Description
Book SynopsisOffers a comprehensive and interdisciplinary view of the research on advanced materials for healthcare technology and applications. This book summarizes the state of knowledge in the field of advanced materials for functional therapeutics, point-of-care diagnostics, translational materials, and up-and-coming bioengineering devices.
Trade Review“Although they claim in the Preface that this book is written for university students and researchers from diverse backgrounds, I believe having read the majority of the scientific aspects of the work it really expects the reader to have a very thorough knowledge of polymer chemistry at the nanometer level of particle or pore size and suggest this book is aimed at the researchers in the pharmaceutical industry or academics in pharmaceutical chemistry research rather than researchers into biomaterials.” (Scope, 1 February 2014)
Table of ContentsPreface xvii
1 Stimuli-Responsive Smart Nanoparticles for Biomedical Application 1
Arnab De, Sushil Mishra and Subho Mozumdar
1.1 A Brief Overview of Nanotechnology 2
1.2 Nanoparticulate Delivery Systems 3
1.3 Delivery Systems 4
1.4 Polymers for Nanoparticle Synthesis 11
1.5 Synthesis of Nanovehicles 15
1.6 Dispersion of Preformed Polymers 16
1.7 Emulsion Polymerization 20
1.8 Purification of Nanoparticle 22
1.9 Drying of Nanoparticles 24
1.10 Drug Loading 25
1.11 Drug Release 26
1.12 Conclusion 27
References 27
2 Diagnosis and Treatment of Cancer—Where We Are and Where We Have to Go! 35
Rajiv Lochan Gaur and Richa Srivastava
2.1 Cancer Pathology 36
2.2 Cancer Diagnosis 37
2.3 Treatment 41
Conclusion 42
References 42
3 Advanced Materials for Biomedical Application and Drug Delivery 47
Salam J.J. Titinchi, Mayank P. Singh, Hanna S. Abbo and Ivan R. Green
3.1 Introduction 48
3.2 Anticancer Drug Entrapped Zeolite Structures as Drug Delivery Systems 48
3.3 Mesoporous Silica Nanoparticles and Multifunctional Magnetic Nanoparticles in Biomedical Applications 52
3.4 BioMOFs: Metal-Organic Frameworks for Biological and Medical Applications 64
3.5 Conclusions 75
References 75
4 Nanoparticles for Diagnosis and/or Treatment of Alzheimer’s Disease 85
S.G. Antimisiaris, S. Mourtas, E. Markoutsa, A. Skouras, and K. Papadia
4.1 Introduction 85
4.2 Nanoparticles 86
4.3 Physiological Factors Related with Brain-Located Pathologies: Focus on AD 96
4.4 Current Methodologies to Target AD-Related Pathologies 110
4.5 Nanoparticles for Diagnosis of AD 136
4.6 Nanoparticles for Therapy of AD 146
4.7 Summary of Current Progress and Future Challenges 160
Acknowledgments 161
References 161
5 Novel Biomaterials for Human Health: Hemocompatible Polymeric Micro-and Nanoparticles and Their Application in Biosensor 179
Chong Sun, Xiaobo Wang, Chun Mao and Jian Shen
5.1 Introduction 179
5.2 Design and Preparation of Hemocompatible Polymeric Micro- and Nanoparticles 181
5.3 The Biosafety and Hemocompatibility Evaluation System for Polymeric Micro- and Nanoparticles 183
5.4 Construction of Biosensor for Direct Detection in Whole Blood 188
5.5 Conclusion and Prospect 194
References 195
6 The Contribution of Smart Materials and Advanced Clinical Diagnostic Micro-Devices on the Progress and Improvement of Human Health Care 199
Teles, F.R.R. and Fonseca, L.P.
