Description
Book SynopsisThis is a comprehensive reference that includes the basic science, clinical features, imaging, pathology and treatment of specific viral entities affecting the central nervous system (CNS). It will assist professionals in their attempt to identify, examine and manage viral CNS infections and unravel the therapeutic and diagnostic challenges associated with viral CNS disorders.
Key Features
- Features MRI scans, histopathology and lined diagrams showing pathophysiology
- Much has happened in our understanding of CNS infections in recent years and a comprehensive book that covers the entire subject is much needed.
- There is ongoing interest in infectious disease. The increasing globalization of medicine is putting demands on many more people to become familiar with issues from around that world that they did not see in training.
Trade ReviewThis second edition is a wonderful comprehensive reference for practicing neurologists and infectious disease specialists when faced with patients afflicted with viral-mediated neurological syndromes. A significant upgrade from the first edition, this edition includes newer topics, including West Nile, Ebola, Zika, enterovirus D68, and SARS-CoV-2 viruses, as well as significant advances in methodologies of detection and treatment. Drs. Nath and Berger have provided a very broad coverage to this topic, reflecting their clinical and scientific background, keeping both the clinical and scientific practitioners in mind. This text holds its own as a solidly comprehensive reference text for clinicians, including neurologists and infectious disease specialists, as well as for the immunologist and clinical scientist involved in the pathophysiology of virally mediated neurological illnesses. The editors are well-renowned neuroinfectious specialists in theirnfield who have sought experts from around the world to help contribute chapters to this text. There is a lack of textbooks in this area, and having an authoritative work helps the field progress further, especially with the advances made since the last edition was published in 2003.
Ali A Saherwala, MD(Thomas Jefferson University)
Table of ContentsINTRODUCTION: EPIDEMIOLOGY, SOCIOECONOMIC IMPACT, AND CHALLENGES AHEAD. Introduction to virus structure, classification, replication, and hosts. Neuropathogenesis of viral infections. An approach to pathogen discovery for viral infections of the nervous system. Neuropathology of CNS viral infections and the role of brain biopsy in the diagnosis. DNA VIRUSES. Herpes simplex viruses. Varicella zoster virus infection. Epstein–Barr virus and the nervous system. Cytomegalovirus. Progressive multifocal leukoencephalopathy. Adenovirus. RETROVIRUSES. HIV neurological complications. Human T lymphotropic virus type 1 (HTLV-1). RNA VIRUSES. Rabies and other lyssaviruses. Neurological manifestations of West Nile virus. Chikungunya virus and Japanese encephalitis virus. Arthropod-borne virus encephalitis. Enteroviruses. Measles and its neurological complications. Rubella. Influenza neurologic complications. Nipah encephalitis, a fatal encephalitis with bats as reservoir. MISCELLANEOUS. Von Economo’s encephalitis. Neurological events following immunizations. Central nervous system viral infections complicating immunosuppression. Post-viral syndromes. Viral neuro-oncogenesis: Polyomaviruses and brain tumors. Autoimmune disorders that can be mistaken for viral illness. Antiviral therapeutics for viral infections of the central nervous system. Neurological manifestations of coronavirus infections
