Description
Book SynopsisAny scientist or technician involved in pre-clinical drug studies knows that infusing animal models with test substances is no simple matter, especially if one wants to do it humanely as well as guarantee results that are not compromised by the procedure. The challenge becomes compounded if one is employing a variety of species. What works for a rat or mouse does not necessarily work for a rabbit or primate.
The Handbook of Pre-clinical Continuous Intravenous Infusion answers the needs of researchers and technicians by providing complete instructions for a wide range of infusion techniques delivered to several species. With sections devoted to rats, mice, rabbits, dogs, mini-pigs, and nonhuman primates (both large and small), this thorough text gives step-by-step instructions for the use of a variety of techniques, and equipment. It includes procedures for multidose infusion toxicity and reproductive toxicology studies, and provides guidance on the use of a variety of equipment
Trade Review"…an excellent buy for anyone involved in drug development, risk assessment or within drug licensing agencies and in academic research. …This book represents a benchmark achievement for this technique …it will become the standard for many years to come"
British Toxicology Society Newsletter
Table of ContentsIntroduction. Femoral Cannulation Using the Jacket/Harness Model in the Rat. Femoral Cannulation Using the Tail Cuff Exteriorisation Method in the Rat. Tethering and the Implanted Button Model in the Rat. Multidose Infusion Toxicity Studies in the Rat. Reproductive Infusion Toxicity Studies in the Rat. Femoral Cannulation Using the Tail Cuff Model in the Mouse. Multidose Infusion Toxicity Studies in the Mouse. Jugular Cannulation and Efficacy Studies in the Mouse. Femoral Cannulation of the Rabbit for Reproductive Toxicity Studies. Jugular Cannulation of the Rabbit for Reproductive Toxicity Studies. Jugular Cannulation of the Dog. The Non-Ambulatory Model in Dog Multidose Infusion Toxicity Studies. The Ambulatory Model in Dog Multidose Infusion Toxicity Studies. Surgical Preparation of the Large Primate. Multidose Infusion Toxicity Studies in the Large Primate. Surgical Preparation and Multidose Infusion Toxicity Studies in the Marmoset. Surgical Preparation of the Mini-Pig. Multidose Infusion Toxicity Studies in the Mini-Pig. Reproductive Toxicity Studies in the Mini-Pig. Common Pathological Findings in Continuous Infusion. The Use of Mini-Osmotic Pumps in Continuous Infusion Studies. The Contribution of Vehicles, Rates of Administration and Volumes to Infusion Studies. Equipment for Continuous Intravenous Infusion.
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