Description

Book Synopsis

Presents the Therapeutic Potential for Caspase Inhibitors: Present and Future



Caspases represent one of the most specific protease families described to date. These extremely important enzymes are crucial to the destruction of aberrant cells the body's self-protection mechanism for warding off the growth of abnormal cells, many of which can promote cancer. Design of Caspase Inhibitors as Potential Clinical Agents introduces cutting-edge evidence regarding caspases' role in pro-inflammatory responses. New research now shows that the inhibition of caspase function is a critical component for the treatment of many diseases, including:









  • Arthritic and neurological disorders






  • Lung disease






  • Hereditary fever syndromes






  • Inflammatory bowe

    Trade Review
    ... can be a valuable reference source for scientist and students dealing with the medicinal chemistry and chemical biology aspects of apoptosis, inflammation and related diseases. -Dr. Enrique Perez-Paya, Centro de Investigacion Principe Felipe and CSIC (Spain) in ChemMedChem 2009

    Table of Contents

    Mammalian Caspase Activation Pathways in Apoptosis and Inflammation. Role of Caspases in Inflammation-Driven Diseases. Role of Caspases in Apoptotic-Driven Indications. Kinetics and Catalytic Activity of Caspases. Nonpeptide Small Molecule Inhibitors of Caspases. Identification of Inflammatory Caspase Inhibitors. Identification of Apoptotic Caspase Inhibitors. Discovery of a First-in-Class Apoptotic Caspase Inhibitor. Emricasan (PF-03491390/IDN-6556). Novel Approaches to Caspase Inhibitor Discovery. Therapeutic Potential for Caspase Inhibitors: Present and Future. Index.

Design of Caspase Inhibitors as Potential

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    £204.25

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    RRP £215.00 – you save £10.75 (5%)

    Order before 4pm today for delivery by Mon 3 Aug 2026.

    A Hardback by Tom O'Brien, Steven D. Linton

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      Publisher: Taylor & Francis Inc
      Publication Date: Publication Date: 28/10/2008
      ISBN13: 9781420045406, 978-1420045406
      ISBN10: 1420045407

      Description

      Book Synopsis

      Presents the Therapeutic Potential for Caspase Inhibitors: Present and Future



      Caspases represent one of the most specific protease families described to date. These extremely important enzymes are crucial to the destruction of aberrant cells the body's self-protection mechanism for warding off the growth of abnormal cells, many of which can promote cancer. Design of Caspase Inhibitors as Potential Clinical Agents introduces cutting-edge evidence regarding caspases' role in pro-inflammatory responses. New research now shows that the inhibition of caspase function is a critical component for the treatment of many diseases, including:









      • Arthritic and neurological disorders






      • Lung disease






      • Hereditary fever syndromes






      • Inflammatory bowe

        Trade Review
        ... can be a valuable reference source for scientist and students dealing with the medicinal chemistry and chemical biology aspects of apoptosis, inflammation and related diseases. -Dr. Enrique Perez-Paya, Centro de Investigacion Principe Felipe and CSIC (Spain) in ChemMedChem 2009

        Table of Contents

        Mammalian Caspase Activation Pathways in Apoptosis and Inflammation. Role of Caspases in Inflammation-Driven Diseases. Role of Caspases in Apoptotic-Driven Indications. Kinetics and Catalytic Activity of Caspases. Nonpeptide Small Molecule Inhibitors of Caspases. Identification of Inflammatory Caspase Inhibitors. Identification of Apoptotic Caspase Inhibitors. Discovery of a First-in-Class Apoptotic Caspase Inhibitor. Emricasan (PF-03491390/IDN-6556). Novel Approaches to Caspase Inhibitor Discovery. Therapeutic Potential for Caspase Inhibitors: Present and Future. Index.

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