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Book SynopsisTrade Review"This book has grown since the first edition to maintain its standing as a comprehensive text (including 14 new chapters). Overall, this book provides all the essential knowledge on splenic pathology in one single resource. It is ideal for daily use as a reference but is also an excellent training resource for learners." ©Doody's Review Service, 2022, Anna B Owczarczyk, MD, PHD (University of Michigan Medical School) Doody's Score: 5 Stars!
Table of ContentsSECTION 1: HISTOLOGY, FUNCTION, AND DEVELOPMENT OF SPLEEN NORMAL HISTOLOGY 4 Introduction to Spleen Mohammad A. Vasef, MD and Jeremy C. Wallentine, MD 12 Imaging of Splenic Disorders Mohammad A. Vasef, MD 18 Handling, Processing, and Gross Pathology of Spleen Mohammad A. Vasef, MD 26 Fine-Needle Aspiration and Core Biopsy of Spleen Mohammad A. Vasef, MD 32 Immunohistochemistry of Spleen Aaron Auerbach, MD, MPH 40 Flow Cytometry Nadine Aguilera, MD 46 Molecular Techniques Nadine Aguilera, MD SECTION 2: NONNEOPLASTIC SPLENIC DISORDERS LYMPHOID HYPERPLASIA 54 Florid Follicular Hyperplasia Jeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH 56 Autoimmune Disease Nadine Aguilera, MD 62 HIV in Spleen Nadine Aguilera, MD 68 Castleman Disease Nadine Aguilera, MD 70 Marginal Zone Hyperplasia Jeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH GRANULOMATOUS LESIONS/DISORDERS 72 Lipogranulomas Jeffrey Vos, MD 78 Sarcoidosis Ellina Hall, DO and Aaron Auerbach, MD, MPH 82 Chronic Granulomatous Disease Aaron Auerbach, MD, MPH INFECTIONS 86 Mycobacteriosis Nadine Aguilera, MD 90 Selected Bacterial Infections Aaron Auerbach, MD, MPH 94 Candidiasis Aaron Auerbach, MD, MPH 96 Histoplasmosis Nadine Aguilera, MD 98 Cryptococcosis Nadine Aguilera, MD 100 Coccidioidomycosis Aaron Auerbach, MD, MPH 104 Pneumocystosis Aaron Auerbach, MD, MPH 108 Infectious Mononucleosis Nadine Aguilera, MD 112 Cytomegalovirus Infection Nadine Aguilera, MD 114 Herpes Simplex Virus Infection Aaron Auerbach, MD, MPH and Nadine Aguilera, MD 116 Echinococcosis Aaron Auerbach, MD, MPH 120 Malaria Nadine Aguilera, MD NONINFECTIOUS CYSTS 122 Epithelial Cyst Ellina Hall, DO and Aaron Auerbach, MD, MPH 124 False Cyst Ellina Hall, DO and Aaron Auerbach, MD, MPH NONNEOPLASTIC VASCULAR PROCESSES 126 Chronic Passive Congestion Ellina Hall, DO and Aaron Auerbach, MD, MPH 128 Infarct Jeffrey Vos, MD 136 Peliosis Ellina Hall, DO and Aaron Auerbach, MD, MPH 138 Sclerosing Angiomatoid Nodular Transformation Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD RED CELL DISORDERS 144 Sickle Cell Disease Aaron Auerbach, MD, MPH and Ellina Hall, DO 146 Thalassemia Nadine Aguilera, MD and Aaron Auerbach, MD, MPH 150 Hereditary Spherocytosis Nadine Aguilera, MD 152 Thrombotic Thrombocytopenic Purpura Aaron Auerbach, MD, MPH MISCELLANEOUS LESIONS/DISORDERS 158 Heterotaxy Syndromes Aaron Auerbach, MD, MPH 160 Congenital Splenic Abnormalities Nadine Aguilera, MD 164 Extramedullary Hematopoiesis Ellina Hall, DO and Aaron Auerbach, MD, MPH 166 Gamna-Gandy Bodies Nadine Aguilera, MD 168 Hemophagocytic Lymphohistiocytosis Nadine Aguilera, MD 174 Immune Thrombocytopenic Purpura Ellina Hall, DO and Aaron Auerbach, MD, MPH 178 Niemann-Pick Disease Meenakshi A. Nandedkar, MD and Nadine Aguilera, MD 184 Gaucher Disease Meenakshi A. Nandedkar, MD and Nadine Aguilera, MD 188 Sea-Blue (Ceroid) Histiocytosis Mohammad A. Vasef, MD 192 Gangliosidosis Lysosomal Disorder Mohammad A. Vasef, MD 194 Therapy Effect on Spleen Aaron Auerbach, MD, MPH 202 Traumatic and Nontraumatic Splenic Injuries