Description
Book SynopsisThis book is a critical appraisal of the data and evidence available in literature of the relative roles of the immune response to neoplastic cells. An attempt has been made to render a better understanding of the various modes of impact of the immune response against tumors in general, particularly gliomas in some of the chapters. Autoimmune response is one mode of reactivity to native component cells within the body. Neoplastic transformation, on the other hand, critically necessitated the absence of an effective immune response to the transformed tumor cells in order for the lesion to grow and metastasize. This book is aimed towards a wider readership, but its particularly for oncologists and the various clinical and academic professionals that care for patients with cancer. It is especially meant to provide a clear exposition of known facts regarding the genesis and further development of neoplasms. Examples of some of the commoner lesions are accounted for.
Table of ContentsPreface; Predetermined Interplay of the Projected Malignant Transformation Step as Injury Non-Resolution; Systems of Active Immune Suppression as Integral Malignant Transformation in Infiltrating Glioma Cells; Systems of Failure of Immune Response to Early Carcinogenesis Recharacterize Such Early Carcinogenesis; Mirror Images of Geometric Pre-Setting of the Infiltrating Edges of High-Grade Gliomas; Failed Tumor Immuno-Antigenicity Is Expressed Suppression of an Autoimmunity in Defining Immune Privilege Status of the Lesion; Complex Effectiveness of General Immunity in Modulating the Specific Immune Response in Gliomas; Systems of Malignant Transformation as Integral Immune Nonresponse in Gliomagenesis; Immunodominance as Complex Patterned Interplay of Antigen Quantitation Phenomena in Pressure Immunity; Systems of Unstable Immunodominance of Antigen as Formulas for Central Immunosuppression in Tumor Cell Expansion; Failed Immunosurveillance as Failed Dendritic Cell Antigen PresentationSubstitution of Specific Tumor Antigenicity by Differentiation Associated Antigenicity; Projected Receptivity of Integral Gliomas to Malignant Transformation as Modeled by Dysfunctional Immunomodulation; Tumor Cell Identity as Projected by Immunotoxins within Heterogeneity and Hierarchical Systems of Progression; Dimensions of Reproducible Malignant Transformation as Brain Infiltration by Glioma; Infiltrativeness Attributes Project Schemes of Etiology and Pathogenesis in Sequential Malignant Transformations in Given Individual; Progressively Persistent Tumor Cell Growth and Recurrence and Spread as Interplay Dynamics between Individual Neoplastic Cells; Non-Response of the Immune System as Active Participant in Glioma Cell Genesis, Proliferation, and Spread in Normal Brain Tissues; Pathways of Non-Resolution in Targeting Tumor Cells by the Immune Response; Tumor Cell Antigenicity as Performance Hierarchy of Equilibrating Interactivity of Systems of Receptivity and Activation of Lymphocyte Subsets; Systems of Primary Regional Reformation in Tumor Origin and Mechanics: Regional versus Field Operability; Formulation of an Integral Antitumor Immune Response; Systems of Weak Immunogenicity as Originators of Early Spread and of Incremental Tumor Cell Growth and Proliferation; Index.
