Description

Book Synopsis
Meta--analysis is one of the main statistical methods used in clinical trials. Previous accounts of meta--analysis have given the impression that the topic is a series of separate techniques. This book provides a unified approach, developing the subject from mathematical theory through to practical discussions of implementation.

Trade Review
"…highly recommended as essential reading for medical statisticians…" (Short Book Reviews, April 2003)

"...comprehensive and well illustrated contribution to the subject...useful for graduate students of medical statistics..." (Statistics in Medicine, Vol 23(3), 15 February 2004)



Table of Contents
Introduction

Protocol development

Estimating the treatment difference in an individual trial

Combining estimates of a treatment difference across trials

Meta-analysis using individual patient data

Dealing with heterogeneity

Presentation and interpretation of results

Selection bias

Dealing with non-standard datasets

Inclusion of trials with different study designs

A Bayesian approach to meta-analysis

Sequential methods for meta-analysis

Appendix Methods of estimation and hypothesis testing

Metaanalysis of Controlled Clinical Trials

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    A Hardback by Anne Whitehead

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      Book details

      Publisher John Wiley & Sons Inc
      Published 16 July 2002
      ISBN-13 9780471983705
      978-0471983705
      ISBN-10 0471983705
      Also in:
      Mathematics Epidemiology and Medical statistics Pharmacology

      Description

      Book Synopsis
      Meta--analysis is one of the main statistical methods used in clinical trials. Previous accounts of meta--analysis have given the impression that the topic is a series of separate techniques. This book provides a unified approach, developing the subject from mathematical theory through to practical discussions of implementation.

      Trade Review
      "…highly recommended as essential reading for medical statisticians…" (Short Book Reviews, April 2003)

      "...comprehensive and well illustrated contribution to the subject...useful for graduate students of medical statistics..." (Statistics in Medicine, Vol 23(3), 15 February 2004)



      Table of Contents
      Introduction

      Protocol development

      Estimating the treatment difference in an individual trial

      Combining estimates of a treatment difference across trials

      Meta-analysis using individual patient data

      Dealing with heterogeneity

      Presentation and interpretation of results

      Selection bias

      Dealing with non-standard datasets

      Inclusion of trials with different study designs

      A Bayesian approach to meta-analysis

      Sequential methods for meta-analysis

      Appendix Methods of estimation and hypothesis testing

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