Mohammad A. Vasef, MD SECTION 3: NEOPLASTIC SPLENIC DISORDERS BENIGN MESENCHYMAL LESIONS 208 Introduction to Vascular Lesions Nadine Aguilera, MD 210 Hemangioma Nadine Aguilera, MD 218 Lymphangioma Nadine Aguilera, MD 222 Littoral Cell Angioma Nadine Aguilera, MD 228 Inflammatory Pseudotumor Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 236 Postchemotherapy Histiocyte-Rich Pseudotumor of Spleen Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 242 Splenic Hamartoma Nadine Aguilera, MD 246 Myelolipoma Aaron Auerbach, MD, MPH MALIGNANT OR POTENTIALLY MALIGNANT MESENCHYMAL LESIONS 248 Angiosarcoma Nadine Aguilera, MD 256 Hemangioendothelioma Nadine Aguilera, MD 258 Kaposi Sarcoma Nadine Aguilera, MD 260 Leiomyosarcoma Aaron Auerbach, MD, MPH 266 Gastrointestinal Stromal Tumor Aaron Auerbach, MD, MPH 272 Follicular Dendritic Cell Sarcoma Aaron Auerbach, MD, MPH 280 Inflammatory Pseudotumor-Like Follicular Dendritic Cell Sarcoma Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 286 Langerhans Cell Histiocytosis Guanghua Wang, MD 292 Histiocytic Sarcoma Nadine Aguilera, MD LYMPHOMA 300 Introduction to Lymphoma Mohammad A. Vasef, MD 310 Splenic Marginal Zone Lymphoma Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD 318 Hairy Cell Leukemia Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 326 Hairy Cell Leukemia Variant Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 334 Lymphoplasmacytic Lymphoma Aaron Auerbach, MD, MPH 342 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 350 Follicular Lymphoma Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 358 Mantle Cell Lymphoma Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 366 Leukemic Nonnodal Mantle Cell Lymphoma Mohammad A. Vasef, MD 370 Splenic Diffuse Red Pulp B-Cell Lymphoma Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 376 B-Cell Prolymphocytic Leukemia Aaron Auerbach, MD, MPH and Nadine Aguilera, MD 378 Diffuse Large B-Cell Lymphoma Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 384 Fibrin-Associated Large B-Cell Lymphoma in Splenic False Cyst Mohammad A. Vasef, MD 390 T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Jeffrey Vos, MD 398 Burkitt Lymphoma Aaron Auerbach, MD, MPH 406 Classic Hodgkin Lymphoma Jeffrey Vos, MD 416 Nodular Lymphocyte-Predominant Hodgkin Lymphoma Aaron Auerbach, MD, MPH 426 Peripheral T-Cell Lymphoma, Unspecified Mohammad A. Vasef, MD 432 Hepatosplenic T-Cell Lymphoma Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 440 T-Cell Prolymphocytic Leukemia Mohammad A. Vasef, MD 448 T-Cell Large Granular Lymphocytic Leukemia Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD 456 Aggressive NK-Cell Leukemia Aaron Auerbach, MD, MPH 462 Transformation of Splenic Disorders Nadine Aguilera, MD LEUKEMIA 466 Acute Myeloid Leukemia Nadine Aguilera, MD 474 Lymphoblastic Leukemia/Lymphoma Nadine Aguilera, MD CHRONIC MYELOPROLIFERATIVE NEOPLASMS/MYELODYSPLASTIC SYNDROMES 480 Myeloproliferative Neoplasm Overview Nadine Aguilera, MD 482 Chronic Myeloid Leukemia, BCR::ABL1 Positive Nadine Aguilera, MD 488 Essential Thrombocythemia Jeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH 492 Polycythemia Vera Guanghua Wang, MD 496 Primary Myelofibrosis Jeffrey Vos, MD 506 Mastocytosis Mohammad A. Vasef, MD 514 Chronic Myelomonocytic Leukemia Mohammad A. Vasef, MD PLASMA CELL-ASSOCIATED DISORDERS 520 Amyloidosis Nadine Aguilera, MD 526 Heavy Chain Disease Aaron Auerbach, MD, MPH 530 Plasma Cell Myeloma/Plasmacytoma Nadine Aguilera, MD and Aaron Auerbach, MD, MPH METASTASIS 534 Metastatic Tumors Ellina Hall, DO and Aaron Auerbach, MD, MPH