6.1 Introduction 200
6.2 Physiological Biomarkers as Targets in Clinical Diagnostic Bioassays 202
6.3 Biosensors 205
6.4 Advanced Materials and Nanostructures for Health Care Applications 217
6.5 Applications of Micro-Devices to Some Important Clinical Pathologies 223
6.6 Conclusions and Future Prospects 227
Acknowledgment 227
References 228
7 Hierarchical Modeling of Elastic Behavior of Human Dental Tissue Based on Synchrotron Diffraction Characterization 233
TanSui and Alexander M. Korsunsky
7.1 Introduction 233
7.2 Experimental Techniques 236
7.3 Model Formulation 238
7.4 Experimental Results and Model Validation 245
7.5 Discussion 251
7.6 Conclusions 255
Acknowledgments 256
Appendix 256
References 260
8 Biodegradable Porous Hydrogels 263
Martin Pradny, Miroslav Vetrik, Martin Hruby and Jiri Michalek
8.1 Introduction 263
8.2 Methods of Preparation of Porous Hydrogels 265
8.3 Hydrogels Crosslinked With Degradable Crosslinkers 271
8.4 Hydrogels Degradable in the Main Chain 276
8.5 Conclusions 281
Acknowledgments 281
References 283
9 Hydrogels: Properties, Preparation, Characterization and Biomedical Applications in Tissue Engineering, Drug Delivery and Wound Care 289
Mohammad Sirousazar, Mehrdad Forough, Khalil Farhadi, Yasaman Shaabani and Rahim Molaei
9.1 Introduction 289
9.2 Types of Hydrogels 290
9.3 Properties of Hydrogels 295
9.4 Preparation Methods of Hydrogels 299
9.5 Characterization of Hydrogels 305
9.6 Biomedical Applications of Hydrogels 308
9.7 Hydrogels for Wound Management 319
9.8 Recent Developments on Hydrogels 337
9.9 Conclusions 340
References 341
10 Modified Natural Zeolites—Functional Characterization and Biomedical Application 353
Jela Miliæ, Aleksandra Dakoviæ, Danina Krajišnik and George E. Rottinghaus
10.1 Introduction 354
10.2 Surfactant Modified Zeolites (SMZs) 359
10.3 Minerals as Pharmaceutical Excipients 366
10.4 SMZs for Pharmaceutical Application 372
10.5 Conclusions 389
Acknowledgement 390
References 390
11 Supramolecular Hydrogels Based on Cyclodextrin Poly(Pseudo)Rotaxane for New and Emerging Biomedical Applications 397
JinHuang, Jing Hao, Debbie P. Anderson and Peter R. Chang
11.1 Introduction 398
11.2 Fabrication of Cyclodextrin Poly(pseudo)rotaxane-Based Hydrogels 400
11.3 Stimulus-Response Properties of Cyclodextrin Poly(pseudo)rotaxane Based Hydrogels 409
11.4 Nanocomposite Supramolecular Hydrogels 413
11.5 Biomedical Application of Cyclodextrin Poly(pseudo)rotaxane-Based Hydrogels 420
11.6 Conclusions and Prospects 425
References 425
12 Polyhydroxyalkanoate-Based Biomaterials for Applicationsin Biomedical Engineering 431
Chenghao Zhu and Qizhi Chen
12.1 Introduction
12.2 Synthesis of PHAs 433
12.3 Processing and its Influence on the Mechanical Properties of PHAs 435
12.4 Mechanical Properties of PHA Sheets/Films 436
12.5 PHA-Based Polymer Blends 439
12.6 Summary 451
References 451
13 Biomimetic Molecularly Imprinted Polymers as Smart Materials and Future Perspective in Health Care 457
Mohammad Reza Ganjali, Farnoush Faridbod and Parviz Norouzi
13.1 Molecularly Imprinted Polymer Technology 458
13.2 Synthesis of MIPs 458
13.3 Application of MIPs 463
13.4 Biomimetic Molecules 464
13.5 MIPs as Receptors in Bio-Molecular Recognition 465
13.6 MIPs as Sensing Elements in Sensors/Biosensors 466
13.7 MIPs as Drug Delivery Systems 467
13.8 MIPs as Sorbent Materials in Separation Science 475
13.9 Future Perspective of MIP Technologies 480
13.10 Conclusion 480
References 480
14 The Role of Immunoassays in Urine Drug Screening 485
Niina J. Ronkainen and Stanley L. Okon
14.1 Introduction 486
14.2 Urine and Other Biological Specimens 489
14.3 Immunoassays 491
14.4 Drug Screening with Immunoassays 504
14.5 Immunoassay Specificity: False Negative and False Positive Test Results 507
14.6 Confirmatory Secondary Testing Using Chromatography Instruments 510
Conclusion 513
References
