Description
Book SynopsisVolume 1: Drug Discovery thoroughly describes conceptualizing a drug, creating a library of candidates for testing, screening those candidates for in vitro and in vivo activity, conducting and analyzing the results of clinical trials, and revising the drug as necessary.
Trade Review"...provides a nice survey of most of the key topics facing discovery houses today." (
Doody's Health Services)
"This reasonably priced book is well-written and produced. It has a useful 32-page index, and it may be considered for acquisition by individuals and libraries." (Journal of Medicinial Chemistry, October 5, 2006)
Table of ContentsContributors.
Preface.
1. From Patent to Prescription: Paving the Perilous Path to Profit (Richard J. Pariza).
2. Medicinal Chemistry in the New Millennium: A Glance into the Future (Paul W. Erhardt).
ADMET-Related Synergies, 59
3. Contemporary Drug Discovery (Lester A. Mitscher and Apurba Dutta).
4. Combinatorial Chemistry in the Drug Discovery Process (Ian Hughes).
5. Parallel Solution-Phase Synthesis (Norton P. Peet and Hwa-Ok Kim).
6. Timing of Analog Research in Medicinal Chemistry (János Fischer and Anikó Gere).
7. Possible Alternatives to High-Throughput Screening (Camille G. Wermuth).
8. Proteomics and Drug Discovery (Susan Dana Jones and Peter G. Warren).
Appendix: Public-Domain Software Tools and Databases.
9. Using Drug Metabolism Databases During Drug Design and Development (Paul W. Erhardt).
10. Discovery of the Antiulcer Drug Tagamet (C. Robin Ganellin).
11. Discovery of Potent Nonpeptide Vasopressin Receptor Antagonists (Bruce E. Maryanoff).
12. Discovery and Development of the Ultrashort-Acting Analgesic Remifentanil (Paul L. Feldman).
13. Discovery and Development of Nevirapine (Karl Grozinger, John Proudfoot, and Karl Hargrave).
14. Applications of Nuclear Imaging in Drug Discovery and Development (John W. Babich and William C. Eckelman).
15. Polymeric Sequestrants as Nonabsorbed Human Therapeutics (Pradeep K. Dhal, Chad C. Huval, and S. Randall Holmes-Farley).
16. Botanical Immunomodulators and Chemoprotectants in Cancer Therapy (Bhushan Patwardhan, Sham Diwanay, and Manish Gautam).
Index.
