huw R. Morris and Martin Rossor

17 Argyrophilic Grain Disease, 165
Markus Tolnay and Heiko Braak

18 Parkinsonism–Dementia Complex of Guam, 171
Kiyomitsu Oyanagi, Tomoyo Hashimoto and Mineo Yamazaki

19 Postencephalitic Parkinsonism, 179
Kurt A. Jellinger

Part 4 Synucleinopathies

20 Introduction to a-Synucleinopathies, 191
Maria Grazia Spillantini

21 Parkinson's Disease, 194
Kurt A. Jellinger

22 Dementia with Lewy Bodies and Parkinson's Disease Dementia, 224
Paul G. Ince

23 Lewy Bodies in Conditions other than Disorders of a-Synuclein, 238
Coro Paisán-Ruiz, Laura Parkkinen and Tamas Revesz

24 Multiple System Atrophy, 242
Janice L. Holton, Andrew J. Lees and Tamas Revesz

Part 5 Trinucleotide Repeat Disorders

25 Introduction to Trinucleotide Repeat Diseases, 255
H. Brent Clark

26 Huntington's Disease, 258
John C. Hedreen and Raymund A.C. Roos

27 Spinocerebellar Ataxias, 273
Hidehiro Mizusawa, H. Brent Clark and Arnulf H. Koeppen

28 Friedreich's Ataxia, 288
Arnulf H. Koeppen

29 Dentatorubral-pallidoluysian Atrophy, 299
Hitoshi Takahashi, Mitsunori Yamada and Shoji Tsuji

30 Spinal and Bulbar Muscular Atrophy, 307
Gen Sobue, Hiroaki Adachi and Masahisa Katsuno

Part 6 Prion Disorders

31 Introduction to Prion Disorders, 315
Adriano Aguzzi and Veronika Kana

32 Sporadic Creutzfeldt–Jakob Disease, 322
Herbert Budka, Mark W. Head, James W. Ironside, Pierluigi Gambetti, Piero Parchi and Fabrizio Tagliavini

33 Genetic Creutzfeldt–Jakob Disease, 336
Piero Parchi, Pierluigi Gambetti and Sabina Capellari

34 Fatal Familial and Sporadic Insomnia, 346
Piero Parchi, Sabina Capellari and Pierluigi Gambetti

35 A New Prion Disease: Protease-Sensitive Prionopathy, 350
Pierluigi Gambetti, Gianfranco Puoti, Qingzhong Kong and Wenquan Zou

36 Variant Creutzfeldt–Jakob Disease, 354
James W. Ironside, Mark W. Head and Robert G. Will

37 Gerstmann–Sträussler–Scheinker Disease, 364
Bernardino Ghetti, Fabrizio Tagliavini, Gabor G. Kovacs and Pedro Piccardo

38 Kuru, 378
Catriona Ann McLean

39 Iatrogenic Creutzfeldt–Jakob Disease, 381
James W. Ironside, Richard S.G. Knight and Mark W. Head

Part 7 Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis/Motor Neuron Disease

40 Introduction, 389
James Lowe

41 Frontotemporal Lobar Degeneration with TDP-43 Pathology, 393
Ian R.A. Mackenzie and Manuela Neumann

42 Neuronal Intermediate Filament Inclusion Disease, 404
Nigel J. Cairns

43 Frontotemporal Lobar Degeneration with FUS Immunoreactive Inclusions, 412
Manuela Neumann and Ian R.A. Mackenzie

44 Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis and Spinal Muscular Atrophy, 418
Michael J. Strong, Tibor Hortobágyi, Koichi Okamoto and Shinsuke Kato

Part 8 Other Neurodegenerative Disorders

45 Introduction: Genetic Analysis as a Lumper and Splitter in Neurodegenerative Disease, 437
John E. Duda

46 Inherited Amyloidoses and Neurodegeneration: Familial British Dementia and Familial Danish Dementia, 439
Tamas Revesz, Agueda Rostagno, Gordon Plant, Tammaryn Lashley, Blas Frangione, Jorge Ghiso and Janice L. Holton

