Description

Book Synopsis
In sequential clinical trials, data from patients treated at the beginning of a trial can be analyzed while the trial is still in progress and subsequent patients can be recruited. This analysis provides stopping rules whereby the number of patients involved can be limited without affecting the results.

Trade Review
"...This book is clear, it provides many details and is well written..." (Statistical Methods in Medical Research, No.11, 2002)

Table of Contents
Clinical Trials.

Allocating Patients to Treatments.

Measurement of Treatment Difference.

The Design of a Sequential Trial Using the Boundaries Approach.

The Analysis of a Sequential Trial.

Alternative Approaches to the Design and Analysis of Sequential Clinical Trials.

Prognostic Factors.

The Comparison of More than Two Treatments.

Implementation of Sequential Methods: Some Examples.

References.

Appendix.

Index.

Design Analysis of Sequentual 2e Statistics in

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      Book details

      Publisher John Wiley & Sons Inc
      Published 25 June 1997
      ISBN-13 9780471975502
      978-0471975502
      ISBN-10 0471975508
      Also in:
      Mathematics Epidemiology and Medical statistics

      Description

      Book Synopsis
      In sequential clinical trials, data from patients treated at the beginning of a trial can be analyzed while the trial is still in progress and subsequent patients can be recruited. This analysis provides stopping rules whereby the number of patients involved can be limited without affecting the results.

      Trade Review
      "...This book is clear, it provides many details and is well written..." (Statistical Methods in Medical Research, No.11, 2002)

      Table of Contents
      Clinical Trials.

      Allocating Patients to Treatments.

      Measurement of Treatment Difference.

      The Design of a Sequential Trial Using the Boundaries Approach.

      The Analysis of a Sequential Trial.

      Alternative Approaches to the Design and Analysis of Sequential Clinical Trials.

      Prognostic Factors.

      The Comparison of More than Two Treatments.

      Implementation of Sequential Methods: Some Examples.

      References.

      Appendix.

      Index.

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