Description
Book SynopsisMitochondria have been pivotal in the development of some of the most important ideas in modern biology. Since the discovery that the organelle has its own DNA and specific mutations were found in association with neuromuscular and cardiovascular diseases and with aging, an extraordi-nary number of publications have followed, and the term mitochondrial medicine was coined. Furthermore, our understanding of the multiple roles that mitochondria play in cardiac cell homeostasis opened the door for intensive experimentation to understand the pathogenesis and to find new treatments for cardiovascular diseases. Besides its role in adenosine triphosphate generation, mitochondria regu-late a complex network of cellular interactions, involving (1) generation and detoxification of reactive oxygen species, including superoxide anion, hy-drogen peroxide, and hydroxyl radical; (2) maintenance of the antioxidant glutathione in a reduced state and adequate level of mitochondrial matrix superoxide dis
Table of ContentsAn Introduction to Mitochondria and the Heart.- Mitochondrial Bioenergetics in the Heart.- Heart Mitochondrial Biogenesis.- ROS Generation, Antioxidants, and Cell Death.- Myocardial Ischemia and Cardioprotection.- Mitochondria Dysfunction in Cardiomyopathy and Heart Failure.- Fatty Acid and Glucose Metabolism in Cardiac Disease.- Mitochondria in Pediatric Cardiology.- Mitochondria and the Aging Heart.- Heart Mitochondria Signaling Pathways.- Treatment of Mitochondrial-Based Cardiac Diseases. Targeting the Organelle.- Future Frontiers in Mitochondrial Cardiac Biology.