47 Neurodegeneration with Brain Iron Accumulation, 446
John E. Duda and Kurt A. Jellinger

48 Familial Encephalopathy with Neuroserpin Inclusion Bodies, 456
Richard L. Davis and George H. Collins

49 Hereditary Ferritinopathies, 461
Ruben Vidal, Marie Bernadette Delisle, Olivier Rascol and Bernardino Ghetti

Index, 467

Neurodegeneration

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    A Hardback by Dennis Dickson, Roy O. Weller

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      View other formats and editions of Neurodegeneration by Dennis Dickson

      Publisher: John Wiley and Sons Ltd
      Publication Date: 04/11/2011
      ISBN13: 9781405196932, 978-1405196932
      ISBN10: 1405196939
      Also in:
      Education Alzheimer’s, dementia and Parkinson’s disease Pathology

      Description

      Book Synopsis
      Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, a-synuclein and TDP-43) and in the extracellular compartments (e.g. ß-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel

      Trade Review

      “Overall, this textbook provides useful and systematic information on the basic mechanisms of neurodegenerative diseases. It will provide useful for resident trainees, neurologists and pathologists.” (Canadian Journal of Neurological Sciences, 1 November 2012)



      Table of Contents
      List of Contributors, viii

      Preface, xii

      List of Abbreviations, xiii

      Part 1 Introduction: Basic Mechanisms of Neurodegeneration

      1 Introduction to Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders, 3
      Dennis W. Dickson

      2 Cell Death and Neurodegeneration, 6
      Violetta N. Pivtoraiko and Kevin A. Roth

      3 Oxidative Stress and Balance in Neurodegenerative Diseases, 10
      George Perry, Siddhartha Mondragón-Rodríguez, Akihiko Nunomura, Xiongwei Zhu, Paula I. Moreira and Mark A. Smith

      4 Protein Aggregation in Neurodegeneration, 13
      Adriano Aguzzi and Veronika Kana

      5 Protein Degradation in Neurodegeneration: The Ubiquitin Pathway, 18
      Lynn Bedford, Robert Layfi eld, Nooshin Rezvani, Simon Paine, James Lowe and R. John Mayer

      6 Genetics of Neurodegeneration, 22
      John Hardy

      7 Transgenic Animal Models of Proteinopathies, 26
      Naruhiko Sahara, Heather Melrose, Simon D'Alton and Jada Lewis

      Part 2 Alzheimer's Disease and Aging

      8 Clinical Aspects of Alzheimer's Disease, 39
      David Knopman

      9 Genetics of Alzheimer's Disease, 51
      Lars Bertram and Rudolph E. Tanzi

      10 Neuropathology of Alzheimer's Disease and its Variants, 62
      Charles Duyckaerts and Dennis Dickson

      11 Amyloid-ß Production, 92
      Colin L. Masters and Konrad Beyreuther

      12 Elimination of Amyloid ß from the Brain, its Failure in Alzheimer's Disease and Implications for Therapy, 97
      Roy O. Weller, Seth Love and James A.R. Nicoll

      Part 3 Tauopathies

      13 Introduction to the Tauopathies, 105
      Michel Goedert

      14 Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17, 110
      Bernardino Ghetti, Zbigniew K. Wszolek, Bradley F. Boeve, Salvatore Spina and Michel Goedert

      15 Progressive Supranuclear Palsy and Corticobasal Degeneration, 135
      Dennis W. Dickson, Jean-Jaques Hauw, Yves Agid and Irene Litvan

      16 Pick's Disease, 156
      David G. Munoz, Huw R. Morris and Martin Rossor

      17 Argyrophilic Grain Disease, 165
      Markus Tolnay and Heiko Braak

      18 Parkinsonism–Dementia Complex of Guam, 171
      Kiyomitsu Oyanagi, Tomoyo Hashimoto and Mineo Yamazaki

      19 Postencephalitic Parkinsonism, 179
      Kurt A. Jellinger

      Part 4 Synucleinopathies

      20 Introduction to a-Synucleinopathies, 191
      Maria Grazia Spillantini

      21 Parkinson's Disease, 194
      Kurt A. Jellinger

      22 Dementia with Lewy Bodies and Parkinson's Disease Dementia, 224
      Paul G. Ince

      23 Lewy Bodies in Conditions other than Disorders of a-Synuclein, 238
      Coro Paisán-Ruiz, Laura Parkkinen and Tamas Revesz

