Description
Book SynopsisThis book covers important advances in enzymology, explaining the behavior of enzymes and how they can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. Advances in Enzymology focuses on enzymes, the primary catalysts of life processes. The explanation of the behavior of enzymes can be found via studies of their chemical mechanisms and can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. The transglutaminases, first described in 1957, are a large, widely-distributed family of enzymes canonically responsible for the amidation/transamidation of protein side chains. The extraordinary diversity of names associated with various enzymatic activities now recognized and aggregated as transglutaminase bears witness to the remarkable diversity of biological roles associated with the activity, including myriad human diseases.
Table of ContentsContributors vii
Preface ix
Structure and Regulation of Type 2 Transglutaminase in Relation to Its Physiological Functions and Pathological Roles 1
Carlo M. Bergamini, Russell J. Collighan, Zhuo Wang, and Martin Griffin
Physiopathological Roles of Human Transglutaminase 2 47
Vittorio Gentile
Transglutaminase in Epidermis and Neurological Disease or What Makes a Good Cross-Linking Substrate 97
Guylaine Hoffner, Amandine VanHoutteghem, William Andre, and Philippe Djian
Transglutaminase 2: A New Paradigm for NF-B Involvement in Disease 161
Soo-Youl Kim
Transglutaminase 2 At the Crossroads between Cell Death and Survival 197
Mauro Piacentini, Manuela D’Eletto, Laura Falasca, Maria Grazia Farrace, and Carlo Rodolfo
Tissue Transglutaminase and Its Role in Human Cancer Progression 247
Bo Li, Richard A. Cerione, and Marc Antonyak
Transglutaminase 2 Dysfunctions in the Development of Autoimmune Disorders: Celiac Disease and TG2−/−Mouse 295
Zsuzsa Szondy, Ilma Korponay-Szabo, Robert Kiraly, and Laszlo Fesus
Effects and Analysis of Transglutamination on Protein Aggregation and Clearance in Neurodegenerative Diseases 347
Zoltan Nemes
Transglutaminase-Mediated Remodeling of the Human Erythrocyte Membrane Skeleton: Relevance for Erythrocyte Diseases with Shortened Cell Lifespan 385
Laszlo Lorand, S. N. Prasanna Murthy, Anwar A. Khan, Weihua XUE, Oksana Lockridge, and Athar H. Chishti
Irreversible Inhibitors of Tissue Transglutaminase 415
Jeffrey W. Keillor, Nicolas Chabot, Isabelle Roy, Amina Mulani, Olivier Leogane, and Christophe Pardin
Methionine Adenosyltransferase (S-Adenosylmethionine Synthetase) 449
Marıa A. Pajares and George D. Markham
Index 523
