Description
Book SynopsisCOMBINATORIAL CHEMISTRY AND MOLECULAR DIVERSITY IN DRUG DISCOVERY
Edited by Eric M. Gordon and James F. Kerwin, Jr.
Increasing pressure to identify, optimize, develop, and commercialize novel drugs more rapidly and more cost-effectively has led to an urgent demand for technologies that can reduce the time to market for new products. Molecular diversity, of both natural and synthetic materials, provides a valuable source of compounds for identifying and optimizing new drug leads. Through the rapidly evolving technology of combinatorial chemistry, it is now possible to produce libraries of small molecules to screen for novel bioactivities. This powerful new technology has begun to help pharmaceutical companies find new drug candidates quickly, save significant dollars in preclinical development costs, and ultimately change their fundamental approach to drug discovery.
Comprising the work of the leading authorities in the area of molecular diversity
Trade Review"This monograph does an excellent job summarizing many of the important aspects regarding the synthesis, manipulation, and screening of combinatorial molecules for pharmacological activity...The editors are to be commended on assembling an admirable resource..." (The Quarterly Review of Biology Vol. 76, No. 2, June 2001)
Table of ContentsPartial table of contents:
COMBINATORIAL CHEMISTRY AND MOLECULAR DIVERSITY: AN INTRODUCTION.
Historical Overview of the Developing Field of Molecular Diversity (J. Chabala, et al.).
Solid-Phase Peptide Synthesis, Lead Generation, and Optimization (B. Seligman, et al.).
Oligonucleotide Libraries as a Source of Molecular Diversity (H.-Y. Mei, et al.).
SMALL MOLECULAR LIBRARIES.
Protease Inhibitor Libraries (D. Patel & D. Campbell).
Scaffolds for Small Molecule Libraries (M. Pavia).
Encoded Combinatorial Chemistry (J. Jacobs & Z.-J. Ni).
Parallel Organic Synthesis in Array Format (S. Hall).
AUTOMATION, ANALYTICAL, AND COMPUTATIONAL METHODS.
Automation of Combinatorial Chemistry for Large Libraries (M. Needels & J. Sugarman).
Quantifying Diversity (Y. Martin, et al.).
BIOLOGICAL DIVERSITY.
Protein Scaffolds for Peptide Libraries (R. Hoess).
SCREENING.
Strategies for Screening Combinatorial Libraries (B. Beutel).
COMBINATORIAL DRUG SCREENING AND DEVELOPMENT.
Combinatorial Technologies: Prospects and Future Issues (J. Kerwin).
Appendix.
Index.
