Description
Book SynopsisMeta--analysis is one of the main statistical methods used in clinical trials. Previous accounts of meta--analysis have given the impression that the topic is a series of separate techniques. This book provides a unified approach, developing the subject from mathematical theory through to practical discussions of implementation.
Trade Review"…highly recommended as essential reading for medical statisticians…" (Short Book Reviews, April 2003)
"...comprehensive and well illustrated contribution to the subject...useful for graduate students of medical statistics..." (Statistics in Medicine, Vol 23(3), 15 February 2004)
Table of ContentsIntroduction
Protocol development
Estimating the treatment difference in an individual trial
Combining estimates of a treatment difference across trials
Meta-analysis using individual patient data
Dealing with heterogeneity
Presentation and interpretation of results
Selection bias
Dealing with non-standard datasets
Inclusion of trials with different study designs
A Bayesian approach to meta-analysis
Sequential methods for meta-analysis
Appendix Methods of estimation and hypothesis testing
