Description
Book SynopsisThis book aims to provide a comprehensive examination of the field of molecular chaperone inhibition and its application to pharmaceutical research. With several small molecule inhibitors in oncology clinical development, there is clearly intense interest in the chaperones as a molecular target. Filling a significant gap in the market by providing a detailed comparison of discovery programs across the industry, this text will find broad interest among researchers in the field of molecular chaperone pharmaceutical research, oncology research, and medicinal chemistry. Arranged into three main sections the book covers structure and function, small molecule inhibitors and concludes with a section discussing clinical perspectives. With specific chapters covering the discovery of key molecules such as, BIIB028, STA-9090, Serenex Hsp90 inhibitor, NVP-AUY922 and NVP-HSP990, this comprehensive text is an essential treatise for researchers working in academia and industry.
Trade Review"…this 422- page volume adds greatly to the discussion by reporting many of the more recent advances in targeting Hsp90, whilst including an elegant overview of the advances in Hsp70 research, an area that has received considerably less re- search attention until more recently. The editors have assembled work from a variety of leading experts in the molecular chaperone field…" "…the authors have produced an outstanding overview of the subject that will be an extremely useful account for a wide variety of scientists…" "…the authors present an excellent and thought-provoking outlook on the future of the subject" "Overall the book is very well written, should appeal to academic and industrial medicinal chemists and to those in closely related fields. The text will prove particularly useful to those of a more biological persuasion or those looking to study Hsp70, and would be an excellent addition to any science or medical-based library." -- Dr. Russell R. A. Kitson, University of Nottingham * Chemmedchem review in March 2015 issue *
Table of ContentsSection I Structure and Function: Conformational Dynamics, Structure and Functional Interactions of Hsp90 Chaperones; Structural Basis of Hsp90 Function; Structure and Function of Hsp70 - TBD; Exploiting the Dependency of Cancer Cells on Molecular Chaperones; Section II Small Molecule Inhibitors; Discovery of BIIB028; Discovery of STA-9090; Discovery of Serenex Hsp90 Inhibitor; Discovery of NVP-AUY922; Discovery of NVP-HSP990; Inhibitors of Hsp90 C-Terminal Domain; Hsp70 Inhibitors; Section III Clinical Perspectives; Clinical Development of Hsp90 Inhibitors as Anti-Cancer Agents; Hsp90 as a Potential Anti-Malarial Agent; Biomarker Development and Indication Selection; Other Disease Indications