      24 Multiple System Atrophy, 242
      Janice L. Holton, Andrew J. Lees and Tamas Revesz

      Part 5 Trinucleotide Repeat Disorders

      25 Introduction to Trinucleotide Repeat Diseases, 255
      H. Brent Clark

      26 Huntington's Disease, 258
      John C. Hedreen and Raymund A.C. Roos

      27 Spinocerebellar Ataxias, 273
      Hidehiro Mizusawa, H. Brent Clark and Arnulf H. Koeppen

      28 Friedreich's Ataxia, 288
      Arnulf H. Koeppen

      29 Dentatorubral-pallidoluysian Atrophy, 299
      Hitoshi Takahashi, Mitsunori Yamada and Shoji Tsuji

      30 Spinal and Bulbar Muscular Atrophy, 307
      Gen Sobue, Hiroaki Adachi and Masahisa Katsuno

      Part 6 Prion Disorders

      31 Introduction to Prion Disorders, 315
      Adriano Aguzzi and Veronika Kana

      32 Sporadic Creutzfeldt–Jakob Disease, 322
      Herbert Budka, Mark W. Head, James W. Ironside, Pierluigi Gambetti, Piero Parchi and Fabrizio Tagliavini

      33 Genetic Creutzfeldt–Jakob Disease, 336
      Piero Parchi, Pierluigi Gambetti and Sabina Capellari

      34 Fatal Familial and Sporadic Insomnia, 346
      Piero Parchi, Sabina Capellari and Pierluigi Gambetti

      35 A New Prion Disease: Protease-Sensitive Prionopathy, 350
      Pierluigi Gambetti, Gianfranco Puoti, Qingzhong Kong and Wenquan Zou

      36 Variant Creutzfeldt–Jakob Disease, 354
      James W. Ironside, Mark W. Head and Robert G. Will

      37 Gerstmann–Sträussler–Scheinker Disease, 364
      Bernardino Ghetti, Fabrizio Tagliavini, Gabor G. Kovacs and Pedro Piccardo

      38 Kuru, 378
      Catriona Ann McLean

      39 Iatrogenic Creutzfeldt–Jakob Disease, 381
      James W. Ironside, Richard S.G. Knight and Mark W. Head

      Part 7 Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis/Motor Neuron Disease

      40 Introduction, 389
      James Lowe

      41 Frontotemporal Lobar Degeneration with TDP-43 Pathology, 393
      Ian R.A. Mackenzie and Manuela Neumann

      42 Neuronal Intermediate Filament Inclusion Disease, 404
      Nigel J. Cairns

      43 Frontotemporal Lobar Degeneration with FUS Immunoreactive Inclusions, 412
      Manuela Neumann and Ian R.A. Mackenzie

      44 Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis and Spinal Muscular Atrophy, 418
      Michael J. Strong, Tibor Hortobágyi, Koichi Okamoto and Shinsuke Kato

      Part 8 Other Neurodegenerative Disorders

      45 Introduction: Genetic Analysis as a Lumper and Splitter in Neurodegenerative Disease, 437
      John E. Duda

      46 Inherited Amyloidoses and Neurodegeneration: Familial British Dementia and Familial Danish Dementia, 439
      Tamas Revesz, Agueda Rostagno, Gordon Plant, Tammaryn Lashley, Blas Frangione, Jorge Ghiso and Janice L. Holton

      47 Neurodegeneration with Brain Iron Accumulation, 446
      John E. Duda and Kurt A. Jellinger

      48 Familial Encephalopathy with Neuroserpin Inclusion Bodies, 456
      Richard L. Davis and George H. Collins

      49 Hereditary Ferritinopathies, 461
      Ruben Vidal, Marie Bernadette Delisle, Olivier Rascol and Bernardino Ghetti

      Index, 467

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