Description
Book SynopsisThe structure of DNA varies along its sequence, which can lead to sequence-dependent variations in the fidelity of DNA copying and repair. And because the probability of distinct classes of mutations varies along a DNA sequence, variation that affects fitness will have evolutionary implications, as selection acts on heritable variation.
This Annals volume brings together a broad interdisciplinary group of researchers to explore the impact of increasing understanding of DNA structure, repair, replication, and organization on interrelated subjects ranging from evolution, to dependence of the effect of mutagens on environmental and sequence context, to noncanonical forms of information representation in genomes.
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Table of ContentsOverview of the creative genome: effects of genome structure and sequence on the generation of variation and evolution 1.
Lynn Helena Caporale
Genome hyperevolution and the success of a parasite 11.
J. David Barry, James P. J. Hall, and Lindsey Plenderleith
The tricky path to recombining X and Y chromosomes in meiosis 18.
Liisa Kauppi, Maria Jasin, and Scott Keeney
Sites of genetic instability in mitosis and cancer 24.
Anne M. Casper, Danielle M. Rosen, and Kaveri D. Rajula
The genome: an isochore ensemble and it’s evolution 31.
Giorgio Bernardi
Multiple levels of meaning in DNA sequences, and one more 35.
Edward N. Trifonov, Zeev Volkovich, and Zakharia M. Frenkel
Evolution of simple sequence repeat-mediated phase variation in bacterial genomes 39.
Christopher D. Bayliss and Michael E. Palmer
Indirect selection of implicit mutation protocols 45.
David G. King
G4 motifs in human genes 53.
Nancy Maizels
Adaptive radiation of venomous marine snail lineages and the accelerated evolution of venom peptide genes 61.
Baldomero M. Olivera, Maren Watkins, Pradip Bandyopadhyay, Julita S. Imperial, Edgar P. Heimer de la Cotera, Manual B. Aguilar, Estuardo Lopez Vera, Gisela P. Concepcion, and Arturo Lluisma
Integrons and gene cassettes: hotspots of diversity in bacterial genomes 71.
Ruth M. Hall
Creative deaminases, self-inflicted damage, and genome evolution 79.
Silvestro G. Conticello
Three-dimensional architecture of the IgH locus facilitates class switch recombination 86.
Amy L. Kenter, Scott Feldman, Robert Wuerffel, Ikbel Achour, Lili Wang, and Satyendra Kumar
Preaching about the converted: how meiotic gene conversion influences genomic diversity 95.
Francesca Cole, Scott Keeney, and Maria Jasin
Gross chromosomal rearrangement mediated by DNA replication in stressed cells: evidence from Escherichia coli 103.
J.M. Moore, Hallie Wimberly, P.C. Thorton, Susan M. Rosenberg, and P.J. Hastings
Implications of genetic heterogeneity in cancer 110.
Michael W. Schmitt, Marc J. Prindle, and Lawrence A. Loeb
Corrigendum for Ann. N.Y. Acad. Sci. 2009. 1182: 47-57 117.
