Description
Book SynopsisThis book describes both the technologies used in the discovery of melanoma biomarkers and the clinical application of these biomarkers for diagnosis and staging of disease, determination of prognosis, treatment planning, monitoring of response to therapy, identification of novel therapeutic targets and drug development. A broad range of biomarkers (DNA/chromosomal, mRNA, microRNA, mitochondrial DNA, epigenetic and protein) is outlined. As therapies for melanoma become increasingly more target specific, the identification, validation and use of biomarkers will invariably play a greater role in the management of patients with this disease. Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma is an essential resource for oncologists, dermatologists, dermatopathologists, general pathologists with an interest in melanoma, and melanoma researchers.
Trade ReviewFrom the reviews:
“This is a comprehensive overview of biomarkers as they relate to pathogenesis and clinical utility in the diagnosis, staging, and treatment of melanoma. … The audience is practitioners specializing in melanoma, including dermatologists, surgeons, and oncologists, as well as researchers in the field. … book broadly explores the role of molecular diagnostic techniques and specific biomarkers which may serve to facilitate more accurate diagnoses and identify early-stage melanoma patients with high risk for metastasis. … I highly recommend this book for melanoma clinicians and researchers.” (Susan M. Swetter, Doody’s Book Reviews, July, 2012)
Table of ContentsTable of Contents:
1. Introduction to Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma
Michael J. Murphy
2. Diagnostic and Prognostic Biomarkers in Melanoma: Current State of Play
Jochen Utikal, Jürgen C. Becker, and Selma Ugurel
3. Molecular Pathogenesis of Melanoma: Established and Novel Pathways
Paolo Antonio Ascierto, Maria Libera Ascierto, Mariaelena Capone, Zendee Elaba, Michael J. Murphy, and Giuseppe Palmieri
4. Staging of Melanoma
Zendee Elaba, Michael J. Murphy, Philip Kerr, and Jane M. Grant-Kels
5. Clinical and Histopathological Parameters in Melanoma
Cheryl Bilinski, Avery LaChance, and Michael J. Murphy
6. Genetic/Epigenetic Biomarkers: Distinction of Melanoma from Other Melanocytic Neoplasms
Minoru Takata
7. mRNA Biomarkers in Melanoma
Giovanna Chiorino and Maria Scatolini
8. Epigenetic Biomarkers in Melanoma
Suhu Liu, Suping Ren, Paul M. Howell Jr., and Adam I. Riker
9. microRNA Biomarkers in Melanoma
Jim Kozubek, Faseeha Altaf and Soheil S. Dadras
10. MicroRNAs as Biomarkers and Therapeutic Targets in Melanoma
Daniel W. Mueller, Anja K. Bosserhoff
11. Mitochondrial DNA Biomarkers in Melanoma
Mark L. Steinberg
12. Tissue-Based Protein Biomarkers in Melanoma: Immunohistochemistry: (A) Diagnosis
Steven J. Ohsie, Basil A. Horst, Alister Cochran, and Scott W. Binder
13. Tissue-Based Protein Biomarkers in Melanoma: Immunohistochemistry: (B) Prognostication
Basil A. Horst, Steven J. Ohsie, Alister Cochran, and Scott W. Binder
14. Tissue-Based Protein Biomarkers in Melanoma: Mass Spectrometry-Based Strategies
Michael J. Murphy, Karim Rezaul, and David K. Han
15. Serological Biomarkers in Melanoma
Mel Ziman, Michael Millward, Robert Pearce, and Mark Lee
16. Molecular Markers of Lymph Node Disease in Melanoma
Sandro Pasquali, Augustinus P.T. van der Ploeg, and Simone Mocellin
17. Melanoma Cell Propagation: Cancer Stem Cell, Clonal Evolution and Interconversion Models of Tumorigenicity
Qiuzhen Liu, Marianna Sabatino, David F. Stroncek, Ping Jin, Francesco M. Marincola, and Ena Wang
18. Surgical Management of Melanoma: Concept of Field Cancerization and Molecular Evaluation of Tissue Margins
Amanda Phelps and Michael J. Murphy
19. Chemotherapy for Melanoma
Hedwig Stanisz, Thomas Vogt, and Knuth Rass
20. Molecular-Targeted Therapy for Melanoma
Alessia E. Russo, Ylenia Bevelacqua, Andrea Marconi, Andrea Veronesi, and Massimo Libra
21. Anti-Angiogenesis Therapy for Melanoma
Roberta Ferraldeschi and Paul Lorigan
22. Immunological Biomarkers and Immunotherapy for Melanoma
Jochen T. Schaefer
23. Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma: An Overview
Ahmad A. Tarhini and John M. Kirkwood
